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Select item 111439231.

Mechanisms of thyrotropin receptor–mediated phenotype variability deciphered by gene mutations and M453T-knockin model

Kristiina Makkonen, Meeri Jännäri, Luís Crisóstomo, Matilda Kuusi, Konrad Patyra, Vladyslav Melnyk, Veli Linnossuo, Johanna Ojala, Rowmika Ravi, Christoffer Löf, Juho-Antti Mäkelä, Päivi Miettinen, Saila Laakso, Marja Ojaniemi, Jarmo Jääskeläinen, Markku Laakso, Filip Bossowski, Beata Sawicka, Karolina Stożek, Artur Bossowski, Gunnar Kleinau, Patrick Scheerer, FinnGen FinnGen, Mary Pat Reeve, Jukka Kero

JCI Insight. 2024 Feb 22; 9(4): e167092. Published online 2024 Jan 9. doi: 10.1172/jci.insight.167092

PMCID:: PMC11143923

Abstract Article PDF–20M

Select item 110961762.

Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis

Zhenlei Zhang, Yufan Wu, Jinrong Fu, Xiujie Yu, Yang Su, Shikai Jia, Huili Cheng, Yan Shen, Xianghui He, Kai Ren, Xiangqian Zheng, Haixia Guan, Feng Rao, Li Zhao

Nat Commun. 2024; 15: 4108. Published online 2024 May 15. doi: 10.1038/s41467-024-48173-9

Correction in:: Nat Commun. 2024; 15: 4936.

PMCID:: PMC11096176

Abstract Article PDF–5.7M

Select item 106665723.

TSH Pulses Finely Tune Thyroid Hormone Release and TSH Receptor Transduction

Anne Guillou, Yasmine Kemkem, Chrystel Lafont, Pierre Fontanaud, Davide Calebiro, Pauline Campos, Xavier Bonnefont, Tatiana Fiordelisio-Coll, Ying Wang, Emilie Brûlé, Daniel J Bernard, Paul Le Tissier, Frederik Steyn, Patrice Mollard

Endocrinology. 2024 Jan; 165(1): bqad164. Published online 2023 Nov 2. doi: 10.1210/endocr/bqad164

PMCID:: PMC10666572

Abstract Article

Select item 105636344.

Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice

Markus Eszlinger, Alexandra Stephenson, Shideh Mirhadi, Konrad Patyra, Michael F Moran, Moosa Khalil, Jukka Kero, Ralf Paschke

Eur Thyroid J. 2023 Dec 1; 12(6): e230049. Prepublished online 2023 Sep 1. Published online 2023 Oct 3. doi: 10.1530/ETJ-23-0049

PMCID:: PMC10563634

Abstract Article PDF–1.7M

Select item 88308875.

Differences in pathways contributing to thyroid hormone effects on postnatal cartilage calcification versus secondary ossification center development

Gustavo A Gomez, Patrick Aghajanian, Sheila Pourteymoor, Destiney Larkin, Subburaman Mohan

eLife. 2022; 11: e76730. Published online 2022 Jan 31. doi: 10.7554/eLife.76730

PMCID:: PMC8830887

Abstract Article PDF–14M

Select item 82839716.

Long Term Rescue of the TSH Receptor Knock-Out Mouse – Thyroid Stem Cell Transplantation Restores Thyroid Function

Rauf Latif, Risheng Ma, Syed A. Morshed, Bengu Tokat, Terry F. Davies

Front Endocrinol (Lausanne) 2021; 12: 706101. Published online 2021 Jul 2. doi: 10.3389/fendo.2021.706101

PMCID:: PMC8283971

Abstract Article PDF–2.9M

Select item 81983327.

The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice

Vaishnavi Venugopalan, Alaa Al-Hashimi, Jonas Weber, Maren Rehders, Maria Qatato, Eva K. Wirth, Ulrich Schweizer, Heike Heuer, François Verrey, Klaudia Brix

Int J Mol Sci. 2021 Jun; 22(11): 5776. Published online 2021 May 28. doi: 10.3390/ijms22115776

PMCID:: PMC8198332

Abstract Article PDF–5.4M

Select item 81080678.

Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion

Chiara Sardella, Carine Winkler, Laure Quignodon, Jonathan A. Hardman, Barbara Toffoli, Greta Maria Paola Giordano Attianese, Jennifer E. Hundt, Liliane Michalik, Charles R. Vinson, Ralf Paus, Béatrice Desvergne, Federica Gilardi

J Invest Dermatol. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: J Invest Dermatol. 2018 Mar; 138(3): 500–510. Published online 2017 Sep 28. doi: 10.1016/j.jid.2017.09.024

PMCID:: PMC8108067

Abstract Article PDF–2.4M

Select item 74867779.

The paradoxical lean phenotype of hypothyroid mice is marked by increased adaptive thermogenesis in the skeletal muscle

Rachel R. Kaspari, Andrea Reyna-Neyra, Lara Jung, Alejandra Paola Torres-Manzo, Sandro M. Hirabara, Nancy Carrasco

Proc Natl Acad Sci U S A. 2020 Sep 8; 117(36): 22544–22551. Published online 2020 Aug 21. doi: 10.1073/pnas.2008919117

PMCID:: PMC7486777

Abstract Article PDF–1.2M

Select item 743503810.

Adipose‐specific inactivation of thyroid stimulating hormone receptors in mice modifies body weight, temperature and gene expression in adipocytes

Veroniqa Lundbäck, Agné Kulyté, Ingrid Dahlman, Claude Marcus

Physiol Rep. 2020 Aug; 8(16): e14538. Published online 2020 Aug 18. doi: 10.14814/phy2.14538

PMCID:: PMC7435038

Abstract Article PDF–853K

Select item 697000211.

Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D Acetylation

Xiaolei Wang, Jinbao Mao, Xinli Zhou, Qiu Li, Ling Gao, Jiajun Zhao

Oxid Med Cell Longev. 2020; 2020: 1249630. Published online 2020 Jan 6. doi: 10.1155/2020/1249630

PMCID:: PMC6970002

Abstract Article PDF–1.5M

Select item 690725912.

LPS immune challenge reduces arcuate nucleus TSHR and CART mRNA and elevates plasma CART peptides

Jonathan R. Burgos, Britt-Marie Iresjö, Linda Olsson, Ulrika Smedh

BMC Neurosci. 2019; 20: 59. Published online 2019 Dec 11. doi: 10.1186/s12868-019-0539-z

PMCID:: PMC6907259

Abstract Article PDF–1.1M

Select item 677653313.

Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice

Raffaele Gerlini, Elena Amendola, Andrea Conte, Valeria Valente, Mara Tornincasa, Sara Carmela Credendino, Francesca Cammarota, Chiara Gentile, Luigi Di Guida, Simona Paladino, Gabriella De Vita, Alfredo Fusco, Giovanna Maria Pierantoni

Cell Death Dis. 2019 Oct; 10(10): 747. Published online 2019 Oct 3. doi: 10.1038/s41419-019-1975-5

PMCID:: PMC6776533

Abstract Article PDF–5.8M

Select item 670703314.

A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans

Sandra M. McLachlan, Holly A. Aliesky, Basil Rapoport

Thyroid. 2019 Aug 1; 29(8): 1138–1146. Published online 2019 Aug 19. doi: 10.1089/thy.2019.0260

PMCID:: PMC6707033

Abstract Article PDF–344K

Select item 654486715.

Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice

Anamika Singh, Masum M. Mia, Dasan Mary Cibi, Ashutosh Kumar Arya, Sanjay Kumar Bhadada, Manvendra K. Singh

J Biol Chem. 2019 May 24; 294(21): 8336–8347. Published online 2019 Apr 12. doi: 10.1074/jbc.RA118.007063

PMCID:: PMC6544867

Abstract Article PDF–4.4M

Select item 650421316.

Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques

Chongbo Yang, Ming Lu, Wenbin Chen, Zhao He, Xu Hou, Mei Feng, Hongjia Zhang, Tao Bo, Xiaoming Zhou, Yong Yu, Haiqing Zhang, Meng Zhao, Laicheng Wang, Chunxiao Yu, Ling Gao, Wenjian Jiang, Qunye Zhang, Jiajun Zhao

J Exp Med. 2019 May 6; 216(5): 1182–1198. Published online 2019 Apr 2. doi: 10.1084/jem.20181473

Correction in:: J Exp Med. 2022 Feb 7; 219(2): jem.2018147312212021c.

PMCID:: PMC6504213

Abstract Article PDF–3.8M

Select item 650125017.

The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice

Yu Yang, Yu Chen, Jie Chen, Danyu Zhang, Jianhua Wang, Xiaodong Mao, Xiao Wei, Xingjia Li, Xianghua Ma, Chao Liu, Kun Wang

J Diabetes Res. 2019; 2019: 9536032. Published online 2019 Apr 15. doi: 10.1155/2019/9536032

PMCID:: PMC6501250

Abstract Article PDF–2.5M

Select item 628438718.

TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology

Athanasia Stoupa, Frédéric Adam, Dulanjalee Kariyawasam, Catherine Strassel, Sanjay Gawade, Gabor Szinnai, Alexandre Kauskot, Dominique Lasne, Carsten Janke, Kathiresan Natarajan, Alain Schmitt, Christine Bole‐Feysot, Patrick Nitschke, Juliane Léger, Fabienne Jabot‐Hanin, Frédéric Tores, Anita Michel, Arnold Munnich, Claude Besmond, Raphaël Scharfmann, François Lanza, Delphine Borgel, Michel Polak, Aurore Carré

EMBO Mol Med. 2018 Dec; 10(12): e9569. Published online 2018 Nov 19. doi: 10.15252/emmm.201809569

PMCID:: PMC6284387

Abstract Article PDF–2.4M

Select item 586818119.

CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice

Jin Li, Su-Ping Deng, Gang Wei, Peng Yu

Database (Oxford) 2018; 2018: bay012. Published online 2018 Mar 23. doi: 10.1093/database/bay012

PMCID:: PMC5868181

Abstract Article PDF–653K

Select item 570715520.

GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation

Hong Soon Kang, Dhirendra Kumar, Grace Liao, Kristin Lichti-Kaiser, Kevin Gerrish, Xiao-Hui Liao, Samuel Refetoff, Raja Jothi, Anton M. Jetten

J Clin Invest. 2017 Dec 1; 127(12): 4326–4337. Published online 2017 Oct 30. doi: 10.1172/JCI94417

PMCID:: PMC5707155

Abstract Article PDF–9.8M

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