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Select item 112277051.

Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation

M. L. Schiavone, L. Crisafulli, C. Camisaschi, G. De Simone, F. R. Liberati, E. Palagano, N. Rucci, F. Ficara, Cristina Sobacchi

Stem Cell Res Ther. 2024; 15: 203. Published online 2024 Jul 6. doi: 10.1186/s13287-024-03803-3

PMCID:: PMC11227705

Abstract Article PDF–2.8M

Select item 111408532.

Osteocyte RANKL Drives Bone Resorption in Mouse Ligature‐Induced Periodontitis

Mizuho Kittaka, Tetsuya Yoshimoto, Marcus E Levitan, Rina Urata, Roy B Choi, Yayoi Teno, Yixia Xie, Yukiko Kitase, Matthew Prideaux, Sarah L Dallas, Alexander G Robling, Yasuyoshi Ueki

J Bone Miner Res. 2023 Oct 1; 38(10): 1521–1540. Published online 2023 Oct 1. doi: 10.1002/jbmr.4897

PMCID:: PMC11140853

Abstract Article PDF–4.2M

Select item 106199383.

RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes

Nagesha Guthalu Kondegowda, Joanna Filipowska, Jeong-su Do, Nancy Leon-Rivera, Rosemary Li, Rollie Hampton, Selassie Ogyaadu, Camilla Levister, Josef M. Penninger, Helena Reijonen, Carol J. Levy, Rupangi C. Vasavada

Sci Adv. 2023 Nov 3; 9(44): eadf5238. Published online 2023 Nov 1. doi: 10.1126/sciadv.adf5238

PMCID:: PMC10619938

Abstract Article PDF–1.9M

Select item 104998794.

Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development

Yongzhen Lai, Yan Guo, Caiyu Liao, Chuanqing Mao, Jing Liu, Chengyan Ren, Wen Yang, Lin Luo, Weihui Chen

Sci Rep. 2023; 13: 15170. Published online 2023 Sep 13. doi: 10.1038/s41598-023-42423-4

PMCID:: PMC10499879

Abstract Article PDF–6.8M

Select item 104437945.

Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation

Kazuaki Miyagawa, Hirofumi Tenshin, Patrick L. Mulcrone, Jesus Delgado-Calle, Mark A. Subler, Jolene J. Windle, John M. Chirgwin, G. David Roodman, Noriyoshi Kurihara

JCI Insight. 2023 Jul 24; 8(14): e159838. Published online 2023 Jul 24. doi: 10.1172/jci.insight.159838

PMCID:: PMC10443794

Abstract Article PDF–3.5M

Select item 104174156.

Α Humanized RANKL Transgenic Mouse Model of Progestin-Induced Mammary Carcinogenesis for Evaluation of Novel Therapeutics

Anthi Kolokotroni, Evi Gkikopoulou, Vagelis Rinotas, Lydia Ntari, Danae Zareifi, Maritina Rouchota, Sophia Sarpaki, Ilias Lymperopoulos, Leonidas G. Alexopoulos, George Loudos, Maria C. Denis, Niki Karagianni, Eleni Douni

Cancers (Basel) 2023 Aug; 15(15): 4006. Published online 2023 Aug 7. doi: 10.3390/cancers15154006

PMCID:: PMC10417415

Abstract Article PDF–3.9M

Select item 104158067.

CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system

Dominique J. Laster, Nisreen S. Akel, James A. Hendrixson, Alicen James, Julie A. Crawford, Qiang Fu, Stuart B. Berryhill, Jeff D. Thostenson, Intawat Nookaew, Charles A. O’Brien, Melda Onal

iScience. 2023 Aug 18; 26(8): 107428. Published online 2023 Jul 20. doi: 10.1016/j.isci.2023.107428

PMCID:: PMC10415806

Abstract Article PDF–4.8M

Select item 102558308.

Histopathologic and Transcriptomic Phenotypes of a Conditional RANKL Transgenic Mouse Thymus

Maria M. Szwarc, Lan Hai, Vineet K. Maurya, Kimal Rajapakshe, Dimuthu Perera, Michael M. Ittmann, Qianxing Mo, Yong Lin, Matthew L. Bettini, Cristian Coarfa, John P. Lydon

Cytokine. Author manuscript; available in PMC 2023 Jun 9.

Published in final edited form as: Cytokine. 2022 Dec; 160: 156022. Published online 2022 Sep 11. doi: 10.1016/j.cyto.2022.156022

PMCID:: PMC10255830

Abstract Article PDF–1.9M

Select item 102532259.

RANKL Inhibition Reduces Cardiac Hypertrophy in mdx Mice and Possibly in Children with Duchenne Muscular Dystrophy

Laetitia Marcadet, Emma Sara Juracic, Nasrin Khan, Zineb Bouredji, Hideo Yagita, Leanne M. Ward, A. Russell Tupling, Anteneh Argaw, Jérôme Frenette

Cells. 2023 Jun; 12(11): 1538. Published online 2023 Jun 3. doi: 10.3390/cells12111538

PMCID:: PMC10253225

Abstract Article PDF–4.5M

Select item 1025275710.

Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice

Verena Fischer, Jasmin Maria Bülow, Benjamin Thilo Krüger, Deniz Ragipoglu, Anna Vikman, Melanie Haffner-Luntzer, Konstantinos Katsoulis-Dimitriou, Anne Dudeck, Anita Ignatius

Int J Mol Sci. 2023 Jun; 24(11): 9135. Published online 2023 May 23. doi: 10.3390/ijms24119135

PMCID:: PMC10252757

Abstract Article PDF–6.3M

Select item 996781911.

Crucial Role of Lysine-Specific Histone Demethylase 1 in RANKL-Mediated Osteoclast Differentiation

Mina Ding, Zhihao Chen, Eunjin Cho, Sang-Wook Park, Tae-Hoon Lee

Int J Mol Sci. 2023 Feb; 24(4): 3605. Published online 2023 Feb 10. doi: 10.3390/ijms24043605

PMCID:: PMC9967819

Abstract Article PDF–6.7M

Select item 972466412.

A20 controls RANK‐dependent osteoclast formation and bone physiology

Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amélie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D Zajac, Rachel A Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J M Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo

EMBO Rep. 2022 Dec; 23(12): e55233. Published online 2022 Oct 4. doi: 10.15252/embr.202255233

PMCID:: PMC9724664

Abstract Article PDF–3.0M

Select item 930372413.

Excessive osteoclast activation by osteoblast paracrine factor RANKL is a major cause of the abnormal long bone phenotype in Apert syndrome model mice

Hye‐Rim Shin, Bong‐Soo Kim, Hyun‐Jung Kim, Heein Yoon, Woo‐Jin Kim, Je‐Yong Choi, Hyun‐Mo Ryoo

J Cell Physiol. 2022 Apr; 237(4): 2155–2168. Published online 2022 Jan 20. doi: 10.1002/jcp.30682

PMCID:: PMC9303724

Abstract Article PDF–13M

Select item 929399114.

Periosteal stem cells control growth plate stem cells during postnatal skeletal growth

Masayuki Tsukasaki, Noriko Komatsu, Takako Negishi-Koga, Nam Cong-Nhat Huynh, Ryunosuke Muro, Yutaro Ando, Yuka Seki, Asuka Terashima, Warunee Pluemsakunthai, Takeshi Nitta, Takashi Nakamura, Tomoki Nakashima, Shinsuke Ohba, Haruhiko Akiyama, Kazuo Okamoto, Roland Baron, Hiroshi Takayanagi

Nat Commun. 2022; 13: 4166. Published online 2022 Jul 18. doi: 10.1038/s41467-022-31592-x

PMCID:: PMC9293991

Abstract Article PDF–11M

Select item 924316115.

IFT20 governs mesenchymal stem cell fate through positively regulating TGF-β-Smad2/3-Glut1 signaling mediated glucose metabolism

Yang Li, Shuting Yang, Yang Liu, Ling Qin, Shuying Yang

Redox Biol. 2022 Aug; 54: 102373. Published online 2022 Jun 20. doi: 10.1016/j.redox.2022.102373

PMCID:: PMC9243161

Abstract Article PDF–15M

Select item 892049516.

Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling

Yonggang Ma, Xueni Shi, Hongyan Zhao, Ruilong Song, Hui Zou, Jiaqiao Zhu, Zongping Liu

Int J Mol Med. 2022 May; 49(5): 59. Published online 2022 Mar 9. doi: 10.3892/ijmm.2022.5115

PMCID:: PMC8920495

Abstract Article PDF–6.3M

Select item 887708217.

Serial Passaging of RAW 264.7 Cells Modulates Intracellular AGE Formation and Downregulates RANKL-Induced In Vitro Osteoclastogenesis

Tanzima Tarannum Lucy, A. N. M. Mamun-Or-Rashid, Masayuki Yagi, Yoshikazu Yonei

Int J Mol Sci. 2022 Feb; 23(4): 2371. Published online 2022 Feb 21. doi: 10.3390/ijms23042371

PMCID:: PMC8877082

Abstract Article PDF–9.4M

Select item 881018818.

MYC-mediated miR-320a affects receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast formation by regulating phosphatase and tensin homolog (PTEN)

Hao Chen, Shaoshuo Li, Heng Yin, Zhen Hua, Yang Shao, Jie Wei, Jianwei Wang

Bioengineered. 2021; 12(2): 12677–12687. Published online 2021 Dec 21. doi: 10.1080/21655979.2021.2008666

PMCID:: PMC8810188

Abstract Article PDF–2.4M

Select item 878416119.

CD169⁺ macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling

Abdouramane Camara, Alice C. Lavanant, Jun Abe, Henri Lee Desforges, Yannick O. Alexandre, Erika Girardi, Zinaida Igamberdieva, Kenichi Asano, Masato Tanaka, Thomas Hehlgans, Klaus Pfeffer, Sébastien Pfeffer, Scott N. Mueller, Jens V. Stein, Christopher G. Mueller

Proc Natl Acad Sci U S A. 2022 Jan 18; 119(3): e2108540119. Published online 2022 Jan 14. doi: 10.1073/pnas.2108540119

PMCID:: PMC8784161

Abstract Article PDF–2.7M

Select item 875979420.

RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

Zhiying Yue, Xin Niu, Zengjin Yuan, Qin Qin, Wenhao Jiang, Liang He, Jingduo Gao, Yi Ding, Yanxi Liu, Ziwei Xu, Zhenxi Li, Zhengfeng Yang, Rong Li, Xiwen Xue, Yankun Gao, Fei Yue, Xiang H.-F. Zhang, Guohong Hu, Yi Wang, Yi Li, Geng Chen, Stefan Siwko, Alison Gartland, Ning Wang, Jianru Xiao, Mingyao Liu, Jian Luo

J Clin Invest. 2022 Jan 18; 132(2): e144579. Published online 2022 Jan 18. doi: 10.1172/JCI144579