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Select item 99369781.

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio

Hepatology. 2023 Mar; 77(3): 874–887. Published online 2023 Feb 17. doi: 10.1002/hep.32581

PMCID:: PMC9936978

Abstract Article PDF–990K

Select item 93810402.

MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation

Rafael Romero-Becerra, Alfonso Mora, Elisa Manieri, Ivana Nikolic, Ayelén Melina Santamans, Valle Montalvo-Romeral, Francisco Miguel Cruz, Elena Rodríguez, Marta León, Luis Leiva-Vega, Laura Sanz, Víctor Bondía, David Filgueiras-Rama, Luis Jesús Jiménez-Borreguero, José Jalife, Barbara Gonzalez-Teran, Guadalupe Sabio

eLife. 2022; 11: e75250. Published online 2022 Aug 16. doi: 10.7554/eLife.75250

PMCID:: PMC9381040

Abstract Article PDF–8.2M

Select item 92039323.

NR2F1 is a barrier to dissemination of early stage breast cancer cells

Carolina Rodriguez-Tirado, Nupura Kale, Maria J. Carlini, Nitisha Shrivastava, Alcina A. Rodrigues, Bassem Khalil, Jose J. Bravo-Cordero, Yan Hong, Melissa Alexander, Jiayi Ji, Fariba Behbod, Maria S. Sosa

Cancer Res. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: Cancer Res. 2022 Jun 15; 82(12): 2313–2326. doi: 10.1158/0008-5472.CAN-21-4145

PMCID:: PMC9203932

Abstract Article PDF–2.1M

Select item 87090044.

MEK6 Overexpression Exacerbates Fat Accumulation and Inflammatory Cytokines in High-Fat Diet-Induced Obesity

Suyeon Lee, Myoungsook Lee

Int J Mol Sci. 2021 Dec; 22(24): 13559. Published online 2021 Dec 17. doi: 10.3390/ijms222413559

PMCID:: PMC8709004

Abstract Article PDF–3.8M

Select item 83132395.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 81204586.

MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis

Chunlu Li, Chengsi Deng, Tingting Zhou, Jiapeng Hu, Bing Dai, Fei Yi, Na Tian, Lijun Jiang, Xiang Dong, Qingfeng Zhu, Siyi Zhang, Hongyan Cui, Liu Cao, Yunxiao Shang

Int J Biol Sci. 2021; 17(7): 1795–1807. Published online 2021 Apr 23. doi: 10.7150/ijbs.59715

PMCID:: PMC8120458

Abstract Article PDF–3.7M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 77925078.

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis

Frode Norheim, Karthickeyan Chella Krishnan, Thomas Bjellaas, Laurent Vergnes, Calvin Pan, Brian W Parks, Yonghong Meng, Jennifer Lang, James A Ward, Karen Reue, Margarete Mehrabian, Thomas E Gundersen, Miklós Péterfy, Knut T Dalen, Christian A Drevon, Simon T Hui, Aldons J Lusis, Marcus M Seldin

Mol Syst Biol. 2021 Jan; 17(1): e9684. Published online 2021 Jan 8. doi: 10.15252/msb.20209684

PMCID:: PMC7792507

Abstract Article PDF–1.5M

Select item 73071889.

Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling

Shah Md. Toufiqur Rahman, Wenyuan Zhou, Alexander Deiters, Jason M. Haugh

J Biol Chem. 2020 Jun 19; 295(25): 8494–8504. Published online 2020 May 5. doi: 10.1074/jbc.RA119.012079

PMCID:: PMC7307188

Abstract Article PDF–1.9M

Select item 586818110.

CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice

Jin Li, Su-Ping Deng, Gang Wei, Peng Yu

Database (Oxford) 2018; 2018: bay012. Published online 2018 Mar 23. doi: 10.1093/database/bay012

PMCID:: PMC5868181

Abstract Article PDF–653K

Select item 584288911.

Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination

Nick Warr, Pam Siggers, Gwenn-Aël Carré, Sara Wells, Andy Greenfield

Biol Reprod. Author manuscript; available in PMC 2018 Mar 8.

Published in final edited form as: Biol Reprod. 2016 May; 94(5): 103. Published online 2016 Mar 23. doi: 10.1095/biolreprod.115.138057

PMCID:: PMC5842889

Abstract Article PDF–1.1M

Select item 563678412.

MKK6 controls T3-mediated browning of white adipose tissue

Nuria Matesanz, Edgar Bernardo, Rebeca Acín-Pérez, Elisa Manieri, Sonia Pérez-Sieira, Lourdes Hernández-Cosido, Valle Montalvo-Romeral, Alfonso Mora, Elena Rodríguez, Luis Leiva-Vega, Ana Victoria Lechuga-Vieco, Jesús Ruiz-Cabello, Jorge L. Torres, Maria Crespo-Ruiz, Francisco Centeno, Clara V. Álvarez, Miguel Marcos, Jose Antonio Enríquez, Ruben Nogueiras, Guadalupe Sabio

Nat Commun. 2017; 8: 856. Published online 2017 Oct 11. doi: 10.1038/s41467-017-00948-z

PMCID:: PMC5636784

Abstract Article PDF–1.9M

Select item 538122613.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 493548614.

p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2

Christopher M. Schonhoff, Se Won Park, Cynthia R.L. Webster, M. Sawkat Anwer

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1; 310(11): G999–G1005. Published online 2016 Mar 24. doi: 10.1152/ajpgi.00005.2016

PMCID:: PMC4935486

Abstract Article

Select item 428173215.

p38α MAPK Is Required for Tooth Morphogenesis and Enamel Secretion

Matthew B. Greenblatt, Jung-Min Kim, Hwanhee Oh, Kwang Hwan Park, Min-Kyung Choo, Yasuyo Sano, Coralee E. Tye, Ziedonis Skobe, Roger J. Davis, Jin Mo Park, Marianna Bei, Laurie H. Glimcher, Jae-Hyuck Shim

J Biol Chem. 2015 Jan 2; 290(1): 284–295. Published online 2014 Nov 18. doi: 10.1074/jbc.M114.599274

PMCID:: PMC4281732

Abstract Article PDF–4.5M

Select item 424632116.

K-Ras^V14I recapitulates Noonan syndrome in mice

Isabel Hernández-Porras, Salvatore Fabbiano, Alberto J. Schuhmacher, Alexandra Aicher, Marta Cañamero, Juan Antonio Cámara, Lorena Cussó, Manuel Desco, Christopher Heeschen, Francisca Mulero, Xosé R. Bustelo, Carmen Guerra, Mariano Barbacid

Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46): 16395–16400. Published online 2014 Oct 30. doi: 10.1073/pnas.1418126111

PMCID:: PMC4246321

Abstract Article PDF–1.0M

Select item 419391917.

Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38

Amelia Escolano, Sara Martínez-Martínez, Arántzazu Alfranca, Katia Urso, Helena M Izquierdo, Mario Delgado, Francisco Martín, Guadalupe Sabio, David Sancho, Pablo Gómez-del Arco, Juan Miguel Redondo

EMBO J. 2014 May 16; 33(10): 1117–1133. Published online 2014 Mar 4. doi: 10.1002/embj.201386369

PMCID:: PMC4193919

Abstract Article PDF–1.7M

Select item 388225918.

Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss

David L. Boyle, Deepa Hammaker, Meghan Edgar, Mario M. Zaiss, Stefan Teufel, Jean Pierre David, Georg Schett, Gary S. Firestein

PLoS One. 2014; 9(1): e84818. Published online 2014 Jan 6. doi: 10.1371/journal.pone.0084818

Correction in:: PLoS One. 2014; 9(1): 10.1371/annotation/4fbfa4f0-cb27-4ec4-80d6-3b0ed5e9e8b8.

PMCID:: PMC3882259

Abstract Article PDF–964K

Select item 369784119.

Translational control of NKT cell cytokine production by p38 MAP kinase

Viswas K. Nagaleekar, Guadalupe Sabio, Idil Aktan, Alan Chant, Isaac W. Howe, Tina M. Thornton, Patrick J. Benoit, Roger J. Davis, Mercedes Rincon, Jonathan E. Boyson

J Immunol. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: J Immunol. 2011 Apr 1; 186(7): 4140–4146. Published online 2011 Mar 2. doi: 10.4049/jimmunol.1002614

PMCID:: PMC3697841

Abstract Article PDF–1.3M

Select item 359707620.

MKK6 Phosphorylation Regulates Production of Superoxide by Enhancing Rac GTPase Activity

MAGED M. HARRAZ, ANDREA PARK, DUANE ABBOTT, WEIHONG ZHOU, YULONG ZHANG, JOHN F. ENGELHARDT

Antioxid Redox Signal. Author manuscript; available in PMC 2013 Mar 14.

Published in final edited form as: Antioxid Redox Signal. 2007 Nov; 9(11): 1803–1813. doi: 10.1089/ars.2007.1579

PMCID:: PMC3597076

Abstract Article PDF–1.2M

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