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Items: 1 to 20 of 235

1.
METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1
Zhengtao Yu, Ying Xia, Jiameng Li, Junwen Jiang, You Li, Youjun Li, Liu Wang
Biol Direct. 2024; 19: 92. Published online 2024 Oct 16. doi: 10.1186/s13062-024-00536-4
PMCID:
PMC11481594
AbstractArticlePDF–7.9M
2.
The indispensability of methyltransferase-like 3 in the immune system: from maintaining homeostasis to driving function
Mingfu Zhang, Zhixian Gou, Yi Qu, Xiaojuan Su
Front Immunol. 2024; 15: 1456891. Published online 2024 Oct 2. doi: 10.3389/fimmu.2024.1456891
PMCID:
PMC11479892
AbstractArticlePDF–982K
3.
METTL3/IGF2BP1 influences the development of non‐small‐cell lung cancer by mediating m6A methylation modification of TRPV1
Wenjie Bai, Gang Xiao, Guijing Xie, Zhibo Chen, Xie Xu, Jie Zeng, Jianjiang Xie
Thorac Cancer. 2024 Sep; 15(26): 1871–1881. Published online 2024 Aug 1. doi: 10.1111/1759-7714.15381
PMCID:
PMC11462973
AbstractArticlePDF–5.4M
4.
Up-regulation of RNA m6A methyltransferase like-3 expression contributes to arsenic and benzo[a]pyrene co-exposure-induced cancer stem cell-like property and tumorigenesis
Zhishan Wang, Mohammad Burhan Uddin, Po-Shun Wang, Zulong Liu, David Barzideh, Chengfeng Yang
Toxicol Appl Pharmacol. Author manuscript; available in PMC 2024 Sep 5.
Published in final edited form as: Toxicol Appl Pharmacol. 2023 Dec 15; 481: 116764. Published online 2023 Nov 14. doi: 10.1016/j.taap.2023.116764
PMCID:
PMC11375689
AbstractArticlePDF–1.8M
5.
METTL3-mediated N6-methyladenosine modification of STAT5A promotes gastric cancer progression by regulating KLF4
Yichen Zang, Zhuangfei Tian, Dandan Wang, Yaxuan Li, Wenhui Zhang, Cunying Ma, Zhenzhi Liao, Wenrong Gao, Lilin Qian, Xia Xu, Jihui Jia, Zhifang Liu
Oncogene. 2024; 43(30): 2338–2354. Published online 2024 Jun 15. doi: 10.1038/s41388-024-03085-2
PMCID:
PMC11271408
AbstractArticlePDF–7.9M
6.
Intracellular Fusobacterium nucleatum infection increases METTL3-mediated m6A methylation to promote the metastasis of esophageal squamous cell carcinoma
Songhe Guo, Fangfang Chen, Linfang Li, Shuheng Dou, Qifan Li, Yuying Huang, Zijun Li, Wanli Liu, Ge Zhang
J Adv Res. 2024 Jul; 61: 165–178. Published online 2023 Aug 22. doi: 10.1016/j.jare.2023.08.014
PMCID:
PMC11258656
AbstractArticlePDF–4.2M
7.
METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer
Tao Wang, Xu Li, Yue Tao, Xiaojun Wang, Limeng Li, Jianjun Liu
J Transl Med. 2024; 22: 643. Published online 2024 Jul 9. doi: 10.1186/s12967-024-05463-6
PMCID:
PMC11234709
AbstractArticlePDF–11M
8.
METTL3 regulates thyroid cancer differentiation and chemosensitivity by modulating PAX8
Ning Kang, Zewei Zhao, Zhongyu Wang, Junya Ning, Huijuan Wang, Wei Zhang, Xianhui Ruan, Ming Gao, Xiangqian Zheng
Int J Biol Sci. 2024; 20(9): 3426–3441. Published online 2024 Jun 17. doi: 10.7150/ijbs.84797
PMCID:
PMC11234206
AbstractArticlePDF–10M
9.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
10.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
11.
N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension
Kang Kang, Jingjing Xiang, Xingshi Zhang, Yuting Xie, Mengting Zhou, Le Zeng, Junhao Zhuang, Jiahao Kuang, Yuanyuan Lin, Bozhe Hu, Qianmin Xiong, Qing Yin, Qiang Su, Xiaoyun Liao, Jun Wang, Yanqin Niu, Cuilian Liu, Jinglin Tian, Deming Gou
Cell Mol Biol Lett. 2024; 29: 69. Published online 2024 May 13. doi: 10.1186/s11658-024-00590-w
PMCID:
PMC11089701
AbstractArticlePDF–1.5M
12.
METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability
Huafu Li, Chunming Wang, Linxiang Lan, Leping Yan, Wuguo Li, Ian Evans, E. Josue Ruiz, Qiao Su, Guangying Zhao, Wenhui Wu, Haiyong Zhang, Zhijun Zhou, Zhenran Hu, Wei Chen, Joaquim M. Oliveira, Axel Behrens, Rui L. Reis, Changhua Zhang
Cell Mol Life Sci. 2022 Mar; 79(3): 135. Published online 2022 Feb 18. doi: 10.1007/s00018-022-04129-0
PMCID:
PMC11072755
AbstractArticlePDF–9.6M
13.
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Dario F. De Jesus, Zijie Zhang, Natalie K. Brown, Xiaolu Li, Ling Xiao, Jiang Hu, Matthew J. Gaffrey, Garrett Fogarty, Sevim Kahraman, Jiangbo Wei, Giorgio Basile, Tariq M. Rana, Clayton Mathews, Alvin C. Powers, Audrey V. Parent, Mark A. Atkinson, Sirano Dhe-Paganon, Decio L. Eizirik, Wei-Jun Qian, Chuan He, Rohit N. Kulkarni
Nat Cell Biol. Author manuscript; available in PMC 2024 Apr 24.
Published in final edited form as: Nat Cell Biol. 2024 Mar; 26(3): 421–437. Published online 2024 Feb 26. doi: 10.1038/s41556-024-01368-0
PMCID:
PMC11042681
AbstractArticlePDF–8.2M
14.
METTL3 recruiting M2-type immunosuppressed macrophages by targeting m6A-SNAIL-CXCL2 axis to promote colorectal cancer pulmonary metastasis
Peng Ouyang, Kang Li, Wei Xu, Caiyun Chen, Yangdong Shi, Yao Tian, Jin Gong, Zhen Bao
J Exp Clin Cancer Res. 2024; 43: 111. Published online 2024 Apr 11. doi: 10.1186/s13046-024-03035-6
PMCID:
PMC11007974
AbstractArticlePDF–6.8M
15.
Desulfovibrio desulfuricans and its derived metabolites confer resistance to FOLFOX through METTL3
Guifang Li, Huan Liu, Yangmeng Yu, Qian Wang, Chen Yang, Yang Yan, Fang Wang, Yong Mao
eBioMedicine. 2024 Apr; 102: 105041. Published online 2024 Mar 13. doi: 10.1016/j.ebiom.2024.105041
PMCID:
PMC10950750
AbstractArticlePDF–5.0M
16.
METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN
Shujiang Chen, Xiaoqiong Duan, Yanjin He, Wenchuan Chen
Biosci Rep. 2024 Mar 29; 44(3): BSR20231186. Published online 2024 Mar 12. doi: 10.1042/BSR20231186
PMCID:
PMC10932744
AbstractArticlePDF–1.5M
17.
METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability
Xuefei Sun, Xiujiao Meng, Yu Piao, Shaojie Dong, Qianqian Dong
Int J Med Sci. 2024; 21(4): 664–673. Published online 2024 Feb 4. doi: 10.7150/ijms.90485
PMCID:
PMC10920842
AbstractArticlePDF–3.5M
18.
METTL3 as a novel diagnosis and treatment biomarker and its association with glycolysis, cuproptosis and ceRNA in oesophageal carcinoma
Xu‐Sheng Liu, Yu Zhang, Zi‐Yue Liu, Yan Gao, Ling‐Ling Yuan, Dao‐Bing Zeng, Fan Tan, Hua‐Bing Wan, Zhi‐Jun Pei
J Cell Mol Med. 2024 Mar; 28(6): e18195. Published online 2024 Mar 1. doi: 10.1111/jcmm.18195
PMCID:
PMC10907846
AbstractArticlePDF–17M
19.
METTL3/YTHDF2 m6A axis mediates the progression of diabetic nephropathy through epigenetically suppressing PINK1 and mitophagy
Fangfang Wang, Juan Bai, Xin Zhang, Dali Wang, Xin Zhang, Jingwen Xue, Haoyang Chen, Shuxiang Wang, Baojin Chi, Jing Li, Xiaoru Ma
J Diabetes Investig. 2024 Mar; 15(3): 288–299. Published online 2023 Nov 28. doi: 10.1111/jdi.14113
PMCID:
PMC10906015
AbstractArticlePDF–3.8M
20.
The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions
Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M McLeland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery, Jakob Nilsson
EMBO Rep. 2024 Feb; 25(2): 902–926. Published online 2024 Jan 2. doi: 10.1038/s44319-023-00043-z
PMCID:
PMC10897489
AbstractArticlePDF–8.2M

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