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Items: 1 to 20 of 55

1.
In vivo validation of late‐onset Alzheimer's disease genetic risk factors
Michael Sasner, Christoph Preuss, Ravi S. Pandey, Asli Uyar, Dylan Garceau, Kevin P. Kotredes, Harriet Williams, Adrian L. Oblak, Peter Bor‐Chian Lin, Bridget Perkins, Disha Soni, Cindy Ingraham, Audrey Lee‐Gosselin, Bruce T. Lamb, Gareth R. Howell, Gregory W. Carter
Alzheimers Dement. 2024 Jul; 20(7): 4970–4984. Published online 2024 Apr 30. doi: 10.1002/alz.13840
PMCID:
PMC11247676
AbstractArticlePDF–3.3M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition
Alexis Z.L. Shih, Yi-Chun Chen, Thilo Speckmann, Esben Søndergaard, Annette Schürmann, C. Bruce Verchere, Thomas E. Willnow
Mol Metab. 2022 Nov; 65: 101585. Published online 2022 Aug 30. doi: 10.1016/j.molmet.2022.101585
PMCID:
PMC9474563
AbstractArticlePDF–4.1M
4.
SORLA is required for insulin-induced expansion of the adipocyte precursor pool in visceral fat
Vanessa Schmidt, Carla Horváth, Hua Dong, Matthias Blüher, Per Qvist, Christian Wolfrum, Thomas E. Willnow
J Cell Biol. 2021 Dec 6; 220(12): e202006058. Published online 2021 Nov 15. doi: 10.1083/jcb.202006058
PMCID:
PMC8598079
AbstractArticlePDF–4.9M
5.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
6.
The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain
Maria Elena Martinez, Arturo Hernandez
Front Neurosci. 2021; 15: 703730. Published online 2021 Jun 29. doi: 10.3389/fnins.2021.703730
PMCID:
PMC8265566
AbstractArticlePDF–8.3M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis
Jessica Stupack, Xiao-Peng Xiong, Lu-Lin Jiang, Tongmei Zhang, Lisa Zhou, Alex Campos, Barbara Ranscht, William Mobley, Elena B. Pasquale, Huaxi Xu, Timothy Y. Huang
J Neurosci. 2020 Jul 29; 40(31): 5908–5921. doi: 10.1523/JNEUROSCI.0723-20.2020
PMCID:
PMC7392511
AbstractArticlePDF–5.9M
9.
Polarized Trafficking of SorLA in Neurons and MDCK Cells
Stine C. Klinger, Anne Højland, Shweta Jain, Mads Kjolby, Peder Madsen, Anna Dorst Svendsen, Gunilla Olivecrona, Juan S. Bonifacino, Morten S. Nielsen
FEBS J. Author manuscript; available in PMC 2020 Jun 23.
Published in final edited form as: FEBS J. 2016 Jul; 283(13): 2476–2493. Published online 2016 Jun 6. doi: 10.1111/febs.13758
PMCID:
PMC7310423
AbstractArticlePDF–2.1M
10.
Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing
Anja W. Fjorback, Matthew Seaman, Camilla Gustafsen, Arnela Mehmedbasic, Suzanne Gokool, Chengbiao Wu, Daniel Militz, Vanessa Schmidt, Peder Madsen, Jens R. Nyengaard, Thomas E. Willnow, Erik Ilsø Christensen, William B. Mobley, Anders Nykjær, Olav M. Andersen
J Neurosci. 2012 Jan 25; 32(4): 1467–1480. doi: 10.1523/JNEUROSCI.2272-11.2012
PMCID:
PMC6796259
AbstractArticlePDF–3.5M
11.
Distinct Functions for Anterograde and Retrograde Sorting of SORLA in Amyloidogenic Processes in the Brain
Sonya B. Dumanis, Tilman Burgert, Safak Caglayan, Annette Füchtbauer, Ernst-Martin Füchtbauer, Vanessa Schmidt, Thomas E. Willnow
J Neurosci. 2015 Sep 16; 35(37): 12703–12713. doi: 10.1523/JNEUROSCI.0427-15.2015
PMCID:
PMC6795211
AbstractArticlePDF–3.9M
12.
Pax6 Modulates the Dorsoventral Patterning of the Mammalian Telencephalon
Anastassia Stoykova, Dieter Treichel, Marc Hallonet, Peter Gruss
J Neurosci. 2000 Nov 1; 20(21): 8042–8050. doi: 10.1523/JNEUROSCI.20-21-08042.2000
PMCID:
PMC6772738
AbstractArticlePDF–8.5M
13.
Interaction of the Cytosolic Domains of sorLA/LR11 with the Amyloid Precursor Protein (APP) and β-Secretase β-Site APP-Cleaving Enzyme
Robert Spoelgen, Christine A. F. von Arnim, Anne V. Thomas, Ithan D. Peltan, Mirjam Koker, Amy Deng, Michael C. Irizarry, Olav M. Andersen, Thomas E. Willnow, Bradley T. Hyman
J Neurosci. 2006 Jan 11; 26(2): 418–428. doi: 10.1523/JNEUROSCI.3882-05.2006
PMCID:
PMC6674411
AbstractArticlePDF–535K
14.
Zic Deficiency in the Cortical Marginal Zone and Meninges Results in Cortical Lamination Defects Resembling Those in Type II Lissencephaly
Takashi Inoue, Masaharu Ogawa, Katsuhiko Mikoshiba, Jun Aruga
J Neurosci. 2008 Apr 30; 28(18): 4712–4725. doi: 10.1523/JNEUROSCI.5735-07.2008
PMCID:
PMC6670431
AbstractArticlePDF–1.4M
15.
Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene Expression
Michael Rohe, Michael Synowitz, Rainer Glass, Steven M. Paul, Anders Nykjaer, Thomas E. Willnow
J Neurosci. 2009 Dec 9; 29(49): 15472–15478. doi: 10.1523/JNEUROSCI.3960-09.2009
PMCID:
PMC6666105
AbstractArticlePDF–1.6M
16.
Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein
Camilla Gustafsen, Simon Glerup, Lone Tjener Pallesen, Ditte Olsen, Olav M. Andersen, Anders Nykjær, Peder Madsen, Claus Munck Petersen
J Neurosci. 2013 Jan 2; 33(1): 64–71. doi: 10.1523/JNEUROSCI.2371-12.2013
PMCID:
PMC6618638
AbstractArticlePDF–1.9M
17.
SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration
Timothy Y. Huang, Yingjun Zhao, Lu-lin Jiang, Xiaoguang Li, Yan Liu, Yu Sun, Juan C. Piña-Crespo, Bing Zhu, Eliezer Masliah, Thomas E. Willnow, Elena B. Pasquale, Huaxi Xu
J Exp Med. 2017 Dec 4; 214(12): 3669–3685. doi: 10.1084/jem.20171413
PMCID:
PMC5716044
AbstractArticlePDF–1.9M
18.
SorLA in Interleukin-6 Signaling and Turnover
Jakob Vejby Larsen, Claus Munck Petersen
Mol Cell Biol. 2017 Jun 1; 37(11): e00641-16. Prepublished online 2017 Mar 6. Published online 2017 May 16. doi: 10.1128/MCB.00641-16
PMCID:
PMC5440653
AbstractArticlePDF–3.0M
19.
SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein
Timothy Y. Huang, Yingjun Zhao, Xiaoguang Li, Xin Wang, I-Chu Tseng, Robert Thompson, Shichun Tu, Thomas E. Willnow, Yun-wu Zhang, Huaxi Xu
J Neurosci. 2016 Jul 27; 36(30): 7996–8011. doi: 10.1523/JNEUROSCI.0206-16.2016
PMCID:
PMC4961782
AbstractArticlePDF–5.4M
20.
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity
Vanessa Schmidt, Nadja Schulz, Xin Yan, Annette Schürmann, Stefan Kempa, Matthias Kern, Matthias Blüher, Matthew N. Poy, Gunilla Olivecrona, Thomas E. Willnow
J Clin Invest. 2016 Jul 1; 126(7): 2706–2720. Published online 2016 Jun 20. doi: 10.1172/JCI84708
PMCID:
PMC4922706
AbstractArticlePDF–2.9M

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