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Select item 94778451.

Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis

Chao Lu, Pengyun Qiao, Ruihai Fu, Yadi Wang, Jiayi Lu, Xi Ling, Lu Liu, Yujun Sun, Chune Ren, Zhenhai Yu

Cell Death Dis. 2022 Sep; 13(9): 790. Published online 2022 Sep 15. doi: 10.1038/s41419-022-05241-6

Correction in:: Cell Death Dis. 2024 Jul; 15(7): 469.

PMCID:: PMC9477845

Abstract Article PDF–12M

Select item 93383132.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 89473613.

Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28

Rachel K. Toth, Regina Solomon, Noel A. Warfel

Cells. 2022 Mar; 11(6): 1006. Published online 2022 Mar 16. doi: 10.3390/cells11061006

PMCID:: PMC8947361

Abstract Article PDF–2.4M

Select item 89336994.

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation

Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein

J Biol Chem. 2022 Apr; 298(4): 101750. Published online 2022 Feb 23. doi: 10.1016/j.jbc.2022.101750

PMCID:: PMC8933699

Abstract Article PDF–1.6M

Select item 88065595.

Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis

Fengfeng Wang, Tengfei Gu, Yao Chen, Yu Chen, Dan Xiong, Yehan Zhu

Bioengineered. 2021; 12(1): 6724–6737. Published online 2021 Sep 13. doi: 10.1080/21655979.2021.1955578

PMCID:: PMC8806559

Abstract Article PDF–4.0M

Select item 80879466.

Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer

Chao Lu, Pengyun Qiao, Yonghong Sun, Chune Ren, Zhenhai Yu

Clin Transl Med. 2021 Apr; 11(4): e400. Published online 2021 May 1. doi: 10.1002/ctm2.400

PMCID:: PMC8087946

Abstract Article PDF–9.7M

Select item 74273277.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 73920058.

Fructose-1, 6-bisphosphatase 1 interacts with NF-κB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation

Chao Lu, Chune Ren, Tingting Yang, Yonghong Sun, Pengyun Qiao, Xue Han, Zhenhai Yu

Theranostics. 2020; 10(19): 8606–8618. Published online 2020 Jul 9. doi: 10.7150/thno.46861

PMCID:: PMC7392005

Abstract Article PDF–2.7M

Select item 73438079.

PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway

Xuming Tang, Tingting Cao, Yun Zhu, Liyi Zhang, Jinna Chen, Tengfei Liu, Xiaoyan Ming, Shuo Fang, Yun-fei Yuan, Lingxi Jiang, Jian-Dong Huang, Xin-Yuan Guan

Cell Death Dis. 2020 Jul; 11(7): 510. Published online 2020 Jul 2. doi: 10.1038/s41419-020-2700-0

PMCID:: PMC7343807

Abstract Article PDF–5.6M

Select item 716230010.

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection

Wai Fook Leong, Vincent T. K. Chow

Cell Microbiol. 2006 Apr; 8(4): 565–580. Published online 2005 Nov 8. doi: 10.1111/j.1462-5822.2005.00644.x

PMCID:: PMC7162300

Abstract Article PDF–345K

Select item 695946511.

Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression

Pia Kronschnabl, Arnold Grünweller, Roland K. Hartmann, Achim Aigner, Ulrike Weirauch

Int J Oncol. 2020 Feb; 56(2): 448–459. Published online 2019 Dec 10. doi: 10.3892/ijo.2019.4936

PMCID:: PMC6959465

Abstract Article PDF–1.4M

Select item 673394912.

TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells

Amy L. Whillock, Nurbek Mambetsariev, Wai W. Lin, Laura L. Stunz, Gail A. Bishop

Sci Rep. 2019; 9: 12884. Published online 2019 Sep 9. doi: 10.1038/s41598-019-49390-9

Correction in:: Sci Rep. 2019; 9: 17502.

PMCID:: PMC6733949

Abstract Article PDF–2.1M

Select item 622440213.

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

Tingting Yang, Chune Ren, Pengyun Qiao, Xue Han, Li Wang, Shijun Lv, Yonghong Sun, Zhijun Liu, Yu Du, Zhenhai Yu

Oncogene. 2018; 37(45): 5997–6009. Published online 2018 Jul 9. doi: 10.1038/s41388-018-0386-x

Correction in:: Oncogene. 2020; 39(3): 720–721.

PMCID:: PMC6224402

Abstract Article PDF–3.6M

Select item 603950114.

CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia

Qing-Yun Wu, Yuan-Yuan Zhu, Yang Liu, Fang Wei, Yu-Xue Tong, Jiang Cao, Ping Zhou, Ming-Shan Niu, Zhen-Yu Li, Ling-Yu Zeng, Feng Li, Kai-Lin Xu

Cell Death Dis. 2018 Jul; 9(7): 774. Published online 2018 Jul 10. doi: 10.1038/s41419-018-0812-6

PMCID:: PMC6039501

Abstract Article PDF–2.7M

Select item 601070315.

Microenvironment‐induced PIM kinases promote CXCR4‐triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration

Emilia Białopiotrowicz, Patryk Górniak, Monika Noyszewska‐Kania, Bartosz Puła, Hanna Makuch‐Łasica, Grażyna Nowak, Aleksandra Bluszcz, Maciej Szydłowski, Ewa Jabłonska, Karolina Piechna, Tomasz Sewastianik, Anna Polak, Ewa Lech‐Marańda, Bożena K. Budziszewska, Maja Wasylecka‐Juszczyńska, Katarzyna Borg, Krzysztof Warzocha, Wojciech Czardybon, Michał Gałęzowski, Renata Windak, Krzysztof Brzózka, Przemysław Juszczyński

J Cell Mol Med. 2018 Jul; 22(7): 3548–3559. Published online 2018 Apr 17. doi: 10.1111/jcmm.13632

PMCID:: PMC6010703

Abstract Article PDF–1.4M

Select item 599210416.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni

Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444

PMCID:: PMC5992104

Abstract Article PDF–1.2M

Select item 592835717.

PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis

Chune Ren, Tingting Yang, Pengyun Qiao, Li Wang, Xue Han, Shijun Lv, Yonghong Sun, Zhijun Liu, Yu Du, Zhenhai Yu

Mol Oncol. 2018 May; 12(5): 690–704. Published online 2018 Apr 14. doi: 10.1002/1878-0261.12192

PMCID:: PMC5928357

Abstract Article PDF–1.3M

Select item 586588318.

Role of PIM2 in allergic asthma

Wei Du, Tiantian Chen, Yingmeng Ni, Xiaoxia Hou, Youchao Yu, Qi Zhou, Fang Wu, Wei Tang, Guochao Shi

Mol Med Rep. 2017 Nov; 16(5): 7504–7512. Published online 2017 Sep 18. doi: 10.3892/mmr.2017.7499

PMCID:: PMC5865883

Abstract Article PDF–1.3M

Select item 555729219.

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik

Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.

Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834

PMCID:: PMC5557292

Abstract Article PDF–3.4M

Select item 534238920.

PIM kinases as therapeutic targets against advanced melanoma

Batool Shannan, Andrea Watters, Quan Chen, Stefan Mollin, Markus Dörr, Eric Meggers, Xiaowei Xu, Phyllis A. Gimotty, Michela Perego, Ling Li, Joseph Benci, Clemens Krepler, Patricia Brafford, Jie Zhang, Zhi Wei, Gao Zhang, Qin Liu, Xiangfan Yin, Katherine L. Nathanson, Meenhard Herlyn, Adina Vultur

Oncotarget. 2016 Aug 23; 7(34): 54897–54912. Published online 2016 Jul 19. doi: 10.18632/oncotarget.10703

PMCID:: PMC5342389

Abstract Article PDF–8.2M

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