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Select item 111717661.

NLRX1 Mediates the Disruption of Intestinal Mucosal Function Caused by Porcine Astrovirus Infection via the Extracellular Regulated Protein Kinases/Myosin Light–Chain Kinase (ERK/MLCK) Pathway

Jie Tao, Jinghua Cheng, Ying Shi, Benqiang Li, Pan Tang, Jiajie Jiao, Huili Liu

Cells. 2024 Jun; 13(11): 913. Published online 2024 May 25. doi: 10.3390/cells13110913

PMCID:: PMC11171766

Abstract Article PDF–2.0M

Select item 108374822.

NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy

Paul Y. Bi, Samuel A. Killackey, Linus Schweizer, Stephen E. Girardin

Biomed J. 2024 Feb; 47(1): 100635. Published online 2023 Aug 11. doi: 10.1016/j.bj.2023.100635

PMCID:: PMC10837482

Abstract Article PDF–1.3M

Select item 104613773.

NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells

Qian Jiao, Wenxiong Xu, Xiaoyan Guo, Huiyuan Liu, Baolin Liao, Xiang Zhu, Chuming Chen, Fangji Yang, Lina Wu, Chan Xie, Liang Peng

Sci Prog. 2021 Oct-Dec; 104(4): 00368504211058036. Published online 2021 Nov 26. doi: 10.1177/00368504211058036

PMCID:: PMC10461377

Abstract Article PDF–2.8M

Select item 100729064.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 99501835.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 92626146.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 92456487.

Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation

Yan-Ran Xu, Meng-Ling Shi, Yu Zhang, Na Kong, Cong Wang, Yi-Feng Xiao, Shi-Shen Du, Qi-Yun Zhu, Cao-Qi Lei

Proc Natl Acad Sci U S A. 2022 Jun 28; 119(26): e2122805119. Published online 2022 Jun 21. doi: 10.1073/pnas.2122805119

PMCID:: PMC9245648

Abstract Article PDF–2.6M

Select item 91052358.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 85911399.

Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific

Bridget Kastelberg, Tariq Ayubi, Nuria Tubau-Juni, Andrew Leber, Raquel Hontecillas, Josep Bassaganya-Riera, Shiv D. Kale

Front Immunol. 2021; 12: 749504. Published online 2021 Nov 1. doi: 10.3389/fimmu.2021.749504

PMCID:: PMC8591139

Abstract Article PDF–8.1M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 803496111.

Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury

Bin He, Wei Chen, Jingsong Zeng, Wusong Tong, Ping Zheng

Aging (Albany NY) 2021 Mar 31; 13(6): 8127–8145. Published online 2021 Mar 3. doi: 10.18632/aging.202618

PMCID:: PMC8034961

Abstract Article PDF–2.3M

Select item 786581112.

Focusing on the Cell Type Specific Regulatory Actions of NLRX1

Tünde Fekete, Dóra Bencze, Eduárd Bíró, Szilvia Benkő, Kitti Pázmándi

Int J Mol Sci. 2021 Feb; 22(3): 1316. Published online 2021 Jan 28. doi: 10.3390/ijms22031316

PMCID:: PMC7865811

Abstract Article PDF–4.7M

Select item 775950313.

NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart

Hong Zhang, Yang Xiao, Rianne Nederlof, Diane Bakker, Pengbo Zhang, Stephen E. Girardin, Markus W. Hollmann, Nina C. Weber, Sander M. Houten, Michel van Weeghel, Richard G. Kibbey, Coert J. Zuurbier

Front Immunol. 2020; 11: 591815. Published online 2020 Dec 11. doi: 10.3389/fimmu.2020.591815

PMCID:: PMC7759503

Abstract Article PDF–1.6M

Select item 774654814.

Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism

Tiia Snäkä, Nicolas Fasel

Front Cell Infect Microbiol. 2020; 10: 609812. Published online 2020 Dec 4. doi: 10.3389/fcimb.2020.609812

PMCID:: PMC7746548

Abstract Article PDF–2.4M

Select item 737208115.

Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding

Duc T. Tran, Anita Pottekat, Saiful A. Mir, Salvatore Loguercio, Insook Jang, Alexandre Rosa Campos, Kathleen M. Scully, Reyhaneh Lahmy, Ming Liu, Peter Arvan, William E. Balch, Randal J. Kaufman, Pamela Itkin-Ansari

Diabetes. 2020 Aug; 69(8): 1723–1734. Published online 2020 May 26. doi: 10.2337/db20-0245

PMCID:: PMC7372081

Abstract Article PDF–2.0M

Select item 732206716.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 725494117.

MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells

Hanrong Xu, Liefeng Ji, Chunhua Yu, Qiming Chen, Qiangqiang Ge, Yinjiang Lu

Med Sci Monit. 2020; 26: e922497-1–e922497-9. Prepublished online 2020 Mar 27. Published online 2020 May 18. doi: 10.12659/MSM.922497

PMCID:: PMC7254941

Abstract Article PDF–1.0M

Select item 710891118.

HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING

Xiaobo Luo, Christopher R. Donnelly, Wang Gong, Blake R. Heath, Yuning Hao, Lorenza A. Donnelly, Toktam Moghbeli, Yee Sun Tan, Xin Lin, Emily Bellile, Benjamin A. Kansy, Thomas E. Carey, J. Chad Brenner, Lei Cheng, Peter J. Polverini, Meredith A. Morgan, Haitao Wen, Mark E. Prince, Robert L. Ferris, Yuying Xie, Simon Young, Gregory T. Wolf, Qianming Chen, Yu L. Lei

J Clin Invest. 2020 Apr 1; 130(4): 1635–1652. Published online 2020 Feb 24. doi: 10.1172/JCI129497

PMCID:: PMC7108911

Abstract Article PDF–5.4M

Select item 676221519.

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity

Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D. Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, Véronique Blais, Louis Gendron, Carles Vilariño-Güell, A. Dessa Sadovnick, Jenny P. Ting, Peter A. Calabresi, Abdelaziz Amrani, Denis Gris

PLoS Biol. 2019 Sep; 17(9): e3000451. Published online 2019 Sep 16. doi: 10.1371/journal.pbio.3000451

PMCID:: PMC6762215

Abstract Article PDF–4.3M

Select item 624698020.

NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1–UVRAG Complex

Chihiro Aikawa, Shintaro Nakajima, Miho Karimine, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Shunsuke Yamada, Ichiro Nakagawa

Front Cell Infect Microbiol. 2018; 8: 403. Published online 2018 Nov 14. doi: 10.3389/fcimb.2018.00403

PMCID:: PMC6246980

Abstract Article PDF–3.3M

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