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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 90145592.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 83132393.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 75087904.

Heritable Genetic Background Alters Survival and Phenotype of Mll-AF9-Induced Leukemias

Kira Young, Matthew A. Loberg, Elizabeth Eudy, Logan S. Schwartz, Kristina D. Mujica, Jennifer J. Trowbridge

Exp Hematol. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Exp Hematol. 2020 Sep; 89: 61–67.e3. Published online 2020 Aug 6. doi: 10.1016/j.exphem.2020.07.012

PMCID:: PMC7508790

Abstract Article PDF–425K

Select item 73528805.

CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis

Evgenia Sarrou, Laura Richmond, Ruaidhrí J. Carmody, Brenda Gibson, Karen Keeshan

Int J Mol Sci. 2020 Jun; 21(12): 4266. Published online 2020 Jun 15. doi: 10.3390/ijms21124266

PMCID:: PMC7352880

Abstract Article PDF–2.9M

Select item 61138906.

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1

Gina E. Elsen, Francesco Bedogni, Rebecca D. Hodge, Theo K. Bammler, James W. MacDonald, Susan Lindtner, John L. R. Rubenstein, Robert F. Hevner

Front Neurosci. 2018; 12: 571. Published online 2018 Aug 22. doi: 10.3389/fnins.2018.00571

PMCID:: PMC6113890

Abstract Article PDF–4.8M

Select item 52958217.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 50598678.

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model

Qiang Liu, Longgui Chen, Jennifer M Atkinson, David F Claxton, Hong-Gang Wang

Cell Death Dis. 2016 Sep; 7(9): e2361. Published online 2016 Sep 8. doi: 10.1038/cddis.2016.264

PMCID:: PMC5059867

Abstract Article PDF–1.3M

Select item 48481409.

Transcriptomic and epigenomic characterization of the developing bat wing

Walter L. Eckalbar, Stephen A. Schlebusch, Mandy K. Mason, Zoe Gill, Ash V. Parker, Betty M. Booker, Sierra Nishizaki, Christiane Muswamba-Nday, Elizabeth Terhune, Kimberly Nevonen, Nadja Makki, Tara Friedrich, Julia E. VanderMeer, Katherine S. Pollard, Lucia Carbone, Jeff D. Wall, Nicola Illing, Nadav Ahituv

Nat Genet. Author manuscript; available in PMC 2016 Sep 28.

Published in final edited form as: Nat Genet. 2016 May; 48(5): 528–536. Published online 2016 Mar 28. doi: 10.1038/ng.3537

PMCID:: PMC4848140

Abstract Article PDF–2.0M

Select item 484194010.

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

Yuanyuan Li, Benjamin R. Sabari, Tatyana Panchenko, Hong Wen, Dan Zhao, Haipeng Guan, Liling Wan, He Huang, Zhanyun Tang, Yingming Zhao, Robert G. Roeder, Xiaobing Shi, C. David Allis, Haitao Li

Mol Cell. Author manuscript; available in PMC 2017 Apr 21.

Published in final edited form as: Mol Cell. 2016 Apr 21; 62(2): 181–193. doi: 10.1016/j.molcel.2016.03.028

PMCID:: PMC4841940

Abstract Article PDF–3.2M

Select item 483007011.

Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia

Yanan Gao, Juan Gao, Minghao Li, Yawei Zheng, Yajie Wang, Hongyan Zhang, Weili Wang, Yajing Chu, Xiaomin Wang, Mingjiang Xu, Tao Cheng, Zhenyu Ju, Weiping Yuan

J Hematol Oncol. 2016; 9: 36. Published online 2016 Apr 12. doi: 10.1186/s13045-016-0264-3

PMCID:: PMC4830070

Abstract Article PDF–1.5M

Select item 434413212.

AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation

Yuanyuan Li, Hong Wen, Yuanxin Xi, Kaori Tanaka, Haibo Wang, Danni Peng, Yongfeng Ren, Qihuang Jin, Sharon Y.R. Dent, Wei Li, Haitao Li, Xiaobing Shi

Cell. Author manuscript; available in PMC 2015 Feb 27.

Published in final edited form as: Cell. 2014 Oct 23; 159(3): 558–571. doi: 10.1016/j.cell.2014.09.049

PMCID:: PMC4344132

Abstract Article PDF–3.0M

Select item 425354713.

Importance of a Specific Amino Acid Pairing for Murine MLL Leukemias Driven by MLLT1/3 or AFF1/4

Alyson A. Lokken, Nicholas J. Achille, Ming-jin Chang, Jeffrey J. Lin, Aravinda Kuntimaddi, Benjamin I. Leach, Bhavna Malik, Jacqueline B. Nesbit, Shubin Zhang, John H. Bushweller, Nancy J. Zeleznik-Le, Charles S. Hemenway

Leuk Res. Author manuscript; available in PMC 2015 Nov 1.

Published in final edited form as: Leuk Res. 2014 Nov; 38(11): 1309–1315. Published online 2014 Aug 24. doi: 10.1016/j.leukres.2014.08.010

PMCID:: PMC4253547

Abstract Article PDF–583K

Select item 410214314.

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras^G12D acute myeloid leukemia

Junwei Shi, Eric Wang, Johannes Zuber, Amy Rappaport, Meredith Taylor, Christopher Johns, Scott W. Lowe, Christopher R. Vakoc

Oncogene. Author manuscript; available in PMC 2014 Jul 17.

Published in final edited form as: Oncogene. 2013 Feb 14; 32(7): 930–938. Published online 2012 Apr 2. doi: 10.1038/onc.2012.110

PMCID:: PMC4102143

Abstract Article PDF–877K

Select item 397923215.

Physical and functional interaction of Rnf2 with Af9 regulates basal and aldosterone-stimulated transcription of the α-ENaC gene in a renal collecting duct cell line

Zhi-Yuan Yu, Qun Kong, Bruce C. Kone

Biosci Rep. 2013; 33(5): e00076. Prepublished online 2013 Sep 27. Published online 2013 Oct 25. doi: 10.1042/BSR20130086

PMCID:: PMC3979232

Abstract Article PDF–539K

Select item 396495516.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977