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Items: 1 to 20 of 38

1.
The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
Carlos Costas-Insua, Alba Hermoso-López, Estefanía Moreno, Carlos Montero-Fernández, Alicia Álvaro-Blázquez, Irene B Maroto, Andrea Sánchez-Ruiz, Rebeca Diez-Alarcia, Cristina Blázquez, Paula Morales, Enric I Canela, Vicent Casadó, Leyre Urigüen, Gertrudis Perea, Luigi Bellocchio, Ignacio Rodríguez-Crespo, Manuel Guzmán
EMBO Mol Med. 2024 Apr; 16(4): 755–783. Published online 2024 Mar 21. doi: 10.1038/s44321-024-00054-w
PMCID:
PMC11018632
AbstractArticlePDF–3.5M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma
Seth J. Welsh, Benjamin G. Barwick, Erin W. Meermeier, Daniel L. Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E. Sharik, Megan T. Du, Leslie D. Abrego Rocha, Victoria M. Garbitt, Caleb K. Stein, Joachim L. Petit, Nathalie Meurice, Yuliza Tafoya Alvarado, Rodrigo Fonseca, Kennedi T. Todd, Sochilt Brown, Zachery J. Hammond, Nicklus H. Cuc, Courtney Wittenberg, Camille Herzog, Anna V. Roschke, Yulia N. Demchenko, Wei-dong D. Chen, Peng Li, Wei Liao, Warren J. Leonard, Sagar Lonial, Nizar J. Bahlis, Paola Neri, Lawrence H. Boise, Marta Chesi, P. Leif Bergsagel
Blood Cancer Discov. 2024 Jan 8; 5(1): 34–55. Published online 2023 Sep 27. doi: 10.1158/2643-3230.BCD-23-0062
PMCID:
PMC10772542
AbstractArticlePDF–14M
4.
Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells
Rob S. Sellar, Adam S. Sperling, Mikołaj Słabicki, Jessica A. Gasser, Marie E. McConkey, Katherine A. Donovan, Nada Mageed, Dylan N. Adams, Charles Zou, Peter G. Miller, Ravi K. Dutta, Steffen Boettcher, Amy E. Lin, Brittany Sandoval, Vanessa A. Quevedo Barrios, Veronica Kovalcik, Jonas Koeppel, Elizabeth K. Henderson, Emma C. Fink, Lu Yang, Anthony Chan, Sheela Pangeni Pokharel, Erik J. Bergstrom, Rajan Burt, Namrata D. Udeshi, Steven A. Carr, Eric S. Fischer, Chun-Wei Chen, Benjamin L. Ebert
J Clin Invest. 2022 Aug 15; 132(16): e153514. Published online 2022 Aug 15. doi: 10.1172/JCI153514
PMCID:
PMC9374383
AbstractArticlePDF–4.3M
5.
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Adam D. Durbin, Tingjian Wang, Virangika K. Wimalasena, Mark W. Zimmerman, Deyao Li, Neekesh V. Dharia, Luca Mariani, Noha A.M. Shendy, Stephanie Nance, Anand G. Patel, Ying Shao, Maya Mundada, Lily Maxham, Paul M.C. Park, Logan H. Sigua, Ken Morita, Amy Saur Conway, Amanda L. Robichaud, Antonio R. Perez-Atayde, Melissa J. Bikowitz, Taylor R. Quinn, Olaf Wiest, John Easton, Ernst Schönbrunn, Martha L. Bulyk, Brian J. Abraham, Kimberly Stegmaier, A. Thomas Look, Jun Qi
Cancer Discov. 2022 Mar 1; 12(3): 730–751. Published online 2022 Mar 8. doi: 10.1158/2159-8290.CD-21-0385
PMCID:
PMC8904277
AbstractArticlePDF–8.9M
6.
Tumor Burden Limits Bispecific Antibody Efficacy through T-cell Exhaustion Averted by Concurrent Cytotoxic Therapy
Erin W. Meermeier, Seth J. Welsh, Meaghen E. Sharik, Megan T. Du, Victoria M. Garbitt, Daniel L. Riggs, Chang-Xin Shi, Caleb K. Stein, Marco Bergsagel, Bryant Chau, Matthew L. Wheeler, Natalie Bezman, Feng Wang, Pavel Strop, P. Leif Bergsagel, Marta Chesi
Blood Cancer Discov. 2021 Jul; 2(4): 354–369. Published online 2021 May 5. doi: 10.1158/2643-3230.BCD-21-0038
Correction in:
Blood Cancer Discov. 2022 Jan; 3(1): 82.
PMCID:
PMC8266040
AbstractArticlePDF–7.5M
7.
Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1
Uroos Akber, Heeji Jo, Seungje Jeon, Seung-Joo Yang, Sunhwa Bong, Sungsu Lim, Yun Kyung Kim, Zee-Yong Park, Chul-Seung Park
J Neurosci. 2021 Jun 16; 41(24): 5138–5156. doi: 10.1523/JNEUROSCI.2494-20.2021
PMCID:
PMC8211538
AbstractArticlePDF–6.9M
8.
Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase α1
Hyo Jae Kang, Kyung Jin Lee, Jisu Woo, Jiyeon Kim, Yun Kyu Kim, Chang-Hoon Lee, Chul-Gyu Yoo, Kyoung-Hee Lee
Exp Mol Med. 2021 May; 53(5): 885–893. Published online 2021 May 17. doi: 10.1038/s12276-021-00619-6
PMCID:
PMC8178361
AbstractArticlePDF–1.1M
9.
Gluconeogenic signals regulate hepcidin gene expression via a CRBN-KLF15 axis
Jeong-Rang Jo, Sung-Eun Lee, Seungwon An, Balachandar Nedumaran, Swati Ghosh, Keun-Gyu Park, Yong Deuk Kim
BMB Rep. 2021 Apr 30; 54(4): 221–226. Published online 2021 Apr 30. doi: 10.5483/BMBRep.2021.54.4.215
PMCID:
PMC8093939
AbstractArticlePDF–778K
10.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
11.
Crbn modulates calcium influx by regulating Orai1 during efferocytosis
Hyunji Moon, Chanhyuk Min, Gayoung Kim, Deokhwan Kim, Kwanhyeong Kim, Sang-Ah Lee, Byeongjin Moon, Susumin Yang, Juyeon Lee, Seung-Joo Yang, Steve K. Cho, Gwangrog Lee, Chang Sup Lee, Chul-Seung Park, Daeho Park
Nat Commun. 2020; 11: 5489. Published online 2020 Oct 30. doi: 10.1038/s41467-020-19272-0
PMCID:
PMC7603501
AbstractArticlePDF–5.6M
12.
Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout
Seung-Je Jeon, Jinsil Ham, Chul-Seung Park, Boreom Lee
BMB Rep. 2020 Sep 30; 53(9): 484–489. Published online 2020 Sep 30. doi: 10.5483/BMBRep.2020.53.9.119
PMCID:
PMC7526979
AbstractArticlePDF–3.3M
13.
Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes
Rebecca S. Hesterberg, Matthew S. Beatty, Ying Han, Mario R. Fernandez, Afua A. Akuffo, William E. Goodheart, Chunying Yang, Shiun Chang, Christelle M. Colin, Aileen Y. Alontaga, Jessica M. McDaniel, Adam W. Mailloux, Julia M. R. Billington, Lanzhu Yue, Shonagh Russell, Robert J. Gillies, Sang Y. Yun, Muhammad Ayaz, Nicholas J. Lawrence, Harshani R. Lawrence, Xue-Zhong Yu, Jianing Fu, Lancia N. Darville, John M. Koomen, Xiubao Ren, Jane Messina, Kun Jiang, Timothy J. Garrett, Anjali M. Rajadhyaksha, John L. Cleveland, Pearlie K. Epling-Burnette
Blood. 2020 Aug 13; 136(7): 857–870. Prepublished online 2020 May 13. doi: 10.1182/blood.2019003257
PMCID:
PMC7426646
AbstractArticle
14.
CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy
Ssu-Ju Fu, Meng-Chun Hu, Yi-Jheng Peng, Hsin-Yu Fang, Cheng-Tsung Hsiao, Tsung-Yu Chen, Chung-Jiuan Jeng, Chih-Yung Tang
Cells. 2020 Jun; 9(6): 1332. Published online 2020 May 26. doi: 10.3390/cells9061332
PMCID:
PMC7348978
AbstractArticlePDF–5.6M
15.
Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel
Tae-Yong Choi, Seung-Hyun Lee, Yoon-Jung Kim, Jae Ryul Bae, Kwang Min Lee, Youhwa Jo, Soo-Jeong Kim, A-Ram Lee, Sekyu Choi, La-Mee Choi, Sunhoe Bang, Mi-Ryoung Song, Jongkyeong Chung, Kyung Jin Lee, Sung Hyun Kim, Chul-Seung Park, Se-Young Choi
J Neurosci. 2018 Apr 4; 38(14): 3571–3583. doi: 10.1523/JNEUROSCI.2081-17.2018
PMCID:
PMC6596048
AbstractArticlePDF–4.3M
16.
Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53
Liang Zhou, Guoqiang Xu
Cell Death Dis. 2019 Feb; 10(2): 69. Published online 2019 Jan 25. doi: 10.1038/s41419-019-1317-7
PMCID:
PMC6347596
AbstractArticlePDF–2.4M
17.
Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs
Yohannes Gemechu, David Millrine, Shigeru Hashimoto, Jaya Prakash, Ksenia Sanchenkova, Hozaifa Metwally, Parajuli Gyanu, Sujin Kang, Tadamitsu Kishimoto
Proc Natl Acad Sci U S A. 2018 Nov 13; 115(46): 11802–11807. Published online 2018 Oct 29. doi: 10.1073/pnas.1814446115
PMCID:
PMC6243262
AbstractArticlePDF–942K
18.
CrbnI391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice
Emma C. Fink, Marie McConkey, Dylan N. Adams, Saurav D. Haldar, James A. Kennedy, Andrew A. Guirguis, Namrata D. Udeshi, D. R. Mani, Michelle Chen, Brian Liddicoat, Tanya Svinkina, Andrew T. Nguyen, Steven A. Carr, Benjamin L. Ebert
Blood. 2018 Oct 4; 132(14): 1535–1544. Prepublished online 2018 Jul 31. doi: 10.1182/blood-2018-05-852798
PMCID:
PMC6172563
AbstractArticle
19.
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon
Afua A. Akuffo, Aileen Y. Alontaga, Rainer Metcalf, Matthew S. Beatty, Andreas Becker, Jessica M. McDaniel, Rebecca S. Hesterberg, William E. Goodheart, Steven Gunawan, Muhammad Ayaz, Yan Yang, Md Rezaul Karim, Morgan E. Orobello, Kenyon Daniel, Wayne Guida, Jeffrey A. Yoder, Anjali M. Rajadhyaksha, Ernst Schönbrunn, Harshani R. Lawrence, Nicholas J. Lawrence, Pearlie K. Epling-Burnette
J Biol Chem. 2018 Apr 20; 293(16): 6187–6200. Published online 2018 Feb 15. doi: 10.1074/jbc.M117.816868
PMCID:
PMC5912449
AbstractArticlePDF–3.7M
20.
Behavioral characterization of cereblon forebrain-specific conditional null mice: A model for human non-syndromic intellectual disability
Anjali M. Rajadhyaksha, Stephen Ra, Sarah Kishinevsky, Anni S. Lee, Peter Romanienko, Mariel DuBoff, Chingwen Yang, Bojana Zupan, Maureen Byrne, Zeeba R. Daruwalla, Willie Mark, Barry E. Kosofsky, Miklos Toth, Joseph J. Higgins
Behav Brain Res. Author manuscript; available in PMC 2018 Mar 22.
Published in final edited form as: Behav Brain Res. 2012 Jan 15; 226(2): 428–434. Published online 2011 Oct 4. doi: 10.1016/j.bbr.2011.09.039
PMCID:
PMC5864115
AbstractArticlePDF–529K

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