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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106940302.

TRAF6 and TRAF2/3 Binding Motifs in CD40 Differentially Regulate B Cell Function in T-Dependent Antibody Responses and Dendritic Cell Function in Experimental Autoimmune Encephalomyelitis

Ying Lu, Jeffrey Chiang, Ray Zhang, Paul A. Roche, Richard J. Hodes

J Immunol. 2023 Dec 15; 211(12): 1814–1822. Published online 2023 Nov 3. doi: 10.4049/jimmunol.2300607

PMCID:: PMC10694030

Abstract Article PDF–1.8M

Select item 106001343.

Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8⁺ T cells

Diego Calzada-Fraile, Salvador Iborra, Marta Ramírez-Huesca, Inmaculada Jorge, Enrico Dotta, Elena Hernández-García, Noa Martín-Cófreces, Estanislao Nistal-Villán, Esteban Veiga, Jesús Vázquez, Giulia Pasqual, Francisco Sánchez-Madrid

Nat Commun. 2023; 14: 6772. Published online 2023 Oct 25. doi: 10.1038/s41467-023-42480-3

PMCID:: PMC10600134

Abstract Article PDF–2.0M

Select item 104483584.

Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma

Michael T. Patterson, Adam L. Burrack, Yingzheng Xu, Grant H. Hickok, Zoe C. Schmiechen, Samuel Becker, Eduardo Cruz-Hinojoza, Patricia R. Schrank, Ainsley E. Kennedy, Maria M. Firulyova, Ebony A. Miller, Konstantin Zaitsev, Jesse W. Williams, Ingunn M. Stromnes

Cell Rep. Author manuscript; available in PMC 2023 Aug 24.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112732. Published online 2023 Jul 3. doi: 10.1016/j.celrep.2023.112732

PMCID:: PMC10448358

Abstract Article PDF–3.5M

Select item 102026335.

Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state

Laura A Bosmans, Claudia M van Tiel, Suzanne A B M Aarts, Lisa Willemsen, Jeroen Baardman, Bram W van Os, Myrthe den Toom, Linda Beckers, David J Ahern, Johannes H M Levels, Aldo Jongejan, Perry D Moerland, Sanne G S Verberk, Jan van den Bossche, Menno M P J de Winther, Christian Weber, Dorothee Atzler, Claudia Monaco, Norbert Gerdes, Annelie Shami, Esther Lutgens

Cardiovasc Res. 2023 May; 119(5): 1146–1160. Published online 2022 May 19. doi: 10.1093/cvr/cvac084

PMCID:: PMC10202633

Abstract Article PDF–1.7M

Select item 101200856.

B cell peripheral tolerance is promoted by cathepsin B protease

Marissa Y. Chou, Dan Liu, Jinping An, Ying Xu, Jason G. Cyster

Proc Natl Acad Sci U S A. 2023 Apr 18; 120(16): e2300099120. Published online 2023 Apr 11. doi: 10.1073/pnas.2300099120

PMCID:: PMC10120085

Abstract Article PDF–1.6M

Select item 100659877.

CD40 drives CNS autoimmune disease by inducing complementary effector programs via B cells and dendritic cells

Ying Lu, Max Xu, Cayce E. Dorrier, Ray Zhang, Christian T. Mayer, David Wagner, Dorian B. McGavern, Richard J. Hodes

J Immunol. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: J Immunol. 2022 Dec 1; 209(11): 2083–2092. doi: 10.4049/jimmunol.2200439

PMCID:: PMC10065987

Abstract Article PDF–2.1M

Select item 98969658.

Mechanisms of CD40-dependent cDC1 licensing beyond costimulation

Renee Wu, Ray A. Ohara, Suin Jo, Tian-Tian Liu, Stephen T. Ferris, Feiya Ou, Sunkyung Kim, Derek J. Theisen, David A. Anderson, III, Brian W. Wong, Timothy Gershon, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy

Nat Immunol. Author manuscript; available in PMC 2023 Feb 3.

Published in final edited form as: Nat Immunol. 2022 Nov; 23(11): 1536–1550. Published online 2022 Oct 21. doi: 10.1038/s41590-022-01324-w

PMCID:: PMC9896965

Abstract Article PDF–2.6M

Select item 98644389.

Toll-like Receptor 9 Induced Dendritic Cell Activation Promotes Anti-Myeloperoxidase Autoimmunity and Glomerulonephritis

Sharon L. Ford, Kim M. O’Sullivan, A. Richard Kitching, Stephen R. Holdsworth, Poh Yi Gan, Shaun A. Summers

Int J Mol Sci. 2023 Jan; 24(2): 1339. Published online 2023 Jan 10. doi: 10.3390/ijms24021339

PMCID:: PMC9864438

Abstract Article PDF–2.8M

Select item 961785910.

Inhibition of CD40-TRAF6-dependent inflammatory activity halts the onset of diabetic retinopathy in streptozotocin-diabetic mice

Scott J. Howell, Chieh A. Lee, Thomas E. Zapadka, Sarah I. Lindstrom, Brooklyn E. Taylor, Zakary R. R. Taylor, Katherine G. Barber, Patricia R. Taylor

Nutr Diabetes. 2022; 12: 46. Published online 2022 Oct 30. doi: 10.1038/s41387-022-00225-z

PMCID:: PMC9617859

Abstract Article PDF–1.9M

Select item 947460511.

Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD

Chi Ma, Qiong Fu, Laurence P. Diggs, John C. McVey, Justin McCallen, Simon Wabitsch, Benjamin Ruf, Zachary Brown, Bernd Heinrich, Qianfei Zhang, Umberto Rosato, Sophie Wang, Linda Cui, Jay A. Berzofsky, David E. Kleiner, Dale B. Bosco, Long-Jun Wu, Chunwei Walter Lai, Yaron Rotman, Changqing Xie, Firouzeh Korangy, Tim F. Greten

Cancer Cell. Author manuscript; available in PMC 2023 Sep 12.

Published in final edited form as: Cancer Cell. 2022 Sep 12; 40(9): 986–998.e5. Published online 2022 Sep 1. doi: 10.1016/j.ccell.2022.08.004

PMCID:: PMC9474605

Abstract Article PDF–2.3M

Select item 903619112.

Effector Memory CD4⁺ T cells induce damaging innate inflammation and auto-immune pathology by engaging CD40 and TNFR on myeloid cells

Margaret M. McDaniel, Amanpreet Singh Chawla, Aakanksha Jain, Hannah E. Meibers, Irene Saha, Yajing Gao, Viral Jain, Krishna Roskin, Sing Sing Way, Chandrashekhar Pasare

Sci Immunol. Author manuscript; available in PMC 2022 Jul 21.

Published in final edited form as: Sci Immunol. 2022 Jan 21; 7(67): eabk0182. Published online 2022 Jan 21. doi: 10.1126/sciimmunol.abk0182

PMCID:: PMC9036191

Abstract Article PDF–1.1M

Select item 840023413.

Native Collagen II Relieves Bone Impairment through Improving Inflammation and Oxidative Stress in Ageing db/db Mice

Rui Fan, Yuntao Hao, Xinran Liu, Jiawei Kang, Jiani Hu, Ruixue Mao, Rui Liu, Na Zhu, Meihong Xu, Yong Li

Molecules. 2021 Aug; 26(16): 4942. Published online 2021 Aug 15. doi: 10.3390/molecules26164942

Correction in:: Molecules. 2022 Jan; 27(2): 571.

PMCID:: PMC8400234

Abstract Article PDF–7.9M

Select item 839075014.

Downregulation of CD40L–CD40 attenuates seizure susceptibility and severity of seizures

Esther Pototskiy, Katherine Vinokuroff, Andrew Ojeda, C. Kendall Major, Deepak Sharma, Taylor Anderson, Kendall Howard, Ronen Borenstein, Alberto E. Musto

Sci Rep. 2021; 11: 17262. Published online 2021 Aug 26. doi: 10.1038/s41598-021-96760-3

Correction in:: Sci Rep. 2021; 11: 23252.

PMCID:: PMC8390750

Abstract Article PDF–2.9M

Select item 821375615.

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

Michael Lacy, Christina Bürger, Annelie Shami, Maiwand Ahmadsei, Holger Winkels, Katrin Nitz, Claudia M. van Tiel, Tom T. P. Seijkens, Pascal J. H. Kusters, Ela Karshovka, Koen H. M. Prange, Yuting Wu, Sanne L. N. Brouns, Sigrid Unterlugauer, Marijke J. E. Kuijpers, Myrthe E. Reiche, Sabine Steffens, Andreas Edsfeldt, Remco T. A. Megens, Johan W. M. Heemskerk, Isabel Goncalves, Christian Weber, Norbert Gerdes, Dorothee Atzler, Esther Lutgens

Nat Commun. 2021; 12: 3754. Published online 2021 Jun 18. doi: 10.1038/s41467-021-23909-z

PMCID:: PMC8213756

Abstract Article PDF–3.6M

Select item 816859316.

CD40 Activity on Mesenchymal Cells Negatively Regulates OX40L to Maintain Bone Marrow Immune Homeostasis Under Stress Conditions

Barbara Bassani, Claudio Tripodo, Paola Portararo, Alessandro Gulino, Laura Botti, Claudia Chiodoni, Elena Jachetti, Niccolò Bolli, Marilena Ciciarello, Korinna Joehrens, Ioannis Anagnostopoulos, Il-Kang Na, Antonio Curti, Mario P. Colombo, Sabina Sangaletti

Front Immunol. 2021; 12: 662048. Published online 2021 May 18. doi: 10.3389/fimmu.2021.662048