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Select item 116121381.

TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia

Jenny Bröker-Lai, José Rego Terol, Christin Richter, Ilka Mathar, Angela Wirth, Stefan Kopf, Ana Moreno-Pérez, Michael Büttner, Linette Liqi Tan, Mazen Makke, Gernot Poschet, Julia Hermann, Volodymyr Tsvilovskyy, Uwe Haberkorn, Philipp Wartenberg, Sebastian Susperreguy, Michael Berlin, Roger Ottenheijm, Koenraad Philippaert, Moya Wu, Tobias Wiedemann, Stephan Herzig, Anouar Belkacemi, Rebecca T Levinson, Nitin Agarwal, Juan E Camacho Londoño, Bert Klebl, Klaus Dinkel, Frank Zufall, Peter Nussbaumer, Ulrich Boehm, Rüdiger Hell, Peter Nawroth, Lutz Birnbaumer, Trese Leinders-Zufall, Rohini Kuner, Markus Zorn, Dieter Bruns, Yvonne Schwarz, Marc Freichel

EMBO J. 2024 Dec; 43(23): 5813–5836. Published online 2024 Oct 7. doi: 10.1038/s44318-024-00231-0

PMCID:: PMC11612138

Article PDF–3.4M

Select item 111482822.

TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Qiuhua Cao

Front Pharmacol. 2024; 15: 1392328. Published online 2024 May 21. doi: 10.3389/fphar.2024.1392328

PMCID:: PMC11148282

Article PDF–5.1M

Select item 107707193.

TRPC4 deletion elicits behavioral defects in sociability by dysregulating expression of microRNA-138-2

Jee Young Seo, Hye-Ryeong Jo, Seung Hoon Lee, Do Gyeong Kim, Huiju Lee, Ye Lim Kim, Young In Choi, Sung Jun Jung, Hyeon Son

iScience. 2024 Jan 19; 27(1): 108617. Published online 2023 Dec 2. doi: 10.1016/j.isci.2023.108617

PMCID:: PMC10770719

Article PDF–4.8M

Select item 91717724.

TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G_q/11–G_i/o coincidence signals of variable strengths

Jin-bin Tian, Jane Yang, William C. Joslin, Veit Flockerzi, Steven A. Prescott, Lutz Birnbaumer, Michael X. Zhu

Proc Natl Acad Sci U S A. 2022 May 17; 119(20): e2120870119. Published online 2022 May 11. doi: 10.1073/pnas.2120870119

PMCID:: PMC9171772

Article PDF–1.8M

Select item 86946985.

Transcriptional profiling of sequentially generated septal neuron fates

Miguel Turrero García, Sarah K Stegmann, Tiara E Lacey, Christopher M Reid, Sinisa Hrvatin, Caleb Weinreb, Manal A Adam, M Aurel Nagy, Corey C Harwell

eLife. 2021; 10: e71545. Published online 2021 Dec 1. doi: 10.7554/eLife.71545

PMCID:: PMC8694698

Article PDF–5.1M

Select item 82332836.

Mapping the expression of transient receptor potential channels across murine placental development

Katrien De Clercq, Vicente Pérez-García, Rieta Van Bree, Federica Pollastro, Karen Peeraer, Thomas Voets, Joris Vriens

Cell Mol Life Sci. 2021 Jun; 78(11): 4993–5014. Published online 2021 Apr 21. doi: 10.1007/s00018-021-03837-3

PMCID:: PMC8233283

Article PDF–4.1M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Article PDF–2.0M

Select item 73323788.

Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca²⁺-dependent manner

Dhananjay P. Thakur, Qiaochu Wang, Jaepyo Jeon, Jin-Bin Tian, Michael X. Zhu

J Physiol. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: J Physiol. 2020 Jul; 598(13): 2651–2667. Published online 2020 May 22. doi: 10.1113/JP279658

PMCID:: PMC7332378

Article PDF–2.1M

Select item 73263539.

TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations

John J. O'Malley, Frederik Seibt, Jeannie Chin, Michael Beierlein

J Neurosci. 2020 Jun 17; 40(25): 4813–4823. doi: 10.1523/JNEUROSCI.0324-20.2020

PMCID:: PMC7326353

Article PDF–2.0M

Select item 719087410.

RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways

Karina Formoso, Sebastian Susperreguy, Marc Freichel, Lutz Birnbaumer

Sci Rep. 2020; 10: 7227. Published online 2020 Apr 29. doi: 10.1038/s41598-020-61177-x

PMCID:: PMC7190874

Article PDF–4.0M

Select item 715660111.

Analysis of Mrgprb2 Receptor-Evoked Ca²⁺ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice

Volodymyr Tsvilovskyy, Alejandra Solis-Lopez, Julia Almering, Christin Richter, Lutz Birnbaumer, Alexander Dietrich, Marc Freichel

Front Immunol. 2020; 11: 564. Published online 2020 Apr 8. doi: 10.3389/fimmu.2020.00564

PMCID:: PMC7156601

Article PDF–1.6M

Select item 714053012.

Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis

Jizheng Guo, Jie Li, Lin Xia, Yang Wang, Jinhang Zhu, Juan Du, Yungang Lu, Guodong Liu, Xiaoqiang Yao, Bing Shen

Cells. 2020 Mar; 9(3): 547. Published online 2020 Feb 26. doi: 10.3390/cells9030547

PMCID:: PMC7140530

Article PDF–4.0M

Select item 707221613.

Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells

Alberto Arboit, Antonio Reboreda, Motoharu Yoshida

Cells. 2020 Feb; 9(2): 365. Published online 2020 Feb 5. doi: 10.3390/cells9020365

PMCID:: PMC7072216

Article PDF–1.9M

Select item 685605714.

NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression

Sarah K. Williams Avram, Heon-Jin Lee, Jarrett Fastman, Adi Cymerblit-Sabba, Adam Smith, Matthew Vincent, June Song, Michael C. Granovetter, Su-Hyun Lee, Nicholas I. Cilz, Michelle Stackmann, Rahul Chaturvedi, W. Scott Young

Front Behav Neurosci. 2019; 13: 218. Published online 2019 Nov 8. doi: 10.3389/fnbeh.2019.00218

PMCID:: PMC6856057

Article PDF–12M

Select item 677342215.

TRPC channels regulate Ca²⁺-signaling and short-term plasticity of fast glutamatergic synapses

Yvonne Schwarz, Katharina Oleinikov, Barbara Schindeldecker, Amanda Wyatt, Petra Weißgerber, Veit Flockerzi, Ulrich Boehm, Marc Freichel, Dieter Bruns

PLoS Biol. 2019 Sep; 17(9): e3000445. Published online 2019 Sep 19. doi: 10.1371/journal.pbio.3000445

PMCID:: PMC6773422

Article PDF–6.1M

Select item 620330416.

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically-Photosensitive Retinal Ganglion Cells

Zheng Jiang, Wendy W.S. Yue, Lujing Chen, Yanghui Sheng, King-Wai Yau

Cell. Author manuscript; available in PMC 2019 Oct 18.

Published in final edited form as: Cell. 2018 Oct 18; 175(3): 652–664.e12. Published online 2018 Sep 27. doi: 10.1016/j.cell.2018.08.055

PMCID:: PMC6203304

Article PDF–1.2M

Select item 607907617.

Structure of the mouse TRPC4 ion channel

Jingjing Duan, Jian Li, Bo Zeng, Gui-Lan Chen, Xiaogang Peng, Yixing Zhang, Jianbin Wang, David E. Clapham, Zongli Li, Jin Zhang

Nat Commun. 2018; 9: 3102. Published online 2018 Aug 6. doi: 10.1038/s41467-018-05247-9

PMCID:: PMC6079076

Article PDF–2.7M

Select item 604985918.

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A

Sin Ying Cheung, Matthias Henrot, Mohammad Al-Saad, Matthias Baumann, Heiko Muller, Anke Unger, Hussein N. Rubaiy, Ilka Mathar, Klaus Dinkel, Peter Nussbaumer, Bert Klebl, Marc Freichel, Baptiste Rode, Sebastian Trainor, Steven J. Clapcote, Mathias Christmann, Herbert Waldmann, Syed Khawar Abbas, David J. Beech, Naveen S. Vasudev

Oncotarget. 2018 Jul 3; 9(51): 29634–29643. Published online 2018 Jul 3. doi: 10.18632/oncotarget.25659

PMCID:: PMC6049859

Article PDF–5.1M

Select item 600632319.

Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice

Caoimhin S. Griffin, Keith D. Thornbury, Mark A. Hollywood, Gerard P. Sergeant

Sci Rep. 2018; 8: 9264. Published online 2018 Jun 18. doi: 10.1038/s41598-018-27617-5

PMCID:: PMC6006323

Article PDF–2.4M

Select item 587009320.

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

Robin Sachdeva, Andrea Schlotterer, Dagmar Schumacher, Christin Matka, Ilka Mathar, Nadine Dietrich, Rebekka Medert, Ulrich Kriebs, Jihong Lin, Peter Nawroth, Lutz Birnbaumer, Thomas Fleming, Hans-Peter Hammes, Marc Freichel

Mol Metab. 2018 Mar; 9: 156–167. Published online 2018 Jan 5. doi: 10.1016/j.molmet.2018.01.003

PMCID:: PMC5870093

Article PDF–2.2M

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