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Select item 103232521.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Abstract Article

Select item 99321022.

SVEP1 is an endogenous ligand for the orphan receptor PEAR1

Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel

Nat Commun. 2023; 14: 850. Published online 2023 Feb 15. doi: 10.1038/s41467-023-36486-0

Correction in:: Nat Commun. 2023; 14: 1511.

PMCID:: PMC9932102

Abstract Article PDF–8.9M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79593284.

Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population

Joshua P. Lewis, Moeen Riaz, Sophia Xie, Galina Polekhina, Rory Wolfe, Mark Nelson, Andrew M. Tonkin, Christopher M. Reid, Anne M. Murray, John J. McNeil, Alan R. Shuldiner, Paul Lacaze

Clin Pharmacol Ther. Author manuscript; available in PMC 2021 Mar 15.

Published in final edited form as: Clin Pharmacol Ther. 2020 Dec; 108(6): 1289–1298. Published online 2020 Jul 20. doi: 10.1002/cpt.1959

PMCID:: PMC7959328

Abstract Article PDF–1.6M

Select item 73188385.

Lower Platelet Aggregation Is a Risk Factor for Dual Antiplatelet Therapy-Associated Bleeding: A Preliminary Retrospective Study with Genotype Analysis

Dongdong Yuan, Xiangfen Shi, Liping Guo, Gaobiao Wang, Yujie Zhao, Yuling Yang, Hanjuan Zhang, Qiong Huang, Yiqiang Yuan

Med Sci Monit. 2020; 26: e923758-1–e923758-5. Prepublished online 2020 Apr 15. Published online 2020 Jun 16. doi: 10.12659/MSM.923758

PMCID:: PMC7318838

Abstract Article PDF–195K

Select item 71699836.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 68209037.

Variation of PEAR1 DNA methylation influences platelet and leukocyte function

Benedetta Izzi, Francesco Gianfagna, Wen-Yi Yang, Katrien Cludts, Amalia De Curtis, Peter Verhamme, Augusto Di Castelnuovo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Jan A. Staessen, Marc F. Hoylaerts, Licia Iacoviello, on behalf of Moli-family Investigators

Clin Epigenetics. 2019; 11: 151. Published online 2019 Oct 29. doi: 10.1186/s13148-019-0744-8

PMCID:: PMC6820903

Abstract Article PDF–734K

Select item 67089188.

Effect of 106PEAR1 and 168PTGS1 genetic polymorphisms on recurrent ischemic stroke in Chinese patient

Jiali Zhao, Fudi Chen, Lin Lu, Hui Tang, Ruirui Yang, Yongxiang Wang, Yifeng Du

Medicine (Baltimore) 2019 Jul; 98(29): e16457. Published online 2019 Jul 19. doi: 10.1097/MD.0000000000016457

PMCID:: PMC6708918

Abstract Article PDF–197K

Select item 63737559.

Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα

Caroline Kardeby, Knut Fälker, Elizabeth J. Haining, Maarten Criel, Madelene Lindkvist, Ruben Barroso, Peter Påhlsson, Liza U. Ljungberg, Mattias Tengdelius, G. Ed Rainger, Stephanie Watson, Johannes A. Eble, Marc F. Hoylaerts, Jonas Emsley, Peter Konradsson, Steve P. Watson, Yi Sun, Magnus Grenegård

Blood Adv. 2019 Feb 12; 3(3): 275–287. Published online 2019 Jan 30. doi: 10.1182/bloodadvances.2018024950

PMCID:: PMC6373755

Abstract Article PDF–1.9M

Select item 597928910.

Cell-Specific PEAR1 Methylation Studies Reveal a Locus that Coordinates Expression of Multiple Genes

Benedetta Izzi, Fabrizia Noro, Katrien Cludts, Kathleen Freson, Marc F. Hoylaerts

Int J Mol Sci. 2018 Apr; 19(4): 1069. Published online 2018 Apr 3. doi: 10.3390/ijms19041069

PMCID:: PMC5979289

Abstract Article PDF–26M

Select item 594555811.

Effect of PEAR1 Genetic Variants on 1-Year Outcomes in Chinese Patients with Acute Myocardial Infarction After Percutaneous Coronary Intervention

Yi Yao, Xiao-fang Tang, Chen He, Ying Song, Jing-jing Xu, Xian-min Meng, Bo Xu, Run-lin Gao, Jin-qing Yuan

J Atheroscler Thromb. 2018 May 1; 25(5): 454–459. doi: 10.5551/jat.39982

PMCID:: PMC5945558

Abstract Article PDF–146K

Select item 540843412.

PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population

Wen-Yi Yang, Thibault Petit, Nicholas Cauwenberghs, Zhen-Yu Zhang, Chang-Sheng Sheng, Lutgarde Thijs, Erika Salvi, Benedetta Izzi, Christophe Vandenbriele, Fang-Fei Wei, Yu-Mei Gu, Lotte Jacobs, Lorena Citterio, Simona Delli Carpini, Cristina Barlassina, Daniele Cusi, Marc F. Hoylaerts, Peter Verhamme, Tatiana Kuznetsova, Jan A. Staessen

BMC Med Genet. 2017; 18: 45. Published online 2017 Apr 27. doi: 10.1186/s12881-017-0411-x

PMCID:: PMC5408434

Abstract Article PDF–621K

Select item 518182413.

PEAR1 gene polymorphism in a Chinese pedigree with pulmonary thromboembolism

Yingyun Fu, Silong Sun, Jie Liang, Shengguo Liu, Yiqi Jiang, Lan Xu, Junpu Mei

Medicine (Baltimore) 2016 Dec; 95(51): e5687. Published online 2016 Dec 23. doi: 10.1097/MD.0000000000005687

PMCID:: PMC5181824

Abstract Article PDF–504K

Select item 509941814.

Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy

Ling-ling Peng, Yuan-qi Zhao, Zi-yi Zhou, Jing Jin, Min Zhao, Xin-meng Chen, Ling-yan Chen, Ye-feng Cai, Jia-li Li, Min Huang

Acta Pharmacol Sin. 2016 Nov; 37(11): 1442–1448. Published online 2016 Sep 19. doi: 10.1038/aps.2016.90

PMCID:: PMC5099418

Abstract Article PDF–237K

Select item 458322315.

Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction

Adam S. Fisch, Laura M. Yerges-Armstrong, Joshua D. Backman, Hong Wang, Patrick Donnelly, Kathleen A. Ryan, Ankita Parihar, Mary A. Pavlovich, Braxton D. Mitchell, Jeffrey R. O’Connell, William Herzog, Christopher R. Harman, Jonathan D. Wren, Joshua P. Lewis

PLoS One. 2015; 10(9): e0138795. Published online 2015 Sep 25. doi: 10.1371/journal.pone.0138795

PMCID:: PMC4583223

Abstract Article PDF–1.4M

Select item 442439816.

A Human Platelet Receptor Protein Microarray Identifies the High Affinity Immunoglobulin E Receptor Subunit α (FcεR1α) as an Activating Platelet Endothelium Aggregation Receptor 1 (PEAR1) Ligand

Yi Sun, Christophe Vandenbriele, Alexandre Kauskot, Peter Verhamme, Marc F. Hoylaerts, Gavin J. Wright

Mol Cell Proteomics. 2015 May; 14(5): 1265–1274. Published online 2015 Feb 23. doi: 10.1074/mcp.M114.046946

PMCID:: PMC4424398

Abstract Article PDF–1.7M

Select item 421614117.

Genetic Determinants of On-Aspirin Platelet Reactivity: Focus on the Influence of PEAR1

Morten Würtz, Peter H. Nissen, Erik Lerkevang Grove, Steen Dalby Kristensen, Anne-Mette Hvas

PLoS One. 2014; 9(10): e111816. Published online 2014 Oct 31. doi: 10.1371/journal.pone.0111816

PMCID:: PMC4216141

Abstract Article PDF–246K

Select item 371532018.

Genetic Variation in PEAR1 is Associated with Platelet Aggregation and Cardiovascular Outcomes

Joshua P. Lewis, Kathleen Ryan, Jeffrey R. O’Connell, Richard B. Horenstein, Coleen M. Damcott, Quince Gibson, Toni I. Pollin, Braxton D. Mitchell, Amber L. Beitelshees, Ruth Pakzy, Keith Tanner, Afshin Parsa, Udaya S. Tantry, Kevin P. Bliden, Wendy S. Post, Nauder Faraday, William Herzog, Yan Gong, Carl J. Pepine, Julie A. Johnson, Paul A. Gurbel, Alan R. Shuldiner

Circ Cardiovasc Genet. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: Circ Cardiovasc Genet. 2013 Apr; 6(2): 184–192. Published online 2013 Feb 7. doi: 10.1161/CIRCGENETICS.111.964627

PMCID:: PMC3715320

Abstract Article PDF–1.0M

Select item 366044819.

Targeted Deep Resequencing Identifies Coding Variants in the PEAR1 Gene That Play a Role in Platelet Aggregation

Yoonhee Kim, Bhoom Suktitipat, Lisa R. Yanek, Nauder Faraday, Alexander F. Wilson, Diane M. Becker, Lewis C. Becker, Rasika A. Mathias

PLoS One. 2013; 8(5): e64179. Published online 2013 May 21. doi: 10.1371/journal.pone.0064179

PMCID:: PMC3660448

Abstract Article PDF–1.3M

Select item 346449520.

Jedi-1 and MEGF10 Signal Engulfment of Apoptotic Neurons through the Tyrosine Kinase Syk

Jami L. Scheib, Chelsea S. Sullivan, Bruce D. Carter

J Neurosci. 2012 Sep 19; 32(38): 13022–13031. doi: 10.1523/JNEUROSCI.6350-11.2012

PMCID:: PMC3464495

Abstract Article PDF–1.9M

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