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Select item 111131761.

Alzheimer’s disease risk factor lymphocyte-specific protein tyrosine kinase regulates long-term synaptic strengthening, spatial learning and memory

Eun-Jung Kim, Francisco J. Monje, Lin Li, Harald Höger, Daniela D. Pollak, Gert Lubec

Cell Mol Life Sci. 2013 Feb; 70(4): 743–759. Published online 2012 Sep 25. doi: 10.1007/s00018-012-1168-1

PMCID:: PMC11113176

Abstract Article PDF–764K

Select item 106449092.

A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation

Victor G. Lui, Manfred Hoenig, Berenice Cabrera-Martinez, Ryan M. Baxter, Josselyn E. Garcia-Perez, Olivia Bailey, Atanu Acharya, Karl Lundquist, Jesusa Capera, Paul Matusewicz, Frederike A. Hartl, Marco D’Abramo, Josephine Alba, Eva-Maria Jacobsen, Doris Niewolik, Myriam Lorenz, Ulrich Pannicke, Ansgar S. Schulz, Klaus-Michael Debatin, Wolfgang W. Schamel, Susana Minguet, James C. Gumbart, Michael L. Dustin, John C. Cambier, Klaus Schwarz, Elena W.Y. Hsieh

J Exp Med. 2024 Jan 1; 221(1): e20230927. Published online 2023 Nov 14. doi: 10.1084/jem.20230927

PMCID:: PMC10644909

Abstract Article PDF–7.0M

Select item 102945093.

LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer

Goutam Dey, Rashmi Bharti, Chad Braley, Ravi Alluri, Emily Esakov, Katie Crean-Tate, Keith McCrae, Amy Joehlin-Price, Peter G. Rose, Justin Lathia, Zihua Gong, Ofer Reizes

J Ovarian Res. 2023; 16: 122. Published online 2023 Jun 27. doi: 10.1186/s13048-023-01194-2

PMCID:: PMC10294509

Abstract Article PDF–8.5M

Select item 96618404.

LCK‐Mediated RIPK3 Activation Controls Double‐Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A‐ERK Axis

Sung‐Min Hwang, Yu‐Jin Ha, Gi‐Bang Koo, Hyun‐Jin Noh, A‐Yeon Lee, Byeong‐Ju Kim, Sun Mi Hong, Michael J. Morgan, Seong‐il Eyun, Dakeun Lee, Jae‐Seok Roe, Youngsoo Lee, You‐Sun Kim

Adv Sci (Weinh) 2022 Nov; 9(32): 2204522. Published online 2022 Sep 25. doi: 10.1002/advs.202204522

PMCID:: PMC9661840

Abstract Article PDF–5.6M

Select item 88498105.

Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis

Ji Zhou, Xiaoyi Zhang, Lixia Ji, Guohui Jiang

Biomed Res Int. 2022; 2022: 9920744. Published online 2022 Feb 9. doi: 10.1155/2022/9920744

PMCID:: PMC8849810

Abstract Article PDF–1.8M

Select item 85535676.

CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice

Hongxia Duan, Lin Jing, Xiaoqing Jiang, Yanbin Ma, Daji Wang, Jianquan Xiang, Xuehui Chen, Zhenzhen Wu, Huiwen Yan, Junying Jia, Zheng Liu, Jing Feng, Mingzhao Zhu, Xiyun Yan

J Clin Invest. 2021 Nov 1; 131(21): e148568. Published online 2021 Nov 1. doi: 10.1172/JCI148568

PMCID:: PMC8553567

Abstract Article PDF–3.1M

Select item 81596927.

Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling

Shizuka Otsuka, Nicolas Melis, Matthias M. Gaida, Debjani Dutta, Roberto Weigert, Jonathan D. Ashwell

J Clin Invest. 2021 Jun 1; 131(11): e147683. Published online 2021 Jun 1. doi: 10.1172/JCI147683

PMCID:: PMC8159692

Abstract Article PDF–8.2M

Select item 74925218.

Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia

Melanie Märklin, Alexander R. Fuchs, Claudia Tandler, Jonas S. Heitmann, Helmut R. Salih, Joseph Kauer, Leticia Quintanilla-Martinez, Stefan Wirths, Hans-Georg Kopp, Martin R. Müller

Front Immunol. 2020; 11: 1995. Published online 2020 Sep 2. doi: 10.3389/fimmu.2020.01995

PMCID:: PMC7492521

Abstract Article PDF–1.1M

Select item 73550119.

Lck bound to coreceptor is less active than free Lck

Qianru Wei, Joanna Brzostek, Shvetha Sankaran, Javier Casas, Lois Shi-Qi Hew, Jiawei Yap, Xiang Zhao, Lukasz Wojciech, Nicholas R. J. Gascoigne

Proc Natl Acad Sci U S A. 2020 Jul 7; 117(27): 15809–15817. Published online 2020 Jun 22. doi: 10.1073/pnas.1913334117

PMCID:: PMC7355011

Abstract Article PDF–1.5M

Select item 700306310.

Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

Veronika Horkova, Ales Drobek, Daniel Mueller, Celine Gubser, Veronika Niederlova, Lena Wyss, Carolyn G. King, Dietmar Zehn, Ondrej Stepanek

Cell Rep. 2020 Feb 4; 30(5): 1504–1514.e7. Published online 2019 Feb 4. doi: 10.1016/j.celrep.2020.01.008

PMCID:: PMC7003063

Abstract Article

Select item 696044811.

PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours

Florian Wiede, Kun‐Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong‐Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis

EMBO J. 2020 Jan 15; 39(2): e103637. Published online 2019 Dec 5. doi: 10.15252/embj.2019103637

PMCID:: PMC6960448

Abstract Article PDF–4.6M

Select item 685906612.

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen

Nat Immunol. Author manuscript; available in PMC 2020 Apr 7.

Published in final edited form as: Nat Immunol. 2019 Nov 1; 20(11): 1530–1541. Published online 2019 Oct 7. doi: 10.1038/s41590-019-0489-8

PMCID:: PMC6859066

Abstract Article PDF–2.9M

Select item 620224913.

Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT

Wan-Lin Lo, Neel H. Shah, Nagib Ahsan, Veronika Horkova, Ondrej Stepanek, Arthur R. Salomon, John Kuriyan, Arthur Weiss

Nat Immunol. Author manuscript; available in PMC 2018 Dec 18.

Published in final edited form as: Nat Immunol. 2018 Jul; 19(7): 733–741. Published online 2018 Jun 18. doi: 10.1038/s41590-018-0131-1

PMCID:: PMC6202249

Abstract Article PDF–1.0M

Select item 617656214.

Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers

Shan Feng, Xi Cheng, Lin Zhang, Xuemin Lu, Seema Chaudhary, Ruifang Teng, Christian Frederickson, Matthew M. Champion, Ren Zhao, Liang Cheng, Yiyi Gong, Haiteng Deng, Xin Lu

Proc Natl Acad Sci U S A. 2018 Oct 2; 115(40): 10094–10099. Published online 2018 Sep 19. doi: 10.1073/pnas.1800695115

PMCID:: PMC6176562

Abstract Article PDF–1.2M

Select item 592999215.

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling

Jessica Dobbins, Etienne Gagnon, Jernej Godec, Jason Pyrdol, Dario A. A. Vignali, Arlene H. Sharpe, Kai W. Wucherpfennig

Sci Signal. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Sci Signal. 2016 Jul 26; 9(438): ra75. Published online 2016 Jul 26. doi: 10.1126/scisignal.aaf0626

PMCID:: PMC5929992

Abstract Article PDF–887K

Select item 565386516.

The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation

Alissa Marhäll, Julhash U. Kazi, Lars Rönnstrand

Sci Rep. 2017; 7: 13734. Published online 2017 Oct 23. doi: 10.1038/s41598-017-14033-4

PMCID:: PMC5653865

Abstract Article PDF–2.9M

Select item 558412117.

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification

Florian Wiede, Jarrod A. Dudakov, Kun-Hui Lu, Garron T. Dodd, Tariq Butt, Dale I. Godfrey, Andreas Strasser, Richard L. Boyd, Tony Tiganis

J Exp Med. 2017 Sep 4; 214(9): 2733–2758. doi: 10.1084/jem.20161903

PMCID:: PMC5584121

Abstract Article PDF–4.1M

Select item 555885418.

A PHOSPHOSITE WITHIN THE SH2 DOMAIN OF LCK REGULATES ITS ACTIVATION BY CD45

Adam H. Courtney, Jeanine F. Amacher, Theresa A. Kadlecek, Marianne N. Mollenauer, Byron B. Au-Yeung, John Kuriyan, Arthur Weiss

Mol Cell. Author manuscript; available in PMC 2018 Aug 3.

Published in final edited form as: Mol Cell. 2017 Aug 3; 67(3): 498–511.e6. Published online 2017 Jul 20. doi: 10.1016/j.molcel.2017.06.024

PMCID:: PMC5558854

Abstract Article PDF–2.2M

Select item 554428819.

Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells

Thomas C. J. Tan, John Knight, Thomas Sbarrato, Kate Dudek, Anne E. Willis, Rose Zamoyska

Proc Natl Acad Sci U S A. 2017 Jul 25; 114(30): E6117–E6126. Published online 2017 Jul 10. doi: 10.1073/pnas.1700939114

PMCID:: PMC5544288

Abstract Article PDF–1.6M

Select item 544381220.

Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun

Yury V. Shebzukhov, Silke Stanislawiak, Taisiya R. Bezhaeva, Sergei A. Nedospasov, Dmitry V. Kuprash

Sci Rep. 2017; 7: 2339. Published online 2017 May 24. doi: 10.1038/s41598-017-02553-y

PMCID:: PMC5443812

Abstract Article PDF–1.6M

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