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Items: 1 to 20 of 36

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23
Omar Al Rifai, Delia Susan-Resiga, Rachid Essalmani, John W. M. Creemers, Nabil G. Seidah, Mathieu Ferron
Front Endocrinol (Lausanne) 2021; 12: 690681. Published online 2021 Jun 4. doi: 10.3389/fendo.2021.690681
PMCID:
PMC8213403
AbstractArticlePDF–6.4M
3.
Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix
Hikaru Ito, Kanako Nozaki, Kenji Sakimura, Manabu Abe, Shigeto Yamawaki, Hidenori Aizawa
Neuropsychopharmacology. 2021 Jan; 46(2): 442–454. Published online 2020 Sep 17. doi: 10.1038/s41386-020-00843-0
PMCID:
PMC7852607
AbstractArticlePDF–4.8M
4.
Proprotein convertase furin regulates osteocalcin and bone endocrine function
Omar Al Rifai, Jacqueline Chow, Julie Lacombe, Catherine Julien, Denis Faubert, Delia Susan-Resiga, Rachid Essalmani, John W.M. Creemers, Nabil G. Seidah, Mathieu Ferron
J Clin Invest. 2017 Nov 1; 127(11): 4104–4117. Published online 2017 Oct 3. doi: 10.1172/JCI93437
PMCID:
PMC5663350
AbstractArticlePDF–5.4M
5.
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program
John P. Sundberg, Soheil S. Dadras, Kathleen A. Silva, Victoria E. Kennedy, Gaven Garland, Stephen A. Murray, Beth A. Sundberg, Paul N. Schofield, C. Herbert Pratt
PLoS One. 2017; 12(7): e0180682. Published online 2017 Jul 10. doi: 10.1371/journal.pone.0180682
PMCID:
PMC5503261
AbstractArticlePDF–31M
6.
Thrombin activation of protein C requires prior processing by a liver proprotein convertase
Rachid Essalmani, Delia Susan-Resiga, Johann Guillemot, Woojin Kim, Vatsal Sachan, Zuhier Awan, Ann Chamberland, Marie-Claude Asselin, Kévin Ly, Roxane Desjardins, Robert Day, Annik Prat, Nabil G. Seidah
J Biol Chem. 2017 Jun 23; 292(25): 10564–10573. Published online 2017 May 3. doi: 10.1074/jbc.M116.770040
Correction in:
J Biol Chem. 2017 Aug 18; 292(33): 13565.
PMCID:
PMC5481563
AbstractArticlePDF–1.1M
7.
Pcsk5 is required in the early cranio-cardiac mesoderm for heart development
Dorota Szumska, Milena Cioroch, Angela Keeling, Annik Prat, Nabil G. Seidah, Shoumo Bhattacharya
BMC Dev Biol. 2017; 17: 6. Published online 2017 Apr 26. doi: 10.1186/s12861-017-0148-y
PMCID:
PMC5407003
AbstractArticlePDF–4.4M
8.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
9.
Variant mapping and mutation discovery in inbred mice using next-generation sequencing
Jabier Gallego-Llamas, Andrew E. Timms, Krista A. Geister, Anna Lindsay, David R. Beier
BMC Genomics. 2015; 16: 913. Published online 2015 Nov 9. doi: 10.1186/s12864-015-2173-1
PMCID:
PMC4640199
AbstractArticlePDF–1.7M
10.
Global genetic analysis in mice unveils central role for cilia in congenital heart disease
You Li, Nikolai T. Klena, George C Gabriel, Xiaoqin Liu, Andrew J. Kim, Kristi Lemke, Yu Chen, Bishwanath Chatterjee, William Devine, Rama Rao Damerla, Chien-fu Chang, Hisato Yagi, Jovenal T. San Agustin, Mohamed Thahir, Shane Anderton, Caroline Lawhead, Anita Vescovi, Herbert Pratt, Judy Morgan, Leslie Haynes, Cynthia L. Smith, Janan T. Eppig, Laura Reinholdt, Richard Francis, Linda Leatherbury, Madhavi K. Ganapathiraju, Kimimasa Tobita, Gregory J. Pazour, Cecilia W. Lo
Nature. Author manuscript; available in PMC 2015 Nov 28.
Published in final edited form as: Nature. 2015 May 28; 521(7553): 520–524. Published online 2015 Mar 25. doi: 10.1038/nature14269
PMCID:
PMC4617540
AbstractArticlePDF–518K
11.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
12.
Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes
Rachid Essalmani, Delia Susan-Resiga, Ann Chamberland, Marie-Claude Asselin, Maryssa Canuel, Daniel Constam, John W. Creemers, Robert Day, Dany Gauthier, Annik Prat, Nabil G. Seidah
J Biol Chem. 2013 Sep 13; 288(37): 26410–26418. Published online 2013 Aug 5. doi: 10.1074/jbc.M113.501304
PMCID:
PMC3772187
AbstractArticlePDF–1.1M
13.
Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport
Shin Kato, Ruiguang Zhang, Jesse D. Roberts, Jr.
Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15; 305(2): L130–L140. Published online 2013 May 17. doi: 10.1152/ajplung.00391.2012
PMCID:
PMC3726948
AbstractArticle
14.
Latent Transforming Growth Factor β-Binding Proteins-2 and -3 Inhibit the Proprotein Convertase 5/6A
Xiaowei Sun, Rachid Essalmani, Delia Susan-Resiga, Annik Prat, Nabil G. Seidah
J Biol Chem. 2011 Aug 19; 286(33): 29063–29073. Published online 2011 Jun 23. doi: 10.1074/jbc.M111.242479
PMCID:
PMC3190714
AbstractArticlePDF–2.2M
15.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
16.
PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke
Estelle Rousselet, Jadwiga Marcinkiewicz, Jasna Kriz, Ann Zhou, Mary E. Hatten, Annik Prat, Nabil G. Seidah
J Lipid Res. 2011 Jul; 52(7): 1383–1391. doi: 10.1194/jlr.M014118
PMCID:
PMC3111744
AbstractArticlePDF–1.3M
17.
Role of PCSK5 Expression in Mouse Ovarian Follicle Development: Identification of the Inhibin α- and β-Subunits as Candidate Substrates
Monica Antenos, Lei Lei, Min Xu, Anjali Malipatil, Sarah Kiesewetter, Teresa K. Woodruff
PLoS One. 2011; 6(3): e17348. Published online 2011 Mar 8. doi: 10.1371/journal.pone.0017348
PMCID:
PMC3050889
AbstractArticlePDF–2.4M
18.
In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9
Rachid Essalmani, Delia Susan-Resiga, Ann Chamberland, Marianne Abifadel, John W. Creemers, Catherine Boileau, Nabil G. Seidah, Annik Prat
J Biol Chem. 2011 Feb 11; 286(6): 4257–4263. Published online 2010 Dec 8. doi: 10.1074/jbc.M110.192104
PMCID:
PMC3039354
AbstractArticlePDF–920K
19.
Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst
Daniel Mesnard, Daniel B. Constam
J Cell Biol. 2010 Oct 4; 191(1): 129–139. doi: 10.1083/jcb.201005026
PMCID:
PMC2953431
AbstractArticlePDF–7.0M
20.
PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain
Mali Liu, Guoxin Wu, Jennifer Baysarowich, Michael Kavana, George H. Addona, Kathleen K. Bierilo, John S. Mudgett, Guillaume Pavlovic, Ayesha Sitlani, John J. Renger, Brian K. Hubbard, Timothy S. Fisher, Celina V. Zerbinatti
J Lipid Res. 2010 Sep; 51(9): 2611–2618. doi: 10.1194/jlr.M006635
PMCID:
PMC2918444
AbstractArticlePDF–1.0M

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