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Items: 1 to 20 of 53

1.
Reprogramming tumour-associated macrophages to outcompete cancer cells
Xian Zhang, Shun Li, Isha Malik, Mytrang H. Do, Liangliang Ji, Chun Chou, Wei Shi, Kristelle J. Capistrano, Jing Zhang, Ting-Wei Hsu, Briana G. Nixon, Ke Xu, Xinxin Wang, Andrea Ballabio, Laura S. Schmidt, W. Marston Linehan, Ming O. Li
Nature. Author manuscript; available in PMC 2023 Dec 14.
Published in final edited form as: Nature. 2023 Jul; 619(7970): 616–623. Published online 2023 Jun 28. doi: 10.1038/s41586-023-06256-5
PMCID:
PMC10719927
AbstractArticlePDF–5.6M
2.
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
Chuansheng Guo, Zhiyuan You, Hao Shi, Yu Sun, Xingrong Du, Gustavo Palacios, Cliff Guy, Sujing Yuan, Nicole M. Chapman, Seon Ah Lim, Xiang Sun, Jordy Saravia, Sherri Rankin, Yogesh Dhungana, Hongbo Chi
Nature. 2023; 620(7972): 200–208. Published online 2023 Jul 5. doi: 10.1038/s41586-023-06299-8
PMCID:
PMC10396969
AbstractArticlePDF–17M
3.
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis
Chiara Di Malta, Angela Zampelli, Letizia Granieri, Claudia Vilardo, Rossella De Cegli, Laura Cinque, Edoardo Nusco, Salvatore Pece, Daniela Tosoni, Francesca Sanguedolce, Nicolina Cristina Sorrentino, Maria J Merino, Deborah Nielsen, Ramaprasad Srinivasan, Mark W Ball, Christopher J Ricketts, Cathy D Vocke, Martin Lang, Baktiar Karim, Luisa Lanfrancone, Laura S Schmidt, W Marston Linehan, Andrea Ballabio
EMBO Mol Med. 2023 May; 15(5): e16877. Published online 2023 Mar 29. doi: 10.15252/emmm.202216877
PMCID:
PMC10165358
AbstractArticlePDF–5.8M
4.
Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1
Jonathan M. Shillingford, James A. Shayman
Am J Physiol Renal Physiol. 2023 Apr 1; 324(4): F404–F422. Published online 2023 Feb 16. doi: 10.1152/ajprenal.00237.2022
PMCID:
PMC10069964
AbstractArticle
5.
Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1
Bridget S. Gosis, Shogo Wada, Chelsea Thorsheim, Kristina Li, Sunhee Jung, Joshua H. Rhoades, Yifan Yang, Jeffrey Brandimarto, Li Li, Kahealani Uehara, Cholsoon Jang, Matthew Lanza, Nathan B. Sanford, Marc R. Bornstein, Sunhye Jeong, Paul M. Titchenell, Sudha B. Biddinger, Zoltan Arany
Science. Author manuscript; available in PMC 2023 Apr 15.
Published in final edited form as: Science. 2022 Apr 15; 376(6590): eabf8271. Published online 2022 Apr 15. doi: 10.1126/science.abf8271
PMCID:
PMC9811404
AbstractArticlePDF–2.3M
6.
Cigarette smoking is a secondary cause of folliculin loss
Xiuying Li, Yandong Lai, Zachary Lane, Hilary Strollo, Kazuya Tanimura, John C Sembrat, Chunbin Zou, Michael M Myerburg, Mauricio Rojas, Steven Shapiro, Yu Jiang, Toru Nyunoya
Thorax. 2023 Apr; 78(4): 402–408. Published online 2022 Mar 17. doi: 10.1136/thoraxjnl-2021-217197
PMCID:
PMC9612398
AbstractArticlePDF–1.5M
7.
Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways
Mathieu Paquette, Ming Yan, Josué M. J. Ramírez-Reyes, Leeanna El-Houjeiri, Marco Biondini, Catherine R. Dufour, Hyeonju Jeong, Alain Pacis, Vincent Giguère, Jennifer L. Estall, Peter M. Siegel, Étienne Audet-Walsh, Arnim Pause
Sci Rep. 2021; 11: 21268. Published online 2021 Oct 28. doi: 10.1038/s41598-021-99958-7
PMCID:
PMC8553785
AbstractArticlePDF–3.0M
8.
A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity
Mitsuhiro Endoh, Masaya Baba, Tamie Endoh, Akiyoshi Hirayama, Ayako Nakamura-Ishizu, Terumasa Umemoto, Michihiro Hashimoto, Kunio Nagashima, Tomoyoshi Soga, Martin Lang, Laura S. Schmidt, W. Marston Linehan, Toshio Suda
Cell Rep. Author manuscript; available in PMC 2021 Sep 23.
Published in final edited form as: Cell Rep. 2020 Feb 11; 30(6): 1823–1834.e5. doi: 10.1016/j.celrep.2020.01.042
PMCID:
PMC8459211
AbstractArticlePDF–3.0M
9.
FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland
Yasuhiro Isono, Mitsuko Furuya, Tatsu Kuwahara, Daisuke Sano, Kae Suzuki, Ryosuke Jikuya, Taku Mitome, Shinji Otake, Takashi Kawahara, Yusuke Ito, Kentaro Muraoka, Noboru Nakaigawa, Yayoi Kimura, Masaya Baba, Kiyotaka Nagahama, Hiroyuki Takahata, Ichiro Saito, Laura S. Schmidt, W. Marston Linehan, Tatsuhiko Kodama, Masahiro Yao, Nobuhiko Oridate, Hisashi Hasumi
Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Jun 11.
Published in final edited form as: Biochem Biophys Res Commun. 2020 Feb 19; 522(4): 931–938. Published online 2019 Dec 2. doi: 10.1016/j.bbrc.2019.11.184
PMCID:
PMC8195446
AbstractArticlePDF–1.7M
10.
Blood and lymphatic systems are segregated by the FLCN tumor suppressor
Ikue Tai-Nagara, Yukiko Hasumi, Dai Kusumoto, Hisashi Hasumi, Keisuke Okabe, Tomofumi Ando, Fumio Matsuzaki, Fumiko Itoh, Hideyuki Saya, Chang Liu, Wenling Li, Yoh-suke Mukouyama, W. Marston Linehan, Xinyi Liu, Masanori Hirashima, Yutaka Suzuki, Shintaro Funasaki, Yorifumi Satou, Mitsuko Furuya, Masaya Baba, Yoshiaki Kubota
Nat Commun. 2020; 11: 6314. Published online 2020 Dec 9. doi: 10.1038/s41467-020-20156-6
PMCID:
PMC7725783
AbstractArticlePDF–5.1M
11.
A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome
Gennaro Napolitano, Chiara Di Malta, Alessandra Esposito, Mariana E.G. de Araujo, Salvatore Pece, Giovanni Bertalot, Maria Matarese, Valerio Benedetti, Angela Zampelli, Taras Stasyk, Diletta Siciliano, Alessandro Venuta, Marcella Cesana, Claudia Vilardo, Edoardo Nusco, Jlenia Monfregola, Alessia Calcagni, Pier Paolo Di Fiore, Lukas A. Huber, Andrea Ballabio
Nature. Author manuscript; available in PMC 2021 Mar 22.
Published in final edited form as: Nature. 2020 Sep 1; 585(7826): 597–602. Published online 2020 Jul 1. doi: 10.1038/s41586-020-2444-0
PMCID:
PMC7610377
AbstractArticlePDF–5.4M
12.
The transcription factors TFEB and TFE3 link the FLCN-AMPK signaling axis to innate immune response and pathogen resistance
Leeanna El-Houjeiri, Elite Possik, Tarika Vijayaraghavan, Mathieu Paquette, José A Martina, Jalal M. Kazan, Eric H. Ma, Russell Jones, Paola Blanchette, Rosa Puertollano, Arnim Pause
Cell Rep. Author manuscript; available in PMC 2020 Aug 31.
Published in final edited form as: Cell Rep. 2019 Mar 26; 26(13): 3613–3628.e6. doi: 10.1016/j.celrep.2019.02.102
PMCID:
PMC7457953
AbstractArticlePDF–1.8M
13.
AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR
Caterina Collodet, Marc Foretz, Maria Deak, Laurent Bultot, Sylviane Metairon, Benoit Viollet, Gregory Lefebvre, Frederic Raymond, Alice Parisi, Gabriele Civiletto, Philipp Gut, Patrick Descombes, Kei Sakamoto
FASEB J. 2019 Nov; 33(11): 12374–12391. Published online 2019 Aug 19. doi: 10.1096/fj.201900841R
PMCID:
PMC6902666
AbstractArticle
14.
Loss of FLCN inhibits canonical WNT signaling via TFE3
John C Kennedy, Damir Khabibullin, Thomas Hougard, Julie Nijmeh, Wei Shi, Elizabeth P Henske
Hum Mol Genet. 2019 Oct 1; 28(19): 3270–3281. Published online 2019 Jun 10. doi: 10.1093/hmg/ddz158
PMCID:
PMC6859437
AbstractArticlePDF–87M
15.
Myeloid folliculin balances mTOR activation to maintain innate immunity homeostasis
Jia Li, Shogo Wada, Lehn K. Weaver, Chhanda Biswas, Edward M. Behrens, Zoltan Arany
JCI Insight. 2019 Mar 21; 4(6): e126939. Published online 2019 Mar 21. doi: 10.1172/jci.insight.126939
PMCID:
PMC6483010
AbstractArticlePDF–2.2M
16.
Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation
Masaya Baba, Mitsuhiro Endoh, Wenjuan Ma, Hirofumi Toyama, Akiyoshi Hirayama, Keizo Nishikawa, Keiyo Takubo, Hiroyuki Hano, Hisashi Hasumi, Terumasa Umemoto, Michihiro Hashimoto, Nobuko Irie, Chiharu Esumi, Miho Kataoka, Naomi Nakagata, Tomoyoshi Soga, Masahiro Yao, Tomomi Kamba, Takashi Minami, Masaru Ishii, Toshio Suda
J Bone Miner Res. 2018 Oct; 33(10): 1785–1798. Published online 2018 Jun 26. doi: 10.1002/jbmr.3477
PMCID:
PMC6220829
AbstractArticlePDF–2.9M
17.
H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation
Hisashi Hasumi, Yukiko Hasumi, Masaya Baba, Hafumi Nishi, Mitsuko Furuya, Cathy D. Vocke, Martin Lang, Nobuko Irie, Chiharu Esumi, Maria J. Merino, Takashi Kawahara, Yasuhiro Isono, Kazuhide Makiyama, Andrew C. Warner, Diana C. Haines, Ming-Hui Wei, Berton Zbar, Herbert Hagenau, Lionel Feigenbaum, Keiichi Kondo, Noboru Nakaigawa, Masahiro Yao, Adam R. Metwalli, W. Marston Linehan, Laura S. Schmidt
Hum Mol Genet. 2017 Jan 15; 26(2): 354–366. Published online 2016 Nov 23. doi: 10.1093/hmg/ddw392
PMCID:
PMC6075457
AbstractArticlePDF–1.1M
18.
CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice
Jin Li, Su-Ping Deng, Gang Wei, Peng Yu
Database (Oxford) 2018; 2018: bay012. Published online 2018 Mar 23. doi: 10.1093/database/bay012
PMCID:
PMC5868181
AbstractArticlePDF–653K
19.
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
Laura A. Laviolette, Julien Mermoud, Isabel A. Calvo, Nicholas Olson, Myriam Boukhali, Ortrud K. Steinlein, Elisabeth Roider, Elke C. Sattler, Dachuan Huang, Bin Tean Teh, Mo Motamedi, Wilhelm Haas, Othon Iliopoulos
Nat Commun. 2017; 8: 15866. Published online 2017 Jun 28. doi: 10.1038/ncomms15866
PMCID:
PMC5493755
AbstractArticlePDF–2.4M
20.
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue
Shogo Wada, Michael Neinast, Cholsoon Jang, Yasir H. Ibrahim, Gina Lee, Apoorva Babu, Jian Li, Atsushi Hoshino, Glenn C. Rowe, James Rhee, José A. Martina, Rosa Puertollano, John Blenis, Michael Morley, Joseph A. Baur, Patrick Seale, Zoltan Arany
Genes Dev. 2016 Nov 15; 30(22): 2551–2564. doi: 10.1101/gad.287953.116
PMCID:
PMC5159669
AbstractArticlePDF–1.6M

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