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Items: 1 to 20 of 198

1.
5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response
Hanyong Jin, Ji-Hyun Yeom, Eunkyoung Shin, Yoonjie Ha, Haifeng Liu, Daeyoung Kim, Minju Joo, Yong-Hak Kim, Hak Kyun Kim, Minkyung Ryu, Hong-Man Kim, Jeongkyu Kim, Keun P. Kim, Yoonsoo Hahn, Jeehyeon Bae, Kangseok Lee
Nat Commun. 2024; 15: 9273. Published online 2024 Oct 28. doi: 10.1038/s41467-024-53624-4
PMCID:
PMC11519470
AbstractArticlePDF–2.3M
2.
BCL-2 Modulates IRE1α Activation to Attenuate Endoplasmic Reticulum Stress and Pulmonary Fibrosis
Claude Jourdan Le Saux, Tsung Che Ho, Alexis M. Brumwell, Jaymin J. Kathiriya, Ying Wei, Jun-Wei B. Hughes, Kiana Garakani, Kamran Atabai, Vincent C. Auyeung, Ferroz R. Papa, Harold A. Chapman
Am J Respir Cell Mol Biol. 2024 Apr 1; 70(4): 247–258. Published online 2023 Dec 20. doi: 10.1165/rcmb.2023-0109OC
PMCID:
PMC11478128
AbstractArticlePDF–2.6M
3.
The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle
Aniket S Joshi, Meiricris Tomaz da Silva, Anirban Roy, Tatiana E Koike, Mingfu Wu, Micah B Castillo, Preethi H Gunaratne, Yu Liu, Takao Iwawaki, Ashok Kumar
EMBO Rep. 2024 Aug; 25(8): 3627–3650. Published online 2024 Jul 9. doi: 10.1038/s44319-024-00197-4
PMCID:
PMC11316051
AbstractArticlePDF–8.4M
4.
Protein translation rate determines neocortical neuron fate
Ekaterina Borisova, Andrew G. Newman, Marta Couce Iglesias, Rike Dannenberg, Theres Schaub, Bo Qin, Alexandra Rusanova, Marisa Brockmann, Janina Koch, Marieatou Daniels, Paul Turko, Olaf Jahn, David R. Kaplan, Marta Rosário, Takao Iwawaki, Christian M. T. Spahn, Christian Rosenmund, David Meierhofer, Matthew L. Kraushar, Victor Tarabykin, Mateusz C. Ambrozkiewicz
Nat Commun. 2024; 15: 4879. Published online 2024 Jun 7. doi: 10.1038/s41467-024-49198-w
PMCID:
PMC11161512
AbstractArticlePDF–17M
5.
Deletion of IRE1α in podocytes exacerbates diabetic nephropathy in mice
Andrey V. Cybulsky, Joan Papillon, Julie Guillemette, José R. Navarro-Betancourt, Chen-Fang Chung, Takao Iwawaki, I. George Fantus
Sci Rep. 2024; 14: 11718. Published online 2024 May 22. doi: 10.1038/s41598-024-62599-7
PMCID:
PMC11111796
AbstractArticlePDF–12M
6.
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
Dadi Jiang, Youming Guo, Tianyu Wang, Liang Wang, Yuelong Yan, Ling Xia, Rakesh Bam, Zhifen Yang, Hyemin Lee, Takao Iwawaki, Boyi Gan, Albert C. Koong
Nat Commun. 2024; 15: 4114. Published online 2024 May 15. doi: 10.1038/s41467-024-48330-0
PMCID:
PMC11096184
AbstractArticlePDF–3.7M
7.
Stress-induced β-cell early senescence confers protection against type 1 diabetes
Hugo Lee, Gulcan Semra Sahin, Chien-Wen Chen, Shreyash Sonthalia, Sandra Marín Cañas, Hulya Zeynep Oktay, Alexander T. Duckworth, Gabriel Brawerman, Peter J. Thompson, Maria Hatzoglou, Decio L. Eizirik, Feyza Engin
Cell Metab. Author manuscript; available in PMC 2024 Dec 5.
Published in final edited form as: Cell Metab. 2023 Dec 5; 35(12): 2200–2215.e9. Published online 2023 Nov 9. doi: 10.1016/j.cmet.2023.10.014
PMCID:
PMC10842515
AbstractArticlePDF–3.2M
8.
Tumorous IRE1α facilitates CD8+T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma
Yuqi Yang, Sijia Wang, Xiang-xu Wang, Sen Guo, Huina Wang, Qiong Shi, Yangzi Tian, Hao Wang, Tao Zhao, Hengxiang Zhang, Baolu Zhang, Tianwen Gao, Chunying Li, Xiuli Yi, Weinan Guo
Cell Commun Signal. 2024; 22: 83. Published online 2024 Jan 30. doi: 10.1186/s12964-024-01470-8
PMCID:
PMC10826282
AbstractArticlePDF–10M
9.
miR-195b is required for proper cellular homeostasis in the elderly
Maria del Mar Muñoz-Gallardo, Carlos Garcia-Padilla, Cristina Vicente-Garcia, Jaime Carvajal, Amelia Arenega, Diego Franco
Sci Rep. 2024; 14: 810. Published online 2024 Jan 8. doi: 10.1038/s41598-024-51256-8
PMCID:
PMC10774362
AbstractArticlePDF–3.7M
10.
Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection
Jessica Vetters, Mary van Helden, Clint De Nolf, Sofie Rennen, Eva Cloots, Evelien Van De Velde, Farzaneh Fayazpour, Justine Van Moorleghem, Manon Vanheerswynghels, Karl Vergote, Louis Boon, Eric Vivier, Bart N. Lambrecht, Sophie Janssens
iScience. 2023 Dec 15; 26(12): 108570. Published online 2023 Nov 23. doi: 10.1016/j.isci.2023.108570
PMCID:
PMC10755724
AbstractArticlePDF–8.3M
11.
Impaired T cell IRE1α/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction
Sasha Smolgovsky, Abraham L. Bayer, Kuljeet Kaur, Erin Sanders, Mark Aronovitz, Mallory E. Filipp, Edward B. Thorp, Gabriele G. Schiattarella, Joseph A. Hill, Robert M. Blanton, Juan R. Cubillos-Ruiz, Pilar Alcaide
J Clin Invest. 2023 Dec 15; 133(24): e171874. Published online 2023 Dec 15. doi: 10.1172/JCI171874
PMCID:
PMC10721145
AbstractArticlePDF–10M
12.
Increased activity of IRE1 improves the clinical presentation of EAE
Valerie Bracchi-Ricard, Kayla Nguyen, Daniela Ricci, Brian Gaudette, Jorge Henao-Meija, Roberta Brambilla, Tetyana Martynyuk, Tali Gidalevitz, David Allman, John R. Bethea, Yair Argon
FASEB J. Author manuscript; available in PMC 2024 Dec 1.
Published in final edited form as: FASEB J. 2023 Dec; 37(12): e23283. doi: 10.1096/fj.202300769RR
PMCID:
PMC10662669
AbstractArticlePDF–1.0M
13.
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia
Xiao Yang, Tangjun Zhou, Xin Wang, Ying Xia, Xiankun Cao, Xiaofei Cheng, Yu Cao, Peixiang Ma, Hui Ma, An Qin, Jie Zhao
Int J Biol Sci. 2023; 19(15): 4709–4725. Published online 2023 Sep 4. doi: 10.7150/ijbs.82765
PMCID:
PMC10539710
AbstractArticlePDF–9.5M
14.
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α
Gaëlle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frédérick A. Mallette, Ariel M. Wilson, Przemyslaw Sapieha
J Neuroinflammation. 2023; 20: 145. Published online 2023 Jun 21. doi: 10.1186/s12974-023-02793-y
PMCID:
PMC10286485
AbstractArticlePDF–8.3M
15.
Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity
Felipe Flores-Santibañez, Sofie Rennen, Dominique Fernández, Clint De Nolf, Evelien Van De Velde, Sandra Gaete González, Camila Fuentes, Carolina Moreno, Diego Figueroa, Álvaro Lladser, Takao Iwawaki, María Rosa Bono, Sophie Janssens, Fabiola Osorio
Front Immunol. 2023; 14: 1209588. Published online 2023 Jun 6. doi: 10.3389/fimmu.2023.1209588
PMCID:
PMC10279875
AbstractArticlePDF–6.3M
16.
Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration
Dawiyat Massoudi, Seán Gorman, Yien-Ming Kuo, Takao Iwawaki, Scott A. Oakes, Feroz R. Papa, Douglas B. Gould
Invest Ophthalmol Vis Sci. 2023 Apr; 64(4): 30. Published online 2023 Apr 25. doi: 10.1167/iovs.64.4.30
PMCID:
PMC10148664
AbstractArticlePDF–3.6M
17.
Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation
Eun-Ji Park, Hyun-Soo Kim, Do-Hyoung Lee, Su-Min Kim, Joon-Sup Yoon, Ji-Min Lee, Se Jin Im, Ho Lee, Min-Woo Lee, Chang-Woo Lee
Nat Commun. 2023; 14: 1097. Published online 2023 Feb 25. doi: 10.1038/s41467-023-36836-y
PMCID:
PMC9968297
AbstractArticlePDF–4.4M
18.
Integration of ER protein quality control mechanisms defines β cell function and ER architecture
Neha Shrestha, Mauricio Torres, Jason Zhang, You Lu, Leena Haataja, Rachel B. Reinert, Jeffrey Knupp, Yu-Jie Chen, Gunes Parlakgul, Ana Paula Arruda, Billy Tsai, Peter Arvan, Ling Qi
J Clin Invest. 2023 Jan 3; 133(1): e163584. Published online 2023 Jan 3. doi: 10.1172/JCI163584
PMCID:
PMC9797341
AbstractArticlePDF–5.5M
19.
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging
Felipe Cabral‐Miranda, Giovanni Tamburini, Gabriela Martinez, Alvaro O Ardiles, Danilo B Medinas, Yannis Gerakis, Mei‐Li Diaz Hung, René Vidal, Matias Fuentealba, Tim Miedema, Claudia Duran‐Aniotz, Javier Diaz, Cristobal Ibaceta‐Gonzalez, Carleen M Sabusap, Francisca Bermedo‐Garcia, Paula Mujica, Stuart Adamson, Kaitlyn Vitangcol, Hernan Huerta, Xu Zhang, Tomohiro Nakamura, Sergio Pablo Sardi, Stuart A Lipton, Brian K Kennedy, Juan Pablo Henriquez, J Cesar Cárdenas, Lars Plate, Adrian G Palacios, Claudio Hetz
EMBO J. 2022 Nov; 41(22): e111952. Published online 2022 Oct 31. doi: 10.15252/embj.2022111952
PMCID:
PMC9670206
AbstractArticlePDF–2.6M
20.
TGFβ1 regulates HRas-mediated activation of IRE1α through the PERK-RPAP2 axis in keratinocytes
Saie Mogre, Nicholas Blazanin, Hailey Walsh, Jack Ibinson, Chase Minnich, Chih-Chi Andrew Hu, Adam B Glick
Mol Carcinog. Author manuscript; available in PMC 2023 Oct 1.
Published in final edited form as: Mol Carcinog. 2022 Oct; 61(10): 958–971. Published online 2022 Aug 17. doi: 10.1002/mc.23453
PMCID:
PMC9486931
AbstractArticlePDF–2.4M

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