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Items: 1 to 20 of 70

1.
Cell adhesion tunes inflammatory TPL2 kinase signal transduction
Maria Vougioukalaki, Konstantina Georgila, Emmanouil I. Athanasiadis, Aristides G. Eliopoulos
Cell Mol Life Sci. 2022 Mar; 79(3): 156. Published online 2022 Feb 26. doi: 10.1007/s00018-022-04130-7
PMCID:
PMC11072766
AbstractArticlePDF–2.1M
2.
Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma
Qin Yu, Dan Wan, Rong Fu, Feng Li, Yutao Zhang
Sci Rep. 2023; 13: 17346. Published online 2023 Oct 13. doi: 10.1038/s41598-023-44660-z
PMCID:
PMC10576082
AbstractArticlePDF–6.3M
3.
Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma
Gaurab Roy, Ting Yang, Shangxin Liu, Yi-Ling Luo, Yuantao Liu, Qian Zhong
Int J Mol Sci. 2023 Feb; 24(3): 1964. Published online 2023 Jan 19. doi: 10.3390/ijms24031964
PMCID:
PMC9916342
AbstractArticlePDF–5.6M
4.
ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression
Yu You, Diguang Wen, Lu Zeng, Jiao Lu, Xiao Xiao, Yucheng Chen, Hua Song, Zuojin Liu
Int J Biol Sci. 2022; 18(13): 5001–5018. Published online 2022 Aug 1. doi: 10.7150/ijbs.70149
PMCID:
PMC9379398
AbstractArticlePDF–3.5M
5.
Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes
Mary B. Kelley, Taylor J. Geddes, Maria Ochiai, Noah M. Lampl, W. Wade Kothmann, Sara R. Fierstein, Victoria Kent, Kathleen DeCicco-Skinner
PLoS One. 2022; 17(3): e0266017. Published online 2022 Mar 24. doi: 10.1371/journal.pone.0266017
PMCID:
PMC8947257
AbstractArticlePDF–2.7M
6.
Human transcription factor protein interaction networks
Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo
Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5
PMCID:
PMC8828895
AbstractArticlePDF–1.7M
7.
Unravelling the Impact of the Genetic Variant rs1042058 within the TPL2 Risk Gene Locus on Molecular and Clinical Disease Course Patients with Inflammatory Bowel Disease
Yasser Morsy, Nathalie Brillant, Yannick Franc, Michael Scharl, Marcin Wawrzyniak, on behalf of the Swiss IBD Cohort Study Group
Cells. 2021 Dec; 10(12): 3589. Published online 2021 Dec 20. doi: 10.3390/cells10123589
PMCID:
PMC8700574
AbstractArticlePDF–4.0M
8.
Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts
Yosuke Mitsui, Nahoko Tomonobu, Masami Watanabe, Rie Kinoshita, I Wayan Sumardika, Chen Youyi, Hitoshi Murata, Ken-ichi Yamamoto, Takuya Sadahira, Acosta Gonzalez Herik Rodrigo, Hitoshi Takamatsu, Kota Araki, Akira Yamauchi, Masahiro Yamamura, Hideyo Fujiwara, Yusuke Inoue, Junichiro Futami, Ken Saito, Hidekazu Iioka, Eisaku Kondo, Masahiro Nishibori, Shinichi Toyooka, Yasuhiko Yamamoto, Yasutomo Nasu, Masakiyo Sakaguchi
Oncol Res. 2019; 27(8): 945–956. Published online 2019 Aug 8. doi: 10.3727/096504019X15555408784978
PMCID:
PMC7848232
AbstractArticlePDF–5.1M
9.
Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2
Guanwen Wang, Juan Wang, Antao Chang, Dongmei Cheng, Shan Huang, Dan Wu, Sherona Sirkisoon, Shuang Yang, Hui-Kuan Lin, Hui-Wen Lo, Rong Xiang, Peiqing Sun
Oncogene. Author manuscript; available in PMC 2021 Mar 28.
Published in final edited form as: Oncogene. 2020 Nov; 39(47): 7034–7050. Published online 2020 Sep 28. doi: 10.1038/s41388-020-01481-y
Correction in:
Oncogene. 2021 Feb 10
PMCID:
PMC7680376
AbstractArticlePDF–3.1M
10.
TPL2 enforces RAS-induced inflammatory signaling and is activated by point mutations
Paarth B. Dodhiawala, Namrata Khurana, Daoxiang Zhang, Yi Cheng, Lin Li, Qing Wei, Kuljeet Seehra, Hongmei Jiang, Patrick M. Grierson, Andrea Wang-Gillam, Kian-Huat Lim
J Clin Invest. 2020 Sep 1; 130(9): 4771–4790. Published online 2020 Aug 10. doi: 10.1172/JCI137660
PMCID:
PMC7456254
AbstractArticlePDF–23M
11.
A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
Stefanie Voigt, Kai R. Sterz, Fabian Giehler, Anne-Wiebe Mohr, Joanna B. Wilson, Andreas Moosmann, Arnd Kieser
Nat Commun. 2020; 11: 685. Published online 2020 Feb 4. doi: 10.1038/s41467-020-14502-x
PMCID:
PMC7000802
AbstractArticlePDF–2.4M
12.
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability
Divya Achuthankutty, Roshan Singh Thakur, Peter Haahr, Saskia Hoffmann, Alexandros P. Drainas, Anna H. Bizard, Joachim Weischenfeldt, Ian D. Hickson, Niels Mailand
J Cell Biol. 2019 Dec 2; 218(12): 3943–3953. Published online 2019 Oct 15. doi: 10.1083/jcb.201905064
PMCID:
PMC6891097
AbstractArticlePDF–2.7M
13.
Identification of targetable recurrent MAP3K8 rearrangements in melanomas lacking known driver mutations
Brian D. Lehmann, Timothy M. Shaver, Douglas B. Johnson, Zhu Li, Paula I. Gonzalez-Ericsson, Violeta Sánchez, Yu Shyr, Melinda E. Sanders, Jennifer A. Pietenpol
Mol Cancer Res. Author manuscript; available in PMC 2020 Mar 1.
Published in final edited form as: Mol Cancer Res. 2019 Sep; 17(9): 1842–1853. Published online 2019 Jun 11. doi: 10.1158/1541-7786.MCR-19-0257
PMCID:
PMC6726520
AbstractArticlePDF–2.3M
14.
The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines
Oksana B. Serebrennikova, Maria D. Paraskevopoulou, Elia Aguado-Fraile, Vasiliki Taraslia, Wenying Ren, Geeta Thapa, Jatin Roper, Keyong Du, Carlo M. Croce, Philip N. Tsichlis
Proc Natl Acad Sci U S A. 2019 Jul 9; 116(28): 14039–14048. Published online 2019 Jun 25. doi: 10.1073/pnas.1901465116
PMCID:
PMC6628646
AbstractArticlePDF–1.3M
15.
Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8
Laurent M. Paardekooper, Maura B. Bendix, Andrea Ottria, Lieke W. de Haer, Martin ter Beest, Timothy R.D.J. Radstake, Wioleta Marut, Geert van den Bogaart
Biosci Rep. 2018 Dec 21; 38(6): BSR20182019. Prepublished online 2018 Nov 21. Published online 2018 Dec 14. doi: 10.1042/BSR20182019
PMCID:
PMC6294625
AbstractArticlePDF–1.3M
16.
Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK‐ERK and NF‐κB pathways in a model of chronic myeloid leukemia
Anna Chorzalska, Nagib Ahsan, R. Shyama Prasad Rao, Karim Roder, Xiaoqing Yu, John Morgan, Alexander Tepper, Steven Hines, Peng Zhang, Diana O. Treaba, Ting C. Zhao, Adam J. Olszewski, John L. Reagan, Olin Liang, Philip A. Gruppuso, Patrycja M. Dubielecka
Mol Oncol. 2018 May; 12(5): 630–647. Published online 2018 Apr 6. doi: 10.1002/1878-0261.12186
PMCID:
PMC5928369
AbstractArticlePDF–1.5M
17.
Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection
Benoit Besson, Florian Sonthonnax, Magalie Duchateau, Youcef Ben Khalifa, Florence Larrous, Hyeju Eun, Véronique Hourdel, Mariette Matondo, Julia Chamot-Rooke, Regis Grailhe, Hervé Bourhy
PLoS Pathog. 2017 Oct; 13(10): e1006697. Published online 2017 Oct 30. doi: 10.1371/journal.ppat.1006697
PMCID:
PMC5679641
AbstractArticlePDF–8.5M
18.
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik
Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.
Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834
PMCID:
PMC5557292
AbstractArticlePDF–3.4M
19.
miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma
Xi Zhang, Peng Jiang, Ling Shuai, Kai Chen, Zhonghu Li, Yujun Zhang, Yan Jiang, Xiaowu Li
J Exp Clin Cancer Res. 2016; 35: 176. Published online 2016 Nov 11. doi: 10.1186/s13046-016-0452-6
PMCID:
PMC5106831
AbstractArticlePDF–2.6M
20.
A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion
Matija Hedl, Clara Abraham
Gut. Author manuscript; available in PMC 2017 Nov 1.
Published in final edited form as: Gut. 2016 Nov; 65(11): 1799–1811. Published online 2015 Jul 27. doi: 10.1136/gutjnl-2014-308922
PMCID:
PMC5106344
AbstractArticlePDF–5.1M

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