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Items: 1 to 20 of 100

1.
Unveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma
Xing Jin, Lei Liu, Dan Liu, Jia Wu, Congcong Wang, Siliang Wang, Fengying Wang, Guanzhen Yu, Xiaoxia Jin, Yu-Wen Xue, Dan Jiang, Yan Ni, Xi Yang, Ming-Song Wang, Zhi-Wei Wang, Yuriy L. Orlov, Wei Jia, Gerry Melino, Ji-Bin Liu, Wen-Lian Chen
Cell Death Differ. 2024 May; 31(5): 558–573. Published online 2024 Apr 3. doi: 10.1038/s41418-024-01285-7
PMCID:
PMC11094133
AbstractArticlePDF–7.3M
2.
Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia
David E. Phelan, Ben Reddan, Masahiko Shigemura, Jacob I. Sznajder, Daniel Crean, Eoin P. Cummins
Int J Mol Sci. 2024 Mar; 25(5): 2852. Published online 2024 Mar 1. doi: 10.3390/ijms25052852
PMCID:
PMC10931687
AbstractArticlePDF–3.1M
3.
Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology
Ángel Juan García-Yagüe, Antonio Cuadrado
Int J Mol Sci. 2023 Aug; 24(15): 12280. Published online 2023 Jul 31. doi: 10.3390/ijms241512280
PMCID:
PMC10419244
AbstractArticlePDF–1.9M
4.
Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis
Nila H. Servaas, Sanne Hiddingh, Eleni Chouri, Catharina G. K. Wichers, Alsya J. Affandi, Andrea Ottria, Cornelis P. J. Bekker, Marta Cossu, Sandra C. Silva‐Cardoso, Maarten van der Kroef, Anneline C. Hinrichs, Tiago Carvalheiro, Nadia Vazirpanah, Lorenzo Beretta, Marzia Rossato, Femke Bonte‐Mineur, Timothy R. D. J. Radstake, Jonas J. W. Kuiper, Marianne Boes, Aridaman Pandit
Arthritis Rheumatol. 2023 Feb; 75(2): 279–292. Published online 2022 Dec 8. doi: 10.1002/art.42319
PMCID:
PMC10108054
AbstractArticlePDF–3.0M
5.
The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2
Tim Vierbuchen, Shiuli Agarwal, John L. Johnson, Liraz Galia, Xuqiu Lei, Karina Stein, David Olagnier, Karoline I. Gaede, Christian Herzmann, Christian K. Holm, Holger Heine, Athma Pai, Aisling O’Hara Hall, Kasper Hoebe, Katherine A. Fitzgerald
Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2213715120. Published online 2022 Dec 28. doi: 10.1073/pnas.2213715120
PMCID:
PMC9910463
AbstractArticlePDF–4.6M
6.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
7.
Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells
Fengchun Ye, David Alvarez-Carbonell, Kien Nguyen, Konstantin Leskov, Yoelvis Garcia-Mesa, Sheetal Sreeram, Saba Valadkhan, Jonathan Karn
PLoS Pathog. 2022 Jul; 18(7): e1010110. Published online 2022 Jul 7. doi: 10.1371/journal.ppat.1010110
PMCID:
PMC9295971
AbstractArticlePDF–6.3M
8.
NURR1 expression regulates retinal pigment epithelial–mesenchymal transition and age-related macular degeneration phenotypes
Pei-Li Yao, Vipul M. Parmar, Mayur Choudhary, Goldis Malek
Proc Natl Acad Sci U S A. 2022 Jul 12; 119(28): e2202256119. Published online 2022 Jul 8. doi: 10.1073/pnas.2202256119
PMCID:
PMC9282432
AbstractArticlePDF–4.3M
9.
The role of NURR1 in metabolic abnormalities of Parkinson’s disease
Murad Al-Nusaif, Yuting Yang, Song Li, Cheng Cheng, Weidong Le
Mol Neurodegener. 2022; 17: 46. Published online 2022 Jun 27. doi: 10.1186/s13024-022-00544-w
PMCID:
PMC9235236
AbstractArticlePDF–1.1M
10.
Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma
Mehrdad Zarei, Rupesh Shrestha, Sneha Johnson, Zuhua Yu, Keshav Karki, Ali Vaziri-Gohar, Jessica Epps, Heng Du, Larry Suva, Mahsa Zarei, Stephen Safe
Cancer Res Commun. 2021 Nov; 1(2): 65–78. Published online 2021 Nov 3. doi: 10.1158/2767-9764.CRC-21-0073
PMCID:
PMC9109828
AbstractArticlePDF–6.5M
11.
Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 (SYNGR3) Gene: The Effects of NURR1 on Its Expression
Lingfei Li, Philip Wing-Lok Ho, Huifang Liu, Shirley Yin-Yu Pang, Eunice Eun-Seo Chang, Zoe Yuen-Kiu Choi, Yasine Malki, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong Ho
Int J Mol Sci. 2022 Apr; 23(7): 3646. Published online 2022 Mar 26. doi: 10.3390/ijms23073646
PMCID:
PMC8998927
AbstractArticlePDF–4.0M
12.
Exosomal lncRNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1)contributes to the progression of allergic rhinitis via modulating microRNA-511/Nuclear Receptor Subfamily 4 Group A Member 2 (NR4A2) axis
Tao Wang, Weiyu Cai, Qinwei Wu, Dong Chen, Peihua Wang, Zhou Xu
Bioengineered. 2021; 12(1): 8067–8079. Published online 2021 Oct 21. doi: 10.1080/21655979.2021.1982313
PMCID:
PMC8806616
AbstractArticlePDF–4.0M
13.
NR4A2 expression is not altered in placentas from cases of growth restriction or preeclampsia, but is reduced in hypoxic cytotrophoblast
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Susan P. Walker, Owen Stock, Katie M. Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Natalie J. Hannan
Sci Rep. 2021; 11: 20670. Published online 2021 Oct 19. doi: 10.1038/s41598-021-00192-y
PMCID:
PMC8526588
AbstractArticlePDF–1.5M
14.
Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response
David E. Phelan, Masahiko Shigemura, Sarah Aldhafiri, Catarina Mota, Thomas J. Hall, Jacob I. Sznajder, Evelyn P. Murphy, Daniel Crean, Eoin P. Cummins
Front Immunol. 2021; 12: 676644. Published online 2021 Jun 25. doi: 10.3389/fimmu.2021.676644
PMCID:
PMC8267906
AbstractArticlePDF–3.4M
15.
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale
Science. Author manuscript; available in PMC 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239
PMCID:
PMC8009048
AbstractArticlePDF–2.6M
16.
Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study
Elizabeth Ruiz-Sánchez, Janet Jiménez-Genchi, Yessica M. Alcántara-Flores, Carlos J. Castañeda-González, Carlos L. Aviña-Cervantes, Petra Yescas, María del Socorro González-Valadez, Nancy Martínez-Rodríguez, Antonio Ríos-Ortiz, Martha González-González, María E. López-Navarro, Patricia Rojas
BMC Psychiatry. 2021; 21: 86. Published online 2021 Feb 9. doi: 10.1186/s12888-021-03081-w
PMCID:
PMC7871565
AbstractArticlePDF–950K
17.
CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function
Justin C. Boucher, Gongbo Li, Hiroshi Kotani, Maria L. Cabral, Dylan Morrissey, Sae Bom Lee, Kristen Spitler, Nolan J. Beatty, Estelle V. Cervantes, Bishwas Shrestha, Bin Yu, Aslamuzzaman Kazi, Xuefeng Wang, Said M. Sebti, Marco L. Davila
Cancer Immunol Res. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Cancer Immunol Res. 2021 Jan; 9(1): 62–74. Published online 2020 Nov 13. doi: 10.1158/2326-6066.CIR-20-0253
Correction in:
Cancer Immunol Res. 2021 Apr; 9(4): 486.
PMCID:
PMC7864379
AbstractArticlePDF–2.0M
18.
De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy
Sakshi Singh, Aditi Gupta, Michael Zech, Ashley N. Sigafoos, Karl J. Clark, Yasemin Dincer, Matias Wagner, Jennifer B. Humberson, Sarah Green, Koen van Gassen, Tracy Brandt, Rhonda E. Schnur, Francisca Millan, Yue Si, Volker Mall, Juliane Winkelmann, Ralitza H. Gavrilova, Eric W. Klee, Kendra Engleman, Nicole P. Safina, Rachel Slaugh, Emily M. Bryant, Wen-Hann Tan, Jorge Granadillo, Sunita N. Misra, G. Bradley Schaefer, Shelley Towner, Eva H. Brilstra, Bobby P. C. Koeleman
Genet Med. 2020; 22(8): 1413–1417. Published online 2020 May 5. doi: 10.1038/s41436-020-0815-4
PMCID:
PMC7394879
AbstractArticlePDF–489K
19.
De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay
Lisenka E.L.M. Vissers, Sreehari Kalvakuri, Elke de Boer, Sinje Geuer, Machteld Oud, Inge van Outersterp, Michael Kwint, Melde Witmond, Simone Kersten, Daniel L. Polla, Dilys Weijers, Amber Begtrup, Kirsty McWalter, Anna Ruiz, Elisabeth Gabau, Jenny E.V. Morton, Christopher Griffith, Karin Weiss, Candace Gamble, James Bartley, Hilary J. Vernon, Kendra Brunet, Claudia Ruivenkamp, Sarina G. Kant, Paul Kruszka, Austin Larson, Alexandra Afenjar, Thierry Billette de Villemeur, Kimberly Nugent, the DDD Study, F. Lucy Raymond, Hanka Venselaar, Florence Demurger, Claudia Soler-Alfonso, Dong Li, Elizabeth Bhoj, Ian Hayes, Nina Powell Hamilton, Ayesha Ahmad, Rachel Fisher, Myrthe van den Born, Marjolaine Willems, Arthur Sorlin, Julian Delanne, Sebastien Moutton, Philippe Christophe, Frederic Tran Mau-Them, Antonio Vitobello, Himanshu Goel, Lauren Massingham, Chanika Phornphutkul, Jennifer Schwab, Boris Keren, Perrine Charles, Maaike Vreeburg, Lenika De Simone, George Hoganson, Maria Iascone, Donatella Milani, Lucie Evenepoel, Nicole Revencu, D. Isum Ward, Kaitlyn Burns, Ian Krantz, Sarah E. Raible, Jill R. Murrell, Kathleen Wood, Megan T. Cho, Hans van Bokhoven, Maximilian Muenke, Tjitske Kleefstra, Rolf Bodmer, Arjan P.M. de Brouwer
Am J Hum Genet. 2020 Jul 2; 107(1): 164–172. Published online 2020 Jun 17. doi: 10.1016/j.ajhg.2020.05.017
PMCID:
PMC7332645
AbstractArticlePDF–1.0M
20.
Genome-Wide Analysis Identifies NURR1-Controlled Network of New Synapse Formation and Cell Cycle Arrest in Human Neural Stem Cells
Soo Min Kim, Soo Young Cho, Min Woong Kim, Seung Ryul Roh, Hee Sun Shin, Young Ho Suh, Dongho Geum, Myung Ae Lee
Mol Cells. 2020 Jun 30; 43(6): 551–571. Published online 2020 Jun 10. doi: 10.14348/molcells.2020.0071
PMCID:
PMC7332357
AbstractArticlePDF–2.6M

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