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Select item 109457071.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 102431542.

Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR

Chengpeng Yu, Dean Rao, Tiantian Wang, Jiaqi Sheng, Enjun Lv, Long Zhang, Xun Lu, Jingjing Yu, Huifang Liang, Jia Song, Wenjie Huang

J Cell Mol Med. 2023 Jun; 27(11): 1523–1538. Published online 2023 May 2. doi: 10.1111/jcmm.17757

PMCID:: PMC10243154

Abstract Article PDF–51M

Select item 99501833.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 94816024.

Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function

Simon Maria Kienle, Tobias Schneider, Katrin Stuber, Christoph Globisch, Jasmin Jansen, Florian Stengel, Christine Peter, Andreas Marx, Michael Kovermann, Martin Scheffner

Nat Commun. 2022; 13: 5435. Published online 2022 Sep 16. doi: 10.1038/s41467-022-33087-1

PMCID:: PMC9481602

Abstract Article PDF–3.7M

Select item 91714115.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 91052356.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 90506477.

OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor

Chuannan Fan, Qian Wang, Gerard van der Zon, Jiang Ren, Cedrick Agaser, Roderick C. Slieker, Prasanna Vasudevan Iyengar, Hailiang Mei, Peter ten Dijke

Signal Transduct Target Ther. 2022; 7: 126. Published online 2022 Apr 29. doi: 10.1038/s41392-022-00944-w

PMCID:: PMC9050647

Abstract Article PDF–6.9M

Select item 90428228.

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction

Sunan Li, Rongrong Li, Iqbal Ahmad, Xiaomeng Liu, Silas F. Johnson, Liangliang Sun, Yong-Hui Zheng

Nat Commun. 2022; 13: 2242. Published online 2022 Apr 26. doi: 10.1038/s41467-022-30026-y

PMCID:: PMC9042822

Abstract Article PDF–7.5M

Select item 89824069.

Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression

Yuwei Li, Chencheng Yang, Huishan Wang, Ling Zhao, Qinghua Kong, Yu Cang, Shuhua Zhao, Longbao Lv, Yan Li, Bingyu Mao, Pengcheng Ma

J Mol Cell Biol. 2022 Jan; 14(1): mjab082. Published online 2022 Jan 18. doi: 10.1093/jmcb/mjab082

Correction in:: J Mol Cell Biol. 2022 Feb; 14(2): mjac030.

PMCID:: PMC8982406

Abstract Article PDF–4.4M

Select item 882889510.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 874851011.

RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis

Yongsheng Huang, Sijia Liu, Mengjie Shan, Sophie C. Hagenaars, Wilma E. Mesker, Danielle Cohen, Lin Wang, Zhi Zheng, Peter Devilee, Rob A. E. M. Tollenaar, Zhangfu Li, Yongmei Song, Long Zhang, Dan Li, Peter ten Dijke

Cell Death Dis. 2022 Jan; 13(1): 44. Published online 2022 Jan 10. doi: 10.1038/s41419-021-04493-y

PMCID:: PMC8748510

Abstract Article PDF–4.5M

Select item 848772112.

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase

Shuai Zhao, Wafik S. El-Deiry

Oncotarget. 2021 Sep 28; 12(20): 1970–1979. Published online 2021 Sep 28. doi: 10.18632/oncotarget.28081

PMCID:: PMC8487721

Abstract Article PDF–3.1M

Select item 822574113.

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network

Yu-Kun Xia, Yi-Rong Zeng, Meng-Li Zhang, Peng Liu, Fang Liu, Hao Zhang, Chen-Xi He, Yi-Ping Sun, Jin-Ye Zhang, Cheng Zhang, Lei Song, Chen Ding, Yu-Jie Tang, Zhen Yang, Chen Yang, Pu Wang, Kun-Liang Guan, Yue Xiong, Dan Ye

Protein Cell. 2021 Jul; 12(7): 557–577. Published online 2020 Jul 18. doi: 10.1007/s13238-020-00754-2

PMCID:: PMC8225741

Abstract Article PDF–3.1M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810012115.

A novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne–Kalscheuer syndrome

Francisco Bustos, Carmen Espejo-Serrano, Anna Segarra-Fas, Rachel Toth, Alison J. Eaton, Kristin D. Kernohan, Meredith J. Wilson, Lisa G. Riley, Greg M. Findlay

Sci Rep. 2021; 11: 9560. Published online 2021 May 5. doi: 10.1038/s41598-021-88911-3

PMCID:: PMC8100121

Abstract Article PDF–2.1M

Select item 794896416.

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1

Lee D. Harris, Janic Le Pen, Nico Scholz, Juliusz Mieszczanek, Natalie Vaughan, Simon Davis, Georgina Berridge, Benedikt M. Kessler, Mariann Bienz, Julien D.F. Licchesi

J Biol Chem. 2021 Jan-Jun; 296: 100246. Published online 2021 Jan 8. doi: 10.1074/jbc.RA120.015162

PMCID:: PMC7948964

Abstract Article PDF–2.7M

Select item 782056417.

RLIM Is a Candidate Dosage-Sensitive Gene for Individuals with Varying Duplications of Xq13, Intellectual Disability, and Distinct Facial Features

Elizabeth E. Palmer, Renee Carroll, Marie Shaw, Raman Kumar, Andre E. Minoche, Melanie Leffler, Lucinda Murray, Rebecca Macintosh, Dale Wright, Chris Troedson, Fiona McKenzie, Sharron Townshend, Michelle Ward, Urwah Nawaz, Anja Ravine, Cassandra K. Runke, Erik C. Thorland, Marybeth Hummel, Nicola Foulds, Olivier Pichon, Bertrand Isidor, Cédric Le Caignec, Bénédicte Demeer, Joris Andrieux, Salam Hadah Albarazi, Ann Bye, Rani Sachdev, Edwin P. Kirk, Mark J. Cowley, Mike Field, Jozef Gecz

Am J Hum Genet. 2020 Dec 3; 107(6): 1157–1169. Published online 2020 Nov 6. doi: 10.1016/j.ajhg.2020.10.005

PMCID:: PMC7820564

Abstract Article PDF–1.6M

Select item 781571918.

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP_L

Osamu Nakabayashi, Hirotaka Takahashi, Kenta Moriwaki, Sachiko Komazawa-Sakon, Fumiaki Ohtake, Shin Murai, Yuichi Tsuchiya, Yuki Koyahara, Yasushi Saeki, Yukiko Yoshida, Soh Yamazaki, Fuminori Tokunaga, Tatsuya Sawasaki, Hiroyasu Nakano

Commun Biol. 2021; 4: 80. Published online 2021 Jan 19. doi: 10.1038/s42003-020-01603-y

PMCID:: PMC7815719

Abstract Article PDF–4.3M

Select item 761367619.

An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations

Anna Segarra-Fas, Carmen Espejo-Serrano, Francisco Bustos, Houjiang Zhou, Feng Wang, Rachel Toth, Thomas Macartney, Ingolf Bach, Gino Nardocci, Greg M. Findlay

Sci Signal. Author manuscript; available in PMC 2022 Oct 5.

Published in final edited form as: Sci Signal. 2022 Jul 12; 15(742): eabm5995. Published online 2022 Jul 12. doi: 10.1126/scisignal.abm5995

PMCID:: PMC7613676

Abstract Article PDF–2.9M

Select item 756688120.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

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