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Select item 109814461.

NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β

Christopher M. McCurry, Siddharth Sunilkumar, Sandeep M. Subrahmanian, Esma I. Yerlikaya, Allyson L. Toro, Ashley M. VanCleave, Shaunaci A. Stevens, Alistair J. Barber, Jeffery M. Sundstrom, Michael D. Dennis

Invest Ophthalmol Vis Sci. 2024 Mar; 65(3): 34. Published online 2024 Mar 28. doi: 10.1167/iovs.65.3.34

PMCID:: PMC10981446

Abstract Article PDF–2.5M

Select item 109549502.

Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia

Fangmei Li, Jiyu Miao, Rui Liu, Ru Zhang, Aili He

J Cancer Res Clin Oncol. 2024; 150(3): 144. Published online 2024 Mar 20. doi: 10.1007/s00432-024-05676-8

PMCID:: PMC10954950

Abstract Article PDF–9.1M

Select item 106324853.

Nuclear overexpression of DNA damage-inducible transcript 4 (DDIT4) is associated with aggressive tumor behavior in patients with pancreatic tumors

Fatemeh Tajik, Fahimeh Fattahi, Fereshteh Rezagholizadeh, Behnaz Bouzari, Pegah Babaheidarian, Masoud Baghai Wadji, Zahra Madjd

Sci Rep. 2023; 13: 19403. Published online 2023 Nov 8. doi: 10.1038/s41598-023-46484-3

PMCID:: PMC10632485

Abstract Article PDF–3.5M

Select item 104074324.

REDD1-dependent GSK3β dephosphorylation promotes NF-κB activation and macrophage infiltration in the retina of diabetic mice

Siddharth Sunilkumar, Ashley M. VanCleave, Christopher M. McCurry, Allyson L. Toro, Shaunaci A. Stevens, Scot R. Kimball, Michael D. Dennis

J Biol Chem. 2023 Aug; 299(8): 104991. Published online 2023 Jun 29. doi: 10.1016/j.jbc.2023.104991

PMCID:: PMC10407432

Abstract Article PDF–1.7M

Select item 98705775.

PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice

Shaunaci A. Stevens, Maria K. Gonzalez Aguiar, Allyson L. Toro, Esma I. Yerlikaya, Siddharth Sunilkumar, Ashley M. VanCleave, Jessica Pfleger, Elisa A. Bradley, Scot R. Kimball, Michael D. Dennis

Am J Physiol Endocrinol Metab. 2023 Jan 1; 324(1): E62–E72. Published online 2022 Nov 16. doi: 10.1152/ajpendo.00238.2022

PMCID:: PMC9870577

Abstract Article

Select item 96300836.

REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice

Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis

Diabetes. 2022 Nov; 71(11): 2412–2425. Published online 2022 Aug 19. doi: 10.2337/db22-0402

PMCID:: PMC9630083

Abstract Article PDF–14M

Select item 94560737.

Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe?

Ekaterina M. Zhidkova, Evgeniya S. Lylova, Diana D. Grigoreva, Kirill I. Kirsanov, Alena V. Osipova, Evgeny P. Kulikov, Sergey A. Mertsalov, Gennady A. Belitsky, Irina Budunova, Marianna G. Yakubovskaya, Ekaterina A. Lesovaya

Int J Mol Sci. 2022 Sep; 23(17): 9686. Published online 2022 Aug 26. doi: 10.3390/ijms23179686

PMCID:: PMC9456073

Abstract Article PDF–5.3M

Select item 87918448.

Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism

Alec B. Chaves, Edwin R. Miranda, Jacob T. Mey, Brian K. Blackburn, Kelly N. Z. Fuller, Blaise Stearns, Andrew Ludlow, David L. Williamson, 4th, Joseph A. Houmard, Jacob M. Haus

J Appl Physiol (1985) 2022 Feb 1; 132(2): 357–366. Published online 2021 Dec 23. doi: 10.1152/japplphysiol.00229.2021

PMCID:: PMC8791844

Abstract Article

Select item 84760739.

Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

Moritz Hunkeler, Cyrus Y. Jin, Michelle W. Ma, Julie K. Monda, Daan Overwijn, Eric J. Bennett, Eric S. Fischer

Mol Cell. Author manuscript; available in PMC 2021 Sep 27.

Published in final edited form as: Mol Cell. 2021 Sep 2; 81(17): 3468–3480.e7. Published online 2021 Jul 26. doi: 10.1016/j.molcel.2021.06.032

PMCID:: PMC8476073

Abstract Article PDF–2.7M

Select item 845627110.

DDIT4 S‐Nitrosylation Aids p38‐MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production

Zilong Li, Qianwen Zhao, Yunjie Lu, Yangxi Zhang, Luyang Li, Min Li, Xuemin Chen, Donglin Sun, Yunfei Duan, Yong Xu

Adv Sci (Weinh) 2021 Sep; 8(18): 2101957. Published online 2021 Jul 26. doi: 10.1002/advs.202101957

Correction in:: Adv Sci (Weinh). 2022 May; 9(13): 2201652.

PMCID:: PMC8456271

Abstract Article PDF–7.4M

Select item 824940711.

High expression of DNA damage-inducible transcript 4 (DDIT4) is associated with advanced pathological features in the patients with colorectal cancer

Fahimeh Fattahi, Leili Saeednejad Zanjani, Zohreh Habibi Shams, Jafar Kiani, Mitra Mehrazma, Mohammad Najafi, Zahra Madjd

Sci Rep. 2021; 11: 13626. Published online 2021 Jul 1. doi: 10.1038/s41598-021-92720-z

PMCID:: PMC8249407

Abstract Article PDF–4.0M

Select item 820634412.

RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease

Leticia Pérez-Sisqués, Anna Sancho-Balsells, Júlia Solana-Balaguer, Genís Campoy-Campos, Marcel Vives-Isern, Ferran Soler-Palazón, Marta Anglada-Huguet, Miguel-Ángel López-Toledano, Eva-Maria Mandelkow, Jordi Alberch, Albert Giralt, Cristina Malagelada

Cell Death Dis. 2021 Jun; 12(6): 616. Published online 2021 Jun 15. doi: 10.1038/s41419-021-03899-y

PMCID:: PMC8206344

Abstract Article PDF–4.8M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 795624414.

The stress response protein REDD1 as a causal factor for oxidative stress in diabetic retinopathy

William P. Miller, Siddharth Sunilkumar, Michael D. Dennis

Free Radic Biol Med. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Free Radic Biol Med. 2021 Mar; 165: 127–136. Published online 2021 Jan 29. doi: 10.1016/j.freeradbiomed.2021.01.041

PMCID:: PMC7956244

Abstract Article PDF–947K

Select item 760979215.

A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas

Kuo-Hao Ho, Peng-Hsu Chen, Chih-Ming Chou, Chwen-Ming Shih, Yi-Ting Lee, Chia-Hsiung Cheng, Ku-Chung Chen

Neurotherapeutics. 2020 Jul; 17(3): 1212–1227. Published online 2020 Jan 8. doi: 10.1007/s13311-019-00826-0

PMCID:: PMC7609792

Abstract Article PDF–6.2M

Select item 754388616.

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

Abhik K. Banerjee, Mario R. Blanco, Emily A. Bruce, Drew D. Honson, Linlin M. Chen, Amy Chow, Prashant Bhat, Noah Ollikainen, Sofia A. Quinodoz, Colin Loney, Jasmine Thai, Zachary D. Miller, Aaron E. Lin, Madaline M. Schmidt, Douglas G. Stewart, Daniel Goldfarb, Giuditta De Lorenzo, Suzannah J. Rihn, Rebecca M. Voorhees, Jason W. Botten, Devdoot Majumdar, Mitchell Guttman

Cell. 2020 Nov 25; 183(5): 1325–1339.e21. doi: 10.1016/j.cell.2020.10.004

PMCID:: PMC7543886

Abstract Article

Select item 739289717.

Synaptic RTP801 contributes to motor-learning dysfunction in Huntington’s disease

Núria Martín-Flores, Leticia Pérez-Sisqués, Jordi Creus-Muncunill, Mercè Masana, Sílvia Ginés, Jordi Alberch, Esther Pérez-Navarro, Cristina Malagelada

Cell Death Dis. 2020 Jul; 11(7): 569. Published online 2020 Jul 30. doi: 10.1038/s41419-020-02775-5

PMCID:: PMC7392897

Abstract Article PDF–2.7M

Select item 732206718.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 693336119.

Up‐regulation of DDIT4 predicts poor prognosis in acute myeloid leukaemia

Zhiheng Cheng, Yifeng Dai, Yifan Pang, Yang Jiao, Yan Liu, Longzhen Cui, Liang Quan, Tingting Qian, Tiansheng Zeng, Chaozeng Si, Wenhui Huang, Jinghong Chen, Ying Pang, Xu Ye, Jinlong Shi, Lin Fu

J Cell Mol Med. 2020 Jan; 24(1): 1067–1075. Published online 2019 Nov 21. doi: 10.1111/jcmm.14831

PMCID:: PMC6933361

Abstract Article PDF–936K

Select item 692775420.

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong

eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223

PMCID:: PMC6927754

Abstract Article PDF–5.1M

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