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Select item 92316231.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 91052352.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 89239793.

Probing the functional consequence and clinical relevance of CD320 p.E88del, a variant in the transcobalamin receptor gene

Faith Pangilinan, David Watkins, David Bernard, Yue Chen, Ningzheng Dong, Qingyu Wu, Hatice Ozel-Abaan, Manjit Kaur, Michele Caggana, Mark Morrissey, Marilyn L. Browne, James L. Mills, Carol Van Ryzin, Oleg Shchelochkov, Jennifer Sloan, Charles P. Venditti, Kyriakie Sarafoglou, David S. Rosenblatt, Denise M. Kay, Lawrence C. Brody

Am J Med Genet A. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Am J Med Genet A. 2022 Apr; 188(4): 1124–1141. Published online 2022 Feb 2. doi: 10.1002/ajmg.a.62627

PMCID:: PMC8923979

Abstract Article PDF–706K

Select item 85529074.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 85138535.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80026167.

Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter

Joseph Boachie, Antonysunil Adaikalakoteswari, Ilona Goljan, Jinous Samavat, Felino R. Cagampang, Ponnusamy Saravanan

Int J Mol Sci. 2021 Mar; 22(6): 3089. Published online 2021 Mar 17. doi: 10.3390/ijms22063089

PMCID:: PMC8002616

Abstract Article PDF–1.2M

Select item 73491968.

3’-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women

Tae-Keun Ahn, Jung Oh Kim, Hui Jeong An, Han Sung Park, Un Yong Choi, Seil Sohn, Kyoung-Tae Kim, Nam Keun Kim, In-Bo Han

Genes (Basel) 2020 Jun; 11(6): 612. Published online 2020 Jun 2. doi: 10.3390/genes11060612

PMCID:: PMC7349196

Abstract Article PDF–1.9M

Select item 73220679.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 664225010.

Genetic polymorphisms of the cobalamin transport system are associated with idiopathic recurrent implantation failure

Han Sung Park, Jung Oh Kim, Hui Jeong An, Chang Soo Ryu, Eun Ju Ko, Young Ran Kim, Eun Hee Ahn, Woo Sik Lee, Ji Hyang Kim, Nam Keun Kim

J Assist Reprod Genet. 2019 Jul; 36(7): 1513–1522. Published online 2019 May 23. doi: 10.1007/s10815-019-01455-4

PMCID:: PMC6642250

Abstract Article PDF–285K

Select item 629810511.

Ubiquilin 2 modulates ALS/FTD-linked FUS–RNA complex dynamics and stress granule formation

Elizabeth J. Alexander, Amirhossein Ghanbari Niaki, Tao Zhang, Jaya Sarkar, Yang Liu, Raja Sekhar Nirujogi, Akhilesh Pandey, Sua Myong, Jiou Wang

Proc Natl Acad Sci U S A. 2018 Dec 4; 115(49): E11485–E11494. Published online 2018 Nov 15. doi: 10.1073/pnas.1811997115

PMCID:: PMC6298105

Abstract Article PDF–3.7M

Select item 567858112.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 553161113.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 494715414.

Structural basis of transcobalamin recognition by human CD320 receptor

Amer Alam, Jae-Sung Woo, Jennifer Schmitz, Bernadette Prinz, Katharina Root, Fan Chen, Joël S. Bloch, Renato Zenobi, Kaspar P. Locher

Nat Commun. 2016; 7: 12100. Published online 2016 Jul 14. doi: 10.1038/ncomms12100

PMCID:: PMC4947154

Abstract Article PDF–1.1M

Select item 461721115.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 460899716.

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef

Nicholas J. Matheson, Jonathan Sumner, Kim Wals, Radu Rapiteanu, Michael P. Weekes, Raphael Vigan, Julia Weinelt, Michael Schindler, Robin Antrobus, Ana S.H. Costa, Christian Frezza, Clary B. Clish, Stuart J.D. Neil, Paul J. Lehner

Cell Host Microbe. 2015 Oct 14; 18(4): 409–423. doi: 10.1016/j.chom.2015.09.003

PMCID:: PMC4608997

Abstract Article PDF–3.8M

Select item 411277317.

Transcobalamin II Receptor Polymorphisms Are Associated with Increased Risk for Neural Tube Defects

Faith Pangilinan, Adam Mitchell, Julie VanderMeer, Anne M. Molloy, James Troendle, Mary Conley, Peadar N. Kirke, Marie Sutton, Jeffrey M. Sequeira, Edward V. Quadros, John M. Scott, James L. Mills, Lawrence C. Brody

J Med Genet. Author manuscript; available in PMC 2014 Jul 28.

Published in final edited form as: J Med Genet. 2010 Oct; 47(10): 677–685. Published online 2010 Jun 24. doi: 10.1136/jmg.2009.073775

Correction in:: J Med Genet, volume 49 on page 784

PMCID:: PMC4112773

Abstract Article PDF–266K

Select item 404243018.

Immunohistochemical Quantification of the Vitamin B12 Transport Protein (TCII), Cell Surface Receptor (TCII-R) and Ki-67 in Human Tumor Xenografts

Annette M. Sysel, Victor E. Valli, Ray B. Nagle, Joseph A. Bauer

Anticancer Res. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Anticancer Res. 2013 Oct; 33(10): 4203–4212.

PMCID:: PMC4042430

Abstract Article PDF–917K

Select item 375491719.

The Soluble Receptor for Vitamin B₁₂ Uptake (sCD320) Increases during Pregnancy and Occurs in Higher Concentration in Urine than in Serum

Omar Abuyaman, Birgitte H. Andreasen, Camilla Kronborg, Erik Vittinghus, Ebba Nexo

PLoS One. 2013; 8(8): e73110. Published online 2013 Aug 27. doi: 10.1371/journal.pone.0073110

PMCID:: PMC3754917

Abstract Article PDF–360K

Select item 371458520.

Mapping the functional domains of TCblR/CD320, the receptor for cellular uptake of transcobalamin-bound cobalamin

Wenxia Jiang, Yasumi Nakayama, Jeffrey M. Sequeira, Edward V. Quadros

FASEB J. 2013 Aug; 27(8): 2988–2994. doi: 10.1096/fj.13-230185

PMCID:: PMC3714585

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