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Select item 112134641.

UBE2C-induced crosstalk between mono- and polyubiquitination of SNAT2 promotes lymphatic metastasis in bladder cancer

Wenjie Li, Changhao Chen, Hanhao Zheng, Yan Lin, Mingjie An, Daiyin Liu, Yonghai Zhang, Mingchao Gao, Tianhang Lan, Wang He

J Clin Invest. 2024 Jul 1; 134(13): e179122. Published online 2024 Jul 1. doi: 10.1172/JCI179122

PMCID:: PMC11213464

Abstract Article PDF–21M

Select item 111590562.

Clinicopathological relevance of UbcH10 in breast cancer

Takeo Fujita, Hirokuni Ikeda, Kensuke Kawasaki, Naruto Taira, Yutaka Ogasawara, Akira Nakagawara, Hiroyoshi Doihara

Cancer Sci. 2009 Feb; 100(2): 238–248. Published online 2008 Nov 25. doi: 10.1111/j.1349-7006.2008.01026.x

PMCID:: PMC11159056

Abstract Article PDF–900K

Select item 111481843.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 110722754.

Restored UBE2C expression in islets promotes β-cell regeneration in mice by ubiquitinating PER1

Hemin Jiang, Shuai Zheng, Yu Qian, Yuncai Zhou, Hao Dai, Yucheng Liang, Yunqiang He, Rui Gao, Hui Lv, Jie Zhang, Zhiqing Xia, Wenxuan Bian, Tao Yang, Qi Fu

Cell Mol Life Sci. 2023 Aug; 80(8): 226. Published online 2023 Jul 24. doi: 10.1007/s00018-023-04868-8

PMCID:: PMC11072275

Abstract Article PDF–15M

Select item 110272205.

UBE2C promotes the proliferation of acute myeloid leukemia cells through PI3K/AKT activation

Li Wang, Shuqin Zhao, Yongling Wang, Jianying Liu, Xiaoli Wang

BMC Cancer. 2024; 24: 497. Published online 2024 Apr 18. doi: 10.1186/s12885-024-12212-x

PMCID:: PMC11027220

Abstract Article PDF–4.2M

Select item 107249386.

Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma

Khaa Hoo Ong, Hong-Yue Lai, Ding-Ping Sun, Tzu-Ju Chen, Steven Kuan-Hua Huang, Yu-Feng Tian, Chia-Lin Chou, Yow-Ling Shiue, Ti-Chun Chan, Chien-Feng Li, Yu-Hsuan Kuo

Eur J Med Res. 2023; 28: 593. Published online 2023 Dec 15. doi: 10.1186/s40001-023-01575-9

PMCID:: PMC10724938

Abstract Article PDF–1.5M

Select item 106544707.

UBE2C promotes malignancy of cutaneous squamous cell carcinoma

Ruiting Luo, Ruimin Bai, Jiaqi Guo, Ningyi Xian, Yan Zheng

Skin Res Technol. 2023 Nov; 29(11): e13526. Published online 2023 Nov 16. doi: 10.1111/srt.13526

PMCID:: PMC10654470

Abstract Article PDF–5.2M

Select item 106500738.

Role of UBE2C in Brain Cancer Invasion and Dissemination

Stefani Domentean, Eunice Paisana, Rita Cascão, Claudia C. Faria

Int J Mol Sci. 2023 Nov; 24(21): 15792. Published online 2023 Oct 31. doi: 10.3390/ijms242115792

PMCID:: PMC10650073

Abstract Article PDF–1.0M

Select item 105805429.

Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency

Dan Liu, Xiaohong Guan, Wenqiang Liu, Yanping Jia, Hong Zhou, Chenxiang Xi, Mei Zhao, Yuan Fang, Li Wu, Kunming Li

J Ovarian Res. 2023; 16: 203. Published online 2023 Oct 17. doi: 10.1186/s13048-023-01266-3

PMCID:: PMC10580542

Abstract Article PDF–7.2M

Select item 1046956010.

Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development

Sarai T. Dean, Chiharu Ishikawa, Xiaoqin Zhu, Sean Walulik, Timothy Nixon, Jessica K. Jordan, Samantha Henderson, Michael Wyder, Nathan Salomonis, Mark Wunderlich, Kenneth D. Greis, Daniel T. Starczynowski, Andrew G. Volk

Blood Adv. 2023 Sep 12; 7(17): 4822–4837. Published online 2023 May 22. doi: 10.1182/bloodadvances.2022009438

PMCID:: PMC10469560

Abstract Article PDF–4.2M

Select item 1045706511.

Comprehensive analysis of UBE2C expression and its potential roles and mechanisms in hepatocellular carcinoma

Xiao Li, Zhaosheng Ma, Linhang Mei

Aging (Albany NY) 2023 Aug 15; 15(15): 7397–7407. Published online 2023 Aug 14. doi: 10.18632/aging.204792

PMCID:: PMC10457065

Abstract Article PDF–1.2M

Select item 1039989512.

System analysis identifies UBE2C as a novel oncogene target for adrenocortical carcinoma

Renlun Huang, Lang Guo, Chiwei Chen, Yuyang Xiang, Guohao Li, Jieyan Zheng, Yanping Wu, Xiu Yuan, Jianfu Zhou, Wenxi Gao, Songtao Xiang

PLoS One. 2023; 18(8): e0289418. Published online 2023 Aug 3. doi: 10.1371/journal.pone.0289418

PMCID:: PMC10399895

Abstract Article PDF–5.1M

Select item 1036755913.

FOXM1-regulated ZIC2 promotes the malignant phenotype of renal clear cell carcinoma by activating UBE2C/mTOR signaling pathway

Zhengtong Lv, Miao Wang, Huimin Hou, Guyu Tang, Haozhe Xu, Xuan Wang, Yuan Li, Jianye Wang, Ming Liu

Int J Biol Sci. 2023; 19(11): 3293–3306. Published online 2023 Jun 26. doi: 10.7150/ijbs.84067

PMCID:: PMC10367559

Abstract Article PDF–8.0M

Select item 1024855414.

The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity

Sahezeel Awadia, Merna Sitto, Sundaresh Ram, Wenbin Ji, Yajing Liu, Raheema Damani, Dipankar Ray, Theodore S. Lawrence, Craig J. Galban, Steven D. Cappell, Alnawaz Rehemtulla

J Biol Chem. 2023 Jun; 299(6): 104786. Published online 2023 May 4. doi: 10.1016/j.jbc.2023.104786