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Items: 1 to 20 of 55

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Pathogenic mycobacterium upregulates cholesterol 25-hydroxylase to promote granuloma development via foam cell formation
Shuang Zhou, Ding Zhang, Dan Li, Hankun Wang, Cairong Ding, Jingrui Song, Weifeng Huang, Xuan Xia, Ziwei Zhou, Shanshan Han, Zhu Jin, Bo Yan, Jacqueline Gonzales, Laura E. Via, Lu Zhang, Decheng Wang
iScience. 2024 Mar 15; 27(3): 109204. Published online 2024 Feb 12. doi: 10.1016/j.isci.2024.109204
PMCID:
PMC10901098
AbstractArticlePDF–8.0M
3.
Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss
Thanh-Tam Tran, Gyuseok Lee, Yun Hyun Huh, Ki-Ho Chung, Sun Young Lee, Ka Hyon Park, Seung Hee Kwon, Min-Suk Kook, Jang-Soo Chun, Jeong-Tae Koh, Je-Hwang Ryu
Exp Mol Med. 2023 Dec; 55(12): 2553–2563. Published online 2023 Dec 1. doi: 10.1038/s12276-023-01122-w
PMCID:
PMC10767058
AbstractArticlePDF–2.3M
4.
Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice
Michael B. Fessler, Jennifer H. Madenspacher, Paul J. Baker, Kerry L. Hilligan, Andrea C. Bohrer, Ehydel Castro, Julie Meacham, Shih-Heng Chen, Reed F. Johnson, Jeffrey G. McDonald, Negin P. Martin, Charles J. Tucker, Debabrata Mahapatra, Mark Cesta, Katrin D. Mayer-Barber
Am J Respir Cell Mol Biol. 2023 Dec 1; 69(6): 638–648. Published online 2023 Aug 14. doi: 10.1165/rcmb.2023-0007OC
PMCID:
PMC10704115
AbstractArticlePDF–1.6M
5.
ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes
Zhen Lu, Noreen McBrearty, Jinyun Chen, Vivek S. Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M. Weljie, Daniel P. Beiting, Zhen Miao, Subin S. George, Allison Berger, Gurpanna Saggu, J. Alan Diehl, Constantinos Koumenis, Serge Y. Fuchs
Cell Metab. Author manuscript; available in PMC 2023 Sep 12.
Published in final edited form as: Cell Metab. 2022 Sep 6; 34(9): 1342–1358.e7. doi: 10.1016/j.cmet.2022.08.007
Correction in:
Cell Metab. 2024 Apr 10
PMCID:
PMC10496461
AbstractArticlePDF–3.6M
6.
Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol
Michela Frascoli, Enxhi Ferraj, Bing Miu, Justin Malin, Nicholas Spidale, Jennifer Cowan, Susannah C. Shissler, Robert Brink, Ying Xu, Jason G. Cyster, Avinash Bhandoola, Joonsoo Kang, Andrea Reboldi
Immunity. Author manuscript; available in PMC 2024 Mar 14.
Published in final edited form as: Immunity. 2023 Mar 14; 56(3): 562–575.e6. Published online 2023 Feb 25. doi: 10.1016/j.immuni.2023.01.025
PMCID:
PMC10306310
AbstractArticlePDF–1.8M
7.
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut resident plasma cells
Simona Ceglia, Alyssa Berthelette, Kelsey Howley, Yun Li, Benedikt Mortzfeld, Shakti K. Bhattarai, Nicole K. H. Yiew, Ying Xu, Robert Brink, Jason G. Cyster, Lora V. Hooper, Gwendalyn J. Randolph, Vanni Bucci, Andrea Reboldi
Nat Immunol. Author manuscript; available in PMC 2023 Jun 6.
Published in final edited form as: Nat Immunol. 2023 Mar; 24(3): 531–544. Published online 2023 Jan 19. doi: 10.1038/s41590-022-01413-w
PMCID:
PMC10243503
AbstractArticlePDF–7.1M
8.
Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection
Soo Jung Cho, Alexander Pronko, Jianjun Yang, Kassandra Pagan, Heather Stout-Delgado
Cells. 2023 Feb; 12(4): 570. Published online 2023 Feb 10. doi: 10.3390/cells12040570
PMCID:
PMC9953875
AbstractArticlePDF–2.1M
9.
Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin
Hayato Takahashi, Hisashi Nomura, Hisato Iriki, Akiko Kubo, Koichi Isami, Yohei Mikami, Miho Mukai, Takashi Sasaki, Jun Yamagami, Jun Kudoh, Hiromi Ito, Aki Kamata, Yutaka Kurebayashi, Hiroki Yoshida, Akihiko Yoshimura, Hong-Wei Sun, Makoto Suematsu, Jonh J. O’Shea, Yuka Kanno, Masayuki Amagai
Sci Immunol. Author manuscript; available in PMC 2022 Dec 23.
Published in final edited form as: Sci Immunol. 2021 Oct 15; 6(64): eabb6444. Published online 2021 Oct 8. doi: 10.1126/sciimmunol.abb6444
PMCID:
PMC9780739
AbstractArticlePDF–2.3M
10.
CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways
Martina Dicker, Yingcong Li, Daniel A. Giles, Greet Verstichel, Viankail Cedillo Castelan, Gabriel Ascui-Gac, Ting-Fang Chou, Tamara Perez-Jeldres, Hilde Cheroutre, Mitchell Kronenberg
Front Immunol. 2022; 13: 1034648. Published online 2022 Oct 28. doi: 10.3389/fimmu.2022.1034648
PMCID:
PMC9652117
AbstractArticlePDF–15M
11.
Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer
Zhen Lu, Jinyun Chen, Pengfei Yu, Matthew J. Atherton, Jun Gui, Vivek S. Tomar, Justin D. Middleton, Neil T. Sullivan, Sunil Singhal, Subin S. George, Ashley G. Woolfork, Aalim M. Weljie, Tsonwin Hai, Evgeniy B. Eruslanov, Serge Y. Fuchs
Nat Commun. 2022; 13: 6623. Published online 2022 Nov 4. doi: 10.1038/s41467-022-34428-w
PMCID:
PMC9636202
AbstractArticlePDF–6.2M
12.
A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol
Yukitoshi Izumi, Anil G. Cashikar, Kathiresan Krishnan, Steven M. Paul, Douglas F. Covey, Steven J. Mennerick, Charles F. Zorumski
J Neurosci. 2021 Dec 8; 41(49): 10054–10064. doi: 10.1523/JNEUROSCI.1502-21.2021
PMCID:
PMC8660051
AbstractArticlePDF–1.9M
13.
The cholesterol metabolite 25-hydroxycholesterol restricts activation of the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation
Bruno C. Trindade, Simona Ceglia, Alyssa Berthelette, Fiona Raso, Kelsey Howley, Jagan R. Muppidi, Andrea Reboldi
Immunity. Author manuscript; available in PMC 2022 Oct 12.
Published in final edited form as: Immunity. 2021 Oct 12; 54(10): 2273–2287.e6. doi: 10.1016/j.immuni.2021.09.004
PMCID:
PMC8570345
AbstractArticlePDF–2.0M
14.
Tumor Necrosis Factor-alpha utilizes MAPK/NFκB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway
Swechha M. Pokharel, Kim Chiok, Niraj K. Shil, Indira Mohanty, Santanu Bose
PLoS One. 2021; 16(9): e0257576. Published online 2021 Sep 22. doi: 10.1371/journal.pone.0257576
PMCID:
PMC8457477
AbstractArticlePDF–1.5M
15.
Regulation of intercellular biomolecule transfer–driven tumor angiogenesis and responses to anticancer therapies
Zhen Lu, Angelica Ortiz, Ioannis I. Verginadis, Amy R. Peck, Farima Zahedi, Christina Cho, Pengfei Yu, Rachel M. DeRita, Hongru Zhang, Ryan Kubanoff, Yunguang Sun, Andrew T. Yaspan, Elise Krespan, Daniel P. Beiting, Enrico Radaelli, Sandra W. Ryeom, J. Alan Diehl, Hallgeir Rui, Constantinos Koumenis, Serge Y. Fuchs
J Clin Invest. 2021 May 17; 131(10): e144225. Published online 2021 May 17. doi: 10.1172/JCI144225
PMCID:
PMC8121529
AbstractArticlePDF–9.0M
16.
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins
Quan D. Zhou, Xun Chi, Min Sub Lee, Wei Yuan Hsieh, Jonathan J. Mkrtchyan, An-Chieh Feng, Cuiwen He, Autumn G York, Viet L. Bui, Eliza B. Kronenberger, Alessandra Ferrari, Xu Xiao, Allison E. Daly, Elizabeth J. Tarling, Robert Damoiseaux, Philip O. Scumpia, Stephen T. Smale, Kevin J. Williams, Peter Tontonoz, Steven J. Bensinger
Nat Immunol. Author manuscript; available in PMC 2021 Jan 2.
Published in final edited form as: Nat Immunol. 2020 Jul; 21(7): 746–755. Published online 2020 Jun 8. doi: 10.1038/s41590-020-0695-4
PMCID:
PMC7778040
AbstractArticlePDF–4.4M
17.
Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function
Na Sheng, Zhongnan Ma, Yi Zhou, Juan Xu, Yan Gao, Xin-Yuan Fu
Sci Rep. 2020; 10: 14246. Published online 2020 Aug 28. doi: 10.1038/s41598-020-71198-1
PMCID:
PMC7455728
AbstractArticlePDF–6.8M
18.
Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation
Jennifer H. Madenspacher, Eric D. Morrell, Kymberly M. Gowdy, Jeffrey G. McDonald, Bonne M. Thompson, Ginger Muse, Jennifer Martinez, Seddon Thomas, Carmen Mikacenic, Jerry A. Nick, Edward Abraham, Stavros Garantziotis, Renee D. Stapleton, Julie M. Meacham, Mary Jane Thomassen, William J. Janssen, Donald N. Cook, Mark M. Wurfel, Michael B. Fessler
JCI Insight. 2020 Jun 4; 5(11): e137189. Published online 2020 Jun 4. doi: 10.1172/jci.insight.137189
PMCID:
PMC7308063
AbstractArticlePDF–5.7M
19.
Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes
Lucia Russo, Lindsey Muir, Lynn Geletka, Jennifer Delproposto, Nicki Baker, Carmen Flesher, Robert O'Rourke, Carey N. Lumeng
Mol Metab. 2020 Sep; 39: 100983. Published online 2020 Mar 27. doi: 10.1016/j.molmet.2020.100983
PMCID:
PMC7267735
AbstractArticlePDF–3.6M
20.
Inflammation Triggers Liver X Receptor-Dependent Lipogenesis
Sophie R. Liebergall, Jerry Angdisen, Shun Hang Chan, YingJu Chang, Timothy F. Osborne, Alexander F. Koeppel, Stephen D. Turner, Ira G. Schulman
Mol Cell Biol. 2020 Jan; 40(2): e00364-19. Prepublished online 2019 Oct 28. Published online 2020 Jan 3. doi: 10.1128/MCB.00364-19
PMCID:
PMC6944475
AbstractArticlePDF–2.5M

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