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Items: 1 to 20 of 64

1.
IRAK4 is an immunological checkpoint in neuropsychiatric systemic lupus erythematosus
Antoine Ménoret, Federica Agliano, Timofey A. Karginov, Xiangyou Hu, Anthony T. Vella
Sci Rep. 2024; 14: 16393. Published online 2024 Jul 16. doi: 10.1038/s41598-024-63567-x
PMCID:
PMC11252422
AbstractArticlePDF–1.9M
2.
IRAK4 signaling drives resistance to checkpoint immunotherapy in pancreatic ductal adenocarcinoma
Vikas Somani, Daoxiang Zhang, Paarth B. Dodhiawala, Varintra E. Lander, Xiuting Liu, Liang-I Kang, Hung-Po Chen, Brett L. Knolhoff, Lin Li, Patrick M. Grierson, Mariana B. Ruzinova, David G. DeNardo, Kian-Huat Lim
Gastroenterology. Author manuscript; available in PMC 2023 Jun 1.
Published in final edited form as: Gastroenterology. 2022 Jun; 162(7): 2047–2062. Published online 2022 Mar 7. doi: 10.1053/j.gastro.2022.02.035
PMCID:
PMC9387774
AbstractArticlePDF–3.2M
3.
Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion
Alexandre Picard, Xavier Berney, Judit Castillo-Armengol, David Tarussio, Maxime Jan, Ana Rodriguez Sanchez-Archidona, Sophie Croizier, Bernard Thorens
Mol Metab. 2022 Jul; 61: 101479. Published online 2022 Mar 24. doi: 10.1016/j.molmet.2022.101479
PMCID:
PMC9046887
AbstractArticlePDF–2.7M
4.
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors
Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe, Soji Morishita, Misa Imai, Masayoshi Nagata, Marito Araki, Hitoshi Takizawa, Tomofusa Fukuyama, Chrystelle Lamagna, Esteban S. Masuda, Ryoji Ito, Susumu Goyama, Norio Komatsu, Tomoiku Takaku, Toshio Kitamura
Nat Commun. 2022; 13: 271. Published online 2022 Jan 12. doi: 10.1038/s41467-021-27928-8
PMCID:
PMC8755781
AbstractArticlePDF–2.4M
5.
MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling
Rafael Deliz-Aguirre, Fakun Cao, Fenja H.U. Gerpott, Nichanok Auevechanichkul, Mariam Chupanova, YeVin Mun, Elke Ziska, Marcus J. Taylor
J Cell Biol. 2021 Jul 5; 220(7): e202012071. Published online 2021 May 6. doi: 10.1083/jcb.202012071
PMCID:
PMC8105725
AbstractArticlePDF–8.7M
6.
Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins
Sirish K. Ippagunta, Julie A. Pollock, Naina Sharma, Wenwei Lin, Taosheng Chen, Kazuki Tawaratsumida, Anthony A. High, Jaeki Min, Yizhe Chen, R. Kiplin Guy, Vanessa Redecke, John A. Katzenellenbogen, Hans Häcker
Sci Signal. Author manuscript; available in PMC 2020 May 2.
Published in final edited form as: Sci Signal. 2018 Aug 14; 11(543): eaaq1077. Published online 2018 Aug 14. doi: 10.1126/scisignal.aaq1077
PMCID:
PMC7195875
AbstractArticlePDF–1.7M
7.
IRAK4 mediates colitis-induced tumorigenesis and chemoresistance in colorectal cancer
Qiong Li, Yali Chen, Daoxiang Zhang, Julie Grossman, Lin Li, Namrata Khurana, Hongmei Jiang, Patrick M. Grierson, John Herndon, David G. DeNardo, Grant A. Challen, Jingxia Liu, Marianna B. Ruzinova, Ryan C. Fields, Kian-Huat Lim
JCI Insight. 2019 Oct 3; 4(19): e130867. Published online 2019 Oct 3. doi: 10.1172/jci.insight.130867
PMCID:
PMC6795411
AbstractArticlePDF–18M
8.
Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling
Dominic De Nardo, Katherine R. Balka, Yamel Cardona Gloria, Vikram R. Rao, Eicke Latz, Seth L. Masters
J Biol Chem. 2018 Sep 28; 293(39): 15195–15207. Published online 2018 Aug 3. doi: 10.1074/jbc.RA118.003314
PMCID:
PMC6166714
AbstractArticlePDF–2.2M
9.
IRAK4 Activity Controls Immune Responses to Intracellular Bacteria Listeria monocytogenes and Mycobacterium smegmatis
Goutham Pattabiraman, Michael Murphy, Federica Agliano, Keaton Karlinsey, Andrei E. Medvedev
J Leukoc Biol. Author manuscript; available in PMC 2019 Oct 1.
Published in final edited form as: J Leukoc Biol. 2018 Oct; 104(4): 811–820. Published online 2018 May 11. doi: 10.1002/JLB.2A1117-449R
PMCID:
PMC6162151
AbstractArticlePDF–1.0M
10.
Deficiency in Interleukin-1 receptor-associated kinase (IRAK) 4 activity attenuates manifestations of murine Lupus
Michael Murphy, Goutham Pattabiraman, Tissa T. Manavalan, Andrei E. Medvedev
Eur J Immunol. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Eur J Immunol. 2017 May; 47(5): 880–891. Published online 2017 Mar 31. doi: 10.1002/eji.201646641
PMCID:
PMC5575829
AbstractArticlePDF–1.3M
11.
An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-Like Receptor Signaling
Philipp Mertins, Dariusz Przybylski, Nir Yosef, Jana Qiao, Karl Clauser, Raktima Raychowdhury, Thomas M. Eisenhaure, Tanja Maritzen, Volker Haucke, Takashi Satoh, Shizuo Akira, Steven A. Carr, Aviv Regev, Nir Hacohen, Nicolas Chevrier
Cell Rep. Author manuscript; available in PMC 2017 Aug 10.
Published in final edited form as: Cell Rep. 2017 Jun 27; 19(13): 2853–2866. doi: 10.1016/j.celrep.2017.06.016
PMCID:
PMC5551420
AbstractArticlePDF–4.1M
12.
Comprehensive siRNA-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use
Jing Sun, Ning Li, Kyu-Seon Oh, Bhaskar Dutta, Sharat J. Vayttaden, Bin Lin, Thomas S. Ebert, Dominic De Nardo, Joie Davis, Rustam Bagirzadeh, Nicolas W. Lounsbury, Chandrashekhar Pasare, Eicke Latz, Veit Hornung, Iain D. C. Fraser
Sci Signal. Author manuscript; available in PMC 2017 Apr 5.
Published in final edited form as: Sci Signal. 2016 Jan 5; 9(409): ra3. Published online 2016 Jan 5. doi: 10.1126/scisignal.aab2191
PMCID:
PMC5381726
AbstractArticlePDF–1.5M
13.
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase
Beezly S Groh, Feng Yan, Matthew D Smith, Yanbao Yu, Xian Chen, Yue Xiong
EMBO Rep. 2016 May; 17(5): 638–647. Published online 2016 Apr 9. doi: 10.15252/embr.201540500
PMCID:
PMC5341520
AbstractArticlePDF–1.1M
14.
IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice
Jin Huk Choi, Kuan-wen Wang, Duanwu Zhang, Xiaowei Zhan, Tao Wang, Chun-Hui Bu, Cassie L. Behrendt, Ming Zeng, Ying Wang, Takuma Misawa, Xiaohong Li, Miao Tang, Xiaoming Zhan, Lindsay Scott, Sara Hildebrand, Anne R. Murray, Eva Marie Y. Moresco, Lora V. Hooper, Bruce Beutler
Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7): E1196–E1204. Published online 2017 Jan 30. doi: 10.1073/pnas.1621258114
PMCID:
PMC5321007
AbstractArticlePDF–1.1M
15.
Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation
Sarah J. Mancini, Anna D. White, Silvia Bijland, Claire Rutherford, Delyth Graham, Erik A. Richter, Benoit Viollet, Rhian M. Touyz, Timothy M. Palmer, Ian P. Salt
Mol Cell Endocrinol. 2017 Jan 15; 440: 44–56. doi: 10.1016/j.mce.2016.11.010
PMCID:
PMC5228585
AbstractArticlePDF–2.6M
16.
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury
Irina A. Leaf, Shunsaku Nakagawa, Bryce G. Johnson, Jin Joo Cha, Kristen Mittelsteadt, Kevin M. Guckian, Ivan G. Gomez, William A. Altemeier, Jeremy S. Duffield
J Clin Invest. 2017 Jan 3; 127(1): 321–334. Published online 2016 Nov 21. doi: 10.1172/JCI87532
PMCID:
PMC5199713
AbstractArticlePDF–3.3M
17.
Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1
Sambit K. Nanda, Marta Lopez-Pelaez, J. Simon C. Arthur, Francesco Marchesi, Philip Cohen
J Immunol. 2016 Dec 1; 197(11): 4266–4273. Published online 2016 Nov 2. doi: 10.4049/jimmunol.1600788
PMCID:
PMC5114882
AbstractArticlePDF–1.9M
18.
TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS
Ying Wang, Lijing Su, Matthew D. Morin, Brian T. Jones, Landon R. Whitby, Murali M. R. P. Surakattula, Hua Huang, Hexin Shi, Jin Huk Choi, Kuan-wen Wang, Eva Marie Y. Moresco, Michael Berger, Xiaoming Zhan, Hong Zhang, Dale L. Boger, Bruce Beutler
Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7): E884–E893. Published online 2016 Feb 1. doi: 10.1073/pnas.1525639113
Correction in:
Proc Natl Acad Sci U S A. 2016 Apr 5; 113(14): E2096.
Correction in:
Proc Natl Acad Sci U S A. 2021 Jun 15; 118(24): e2106360118.
PMCID:
PMC4763747
AbstractArticlePDF–1.8M
19.
IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms
Lukas F. Mager, Carsten Riether, Christian M. Schürch, Yara Banz, Marie-Hélène Wasmer, Regula Stuber, Alexandre P. Theocharides, Xiaohong Li, Yu Xia, Hirohisa Saito, Susumu Nakae, Gabriela M. Baerlocher, Markus G. Manz, Kathy D. McCoy, Andrew J. Macpherson, Adrian F. Ochsenbein, Bruce Beutler, Philippe Krebs
J Clin Invest. 2015 Jul 1; 125(7): 2579–2591. Published online 2015 May 26. doi: 10.1172/JCI77347
PMCID:
PMC4563674
AbstractArticlePDF–3.4M
20.
Effects of PMA (PHORBOL-12-MYRISTATE-13-ACETATE) on the Developing Rodent Brain
Mark Dzietko, Maria Hahnemann, Oliver Polley, Marco Sifringer, Ursula Felderhoff-Mueser, Christoph Bührer
Biomed Res Int. 2015; 2015: 318306. Published online 2015 Mar 30. doi: 10.1155/2015/318306
PMCID:
PMC4396138
AbstractArticlePDF–2.0M

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