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Items: 1 to 20 of 79

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease
Olga Haberkiewicz, Paweł Lipiński, Rafał R. Starzyński, Aneta Jończy, Patrycja Kurowska, Mateusz Ogórek, Aleksandra Bednarz, Sylwia Herman, Dawid Hatala, Paweł Grzmil, Zenon Rajfur, Zbigniew Baster, Małgorzata Lenartowicz
Int J Mol Sci. 2022 Oct; 23(19): 11441. Published online 2022 Sep 28. doi: 10.3390/ijms231911441
PMCID:
PMC9570402
AbstractArticlePDF–4.6M
3.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
4.
The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2
Dipankar Ash, Varadarajan Sudhahar, Seock-Won Youn, Mustafa Nazir Okur, Archita Das, John P. O’Bryan, Maggie McMenamin, Yali Hou, Jack H. Kaplan, Tohru Fukai, Masuko Ushio-Fukai
Nat Commun. 2021; 12: 3091. Published online 2021 May 25. doi: 10.1038/s41467-021-23408-1
PMCID:
PMC8149886
AbstractArticlePDF–9.4M
5.
Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function
Varadarajan Sudhahar, Mustafa Nazir Okur, John P. O’Bryan, Richard D. Minshall, David Fulton, Masuko Ushio-Fukai, Tohru Fukai
Am J Physiol Cell Physiol. 2020 Nov 1; 319(5): C933–C944. Published online 2020 Sep 16. doi: 10.1152/ajpcell.00151.2020
PMCID:
PMC7789967
AbstractArticle
6.
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice
Liam M. Guthrie, Shivatheja Soma, Sai Yuan, Andres Silva, Mohammad Zulkifli, Thomas C. Snavely, Hannah Faith Greene, Elyssa Nunez, Brogan Lynch, Courtney De Ville, Vinit Shanbhag, Franklin R. Lopez, Arjun Acharya, Michael J. Petris, Byung-Eun Kim, Vishal M. Gohil, James C. Sacchettini
Science. Author manuscript; available in PMC 2020 Jun 19.
Published in final edited form as: Science. 2020 May 8; 368(6491): 620–625. doi: 10.1126/science.aaz8899
PMCID:
PMC7304446
AbstractArticlePDF–1.5M
7.
Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess
Nikita Gudekar, Vinit Shanbhag, Yanfang Wang, Martina Ralle, Gary A. Weisman, Michael J. Petris
Sci Rep. 2020; 10: 7856. Published online 2020 May 12. doi: 10.1038/s41598-020-64521-3
PMCID:
PMC7217913
AbstractArticlePDF–2.5M
8.
Copper Transporter ATP7A Limits Vascular Inflammation and Aortic Aneurysm Development: Role of miR-125b
Varadarajan Sudhahar, Archita Das, Tetsuo Horimatsu, Dipankar Ash, Silvia Leanhart, Olga Antipova, Stefan Vogt, Bhupesh Singla, Gabor Csanyi, Joseph White, Jack H. Kaplan, David Fulton, Neal L. Weintraub, Ha Won Kim, Masuko Ushio-Fukai, Tohru Fukai
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2020 Nov 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Nov; 39(11): 2320–2337. Published online 2019 Sep 26. doi: 10.1161/ATVBAHA.119.313374
PMCID:
PMC6857803
AbstractArticlePDF–3.8M
9.
Genetically Decreased Spinal Cord Copper Concentration Prolongs Life in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Mahmoud Kiaei, Ashley I. Bush, Brett M. Morrison, John H. Morrison, Robert A. Cherny, Irene Volitakis, M. Flint Beal, Jon W. Gordon
J Neurosci. 2004 Sep 8; 24(36): 7945–7950. doi: 10.1523/JNEUROSCI.2000-04.2004
PMCID:
PMC6729922
AbstractArticlePDF–242K
10.
NMDA Receptor Activation Mediates Copper Homeostasis in Hippocampal Neurons
Michelle L. Schlief, Ann Marie Craig, Jonathan D. Gitlin
J Neurosci. 2005 Jan 5; 25(1): 239–246. doi: 10.1523/JNEUROSCI.3699-04.2005
PMCID:
PMC6725203
AbstractArticlePDF–397K
11.
The Evf2 ultraconserved enhancer lncRNA functionally and spatially organizes multi-megabase distant genes in developing forebrain
Ivelisse Cajigas, Abhijit Chakraborty, Kelsey R. Swyter, Hao Luo, Monique Bastidas, Maximilliano Nigro, Elizabeth R. Morris, Sean Chen, Michael J. W. VanGompel, David Leib, Sara J. Kohtz, Marco Martina, Sooky Koh, Ferhat Ay, Jhumku D. Kohtz
Mol Cell. Author manuscript; available in PMC 2019 Sep 20.
Published in final edited form as: Mol Cell. 2018 Sep 20; 71(6): 956–972.e9. Published online 2018 Aug 23. doi: 10.1016/j.molcel.2018.07.024
PMCID:
PMC6428050
AbstractArticlePDF–2.0M
12.
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells
Farzad Asadi, Savita Dhanvantari
Front Endocrinol (Lausanne) 2018; 9: 792. Published online 2019 Jan 18. doi: 10.3389/fendo.2018.00792
PMCID:
PMC6346685
AbstractArticlePDF–3.6M
13.
ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase
Katharina Schmidt, Martina Ralle, Thomas Schaffer, Samuel Jayakanthan, Bilal Bari, Abigael Muchenditsi, Svetlana Lutsenko
J Biol Chem. 2018 Dec 28; 293(52): 20085–20098. Published online 2018 Oct 19. doi: 10.1074/jbc.RA118.004889
PMCID:
PMC6311498
AbstractArticlePDF–3.7M
14.
Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy
Shashank Masaldan, Sharnel A.S. Clatworthy, Cristina Gamell, Zoe M. Smith, Paul S. Francis, Delphine Denoyer, Peter M. Meggyesy, Sharon La Fontaine, Michael A. Cater
Redox Biol. 2018 Jun; 16: 322–331. Published online 2018 Mar 17. doi: 10.1016/j.redox.2018.03.007
PMCID:
PMC5953000
AbstractArticlePDF–2.3M
15.
The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart
Zakery N Baker, Kimberly Jett, Aren Boulet, Amzad Hossain, Paul A Cobine, Byung-Eun Kim, Amr M El Zawily, Ling Lee, Glen F Tibbits, Michael J Petris, Scot C Leary
Hum Mol Genet. 2017 Dec 1; 26(23): 4617–4628. Published online 2017 Sep 4. doi: 10.1093/hmg/ddx344
PMCID:
PMC5886179
AbstractArticlePDF–1.2M
16.
Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees
Stephanie A. Zlatic, Alysia Vrailas-Mortimer, Avanti Gokhale, Lucas J. Carey, Elizabeth Scott, Reid Burch, Morgan M. McCall, Samantha Rudin-Rush, John Bowen Davis, Cortnie Hartwig, Erica Werner, Lian Li, Michael Petris, Victor Faundez
Cell Syst. Author manuscript; available in PMC 2019 Mar 28.
Published in final edited form as: Cell Syst. 2018 Mar 28; 6(3): 368–380.e6. Published online 2018 Jan 31. doi: 10.1016/j.cels.2018.01.008
PMCID:
PMC5876136
AbstractArticlePDF–2.3M
17.
Dynamic changes in copper homeostasis and post-transcriptional regulation of Atp7a during myogenic differentiation
Katherine E. Vest, Amanda L. Paskavitz, Joseph B. Lee, Teresita Padilla-Benavides
Metallomics. 2018 Feb 1; 10(2): 309–322. Published online 2018 Jan 4. doi: 10.1039/c7mt00324b
PMCID:
PMC5824686
AbstractArticle
18.
Akt2 Stabilizes ATP7A, a Cu transporter for SOD3, in Vascular Smooth Muscles: Novel Mechanism to limit Endothelial Dysfunction in Type2 diabetes
Varadarajan Sudhahar, Mustafa Nazir Okur, Zsolt Bagi, John P O'Bryan, Nissim Hay, Ayako Makino, Vijay S Patel, Shane A Phillips, David Stepp, Masuko Ushio-Fukai, Tohru Fukai
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Mar; 38(3): 529–541. Published online 2018 Jan 4. doi: 10.1161/ATVBAHA.117.309819
PMCID:
PMC5823760
AbstractArticlePDF–3.0M
19.
Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis
Haarin Chun, Tracy Catterton, Heejeong Kim, Jaekwon Lee, Byung-Eun Kim
Sci Rep. 2017; 7: 12001. Published online 2017 Sep 20. doi: 10.1038/s41598-017-11961-z
PMCID:
PMC5607234
AbstractArticlePDF–4.8M
20.
Characterizing the molecular phenotype of an Atp7aT985I conditional knock in mouse model for X-linked distal hereditary motor neuropathy (dHMNX)
Gonzalo Perez-Siles, Adrienne Grant, Melina Ellis, Carolyn Ly, Aditi Kidambi, Mamdouh Khalil, Roxana M. Llanos, Sharon La Fontaine, Alleene V. Strickland, Stephan Züchner, Sandra Bermeo, Elysia Neist, Tara C. Brennan-Speranza, Reinaldo I. Takata, Carlos E. Speck-Martins, Julian F.B. Mercer, Garth A. Nicholson, Marina L. Kennerson
Metallomics. Author manuscript; available in PMC 2017 Sep 6.
Published in final edited form as: Metallomics. 2016 Sep 1; 8(9): 981–992. Published online 2016 Jun 13. doi: 10.1039/c6mt00082g
PMCID:
PMC5586149
AbstractArticlePDF–2.8M

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