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Select item 115669941.

H₂S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T cell immunotherapeutic response

Nathaniel Oberholtzer, Paramita Chakraborty, Mohamed Faisal Kassir, James Dressman, Satyajit Das, Stephanie Mills, Susana Comte-Walters, Monika Gooz, Seungho Choi, Rasesh Y. Parikh, Zacharia Hedley, Silvia Vaena, Reid DeMass, Gina Scurti, Martin Romeo, Vamsi K. Gangaraju, Stefano Berto, Elizabeth Hill, Lauren E. Ball, Anand S. Mehta, Eduardo N. Maldonado, Michael I. Nishimura, Besim Ogretmen, Shikhar Mehrotra

Sci Adv. 2024 Nov 15; 10(46): eadp1152. Published online 2024 Nov 15. doi: 10.1126/sciadv.adp1152

PMCID:: PMC11566994

Abstract Article PDF–6.2M

Select item 114014772.

Epithelial organoid supports resident memory CD8 T cell differentiation

Max R. Ulibarri, Ying Lin, Julian C. Ramprashad, Geongoo Han, Mohammad H. Hasan, Farha J. Mithila, Chaoyu Ma, Smita Gopinath, Nu Zhang, J. Justin Milner, Lalit K. Beura

Cell Rep. Author manuscript; available in PMC 2024 Sep 14.

Published in final edited form as: Cell Rep. 2024 Aug 27; 43(8): 114621. Published online 2024 Aug 15. doi: 10.1016/j.celrep.2024.114621

PMCID:: PMC11401477

Abstract Article PDF–3.1M

Select item 112903213.

Therapeutic potential of co-signaling receptor modulation in hepatitis B

Francesco Andreata, Chiara Laura, Micol Ravà, Caroline C. Krueger, Xenia Ficht, Keigo Kawashima, Cristian G. Beccaria, Federica Moalli, Bianca Partini, Valeria Fumagalli, Giulia Nosetto, Pietro Di Lucia, Ilaria Montali, José M. Garcia-Manteiga, Elisa B. Bono, Leonardo Giustini, Chiara Perucchini, Valentina Venzin, Serena Ranucci, Donato Inverso, Marco De Giovanni, Marco Genua, Renato Ostuni, Enrico Lugli, Masanori Isogawa, Carlo Ferrari, Carolina Boni, Paola Fisicaro, Luca G. Guidotti, Matteo Iannacone

Cell. 2024 Jul 25; 187(15): 4078–4094.e21. doi: 10.1016/j.cell.2024.05.038

PMCID:: PMC11290321

Abstract Article

Select item 112614504.

Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development

Christiane Grammer, Julia A. Komorowska, Jeremy B. Swann

iScience. 2024 Jul 19; 27(7): 110258. Published online 2024 Jun 13. doi: 10.1016/j.isci.2024.110258

PMCID:: PMC11261450

Abstract Article PDF–11M

Select item 111902255.

CD8⁺ T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcγRIIB

Kelsey B. Bennion, Danya Liu, Abdelhameed S. Dawood, Megan M. Wyatt, Katie L. Alexander, Mohamed S. Abdel-Hakeem, Chrystal M. Paulos, Mandy L. Ford

Nat Commun. 2024; 15: 5280. Published online 2024 Jun 20. doi: 10.1038/s41467-024-49475-8

PMCID:: PMC11190225

Abstract Article PDF–2.6M

Select item 109426406.

Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss

Erin R Cullen, Mona Safari, Isabelle Mittelstadt, Matthew C Weston

eLife. 2024; 12: RP91323. Published online 2024 Mar 6. doi: 10.7554/eLife.91323

PMCID:: PMC10942640

Abstract Article PDF–13M

Select item 107859507.

TCR signaling promotes formation of a STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments

Yuan-Li Tsai, Marcel Arias-Badia, Theresa Kadlecek, Yee May Lwin, Aahir Srinath, Neel H. Shah, Zhi-En Wang, Diane Barber, John Kuriyan, Lawrence Fong, Arthur Weiss

Immunity. Author manuscript; available in PMC 2024 Dec 12.

Published in final edited form as: Immunity. 2023 Dec 12; 56(12): 2682–2698.e9. doi: 10.1016/j.immuni.2023.11.010

PMCID:: PMC10785950

Abstract Article PDF–3.2M

Select item 107181368.

Thy‐1 knockdown promotes the osteogenic differentiation of GMSCs via the Wnt/β‐catenin pathway

Gufeng Liu, Guixin Zhu, Xiaoyi Wu, Ziqiao Tang, Wenjun Shao, Min Wang, Haibin Xia, Quan Sun, Mingdong Yan

J Cell Mol Med. 2023 Dec; 27(23): 3805–3815. Published online 2023 Oct 2. doi: 10.1111/jcmm.17955

PMCID:: PMC10718136

Abstract Article PDF–6.1M

Select item 106246779.

IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection

Matthew C. Sinton, Praveena R. G. Chandrasegaran, Paul Capewell, Anneli Cooper, Alex Girard, John Ogunsola, Georgia Perona-Wright, Dieudonné M Ngoyi, Nono Kuispond, Bruno Bucheton, Mamadou Camara, Shingo Kajimura, Cécile Bénézech, Neil A. Mabbott, Annette MacLeod, Juan F. Quintana

Nat Commun. 2023; 14: 7070. Published online 2023 Nov 3. doi: 10.1038/s41467-023-42918-8

Correction in:: Nat Commun. 2024; 15: 1833.

PMCID:: PMC10624677

Abstract Article PDF–6.7M

Select item 1058523010.

Cannabinoid receptor 2 signal promotes type 2 immunity in the lung

Tingting Liu, Jiaqi Liu, Hongjie Chen, Xin Zhou, Wei Fu, Ying Cao, Jing Yang

Cell Insight. 2023 Oct; 2(5): 100124. Published online 2023 Oct 6. doi: 10.1016/j.cellin.2023.100124

PMCID:: PMC10585230

Abstract Article PDF–3.4M

Select item 1058304911.

The transcription factor IRF4 determines the anti-tumor immunity of CD8⁺ T cells

Hui Yan, Yulin Dai, Xiaolong Zhang, Hedong Zhang, Xiang Xiao, Jinfei Fu, Dawei Zou, Anze Yu, Tao Jiang, Xian C. Li, Zhongming Zhao, Wenhao Chen

iScience. 2023 Nov 17; 26(11): 108087. Published online 2023 Sep 28. doi: 10.1016/j.isci.2023.108087

PMCID:: PMC10583049

Abstract Article PDF–5.9M

Select item 1054467312.

Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance

Xueliang Gao, Yongxia Wu, Joel M. Chick, Andrea Abbott, Baishan Jiang, David J. Wang, Susana Comte-Walters, Roger H. Johnson, Nathaniel Oberholtzer, Michael I. Nishimura, Steven P. Gygi, Anand Mehta, Denis C. Guttridge, Lauren Ball, Shikhar Mehrotra, Piotr Sicinski, Xue-Zhong Yu, Haizhen Wang

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Apr 25; 42(4): 112314. Published online 2023 Mar 30. doi: 10.1016/j.celrep.2023.112314

PMCID:: PMC10544673

Abstract Article PDF–3.0M

Select item 1049779113.

FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue

Zixin Zhou, Huiying Zhang, Yan Tao, Jinhao Zang, Jingyuan Zhao, Huijie Li, Yalin Wang, Tianci Wang, Hui Zhao, Fuwu Wang, Chun Guo, Faliang Zhu, Haiting Mao, Fengming Liu, Lining Zhang, Qun Wang

Redox Biol. 2023 Nov; 67: 102877. Published online 2023 Sep 9. doi: 10.1016/j.redox.2023.102877

PMCID:: PMC10497791

Abstract Article PDF–13M

Select item 1048113014.

Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma

Juyeun Lee, Michael Nicosia, Ellen S. Hong, Daniel J. Silver, Cathy Li, Defne Bayik, Dionysios C. Watson, Adam Lauko, Kristen E. Kay, Sabrina Z. Wang, Sadie Johnson, Mary McGraw, Matthew M. Grabowski, Danielle D. Kish, Amar B. Desai, Wendy A. Goodman, Scott J. Cameron, Hideho Okada, Anna Valujskikh, Robert L. Fairchild, Manmeet S. Ahluwalia, Justin D. Lathia

Cancer Discov. 2023 Sep 6; 13(9): 2090–2105. Published online 2023 Jun 28. doi: 10.1158/2159-8290.CD-22-0869

PMCID:: PMC10481130

Abstract Article PDF–13M

Select item 1041273715.

DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell development

Alexandra H. Mandarano, Tarsha L. Harris, Blaine M. Creasy, Marie Wehenkel, Marygrace Duggar, Benjamin A. Wilander, Ashutosh Mishra, Jeremy Chase Crawford, Sarah A. Mullen, Katherine M. Williams, Meenu Pillai, Anthony A. High, Maureen A. McGargill

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Feb 28; 42(2): 112106. Published online 2023 Feb 13. doi: 10.1016/j.celrep.2023.112106

PMCID:: PMC10412737

Abstract Article PDF–1.9M

Select item 1034478716.

mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission

Nuria Martinez-Lopez, Pamela Mattar, Miriam Toledo, Henrietta Bains, Manu Kalyani, Marie Louise Aoun, Mridul Sharma, Laura Beth J. McIntire, Leslie Gunther-Cummins, Frank P. Macaluso, Jennifer T. Aguilan, Simone Sidoli, Mathieu Bourdenx, Rajat Singh

Nat Cell Biol. 2023; 25(7): 989–1003. Published online 2023 Jun 29. doi: 10.1038/s41556-023-01163-3

PMCID:: PMC10344787

Abstract Article PDF–23M

Select item 1030785217.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 1024690018.

CD4⁺ T cells aggravate hemorrhagic brain injury

Samuel X. Shi, Yuwen Xiu, Yan Li, Meng Yuan, Kaibin Shi, Qiang Liu, Xiaoying Wang, Wei-Na Jin

Sci Adv. 2023 Jun; 9(23): eabq0712. Published online 2023 Jun 7. doi: 10.1126/sciadv.abq0712

PMCID:: PMC10246900

Abstract Article PDF–2.2M

Select item 1018230019.

Natural γδT17 cell development and functional acquisition is governed by the mTORC2-c-Maf-controlled mitochondrial fission pathway

Yunke Wang, Hui Qin, Yihua Cai, Xu Chen, Hong Li, Diego Elias Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Julia H. Chariker, Harshini Sarojini, Sufan Chien, Eric C. Rouchka, Huang-Ge Zhang, Jie Zheng, Fuming Qiu, Jun Yan

iScience. 2023 May 19; 26(5): 106630. Published online 2023 Apr 10. doi: 10.1016/j.isci.2023.106630

PMCID:: PMC10182300

Abstract Article PDF–8.7M

Select item 1000222320.

TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity

Mahinbanu Mammadli, Liye Suo, Jyoti Misra Sen, Mobin Karimi

Int J Mol Sci. 2023 Mar; 24(5): 4326. Published online 2023 Feb 21. doi: 10.3390/ijms24054326

PMCID:: PMC10002223

Abstract Article PDF–6.9M

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