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Select item 102409981.

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805

Yunpeng Bai, Guimei Yu, Hong-Ming Zhou, Ovini Amarasinghe, Yuan Zhou, Peipei Zhu, Qinglin Li, Lujuan Zhang, Frederick Nguele Meke, Yiming Miao, Eli Chapman, W. Andy Tao, Zhong-Yin Zhang

Autophagy. 2023; 19(5): 1562–1581. Published online 2022 Nov 7. doi: 10.1080/15548627.2022.2140558

PMCID:: PMC10240998

Abstract Article PDF–4.4M

Select item 96229112.

Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis

Fei Kang, Li Xie, Tairan Qin, Yifan Miao, Youhou Kang, Toshimasa Takahashi, Tao Liang, Huanli Xie, Herbert Y. Gaisano

Nat Commun. 2022; 13: 6512. Published online 2022 Oct 31. doi: 10.1038/s41467-022-33986-3

PMCID:: PMC9622911

Abstract Article PDF–2.8M

Select item 91197363.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699835.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 64614476.

Pancreatitis-Induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis

Subhankar Dolai, Tao Liang, Abrahim I. Orabi, Douglas Holmyard, Li Xie, Dafna Greitzer-Antes, Youhou Kang, Huanli Xie, Tanveer A. Javed, Patrick P. Lam, Deborah C. Rubin, Peter Thorn, Herbert Y. Gaisano

Gastroenterology. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Gastroenterology. 2018 May; 154(6): 1805–1821.e5. Published online 2018 Jan 31. doi: 10.1053/j.gastro.2018.01.025

PMCID:: PMC6461447

Abstract Article PDF–3.3M

Select item 59812187.

STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway

Yongxia Wang, Honghai Xu, Hongli Jiao, Shuyang Wang, Zhiyuan Xiao, Yali Zhao, Jiaxin Bi, Wenting Wei, Shanshan Liu, Junfeng Qiu, Tingting Li, Li Liang, Yaping Ye, Wenting Liao, Yanqing Ding

Cell Death Dis. 2018 Jun; 9(6): 664. Published online 2018 May 31. doi: 10.1038/s41419-018-0675-x

PMCID:: PMC5981218

Abstract Article PDF–3.6M

Select item 49288748.

HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells

Lei Shi, Enqiang Qin, Junnian Zhou, Juanjuan Zhao, Weimin Nie, Tianjun Jiang, Weiwei Chen, Dan Wu, Lei Huang, Liying Liu, Liping Lv, Min Zhao, Zheng Zhang, Fusheng Wang

PLoS One. 2016; 11(6): e0158386. Published online 2016 Jun 30. doi: 10.1371/journal.pone.0158386

PMCID:: PMC4928874

Abstract Article PDF–3.9M

Select item 40097339.

Genome-Wide Association Study for Circulating Tissue Plasminogen Activator (tPA) Levels and Functional Follow-up Implicates Endothelial STXBP5 and STX2

Jie Huang, Jennifer E. Huffman, Munekazu Yamkauchi, Stella Trompet, Folkert W. Asselbergs, Maria Sabater-Lleal, David-Alexandre Trégouët, Wei-Min Chen, Nicholas L. Smith, Marcus E. Kleber, So-Youn Shin, Diane M. Becker, Weihong Tang, Abbas Dehghan, Andrew D. Johnson, Vinh Truong, Lasse Folkersen, Qiong Yang, Tiphaine Oudot-Mellakh, Brendan M. Buckley, Jason H. Moore, Frances M.K. Williams, Harry Campbell, Günther Silbernagel, Veronique Vitart, Igor Rudan, Geoffrey H. Tofler, Gerjan J. Navis, Anita DeStefano, Alan F. Wright, Ming-Huei Chen, Anton J.M. de Craen, Bradford B. Worrall, Alicja R. Rudnicka, Ann Rumley, Ebony B. Bookman, Bruce M. Psaty, Fang Chen, Keith L. Keene, Oscar H. Franco, Bernhard O. Böhm, Andre G. Uitterlinden, Angela M. Carter, J. Wouter Jukema, Naveed Sattar, Joshua C. Bis, Mohammad A. Ikram, the CHARGE consortium Neurology Working Group, Michèle M. Sale, Barbara McKnight, Myriam Fornage, Ian Ford, Kent Taylor, P. Eline Slagboom, Wendy L. McArdle, Fang-Chi Hsu, Anders Franco-Cereceda, Alison H. Goodall, Lisa R. Yanek, Karen L. Furie, Mary Cushman, Albert Hofman, Jacqueline CM. Witteman, Aaron R. Folsom, Saonli Basu, Nena Matijevic, Wiek H. van Gilst, James F. Wilson, Rudi G.J. Westendorp, Sekar Kathiresan, Muredach P. Reilly, the CARDIoGRAM Consortium, Russell P. Tracy, Ozren Polasek, Bernhard R. Winkelmann, Peter J. Grant, Hans L. Hillege, Francois Cambien, David J. Stott, Gordon D. Lowe, Timothy D. Spector, James B. Meigs, Winfried Marz, Per Eriksson, Lewis C. Becker, Pierre-Emmanuel Morange, Nicole Soranzo, Scott M. Williams, Caroline Hayward, Pim van der Harst, Anders Hamsten, Charles J. Lowenstein, David P. Strachan, Christopher J. O'Donnell, the CHARGE Consortium Hemostatic Factor Working Group

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 May; 34(5): 1093–1101. Published online 2014 Feb 27. doi: 10.1161/ATVBAHA.113.302088

Correction in:: volume 34 on page E19

PMCID:: PMC4009733

Abstract Article PDF–877K

Select item 376780710.

Epimorphin-Induced MET Sensitizes Ovarian Cancer Cells to Platinum

Kok-Hooi Yew, Jennifer Crow, Jeff Hirst, Ziyan Pressetto, Andrew K. Godwin

PLoS One. 2013; 8(9): e72637. Published online 2013 Sep 9. doi: 10.1371/journal.pone.0072637

Correction in:: PLoS One. 2013; 8(10): 10.1371/annotation/9c557fb1-7997-4c21-bd11-03bf5c3d4418.

PMCID:: PMC3767807

Abstract Article PDF–1.3M

Select item 352727611.

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Li Xie, Claude Gazin, Sung Mi Park, Lihua J. Zhu, Marie-anne Debily, Ellen L. W. Kittler, Maria L. Zapp, David Lapointe, Stephane Gobeil, Ching-Man Virbasius, Michael R. Green

PLoS Genet. 2012 Dec; 8(12): e1003151. Published online 2012 Dec 20. doi: 10.1371/journal.pgen.1003151

PMCID:: PMC3527276

Abstract Article PDF–1.8M

Select item 351183712.

Effect of genetic variations in Syntaxin Binding Protein-5 and Syntaxin-2 on Von Willebrand Factor concentration and cardiovascular risk

Janine E. van Loon, Frank W.G. Leebeek, Jaap W. Deckers, Diederik W.J. Dippel, Don Poldermans, David P. Strachan, Weihong Tang, Christopher J. O’Donnell, Nicholas L. Smith, Moniek P.M. de Maat

Circ Cardiovasc Genet. Author manuscript; available in PMC 2012 Dec 2.

Published in final edited form as: Circ Cardiovasc Genet. 2010 Dec; 3(6): 507–512. doi: 10.1161/CIRCGENETICS.110.957407

PMCID:: PMC3511837

Abstract Article PDF–378K

Select item 339128113.

Effect of Genetic Variation in STXBP5 and STX2 on von Willebrand Factor and Bleeding Phenotype in Type 1 von Willebrand Disease Patients

Janine E. van Loon, Yvonne V. Sanders, Eva M. de Wee, Marieke J. H. A. Kruip, Moniek P. M. de Maat, Frank W. G. Leebeek

PLoS One. 2012; 7(7): e40624. Published online 2012 Jul 6. doi: 10.1371/journal.pone.0040624

PMCID:: PMC3391281

Abstract Article PDF–267K

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316351415.

Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels

Guillemette Antoni, Tiphaine Oudot-Mellakh, Apostolos Dimitromanolakis, Marine Germain, William Cohen, Philip Wells, Mark Lathrop, France Gagnon, Pierre-Emmanuel Morange, David-Alexandre Tregouet

BMC Med Genet. 2011; 12: 102. Published online 2011 Aug 2. doi: 10.1186/1471-2350-12-102

PMCID:: PMC3163514

Abstract Article PDF–303K

Select item 268304716.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67