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Select item 111872151.

LRG1 and SDR16C5 protein expressions differ according to HPV status in oropharyngeal squamous cell carcinoma

Reija Randén-Brady, Timo Carpén, Laura C. Hautala, Tuomas Tolvanen, Caj Haglund, Sakari Joenväärä, Petri Mattila, Antti Mäkitie, Sanna Lehtonen, Jaana Hagström, Suvi Silén

Sci Rep. 2024; 14: 14148. Published online 2024 Jun 19. doi: 10.1038/s41598-024-64823-w

PMCID:: PMC11187215

Abstract Article PDF–2.1M

Select item 111478632.

High serum levels of leucine-rich α-2 glycoprotein 1 (LRG-1) are associated with poor survival in patients with early breast cancer

Andy Göbel, Tilman D. Rachner, Oliver Hoffmann, Daniel Martin Klotz, Sabine Kasimir-Bauer, Rainer Kimmig, Lorenz C. Hofbauer, Ann-Kathrin Bittner

Arch Gynecol Obstet. 2024; 309(6): 2789–2798. Published online 2024 Feb 28. doi: 10.1007/s00404-024-07434-0

PMCID:: PMC11147863

Abstract Article PDF–897K

Select item 106718513.

Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification

Lucile Grzesiak, Ana Amaya-Garrido, Guylène Feuillet, Nicole Malet, Audrey Swiader, Marie-Kerguelen Sarthou, Amandine Wahart, Damien Ramel, Stéphanie Gayral, Joost Peter Schanstra, Julie Klein, Muriel Laffargue

Int J Mol Sci. 2023 Nov; 24(22): 16537. Published online 2023 Nov 20. doi: 10.3390/ijms242216537

PMCID:: PMC10671851

Abstract Article PDF–3.2M

Select item 106170304.

Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes

Jin Ook Chung, Seon-Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung

Front Endocrinol (Lausanne) 2023; 14: 1232021. Published online 2023 Oct 17. doi: 10.3389/fendo.2023.1232021

PMCID:: PMC10617030

Abstract Article PDF–369K

Select item 104189095.

LRG1 Promotes ECM Integrity by Activating the TGF-β Signaling Pathway in Fibroblasts

Han Na Park, Min Ji Song, Young Eun Choi, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee

Int J Mol Sci. 2023 Aug; 24(15): 12445. Published online 2023 Aug 4. doi: 10.3390/ijms241512445

PMCID:: PMC10418909

Abstract Article PDF–4.6M

Select item 102473876.

Leucine-Rich Alpha-2-Glycoprotein 1 is a Systemic Biomarker of Early Brain Injury and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

Jude P. J. Savarraj, Devin W. McBride, Eunsu Park, Sarah Hinds, Atzhiry Paz, Aaron Gusdon, Ren Xuefang, Sheng Pan, Hilda Ahnstedt, Gabriela Delevati Colpo, Eunhee Kim, Zhongming Zhao, Louise McCullough, Huimahn Alex Choi

Neurocrit Care. Author manuscript; available in PMC 2023 Jun 8.

Published in final edited form as: Neurocrit Care. 2023 Jun; 38(3): 771–780. Published online 2022 Dec 28. doi: 10.1007/s12028-022-01652-7

PMCID:: PMC10247387

Abstract Article PDF–700K

Select item 101174047.

Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence

Esmee P. Hoefsmit, Franziska Völlmy, Elisa A. Rozeman, Irene L.M. Reijers, Judith M. Versluis, Liesbeth Hoekman, Alexander C.J. van Akkooi, Georgina V. Long, Dirk Schadendorf, Reinhard Dummer, Maarten Altelaar, Christian U. Blank

Cancer Res Commun. 2023 Apr; 3(4): 672–683. Published online 2023 Apr 20. doi: 10.1158/2767-9764.CRC-23-0015

PMCID:: PMC10117404

Abstract Article PDF–2.9M

Select item 100944678.

Diagnostic Accuracy of Leucine-Rich α-2-Glycoprotein 1 as a Non-Invasive Salivary Biomarker in Pediatric Appendicitis

Goran Tintor, Miro Jukić, Daniela Šupe-Domić, Ana Jerončić, Zenon Pogorelić

Int J Mol Sci. 2023 Apr; 24(7): 6043. Published online 2023 Mar 23. doi: 10.3390/ijms24076043

PMCID:: PMC10094467

Abstract Article PDF–895K

Select item 98876179.

Urine Leucine-Rich α-2 Glycoprotein 1 (LRG1) Predicts the Risk of Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes

Jian-Jun Liu, Sylvia Liu, Jiexun Wang, Sharon L.T. Pek, Janus Lee, Resham L. Gurung, Keven Ang, Yi Ming Shao, Subramaniam Tavintharan, Wern Ee Tang, Chee Fang Sum, Su Chi Lim

Diabetes Care. 2023 Feb; 46(2): 408–415. Published online 2022 Dec 14. doi: 10.2337/dc22-1611

PMCID:: PMC9887617

Abstract Article PDF–2.6M

Select item 946387810.

Leucine-Rich Alpha-2-Glycoprotein (LRG-1) as a Potential Kidney Injury Marker in Kidney Transplant Recipients

Anna Popova, Aiga Vasiļvolfa, Kārlis Rācenis, Renārs Erts, Baiba Šlisere, Anna Jana Saulīte, Ieva Ziediņa, Inese Folkmane, Harijs Čerņevskis, Juta Kroiča, Aivars Pētersons, Viktorija Kuzema

Ann Transplant. 2022; 27: e936751-1–e936751-6. Prepublished online 2022 Jul 22. Published online 2022 Sep 6. doi: 10.12659/AOT.936751

PMCID:: PMC9463878

Abstract Article PDF–334K

Select item 936919511.

Increased LRG1 Levels in Overweight and Obese Adolescents and Its Association with Obesity Markers, Including Leptin, Chemerin, and High Sensitivity C-Reactive Protein

Rashed Alhammad, Mohamed Abu-Farha, Maha M. Hammad, Thangavel Alphonse Thanaraj, Arshad Channanath, Nada Alam-Eldin, Reem Al-Sabah, Lemia Shaban, Abdulrahman Alduraywish, Fahd Al-Mulla, Abdur Rahman, Jehad Abubaker

Int J Mol Sci. 2022 Aug; 23(15): 8564. Published online 2022 Aug 2. doi: 10.3390/ijms23158564

PMCID:: PMC9369195

Abstract Article PDF–2.2M

Select item 931299912.

Association between Higher Circulating Leucine-Rich α-2 Glycoprotein 1 Concentrations and Specific Plasma Ceramides in Postmenopausal Women with Type 2 Diabetes

Alessandro Mantovani, Alessandro Csermely, Elena Sani, Giorgia Beatrice, Graziana Petracca, Gianluigi Lunardi, Stefano Bonapace, Giuseppe Lippi, Giovanni Targher

Biomolecules. 2022 Jul; 12(7): 943. Published online 2022 Jul 5. doi: 10.3390/biom12070943

PMCID:: PMC9312999

Abstract Article PDF–356K

Select item 893872013.

Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway

Athina Dritsoula, Laura Dowsett, Camilla Pilotti, Marie N. O’Connor, Stephen E. Moss, John Greenwood

Sci Rep. 2022; 12: 4867. Published online 2022 Mar 22. doi: 10.1038/s41598-022-08516-2

Correction in:: Sci Rep. 2022; 12: 5347.

PMCID:: PMC8938720

Abstract Article PDF–3.0M

Select item 880762614.

LRG1 as a novel therapeutic target in eye disease

Giulia De Rossi, Marlene E. Da Vitoria Lobo, John Greenwood, Stephen E. Moss

Eye (Lond) 2022 Feb; 36(2): 328–340. Published online 2022 Jan 5. doi: 10.1038/s41433-021-01807-4

Correction in:: Eye (Lond). 2023 May; 37(7): 1517.

PMCID:: PMC8807626

Abstract Article PDF–2.2M

Select item 880697115.

LRG1 promotes hypoxia-induced cardiomyocyte apoptosis and autophagy by regulating hypoxia-inducible factor-1α

Jiajie Feng, Jiachen Zhan, Shuangshuang Ma

Bioengineered. 2021; 12(1): 8897–8907. Published online 2021 Oct 25. doi: 10.1080/21655979.2021.1988368

PMCID:: PMC8806971

Abstract Article PDF–2.1M

Select item 867083716.

LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance

Sijia He, Jiyoon Ryu, Juanhong Liu, Hairong Luo, Ying Lv, Paul R. Langlais, Jie Wen, Feng Dong, Zhe Sun, Wenjuan Xia, Jane L. Lynch, Ravindranath Duggirala, Bruce J. Nicholson, Mengwei Zang, Yuguang Shi, Fang Zhang, Feng Liu, Juli Bai, Lily Q. Dong

J Clin Invest. 2021 Dec 15; 131(24): e148545. Published online 2021 Dec 15. doi: 10.1172/JCI148545

PMCID:: PMC8670837

Abstract Article PDF–7.4M

Select item 842871017.

Leucine-rich alpha-2-glycoprotein 1 and angiotensinogen as diagnostic biomarkers for Kawasaki disease

Masakatsu Yanagimachi, Sayaka Fukuda, Fumiko Tanaka, Mari Iwamoto, Chiho Takao, Kunihiro Oba, Natsuko Suzuki, Koji Kiyohara, Dai Kuranobu, Norimasa Tada, Ayako Nagashima, Taku Ishii, Yoko Ino, Yayoi Kimura, Nobutoshi Nawa, Takeo Fujiwara, Takuya Naruto, Tomohiro Morio, Shouzaburo Doi, Masaaki Mori

PLoS One. 2021; 16(9): e0257138. Published online 2021 Sep 9. doi: 10.1371/journal.pone.0257138

PMCID:: PMC8428710

Abstract Article PDF–434K

Select item 839626818.

LRG1 Expression Is Elevated in the Eyes of Patients with Neovascular Age-Related Macular Degeneration

Lucia Mundo, Gian Marco Tosi, Stefano Lazzi, Grazia Pertile, Barbara Parolini, Giovanni Neri, Matteo Posarelli, Elena De Benedetto, Tommaso Bacci, Ennio Silvestri, Maria Chiara Siciliano, Stefano Barbera, Maurizio Orlandini, John Greenwood, Stephen E. Moss, Federico Galvagni

Int J Mol Sci. 2021 Aug; 22(16): 8879. Published online 2021 Aug 18. doi: 10.3390/ijms22168879

PMCID:: PMC8396268

Abstract Article PDF–6.8M

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 816015720.

Leucine-rich alpha-2 glycoprotein as a marker of mucosal healing in inflammatory bowel disease

Eriko Yasutomi, Toshihiro Inokuchi, Sakiko Hiraoka, Kensuke Takei, Shoko Igawa, Shumpei Yamamoto, Masayasu Ohmori, Shohei Oka, Yasushi Yamasaki, Hideaki Kinugasa, Masahiro Takahara, Keita Harada, Masaki Furukawa, Kouichi Itoshima, Ken Okada, Fumio Otsuka, Takehiro Tanaka, Toshiharu Mitsuhashi, Jun Kato, Hiroyuki Okada

Sci Rep. 2021; 11: 11086. Published online 2021 May 27. doi: 10.1038/s41598-021-90441-x

PMCID:: PMC8160157

Abstract Article PDF–1.3M

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