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Items: 1 to 20 of 65

1.
A20 controls RANK‐dependent osteoclast formation and bone physiology
Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amélie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D Zajac, Rachel A Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J M Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo
EMBO Rep. 2022 Dec; 23(12): e55233. Published online 2022 Oct 4. doi: 10.15252/embr.202255233
PMCID:
PMC9724664
AbstractArticlePDF–3.0M
2.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
3.
T cell–derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death
Nicholas Chun, Rosalind L. Ang, Mark Chan, Robert L. Fairchild, William M. Baldwin, III, Julian K. Horwitz, Jesse D. Gelles, Jerry Edward Chipuk, Michelle A. Kelliher, Vasile I. Pavlov, Yansui Li, Dirk Homann, Peter S. Heeger, Adrian T. Ting
JCI Insight. 2021 Dec 22; 6(24): e148643. Published online 2021 Dec 22. doi: 10.1172/jci.insight.148643
PMCID:
PMC8783689
AbstractArticlePDF–6.1M
4.
Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death
Rosalind L. Ang, Mark Chan, Diana Legarda, John P. Sundberg, Shao-Cong Sun, Virginia L. Gillespie, Nicholas Chun, Peter S. Heeger, Huabao Xiong, Sergio A. Lira, Adrian T. Ting
Proc Natl Acad Sci U S A. 2021 Dec 14; 118(50): e2001602118. Published online 2021 Dec 9. doi: 10.1073/pnas.2001602118
PMCID:
PMC8685717
AbstractArticlePDF–2.2M
5.
The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains
Carlos Gomez-Diaz, Gustav Jonsson, Katrin Schodl, Luiza Deszcz, Annika Bestehorn, Kevin Eislmayr, Jorge Almagro, Anoop Kavirayani, Mayu Seida, Lilian M. Fennell, Astrid Hagelkruys, Pavel Kovarik, Josef M. Penninger, Fumiyo Ikeda
iScience. 2021 Nov 19; 24(11): 103241. Published online 2021 Oct 8. doi: 10.1016/j.isci.2021.103241
PMCID:
PMC8561004
AbstractArticlePDF–4.4M
6.
Site‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling
Lilian M Fennell, Carlos Gomez Diaz, Luiza Deszcz, Anoop Kavirayani, David Hoffmann, Kota Yanagitani, Alexander Schleiffer, Karl Mechtler, Astrid Hagelkruys, Josef Penninger, Fumiyo Ikeda
EMBO J. 2020 Dec 15; 39(24): e103303. Published online 2020 Nov 20. doi: 10.15252/embj.2019103303
PMCID:
PMC7737615
AbstractArticlePDF–1.9M
7.
Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice
John P. Sundberg, C. Herbert Pratt, Leslie P. Goodwin, Kathleen A. Silva, Victoria E. Kennedy, Christopher S. Potter, Anisa Dunham, Beth A. Sundberg, Harm HogenEsch
PLoS One. 2020; 15(7): e0235295. Published online 2020 Jul 20. doi: 10.1371/journal.pone.0235295
PMCID:
PMC7371178
AbstractArticlePDF–3.5M
8.
RIP1 kinase activity is critical for skin inflammation but not for viral propagation
Joshua D. Webster, Youngsu C. Kwon, Summer Park, Hua Zhang, Nick Corr, Nina Ljumanovic, Adeyemi O. Adedeji, Eugene Varfolomeev, Tatiana Goncharov, Jessica Preston, Sara F. Santagostino, Snahel Patel, Min Xu, Jonathan Maher, Brent S. McKenzie, Domagoj Vucic
J Leukoc Biol. 2020 Jun; 107(6): 941–952. Published online 2020 Jan 27. doi: 10.1002/JLB.3MA1219-398R
PMCID:
PMC7317411
AbstractArticlePDF–8.4M
9.
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
Snahel Patel, Joshua D. Webster, Eugene Varfolomeev, Youngsu C. Kwon, Jason H. Cheng, Juan Zhang, Debra L. Dugger, Kate E. Wickliffe, Allie Maltzman, Swathi Sujatha-Bhaskar, Pawan Bir Kohli, Sreema Ramaswamy, Gauri Deshmukh, Bianca M. Liederer, Rina Fong, Greg Hamilton, Patrick Lupardus, Patrick Caplazi, Wyne P. Lee, Menno van Lookeren Campagne, Adam Johnson, Brent S. McKenzie, Melissa R. Junttila, Kim Newton, Domagoj Vucic
Cell Death Differ. 2020 Jan; 27(1): 161–175. Published online 2019 May 17. doi: 10.1038/s41418-019-0347-0
PMCID:
PMC7206119
AbstractArticlePDF–2.7M
10.
Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation
Todd Douglas, Maya Saleh
J Biol Chem. 2020 Apr 17; 295(16): 5216–5228. Published online 2020 Mar 2. doi: 10.1074/jbc.RA119.011622
PMCID:
PMC7170516
AbstractArticlePDF–4.0M
11.
Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation
Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis
Nat Commun. 2020; 11: 1747. Published online 2020 Apr 8. doi: 10.1038/s41467-020-15466-8
PMCID:
PMC7142081
AbstractArticlePDF–3.7M
12.
68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice
Riikka Siitonen, Emilia Peuhu, Anu Autio, Heidi Liljenbäck, Elina Mattila, Olli Metsälä, Meeri Käkelä, Tiina Saanijoki, Ingrid Dijkgraaf, Sirpa Jalkanen, Johanna Ivaska, Anne Roivainen
J Nucl Med. 2019 Oct; 60(10): 1380–1387. doi: 10.2967/jnumed.118.222026
PMCID:
PMC6785786
AbstractArticlePDF–1.1M
13.
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwai
Nat Commun. 2019; 10: 3878. Published online 2019 Aug 28. doi: 10.1038/s41467-019-11858-7
PMCID:
PMC6713751
AbstractArticlePDF–4.4M
14.
Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
Juan Gao, Yun Bao, Shushu Ge, Peisen Sun, Jiaojiao Sun, Jianmin Liu, Feng Chen, Li Han, Zhongyuan Cao, Jun Qin, Gilbert C. White, Zhen Xu, Yan-Qing Ma
Cell Commun Signal. 2019; 17: 101. Published online 2019 Aug 20. doi: 10.1186/s12964-019-0407-6
PMCID:
PMC6700787
AbstractArticlePDF–2.2M
15.
Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice
Bhesh Raj Sharma, Rajendra Karki, Ein Lee, Qifan Zhu, Prajwal Gurung, Thirumala-Devi Kanneganti
Cell Death Differ. 2019 Apr; 26(4): 741–750. Published online 2018 Jul 23. doi: 10.1038/s41418-018-0159-7
PMCID:
PMC6460383
AbstractArticlePDF–3.0M
16.
Tumour necrosis factor signalling in health and disease
Jonathan Holbrook, Samuel Lara-Reyna, Heledd Jarosz-Griffiths, Michael F. McDermott
Version 1. F1000Res. 2019; 8: F1000 Faculty Rev-111. Published online 2019 Jan 28. doi: 10.12688/f1000research.17023.1
PMCID:
PMC6352924
AbstractArticlePDF–1.8M
17.
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
Min Wu, Yan Chang, Huaibin Hu, Rui Mu, Yucheng Zhang, Xuanhe Qin, Xiaotao Duan, Weihua Li, Haiqing Tu, Weina Zhang, Guang Wang, Qiuying Han, Ailing Li, Tao Zhou, Kazuhiro Iwai, Xuemin Zhang, Huiyan Li
Nat Commun. 2019; 10: 273. Published online 2019 Jan 17. doi: 10.1038/s41467-018-08043-7
PMCID:
PMC6336796
AbstractArticlePDF–4.9M
18.
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak
Nat Commun. 2018; 9: 3910. Published online 2018 Sep 25. doi: 10.1038/s41467-018-06155-8
PMCID:
PMC6156229
AbstractArticlePDF–3.3M
19.
Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization
Hiroaki Fujita, Akira Tokunaga, Satoshi Shimizu, Amanda L. Whiting, Francisco Aguilar-Alonso, Kenji Takagi, Erik Walinda, Yoshiteru Sasaki, Taketo Shimokawa, Tsunehiro Mizushima, Izuru Ohki, Mariko Ariyoshi, Hidehito Tochio, Federico Bernal, Masahiro Shirakawa, Kazuhiro Iwai
Cell Rep. Author manuscript; available in PMC 2019 Apr 24.
Published in final edited form as: Cell Rep. 2018 Apr 24; 23(4): 1192–1204. doi: 10.1016/j.celrep.2018.03.112
PMCID:
PMC6044281
AbstractArticlePDF–1.0M
20.
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L. Haas, Yutaka Shimizu, Charlotta Böiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T. Ashworth, Allison Beal, Tariq Enver, John Bertin, William Kaiser, Andreas Strasser, John Silke, Philippe Bouillet, Henning Walczak
Nature. Author manuscript; available in PMC 2018 Oct 25.
Published in final edited form as: Nature. 2018 May; 557(7703): 112–117. Published online 2018 Apr 25. doi: 10.1038/s41586-018-0064-8
PMCID:
PMC5947819
AbstractArticlePDF–5.6M

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