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Select item 105374871.

Differential Susceptibility to Benzo[a]pyrene Exposure during Gestation and Lactation in Mice with Genetic Variations in the Aryl Hydrocarbon Receptor and Cyp1 Genes

Mackenzie Feltner, Patrick M. Hare, Asia Good, Emma G. Foster, Katelyn Clough, Jade Perry, Amanda Honaker, Angela Kyntchev, Mickayla Kowalski, Christine Perdan Curran

Toxics. 2023 Sep; 11(9): 778. Published online 2023 Sep 13. doi: 10.3390/toxics11090778

PMCID:: PMC10537487

Abstract Article PDF–2.8M

Select item 103659852.

Image-based quantification of histological features as a function of spatial location using the Tissue Positioning System

Ruichen Rong, Yonglong Wei, Lin Li, Tao Wang, Hao Zhu, Guanghua Xiao, Yunguan Wang

eBioMedicine. 2023 Aug; 94: 104698. Published online 2023 Jul 13. doi: 10.1016/j.ebiom.2023.104698

PMCID:: PMC10365985

Abstract Article PDF–5.4M

Select item 92072683.

Lung Epithelial CYP1 Activity Regulates Aryl Hydrocarbon Receptor Dependent Allergic Airway Inflammation

Francesca Alessandrini, Renske de Jong, Maria Wimmer, Ann-Marie Maier, Isis Fernandez, Miriam Hils, Jeroen T. Buters, Tilo Biedermann, Ulrich M. Zissler, Christian Hoffmann, Julia Esser-von-Bieren, Carsten B. Schmidt-Weber, Caspar Ohnmacht

Front Immunol. 2022; 13: 901194. Published online 2022 Jun 6. doi: 10.3389/fimmu.2022.901194

PMCID:: PMC9207268

Abstract Article PDF–6.0M

Select item 87286914.

Molecular Mechanisms of Pulmonary Carcinogenesis by Polycyclic Aromatic Hydrocarbons (PAHs): Implications for Human Lung Cancer

Rachel Stading, Grady Gastelum, Chun Chu, Weiwu Jiang, Bhagavatula Moorthy

Semin Cancer Biol. Author manuscript; available in PMC 2022 Jan 5.

Published in final edited form as: Semin Cancer Biol. 2021 Nov; 76: 3–16. Published online 2021 Jul 7. doi: 10.1016/j.semcancer.2021.07.001

PMCID:: PMC8728691

Abstract Article PDF–1.9M

Select item 84964205.

Liver homeostasis is maintained by midlobular zone 2 hepatocytes

Yonglong Wei, Yunguan G. Wang, Yuemeng Jia, Lin Li, Jung Yoon, Shuyuan Zhang, Zixi Wang, Yu Zhang, Min Zhu, Tripti Sharma, Yu-Hsuan Lin, Meng-Hsiung Hsieh, Jeffrey H. Albrecht, Phuong T. Le, Clifford J. Rosen, Tao Wang, Hao Zhu

Science. Author manuscript; available in PMC 2021 Oct 7.

Published in final edited form as: Science. 2021 Feb 26; 371(6532): eabb1625. doi: 10.1126/science.abb1625

PMCID:: PMC8496420

Abstract Article PDF–6.4M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 78188997.

Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2

Grady Gastelum, Weiwu Jiang, Lihua Wang, Guodong Zhou, Roshan Borkar, Nagireddy Putluri, Bhagavatula Moorthy

Toxicol Sci. 2020 Oct; 177(2): 347–361. Published online 2020 Jul 29. doi: 10.1093/toxsci/kfaa107

PMCID:: PMC7818899

Abstract Article PDF–1.4M

Select item 66572168.

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode, C. R. Wolf

Drug Metab Dispos. 2019 Aug; 47(8): 907–918. Published online 2019 Jul 19. doi: 10.1124/dmd.119.087718

PMCID:: PMC6657216

Abstract Article PDF–1.4M

Select item 65053809.

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

C.J. Henderson, Y. Kapelyukh, N. Scheer, A. Rode, AW. McLaren, A.K. MacLeod, D. Lin, J. Wright, L.A. Stanley, C.R. Wolf

Drug Metab Dispos. 2019 Jun; 47(6): 601–615. Published online 2019 Jun. doi: 10.1124/dmd.119.086397

PMCID:: PMC6505380

Abstract Article PDF–1.7M

Select item 642573010.

Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders

Kelsey Klinefelter, Molly Kromme Hooven, Chloe Bates, Breann T. Colter, Alexandra Dailey, Smitha Krishnan Infante, Izabela Kania-Korwel, Hans-Joachim Lehmler, Alejandro López-Juárez, Clare Pickering Ludwig, Christine Perdan Curran

Mamm Genome. Author manuscript; available in PMC 2019 Mar 20.

Published in final edited form as: Mamm Genome. 2018 Feb; 29(1-2): 112–127. Published online 2017 Dec 2. doi: 10.1007/s00335-017-9728-1

PMCID:: PMC6425730

Abstract Article PDF–1.5M

Select item 591915311.

Cell‐density‐dependent Expression of Cyp1a2 Gene in Monolayer‐cultured Adult Mouse Hepatocytes

Nobuo Nemoto, Junko Sakurai

Jpn J Cancer Res. 1993 Mar; 84(3): 265–271. doi: 10.1111/j.1349-7006.1993.tb02866.x

PMCID:: PMC5919153

Summary PDF–629K

Select item 591914312.

Activation of Cyp1a1 and Cyp1a2 Genes in Adult Mouse Hepatocytes in Primary Culture

Nobuo Nemoto, Junko Sakurai

Jpn J Cancer Res. 1993 Mar; 84(3): 272–278. doi: 10.1111/j.1349-7006.1993.tb02867.x

PMCID:: PMC5919143

Summary PDF–509K

Select item 591867313.

Species Difference among Experimental Rodents in Induction of P450IA Family Enzymes by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

Masakuni Degawa, Ken‐ichiro Kobayashi, Shin‐ichi Miura, Hiroshi Arai, Hiroyasu Esumi, Takashi Sugimura, Yoshiyuki Hashimoto

Jpn J Cancer Res. 1992 Oct; 83(10): 1047–1051. doi: 10.1111/j.1349-7006.1992.tb02720.x

PMCID:: PMC5918673

Summary PDF–504K

Select item 570565514.

2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2

Shangfu Xu, Jie Liu, Jingshan Shi, Zhengtao Wang, Lili Ji

Sci Rep. 2017; 7: 16511. Published online 2017 Nov 28. doi: 10.1038/s41598-017-16688-5

PMCID:: PMC5705655

Abstract Article PDF–8.6M

Select item 441880115.

Disruption of Cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury

Lihua Wang, Krithika Lingappan, Weiwu Jiang, Xanthi I. Couroucli, Stephen E. Welty, Binoy Shivanna, Roberto Barrios, Gangduo Wang, M. Firoze Khan, Frank J. Gonzalez, L Jackson Roberts, Bhagavatula Moorthy

Free Radic Biol Med. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Free Radic Biol Med. 2015 May; 82: 147–159. Published online 2015 Feb 10. doi: 10.1016/j.freeradbiomed.2015.01.019

PMCID:: PMC4418801

Abstract Article PDF–1.9M

Select item 440684916.

Sex-specific differences in hyperoxic lung injury in mice: role of Cytochrome P450 (CYP)1A

Krithika Lingappan, Weiwu Jiang, Lihua Wang, Xanthi I. Couroucli, Bhagavatula Moorthy

Toxicology. Author manuscript; available in PMC 2016 May 4.

Published in final edited form as: Toxicology. 2015 May 4; 331: 14–23. Published online 2015 Feb 19. doi: 10.1016/j.tox.2015.01.019

PMCID:: PMC4406849

Abstract Article PDF–3.7M

Select item 437266717.

N-Hydroxylation of 4-Aminobiphenyl by CYP2E1 Produces Oxidative Stress in a Mouse Model of Chemically Induced Liver Cancer

Shuang Wang, Kim S. Sugamori, Aveline Tung, J. Peter McPherson, Denis M. Grant

Toxicol Sci. 2015 Apr; 144(2): 393–405. Published online 2015 Jan 19. doi: 10.1093/toxsci/kfv006

PMCID:: PMC4372667

Abstract Article PDF–636K

Select item 397503818.

Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and Its Role in Polycyclic Aromatic Hydrocarbon-induced Mitochondrial Dysfunction

Seema Bansal, Adrian N. Leu, Frank J. Gonzalez, F. Peter Guengerich, Anindya Roy Chowdhury, Hindupur K. Anandatheerthavarada, Narayan G. Avadhani

J Biol Chem. 2014 Apr 4; 289(14): 9936–9951. Published online 2014 Feb 4. doi: 10.1074/jbc.M113.525659

PMCID:: PMC3975038

Abstract Article PDF–4.2M

Select item 385960919.

Exposure to Atmospheric Particulate Matter Enhances Th17 Polarization through the Aryl Hydrocarbon Receptor

Michael van Voorhis, Samantha Knopp, Walker Julliard, John H. Fechner, Xiaoji Zhang, James J. Schauer, Joshua D. Mezrich

PLoS One. 2013; 8(12): e82545. Published online 2013 Dec 11. doi: 10.1371/journal.pone.0082545

PMCID:: PMC3859609

Abstract Article PDF–715K

Select item 381045220.

Contributions of the Three CYP1 Monooxygenases to Pro-Inflammatory and Inflammation-Resolution Lipid-Mediator Pathways

Senad Divanovic, Jesmond Dalli, Lucia F. Jorge-Nebert, Leah M. Flick, Marina Gálvez-Peralta, Nicholas D. Boespflug, Traci E. Stankiewicz, Jonathan M. Fitzgerald, Maheshika Somarathna, Christopher L. Karp, Charles N. Serhan, Daniel W. Nebert

J Immunol. Author manuscript; available in PMC 2014 Sep 15.

Published in final edited form as: J Immunol. 2013 Sep 15; 191(6): 10.4049/jimmunol.1300699. Published online 2013 Aug 16. doi: 10.4049/jimmunol.1300699

PMCID:: PMC3810452

Abstract Article PDF–3.9M

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