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Select item 110318421.

Cholesterol trafficking to the ER leads to the activation of CaMKII/JNK/NLRP3 and promotes atherosclerosis

Mustafa Yalcinkaya, Wenli Liu, Tong Xiao, Sandra Abramowicz, Ranran Wang, Nan Wang, Marit Westerterp, Alan R. Tall

J Lipid Res. 2024 Apr; 65(4): 100534. Published online 2024 Mar 22. doi: 10.1016/j.jlr.2024.100534

PMCID:: PMC11031842

Article PDF–3.8M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 106518963.

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, Xian Liu, Dong-Xu Li, Yang Xiao, Xu Chen, Ya-Ting Li, Yi-Qun Zhan, Shen-Si Xiang, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Zhi-Qiang Ge, Xiao-Ming Yang, Rong-Hua Yin

Cell Death Dis. 2023 Nov; 14(11): 743. Published online 2023 Nov 15. doi: 10.1038/s41419-023-06268-z

PMCID:: PMC10651896

Article PDF–6.5M

Select item 100142844.

ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH

Tao Wang, Lu-Yu Zhou, Xin-Min Li, Fang Liu, Lin Liang, Xin-Zhe Chen, Jie Ju, Murugavel Ponnusamy, Kai Wang, Cui-Yun Liu, Kao-Wen Yan, Kun Wang

Mol Ther. 2023 Mar 1; 31(3): 847–865. Published online 2023 Jan 13. doi: 10.1016/j.ymthe.2023.01.011

PMCID:: PMC10014284

Article PDF–4.1M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Article PDF–2.0M

Select item 72636716.

A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation

Louise van der Weyden, Agnieszka Swiatkowska, Vivek Iyer, Anneliese O. Speak, David J. Adams

G3 (Bethesda) 2020 Jun; 10(6): 1869–1877. Published online 2020 Apr 3. doi: 10.1534/g3.120.401128

PMCID:: PMC7263671

Article PDF–1.0M

Select item 64595107.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Article PDF–5.1M

Select item 64504308.

The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination

Ryan Donaghy, Xu Han, Krasimira Rozenova, Kaosheng Lv, Qinqin Jiang, Miriam Doepner, Roger A. Greenberg, Wei Tong

Blood. 2019 Apr 4; 133(14): 1560–1571. Prepublished online 2019 Feb 12. doi: 10.1182/blood-2018-10-877563

PMCID:: PMC6450430

Article

Select item 64184459.

ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination

Guangming Ren, Xuanyi Zhang, Yang Xiao, Wen Zhang, Yu Wang, Wenbing Ma, Xiaohan Wang, Pan Song, Lili Lai, Hui Chen, Yiqun Zhan, Jianhong Zhang, Miao Yu, Changhui Ge, Changyan Li, Ronghua Yin, Xiaoming Yang

EMBO J. 2019 Mar 15; 38(6): e100376. Published online 2019 Feb 20. doi: 10.15252/embj.2018100376

PMCID:: PMC6418445

Article PDF–3.4M

Select item 592777110.

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon

eLife. 2018; 7: e32866. Published online 2018 Apr 20. doi: 10.7554/eLife.32866

PMCID:: PMC5927771

Article PDF–9.1M

Select item 558892811.

Abro1 maintains genome stability and limits replication stress by protecting replication fork stability

Shengfeng Xu, Xiao Wu, Ling Wu, Andy Castillo, Jianxin Liu, Erin Atkinson, Atanu Paul, Dan Su, Katharina Schlacher, Yoshihiro Komatsu, M. James You, Bin Wang

Genes Dev. 2017 Jul 15; 31(14): 1469–1482. doi: 10.1101/gad.299172.117

PMCID:: PMC5588928

Article PDF–12M

Select item 414925612.

The BRCA1-interacting protein, Abraxas, is required for genomic stability and tumor suppression

Andy Castillo, Atanu Paul, Baohua Sun, Ting Hsiang Huang, Yucai Wang, Stephanie A. Yazinski, Jessica Tyler, Lei Li, M James You, Lee Zou, Jun Yao, Bin Wang

Cell Rep. Author manuscript; available in PMC 2014 Dec 15.

Published in final edited form as: Cell Rep. 2014 Aug 7; 8(3): 807–817. Published online 2014 Jul 24. doi: 10.1016/j.celrep.2014.06.050

PMCID:: PMC4149256

Article PDF–1.4M

Select item 381390313.

A Novel BRISC-SHMT Complex Deubiquitinates IFNAR1 and Regulates Interferon Responses

Hui Zheng, Vibhor Gupta, Jeffrey Patterson-Fortin, Sabyasachi Bhattacharya, Kanstantsin Katlinski, Junmin Wu, Bentley Varghese, Christopher J. Carbone, Bernadette Aressy, Serge Y. Fuchs, Roger A. Greenberg

Cell Rep. Author manuscript; available in PMC 2014 Oct 17.

Published in final edited form as: Cell Rep. 2013 Oct 17; 5(1): 10.1016/j.celrep.2013.08.025. Published online 2013 Sep 26. doi: 10.1016/j.celrep.2013.08.025

PMCID:: PMC3813903

Article PDF–4.9M

Select item 357369014.

Abraxas and Rap80 form a novel BRCA1 protein complex required for the DNA damage response

Bin Wang, Shuhei Matsuoka, Bryan Ballif, Dong Zhang, Agata Smogorzewska, Steven Giyi, Stephen J. Elledge

Science. Author manuscript; available in PMC 2013 Feb 15.

Published in final edited form as: Science. 2007 May 25; 316(5828): 1194–1198. doi: 10.1126/science.1139476

PMCID:: PMC3573690

Article PDF–1.4M

Select item 357241015.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Article PDF–1.1M

Select item 334689616.

Head Bobber: An Insertional Mutation Causes Inner Ear Defects, Hyperactive Circling, and Deafness

Giuseppina Somma, Heather M. Alger, Ryan M. McGuire, Jim D. Kretlow, Fernanda R. Ruiz, Svetlana A. Yatsenko, Pawel Stankiewicz, Wilbur Harrison, Etai Funk, Antonio Bergamaschi, John S. Oghalai, Antonios G. Mikos, Paul A. Overbeek, Fred A. Pereira

J Assoc Res Otolaryngol. 2012 Jun; 13(3): 335–349. Published online 2012 Mar 2. doi: 10.1007/s10162-012-0316-5

PMCID:: PMC3346896

Article PDF–1.0M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Article PDF–1.0M

Select item 305733218.

Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination

Lucia Cilenti, Meenakshi P. Balakrishnan, Xiao-Liang Wang, Camilla Ambivero, Martin Sterlicchi, Federica del Monte, Xin L. Ma, Antonis S. Zervos

J Mol Cell Cardiol. Author manuscript; available in PMC 2012 Apr 1.

Published in final edited form as: J Mol Cell Cardiol. 2011 Apr; 50(4): 652–661. Published online 2010 Dec 30. doi: 10.1016/j.yjmcc.2010.12.015

PMCID:: PMC3057332

Article PDF–538K

Select item 302253419.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Article PDF–3.8M

Select item 52892820.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Article PDF–140K

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