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Select item 112147771.

Balancing of mitochondrial translation through METTL8-mediated m³C modification of mitochondrial tRNAs

Eva Schöller, James Marks, Virginie Marchand, Astrid Bruckmann, Christopher A. Powell, Markus Reichold, Christian Daniel Mutti, Katja Dettmer, Regina Feederle, Stefan Hüttelmaier, Mark Helm, Peter Oefner, Michal Minczuk, Yuri Motorin, Markus Hafner, Gunter Meister

Mol Cell. Author manuscript; available in PMC 2024 Jun 30.

Published in final edited form as: Mol Cell. 2021 Dec 2; 81(23): 4810–4825.e12. Published online 2021 Nov 12. doi: 10.1016/j.molcel.2021.10.018

PMCID:: PMC11214777

Abstract Article PDF–2.7M

Select item 98261772.

TRIT1 defect leads to a recognizable phenotype of myoclonic epilepsy, speech delay, strabismus, progressive spasticity, and normal lactate levels

Ewout Muylle, Huafang Jiang, Christin Johnsen, Seul Kee Byeon, Wasantha Ranatunga, Kishore Garapati, Roman M. Zenka, Graeme Preston, Akhilesh Pandey, Tamas Kozicz, Fang Fang, Eva Morava

J Inherit Metab Dis. 2022 Nov; 45(6): 1039–1047. Published online 2022 Sep 21. doi: 10.1002/jimd.12550

PMCID:: PMC9826177

Abstract Article PDF–1.9M

Select item 92792853.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91197364.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 88646955.

Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications

Antonieta L. Salguero, Maggie Chen, Aaron T. Balana, Nam Chu, Hanjie Jiang, Brad A. Palanski, Hwan Bae, Katharine M. Wright, Sara Nathan, Heng Zhu, Sandra B. Gabelli, Matthew R. Pratt, Philip A. Cole

ACS Chem Biol. Author manuscript; available in PMC 2022 Feb 23.

Published in final edited form as: ACS Chem Biol. 2022 Jan 21; 17(1): 68–76. Published online 2021 Dec 23. doi: 10.1021/acschembio.1c00632

PMCID:: PMC8864695

Abstract Article PDF–1.1M

Select item 85838016.

The Effect of tRNA^[Ser]Sec Isopentenylation on Selenoprotein Expression

Noelia Fradejas-Villar, Simon Bohleber, Wenchao Zhao, Uschi Reuter, Annika Kotter, Mark Helm, Rainer Knoll, Robert McFarland, Robert W. Taylor, Yufeng Mo, Kenjyo Miyauchi, Yuriko Sakaguchi, Tsutomu Suzuki, Ulrich Schweizer

Int J Mol Sci. 2021 Nov; 22(21): 11454. Published online 2021 Oct 23. doi: 10.3390/ijms222111454

PMCID:: PMC8583801

Abstract Article PDF–4.5M

Select item 83529647.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75254419.

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion

Hyeon Gyu Seo, Han Byeol Kim, Ji Young Yoon, Tae Hyun Kweon, Yun Soo Park, Jingu Kang, Jinwoo Jung, SeongJin Son, Eugene C. Yi, Tae Ho Lee, Won Ho Yang, Jin Won Cho

Cell Death Dis. 2020 Sep; 11(9): 815. Published online 2020 Sep 29. doi: 10.1038/s41419-020-02999-5

PMCID:: PMC7525441

Abstract Article PDF–3.7M

Select item 720002410.

Targeting mitochondrial and cytosolic substrates of TRIT1 isopentenyltransferase: Specificity determinants and tRNA-i⁶A37 profiles

Abdul Khalique, Sandy Mattijssen, Alexander F. Haddad, Shereen Chaudhry, Richard J. Maraia

PLoS Genet. 2020 Apr; 16(4): e1008330. Published online 2020 Apr 23. doi: 10.1371/journal.pgen.1008330

PMCID:: PMC7200024

Abstract Article PDF–3.9M

Select item 616668211.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 438092812.

Phospho-tyrosine dependent protein–protein interaction network

Arndt Grossmann, Nouhad Benlasfer, Petra Birth, Anna Hegele, Franziska Wachsmuth, Luise Apelt, Ulrich Stelzl

Mol Syst Biol. 2015 Mar; 11(3): 0794. Published online 2015 Mar 26. doi: 10.15252/msb.20145968

PMCID:: PMC4380928

Abstract Article PDF–1.9M

Select item 427263113.

The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer

P.J. Smaldino, D.F. Read, M. Pratt-Hyatt, A.K. Hopper, D.R. Engelke

Gene. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Gene. 2015 Feb 1; 556(1): 13–18. Published online 2014 Sep 26. doi: 10.1016/j.gene.2014.09.049

PMCID:: PMC4272631

Abstract Article PDF–588K

Select item 404695814.

Defective i⁶A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA

John W. Yarham, Tek N. Lamichhane, Angela Pyle, Sandy Mattijssen, Enrico Baruffini, Francesco Bruni, Claudia Donnini, Alex Vassilev, Langping He, Emma L. Blakely, Helen Griffin, Mauro Santibanez-Koref, Laurence A. Bindoff, Ileana Ferrero, Patrick F. Chinnery, Robert McFarland, Richard J. Maraia, Robert W. Taylor

PLoS Genet. 2014 Jun; 10(6): e1004424. Published online 2014 Jun 5. doi: 10.1371/journal.pgen.1004424

PMCID:: PMC4046958

Abstract Article PDF–3.3M

Select item 388955615.

Human Cells Have a Limited Set of tRNA Anticodon Loop Substrates of the tRNA Isopentenyltransferase TRIT1 Tumor Suppressor

Tek N. Lamichhane, Sandy Mattijssen, Richard J. Maraia

Mol Cell Biol. 2013 Dec; 33(24): 4900–4908. doi: 10.1128/MCB.01041-13

PMCID:: PMC3889556

Abstract Article PDF–931K

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 294347617.

Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

Sher L. Hendrickson, James A. Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A. Kingsley, James J. Goedert, Gregory D. Kirk, Edward D. Gomperts, Susan P. Buchbinder, Jennifer L. Troyer, Stephen J. O'Brien

PLoS One. 2010; 5(9): e12862. Published online 2010 Sep 21. doi: 10.1371/journal.pone.0012862

PMCID:: PMC2943476

Abstract Article PDF–461K

Select item 292287018.

Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. Radiologic Technologists

Parveen Bhatti, Michele M. Doody, Preetha Rajaraman, Bruce H. Alexander, Meredith Yeager, Amy Hutchinson, Laurie Burdette, Gilles Thomas, David J. Hunter, Steven L. Simon, Robert M. Weinstock, Marvin Rosenstein, Marilyn Stovall, Dale L. Preston, Martha S. Linet, Robert N. Hoover, Stephen J. Chanock, Alice J. Sigurdson

Radiat Res. Author manuscript; available in PMC 2011 Feb 1.

Published in final edited form as: Radiat Res. 2010 Feb; 173(2): 214–224. doi: 10.1667/RR1985.1

PMCID:: PMC2922870

Abstract Article PDF–345K

Select item 289646419.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

Select item 146180720.

Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria.

J Lemieux, B Lakowski, A Webb, Y Meng, A Ubach, F Bussière, T Barnes, S Hekimi

Genetics. 2001 Sep; 159(1): 147–157. doi: 10.1093/genetics/159.1.147

PMCID:: PMC1461807

Summary PDF–398K

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