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Items: 1 to 20 of 49

1.
Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi
Gi Young Lee, Jeongmin Song
Nat Commun. 2024; 15: 5258. Published online 2024 Jun 19. doi: 10.1038/s41467-024-49590-6
PMCID:
PMC11187135
AbstractArticlePDF–2.9M
2.
Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated with Human-Like Neu5Gc loss
Kunio Kawanishi, Joanna K Coker, Kaare V. Grunddal, Chirag Dhar, Jason Hsiao, Karsten Zengler, Nissi Varki, Ajit Varki, Philip L.S.M. Gordts
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2022 Nov 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Nov; 41(11): 2730–2739. Published online 2021 Sep 30. doi: 10.1161/ATVBAHA.120.315280
PMCID:
PMC8551057
AbstractArticlePDF–1.7M
3.
Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah−/−mdx Mice
Paul T. Martin, Kunio Kawanishi, Anna Ashbrook, Bethannie Golden, Annie Samraj, Kelly E. Crowe, Deborah A. Zygmunt, Jonathan Okerblom, Hai Yu, Agatha Maki, Sandra Diaz, Xi Chen, Paul M.L. Janssen, Ajit Varki
Am J Pathol. 2021 Aug; 191(8): 1474–1486. doi: 10.1016/j.ajpath.2021.04.015
PMCID:
PMC8351128
AbstractArticlePDF–2.1M
4.
Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae
Sudeshna Saha, Alison Coady, Aniruddha Sasmal, Kunio Kawanishi, Biswa Choudhury, Hai Yu, Ricardo U. Sorensen, Jaime Inostroza, Ian C. Schoenhofen, Xi Chen, Anja Münster-Kühnel, Chihiro Sato, Ken Kitajima, Sanjay Ram, Victor Nizet, Ajit Varki
mBio. 2021 Jan-Feb; 12(1): e03226-20. Published online 2021 Jan 19. doi: 10.1128/mBio.03226-20
PMCID:
PMC7845648
AbstractArticlePDF–3.4M
5.
Therapeutic CMP-nonulosonates against multidrug-resistant Neisseria gonorrhoeae
Sunita Gulati, Ian C. Schoenhofen, Theresa Lindhout-Djukic, Melissa J. Schur, Corinna Landig, Sudeshna Saha, Lingquan Deng, Lisa A. Lewis, Bo Zheng, Ajit Varki, Sanjay Ram
J Immunol. Author manuscript; available in PMC 2021 Jun 15.
Published in final edited form as: J Immunol. 2020 Jun 15; 204(12): 3283–3295. Published online 2020 May 20. doi: 10.4049/jimmunol.1901398
PMCID:
PMC7321800
AbstractArticlePDF–962K
6.
Salmonella Typhoid Toxin PltB Subunit and Its Nontyphoidal Salmonella Orthologue Confer Differential Host Adaptation and Virulence
Sohyoung Lee, Yi-An Yang, Shawn K. Milano, Tri Nguyen, Changhwan Ahn, Ji Hyun Sim, Andrew J. Thompson, Eric C. Hillpot, Gyeongshik Yoo, James C. Paulson, Jeongmin Song
Cell Host Microbe. Author manuscript; available in PMC 2021 Jun 10.
Published in final edited form as: Cell Host Microbe. 2020 Jun 10; 27(6): 937–949.e6. Published online 2020 May 11. doi: 10.1016/j.chom.2020.04.005
PMCID:
PMC7292776
AbstractArticlePDF–2.9M
7.
A comparison of the bone and growth phenotype of mdx, mdx:Cmah−/− and mdx:Utrn+/− murine models with the C57BL/10 wild-type mouse
Claire L. Wood, Karla J. Suchacki, Rob van ’t Hof, Will P. Cawthorn, Scott Dillon, Volker Straub, Sze Choong Wong, Syed F. Ahmed, Colin Farquharson
Dis Model Mech. 2020 Feb 1; 13(2): dmm040659. Published online 2020 Jan 10. doi: 10.1242/dmm.040659
PMCID:
PMC6994935
AbstractArticle
8.
Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates
Livia S. Zaramela, Cameron Martino, Frederico Alisson-Silva, Steven D. Rees, Sandra L. Diaz, Léa Chuzel, Mehul B. Ganatra, Christopher H. Taron, Patrick Secrest, Cristal Zuñiga, Jianbo Huang, Dionicio Siegel, Geoffrey Chang, Ajit Varki, Karsten Zengler
Nat Microbiol. Author manuscript; available in PMC 2020 Mar 23.
Published in final edited form as: Nat Microbiol. 2019 Dec; 4(12): 2082–2089. Published online 2019 Sep 23. doi: 10.1038/s41564-019-0564-9
PMCID:
PMC6879853
AbstractArticlePDF–1.6M
9.
Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms
Kunio Kawanishi, Chirag Dhar, Raymond Do, Nissi Varki, Philip L. S. M. Gordts, Ajit Varki
Proc Natl Acad Sci U S A. 2019 Aug 6; 116(32): 16036–16045. Published online 2019 Jul 22. doi: 10.1073/pnas.1902902116
PMCID:
PMC6690033
AbstractArticlePDF–3.0M
10.
Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment
Corinne A Betts, Graham McClorey, Richard Healicon, Suzan M Hammond, Raquel Manzano, Sofia Muses, Vicky Ball, Caroline Godfrey, Thomas M Merritt, Tirsa van Westering, Liz O’Donovan, Kim E Wells, Michael J Gait, Dominic J Wells, Damian Tyler, Matthew J Wood
Hum Mol Genet. 2019 Feb 1; 28(3): 396–406. Published online 2018 Oct 2. doi: 10.1093/hmg/ddy346
PMCID:
PMC6337703
AbstractArticlePDF–3.6M
11.
Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection
Raghubendra Singh Dagur, Amanda Branch-Woods, Saumi Mathews, Poonam S. Joshi, Rolen M. Quadros, Donald W. Harms, Yan Cheng, Shana M. Miles, Samuel J. Pirruccello, Channabasavaiah B. Gurumurthy, Santhi Gorantla, Larisa Y. Poluektova
BMC Immunol. 2019; 20: 2. Published online 2019 Jan 7. doi: 10.1186/s12865-018-0279-3
PMCID:
PMC6322283
AbstractArticlePDF–5.0M
12.
Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution
Jonathan Okerblom, William Fletes, Hemal H. Patel, Simon Schenk, Ajit Varki, Ellen C. Breen
Proc Biol Sci. 2018 Sep 12; 285(1886): 20181656. Published online 2018 Sep 12. doi: 10.1098/rspb.2018.1656
PMCID:
PMC6158528
AbstractArticlePDF–914K
13.
Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy
Alison M. Blain, Elizabeth Greally, Graham McClorey, Raquel Manzano, Corinne A. Betts, Caroline Godfrey, Liz O’Donovan, Thibault Coursindel, Mike J. Gait, Matthew J. Wood, Guy A. MacGowan, Volker W. Straub
PLoS One. 2018; 13(6): e0198897. Published online 2018 Jun 18. doi: 10.1371/journal.pone.0198897
PMCID:
PMC6005479
AbstractArticlePDF–17M
14.
Evolution of host adaptation in the Salmonella typhoid toxin
Xiang Gao, Lingquan Deng, Gabrielle Stack, Hai Yu, Xi Chen, Yuko Naito-Matsui, Ajit Varki, Jorge E. Galán
Nat Microbiol. Author manuscript; available in PMC 2018 Apr 9.
Published in final edited form as: Nat Microbiol. 2017 Dec; 2(12): 1592–1599. Published online 2017 Oct 9. doi: 10.1038/s41564-017-0033-2
Correction in:
Nat Microbiol. 2017 Nov 1
PMCID:
PMC5705260
AbstractArticlePDF–1.0M
15.
Extrinsic sialylation is dynamically regulated by systemic triggers in vivo
Charles T. Manhardt, Patrick R. Punch, Christopher W. L. Dougher, Joseph T. Y. Lau
J Biol Chem. 2017 Aug 18; 292(33): 13514–13520. Published online 2017 Jul 17. doi: 10.1074/jbc.C117.795138
PMCID:
PMC5566511
AbstractArticlePDF–755K
16.
Loss of CMAH During Human Evolution Primed the Monocyte-Macrophage Lineage Towards a More Inflammatory and Phagocytic State
Jonathan J. Okerblom, Flavio Schwarz, Josh Olson, William Fletes, Syed Raza Ali, Paul T. Martin, Christopher K. Glass, Victor Nizet, Ajit Varki
J Immunol. Author manuscript; available in PMC 2018 Mar 15.
Published in final edited form as: J Immunol. 2017 Mar 15; 198(6): 2366–2373. Published online 2017 Feb 1. doi: 10.4049/jimmunol.1601471
PMCID:
PMC5340615
AbstractArticlePDF–856K
17.
Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain
Yuko Naito-Matsui, Leela R. L. Davies, Hiromu Takematsu, Hsun-Hua Chou, Pam Tangvoranuntakul, Aaron F. Carlin, Andrea Verhagen, Charles J. Heyser, Seung-Wan Yoo, Biswa Choudhury, James C. Paton, Adrienne W. Paton, Nissi M. Varki, Ronald L. Schnaar, Ajit Varki
J Biol Chem. 2017 Feb 17; 292(7): 2557–2570. Published online 2017 Jan 3. doi: 10.1074/jbc.M116.768531
PMCID:
PMC5314156
AbstractArticlePDF–2.8M
18.
Streptococcus pneumoniae senses a human-like sialic acid profile via the response regulator CiaR
Karina Hentrich, Jonas Löfling, Anuj Pathak, Victor Nizet, Ajit Varki, Birgitta Henriques-Normark
Cell Host Microbe. Author manuscript; available in PMC 2017 Sep 14.
Published in final edited form as: Cell Host Microbe. 2016 Sep 14; 20(3): 307–317. Published online 2016 Sep 1. doi: 10.1016/j.chom.2016.07.019
PMCID:
PMC5025396
AbstractArticlePDF–1.4M
19.
A Mouse Model for Dietary Xenosialitis: ANTIBODIES TO XENOGLYCAN CAN REDUCE FERTILITY
Fang Ma, Liwen Deng, Patrick Secrest, Linda Shi, June Zhao, Pascal Gagneux
J Biol Chem. 2016 Aug 26; 291(35): 18222–18231. Published online 2016 Jul 5. doi: 10.1074/jbc.M116.739169
PMCID:
PMC5000070
AbstractArticlePDF–2.3M
20.
Sialylation Facilitates the Maturation of Mammalian Sperm and Affects Its Survival in Female Uterus
Xue Ma, Qian Pan, Ying Feng, Biswa P. Choudhury, Qianhong Ma, Pascal Gagneux, Fang Ma
Biol Reprod. 2016 Jun; 94(6): 123. Published online 2016 Apr 13. doi: 10.1095/biolreprod.115.137810
PMCID:
PMC4946803
AbstractArticlePDF–1.4M

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