PMC Links for GEO Profiles (Select 129087473) - PMC

Ming-Yue Fei, Yong Wang, Bin-He Chang, Kai Xue, Fangyi Dong, Dan Huang, Xi-Ya Li, Zi-Juan Li, Cheng-Long Hu, Ping Liu, Ji-Chuan Wu, Peng-Cheng Yu, Ming-Hua Hong, Shu-Bei Chen, Chun-Hui Xu, Bing-Yi Chen, Yi-Lun Jiang, Na Liu, Chong Zhao, Jia-Cheng Jin, Dan Hou, Xin-Chi Chen, Yi-Yi Ren, Chu-Han Deng, Jia-Ying Zhang, Li-juan Zong, Rou-Jia Wang, Fei-Fei Gao, Hui Liu, Qun-Ling Zhang, Ling-Yun Wu, Jinsong Yan, Shuhong Shen, Chun-Kang Chang, Xiao-Jian Sun, Lan Wang

Blood. 2023 Sep 7; 142(10): 903–917. Published online 2023 Jun 18. doi: 10.1182/blood.2022019537

PMCID:: PMC10644073

Abstract Article

Select item 105375134.

Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression

Annalisa Izzo, Ipek Akol, Alejandro Villarreal, Shannon Lebel, Marta Garcia-Miralles, Arquimedes Cheffer, Patrick Bovio, Stefanie Heidrich, Tanja Vogel

Epigenetics Chromatin. 2023; 16: 36. Published online 2023 Sep 28. doi: 10.1186/s13072-023-00511-9

PMCID:: PMC10537513

Abstract Article PDF–6.2M

Select item 105166455.

Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells

Xin Zhao, Xiaomin Li, Haiyang Sun, Xuan Zhao, Tingting Gao, Panpan Shi, Fuquan Chen, Lin Liu, Xinyi Lu

Nucleic Acids Res. 2023 Sep 22; 51(17): 8970–8986. Published online 2023 Jul 31. doi: 10.1093/nar/gkad640

PMCID:: PMC10516645

Abstract Article PDF–3.7M

Select item 104847916.

In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis

David Lara-Astiaso, Ainhoa Goñi-Salaverri, Julen Mendieta-Esteban, Nisha Narayan, Cynthia Del Valle, Torsten Gross, George Giotopoulos, Tumas Beinortas, Mar Navarro-Alonso, Laura Pilar Aguado-Alvaro, Jon Zazpe, Francesco Marchese, Natalia Torrea, Isabel A. Calvo, Cecile K. Lopez, Diego Alignani, Aitziber Lopez, Borja Saez, Jake P. Taylor-King, Felipe Prosper, Nikolaus Fortelny, Brian J. P. Huntly

Nat Genet. 2023; 55(9): 1542–1554. Published online 2023 Aug 14. doi: 10.1038/s41588-023-01471-2

PMCID:: PMC10484791

Abstract Article PDF–18M

Select item 103095897.

Myc promotes polyploidy in murine trophoblast cells and suppresses senescence

Vijay Pratap Singh, Huzaifa Hassan, Fengyan Deng, Dai Tsuchiya, Sean McKinney, Kevin Ferro, Jennifer L. Gerton

Development. 2023 Jun 1; 150(11): dev201581. Published online 2023 Jun 6. doi: 10.1242/dev.201581

PMCID:: PMC10309589

Abstract Article

Select item 103078528.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 98986119.

Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice

Andrew Muranyi, Tobias Ammer, Anna Kechter, Vijay P.S. Rawat, Amit Sinha, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Anca Azoitei, Cagatay Günes, Annalisa Mupo, George Vassiliou, Shiva Bamezai, Christian Buske

Blood Adv. 2023 Feb 14; 7(3): 351–364. Published online 2022 Apr 27. doi: 10.1182/bloodadvances.2022007015

PMCID:: PMC9898611

Abstract Article PDF–2.6M

Select item 963155710.

Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy

Jennifer M. SanMiguel, Elizabeth Eudy, Matthew A. Loberg, Linde A. Miles, Tim Stearns, Jayna J. Mistry, Michael J. Rauh, Ross L. Levine, Jennifer J. Trowbridge

Blood Adv. 2022 Jun 28; 6(12): 3666–3677. Published online 2022 Jun 22. doi: 10.1182/bloodadvances.2022006968

PMCID:: PMC9631557

Abstract Article PDF–1.3M

Select item 948193311.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 935721812.

Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML

Alison E. Meyer, Cary Stelloh, Kirthi Pulakanti, Robert Burns, Joseph B. Fisher, Katelyn E. Heimbruch, Sergey Tarima, Quinlan Furumo, John Brennan, Yongwei Zheng, Aaron D. Viny, George S. Vassiliou, Sridhar Rao

Leukemia. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Leukemia. 2022 Aug; 36(8): 2032–2041. Published online 2022 Jul 1. doi: 10.1038/s41375-022-01632-y

PMCID:: PMC9357218

Abstract Article PDF–1.8M

Select item 934880313.

Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis

Shikha Gupta, Oliver M. Dovey, Ana Filipa Domingues, Oliwia W. Cyran, Caitlin M. Cash, George Giotopoulos, Justyna Rak, Jonathan Cooper, Malgorzata Gozdecka, Liza Dijkhuis, Ryan J. Asby, Noor Al-Jabery, Victor Hernandez-Hernandez, Sudhakaran Prabakaran, Brian J. Huntly, George S. Vassiliou, Cristina Pina

Sci Adv. 2022 Aug; 8(31): eabn4886. Published online 2022 Aug 3. doi: 10.1126/sciadv.abn4886

PMCID:: PMC9348803

Abstract Article PDF–2.2M

Select item 906605114.

NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss

Claudia Morganti, Kyoko Ito, Chie Yanase, Amit Verma, Julie Teruya‐Feldstein, Keisuke Ito

EMBO Rep. 2022 May; 23(5): e54262. Published online 2022 Mar 1. doi: 10.15252/embr.202154262

PMCID:: PMC9066051

Abstract Article PDF–1.5M

Select item 838073015.

METTL1-mediated m⁷G modification of Arg-TCT tRNA drives oncogenic transformation

Esteban A. Orellana, Qi Liu, Eliza Yankova, Mehdi Pirouz, Etienne De Braekeleer, Wencai Zhang, Jihoon Lim, Demetrios Aspris, Erdem Sendinc, Dimitrios A. Garyfallos, Muxin Gu, Raja Ali, Alejandro Gutierrez, Sigitas Mikutis, Gonçalo J. L. Bernardes, Eric S. Fischer, Allan Bradley, George S. Vassiliou, Frank J. Slack, Konstantinos Tzelepis, Richard I. Gregory

Mol Cell. Author manuscript; available in PMC 2022 Aug 19.

Published in final edited form as: Mol Cell. 2021 Aug 19; 81(16): 3323–3338.e14. Published online 2021 Aug 4. doi: 10.1016/j.molcel.2021.06.031

PMCID:: PMC8380730

Abstract Article PDF–2.1M

Select item 831323916.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 793877017.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 786515018.

SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress

Alessandro Ianni, Poonam Kumari, Shahriar Tarighi, Nicolas G. Simonet, Daniela Popescu, Stefan Guenther, Soraya Hölper, Andreas Schmidt, Christian Smolka, Shijing Yue, Marcus Krüger, Claudia Fiorillo, Alejandro Vaquero, Eva Bober, Thomas Braun

Proc Natl Acad Sci U S A. 2021 Feb 2; 118(5): e2015339118. Published online 2021 Jan 25. doi: 10.1073/pnas.2015339118

PMCID:: PMC7865150

Abstract Article PDF–2.4M

Select item 761313419.

Small molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Eliza Yankova, Wesley Blackaby, Mark Albertella, Justyna Rak, Etienne De Braekeleer, Georgia Tsagkogeorga, Ewa S. Pilka, Demetrios Aspris, Dan Leggate, Alan G. Hendrick, Natalie A. Webster, Byron Andrews, Richard Fosbeary, Patrick Guest, Nerea Irigoyen, Maria Eleftheriou, Malgorzata Gozdecka, Joao M. L. Dias, Andrew J. Bannister, Binje Vick, Irmela Jeremias, George S. Vassiliou, Oliver Rausch, Konstantinos Tzelepis, Tony Kouzarides

Nature. Author manuscript; available in PMC 2022 Jul 23.

Published in final edited form as: Nature. 2021 May 1; 593(7860): 597–601. Published online 2021 Apr 26. doi: 10.1038/s41586-021-03536-w

PMCID:: PMC7613134

Abstract Article PDF–4.8M

Select item 741599120.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

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