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Items: 1 to 20 of 48

1.
E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors
Jeroen M Bugter, Peter van Kerkhof, Ingrid Jordens, Eline Janssen, Thi Tran Ngoc Minh, Daniel Iglesias van Montfort, Cara Jamieson, Madelon M Maurice
Life Sci Alliance. 2024 Sep; 7(9): e202402575. Published online 2024 Jul 8. doi: 10.26508/lsa.202402575
PMCID:
PMC11231576
AbstractArticlePDF–1.7M
2.
RNF43 Inactivation Enhances the B‐RAF/MEK Signaling and Creates a Combinatory Therapeutic Target in Cancer Cells
Shih‐Han Hsu, Ya‐Li Tsai, Yeng‐Tseng Wang, Che‐Hung Shen, Yu‐Hsuan Hung, Li‐Tzong Chen, Wen‐Chun Hung
Adv Sci (Weinh) 2024 Mar; 11(12): 2304820. Published online 2024 Jan 15. doi: 10.1002/advs.202304820
PMCID:
PMC10966525
AbstractArticlePDF–5.4M
3.
Inherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family
James M. Chan, Mark Clendenning, Sharelle Joseland, Peter Georgeson, Khalid Mahmood, Jihoon E. Joo, Romy Walker, Julia Como, Susan Preston, Shuyi Marci Chai, Yen Lin Chu, Aaron L. Meyers, Bernard J. Pope, David Duggan, J. Lynn Fink, Finlay A. Macrae, Christophe Rosty, Ingrid M. Winship, Mark A. Jenkins, Daniel D. Buchanan
Fam Cancer. 2024; 23(1): 9–21. Published online 2023 Dec 8. doi: 10.1007/s10689-023-00351-2
PMCID:
PMC10869370
AbstractArticlePDF–2.7M
4.
Pan-cancer analysis identifies RNF43 as a prognostic, therapeutic and immunological biomarker
Yingting Xu, Zhengjun Lin, Yuqiao Ji, Chen Zhang, Xianzhe Tang, Chuan Li, Tang Liu
Eur J Med Res. 2023; 28: 438. Published online 2023 Oct 17. doi: 10.1186/s40001-023-01383-1
PMCID:
PMC10580550
AbstractArticlePDF–13M
5.
RNF43 is a novel tumor-suppressor and prognostic indicator in clear cell renal cell carcinoma
DAWEI ZHU, LEI ZHANG, XIAOKAI SHI, SHENGLIN GAO, CHUANG YUE, LIFENG ZHANG, YU BAI, QIFENG WANG, ATSUSHI OKADA, TAKAHIRO YASUI, CHAO WANG, XINGANG CUI, LI ZUO
Oncol Res. 2021; 29(3): 159–174. Published online 2022 Aug 1. doi: 10.32604/or.2022.03458
PMCID:
PMC10208019
AbstractArticlePDF–17M
6.
Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox
Dirk H. Siepe, Lora K. Picton, K. Christopher Garcia
ACS Synth Biol. 2023 Apr 21; 12(4): 1081–1093. Published online 2023 Apr 3. doi: 10.1021/acssynbio.2c00587
PMCID:
PMC10127277
AbstractArticlePDF–5.0M
7.
RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAFV600E metastatic colorectal cancer
Elena Elez, Javier Ros, Jose Fernández, Guillermo Villacampa, Ana Belén Moreno-Cárdenas, Carlota Arenillas, Kinga Bernatowicz, Raquel Comas, Shanshan Li, David Philip Kodack, Roberta Fasani, Ariadna Garcia, Javier Gonzalo-Ruiz, Alejandro Piris-Gimenez, Paolo Nuciforo, Grainne Kerr, Rossana Intini, Aldo Montagna, Marco Maria Germani, Giovanni Randon, Ana Vivancos, Ron Smits, Diana Graus, Raquel Perez-Lopez, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Rodrigo Dienstmann, Josep Tabernero, Rodrigo A. Toledo
Nat Med. 2022; 28(10): 2162–2170. Published online 2022 Sep 12. doi: 10.1038/s41591-022-01976-z
PMCID:
PMC9556333
AbstractArticlePDF–4.1M
8.
Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer
Abdul Khalid Siraj, Rong Bu, Tariq Masoodi, Sandeep Kumar Parvathareddy, Kaleem Iqbal, Wael Al-Haqawi, Hassan Al-Dossari, Saud Azam, Zeeshan Qadri, Padmanaban Annaiyappanaidu, Fouad Al-Dayel, Khawla Sami Al-Kuraya
Sci Rep. 2022; 12: 13098. Published online 2022 Jul 30. doi: 10.1038/s41598-022-17449-9
PMCID:
PMC9338933
AbstractArticlePDF–1.5M
9.
Characterization of RNF43 frameshift mutations that drive Wnt ligand‐ and R‐spondin‐dependent colon cancer
Daisuke Yamamoto, Hiroko Oshima, Dong Wang, Haruna Takeda, Kenji Kita, Xuelian Lei, Mizuho Nakayama, Kazuhiro Murakami, Takashi Ohama, Hirofumi Takemura, Mutsumi Toyota, Hiromu Suzuki, Noriyuki Inaki, Masanobu Oshima
J Pathol. 2022 May; 257(1): 39–52. Published online 2022 Mar 4. doi: 10.1002/path.5868
PMCID:
PMC9314865
AbstractArticlePDF–30M
10.
A dual-activity topoisomerase complex regulates mRNA translation and turnover
Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang
Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538
PMCID:
PMC9262614
AbstractArticlePDF–3.6M
11.
RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition
Lishan Fang, Dane Ford-Roshon, Max Russo, Casey O’Brien, Xiaozhe Xiong, Carino Gurjao, Maximilien Grandclaudon, Srivatsan Raghavan, Steven M. Corsello, Steven A. Carr, Namrata D. Udeshi, James Berstler, Ewa Sicinska, Kimmie Ng, Marios Giannakis
Nat Commun. 2022; 13: 3181. Published online 2022 Jun 8. doi: 10.1038/s41467-022-30794-7
PMCID:
PMC9177965
AbstractArticlePDF–2.2M
12.
Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer
Andreas Seeber, Francesca Battaglin, Kai Zimmer, Florian Kocher, Yasmine Baca, Joanne Xiu, Gilbert Spizzo, Veronica Novotny-Diermayr, Dietmar Rieder, Alberto Puccini, Jeff Swensen, Michelle Ellis, Richard M. Goldberg, Axel Grothey, Anthony F. Shields, John L. Marshall, Benjamin A. Weinberg, Paul E. Sackstein, Kiat Hon Lim, Gek San Tan, Chadi Nabhan, W. Michael Korn, Arno Amann, Zlatko Trajanoski, Martin D. Berger, Emil Lou, Dominik Wolf, Heinz-Josef Lenz
Clin Cancer Res. 2022 May 2; 28(9): 1863–1870. Published online 2022 Feb 16. doi: 10.1158/1078-0432.CCR-21-3018
PMCID:
PMC9064897
AbstractArticlePDF–631K
13.
RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface
A-Ri Cho, Hee Jung Sul, Yoo Jin Kim, Bohyun Kim, Dae Young Zang
Sci Rep. 2022; 12: 7013. Published online 2022 Apr 29. doi: 10.1038/s41598-022-10868-8
PMCID:
PMC9054848
AbstractArticlePDF–1.6M
14.
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state
Germán Belenguer, Gianmarco Mastrogiovanni, Clare Pacini, Zoe Hall, Anna M. Dowbaj, Robert Arnes-Benito, Aleksandra Sljukic, Nicole Prior, Sofia Kakava, Charles R. Bradshaw, Susan Davies, Michele Vacca, Kourosh Saeb-Parsy, Bon-Kyoung Koo, Meritxell Huch
Nat Commun. 2022; 13: 334. Published online 2022 Jan 17. doi: 10.1038/s41467-021-27923-z
PMCID:
PMC8764073
AbstractArticlePDF–3.7M
15.
RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanářová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybeľ, Karol Kaiser, Lucia Demková, Lucia Kučerová, Tomáš Bárta, David Potěšil, Zbyněk Zdráhal, Karel Souček, Vítězslav Bryja
eLife. 2021; 10: e65759. Published online 2021 Oct 27. doi: 10.7554/eLife.65759
PMCID:
PMC8550759
AbstractArticlePDF–7.4M
16.
Oligodendroglial Ring Finger Protein Rnf43 is an essential injury specific regulator of oligodendrocyte maturation
Jianqin Niu, Guangdan Yu, Xiaorui Wang, Wenlong Xia, Yuxin Wang, Kimberly K. Hoi, Feng Mei, Lan Xiao, Jonah R. Chan, Stephen P.J. Fancy
Neuron. Author manuscript; available in PMC 2022 Oct 6.
Published in final edited form as: Neuron. 2021 Oct 6; 109(19): 3104–3118.e6. Published online 2021 Aug 13. doi: 10.1016/j.neuron.2021.07.018
PMCID:
PMC8547708
AbstractArticlePDF–2.1M
17.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
18.
USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling
Nicole Giebel, Anchel de Jaime‐Soguero, Ana García del Arco, Jonathan J M Landry, Marlene Tietje, Laura Villacorta, Vladimir Benes, Vanesa Fernández‐Sáiz, Sergio P Acebrón
EMBO Rep. 2021 May 5; 22(5): e51415. Published online 2021 Mar 30. doi: 10.15252/embr.202051415
PMCID:
PMC8097334
AbstractArticlePDF–2.3M
19.
RNF43 mutation analysis in serrated polyposis, sporadic serrated polyps and Lynch syndrome polyps
Yasmijn J van Herwaarden, Lieke M Koggel, Femke Simmer, Elisa M. Vink‐Börger, Polat Dura, Gerrit A Meijer, Fokko M Nagengast, Nicoline Hoogerbrugge, Tanya M Bisseling, Iris D Nagtegaal
Histopathology. 2021 Apr; 78(5): 749–758. Published online 2020 Dec 25. doi: 10.1111/his.14286
PMCID:
PMC8048817
AbstractArticlePDF–847K
20.
Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response
Victoria Neumeyer, Anna Brutau-Abia, Michael Allgäuer, Nicole Pfarr, Wilko Weichert, Christina Falkeis-Veits, Elisabeth Kremmer, Michael Vieth, Markus Gerhard, Raquel Mejías-Luque
Cell Mol Gastroenterol Hepatol. 2021; 11(4): 1071–1094. Published online 2020 Nov 11. doi: 10.1016/j.jcmgh.2020.11.005
PMCID:
PMC7898035
AbstractArticlePDF–9.3M

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