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Select item 114815941.

METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1

Zhengtao Yu, Ying Xia, Jiameng Li, Junwen Jiang, You Li, Youjun Li, Liu Wang

Biol Direct. 2024; 19: 92. Published online 2024 Oct 16. doi: 10.1186/s13062-024-00536-4

PMCID:: PMC11481594

Abstract Article PDF–7.9M

Select item 112878832.

miR-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through METTL3-mediated m⁶A modification of HMOX1 to promote recovery of injured rat uterus

Bang Xiao, Yiqing Zhu, Meng Liu, Meiting Chen, Chao Huang, Dabing Xu, Fang Wang, Shuhan Sun, Jinfeng Huang, Ningxia Sun, Fu Yang

Stem Cell Res Ther. 2024; 15: 224. Published online 2024 Jul 29. doi: 10.1186/s13287-024-03846-6

Correction in:: Stem Cell Res Ther. 2024; 15: 357.

PMCID:: PMC11287883

Abstract Article PDF–8.5M

Select item 100882333.

METTL3 enhances dentinogenesis differentiation of dental pulp stem cells via increasing GDF6 and STC1 mRNA stability

Yue Pan, Ying Liu, Dixin Cui, Sihan Yu, Yachuan Zhou, Xin Zhou, Wei Du, Liwei Zheng, Mian Wan

BMC Oral Health. 2023; 23: 209. Published online 2023 Apr 11. doi: 10.1186/s12903-023-02836-z

PMCID:: PMC10088233

Abstract Article PDF–3.8M

Select item 99011134.

Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner

Yangyang Chen, Xiaoxia Liu, Lun Li, Xiyang He, Fanghui Zheng, Yang Zhang, Hui Gao, Zhishan Jin, Di Wu, Qianhua Wang, Hui Tao, Yin Zhao, Weifang Liu, Li Zou

Mol Med. 2023; 29: 19. Published online 2023 Feb 6. doi: 10.1186/s10020-023-00604-x

PMCID:: PMC9901113

Abstract Article PDF–15M

Select item 97300125.

Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner

Wei Lin, Yuan Liu, Yifei Zhou, Mengying Lin, Congxu Liu, Ying Tang, Bin Wu, Chun Lin

Mol Pain. 2022; 18: 17448069221144540. Published online 2022 Dec 5. doi: 10.1177/17448069221144540

PMCID:: PMC9730012

Abstract Article PDF–2.1M

Select item 93914616.

METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m⁶A-YTHDF2-dependent manner

Jiaren Li, Hanyu Yao, Jin Huang, Chao Li, Yichuan Zhang, Ran Xu, Zhenting Wang, Zhi Long, Jin Tang, Long Wang

Cell Death Dis. 2022 Aug; 13(8): 723. Published online 2022 Aug 19. doi: 10.1038/s41419-022-05162-4

PMCID:: PMC9391461

Abstract Article PDF–5.9M

Select item 91365137.

METTL3‐m⁶A methylase regulates the osteogenic potential of bone marrow mesenchymal stem cells in osteoporotic rats via the Wnt signalling pathway

Tianli Wu, Hui Tang, Jianghua Yang, Zhihao Yao, Long Bai, Yuping Xie, Qing Li, Jingang Xiao

Cell Prolif. 2022 May; 55(5): e13234. Published online 2022 Apr 25. doi: 10.1111/cpr.13234

PMCID:: PMC9136513

Abstract Article PDF–14M

Select item 88319448.

New insights into the central sympathetic hyperactivity post‐myocardial infarction: Roles of METTL3‐mediated m⁶A methylation

Lei Qi, Hui Hu, Ye Wang, Hesheng Hu, Kang Wang, Pingjiang Li, Jie Yin, Yugen Shi, Yu Wang, Yuepeng Zhao, Hangji Lyu, Meng Feng, Mei Xue, Xinran Li, Yan Li, Suhua Yan

J Cell Mol Med. 2022 Feb; 26(4): 1264–1280. Published online 2022 Jan 17. doi: 10.1111/jcmm.17183

PMCID:: PMC8831944

Abstract Article PDF–2.1M

Select item 83401289.

METTL3/METTL14 Transactivation and m⁶A-Dependent TGF-β1 Translation in Activated Kupffer Cells

Yue Feng, Haibo Dong, Bo Sun, Yun Hu, Yang Yang, Yimin Jia, Longfei Jia, Xiang Zhong, Ruqian Zhao

Cell Mol Gastroenterol Hepatol. 2021; 12(3): 839–856. Published online 2021 May 13. doi: 10.1016/j.jcmgh.2021.05.007

PMCID:: PMC8340128

Abstract Article PDF–5.5M

Select item 638710910.

Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells

Cheng Tian, Yanlan Huang, Qimeng Li, Zhihui Feng, Qiong Xu

Int J Mol Sci. 2019 Feb; 20(3): 551. Published online 2019 Jan 28. doi: 10.3390/ijms20030551

PMCID:: PMC6387109

Abstract Article PDF–3.8M

Select item 600751411.

SUMOylation of the m⁶A-RNA methyltransferase METTL3 modulates its function

Yuzhang Du, Guofang Hou, Hailong Zhang, Jinzhuo Dou, Jianfeng He, Yanming Guo, Lian Li, Ran Chen, Yanli Wang, Rong Deng, Jian Huang, Bin Jiang, Ming Xu, Jinke Cheng, Guo-Qiang Chen, Xian Zhao, Jianxiu Yu

Nucleic Acids Res. 2018 Jun 1; 46(10): 5195–5208. Published online 2018 Feb 28. doi: 10.1093/nar/gky156

PMCID:: PMC6007514

Abstract Article PDF–6.9M

Select item 585822612.

Zc3h13 regulates nuclear RNA m⁶A methylation and mouse embryonic stem cell self-renewal

Jing Wen, Ruitu Lv, Honghui Ma, Hongjie Shen, Chenxi He, Jiahua Wang, Fangfang Jiao, Hang Liu, Pengyuan Yang, Li Tan, Fei Lan, Yujiang Geno Shi, Chuan He, Yang Shi, Jianbo Diao

Mol Cell. Author manuscript; available in PMC 2019 Mar 15.

Published in final edited form as: Mol Cell. 2018 Mar 15; 69(6): 1028–1038.e6. doi: 10.1016/j.molcel.2018.02.015

PMCID:: PMC5858226

Abstract Article PDF–1.6M

Select item 585595113.

Interactions, localization, and phosphorylation of the m⁶A generating METTL3–METTL14–WTAP complex

Eva Schöller, Franziska Weichmann, Thomas Treiber, Sam Ringle, Nora Treiber, Andrew Flatley, Regina Feederle, Astrid Bruckmann, Gunter Meister

RNA. 2018 Apr; 24(4): 499–512. doi: 10.1261/rna.064063.117

PMCID:: PMC5855951

Abstract Article PDF–8.1M

Select item 582692614.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 572990815.

m⁶A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway

Hua-Bing Li, Jiyu Tong, Shu Zhu, Pedro J. Batista, Erin E. Duffy, Jun Zhao, Will Bailis, Guangchao Cao, Lina Kroehling, Yuanyuan Chen, Geng Wang, James P. Broughton, Y. Grace Chen, Yuval Kluger, Matthew D. Simon, Howard Y. Chang, Zhinan Yin, Richard A. Flavell

Nature. Author manuscript; available in PMC 2018 Feb 9.

Published in final edited form as: Nature. 2017 Aug 17; 548(7667): 338–342. Published online 2017 Aug 9. doi: 10.1038/nature23450

PMCID:: PMC5729908

Abstract Article PDF–2.8M

Select item 567943516.

Temporal Control of Mammalian Cortical Neurogenesis by m⁶A Methylation

Ki-Jun Yoon, Francisca Rojas Ringeling, Caroline Vissers, Fadi Jacob, Michael Pokrass, Dennisse Jimenez-Cyrus, Yijing Su, Nam-Shik Kim, Yunhua Zhu, Lily Zheng, Sunghan Kim, Xinyuan Wang, Louis C. Doré, Peng Jin, Sergi Regot, Xiaoxi Zhuang, Stefan Canzar, Chuan He, Guo-li Ming, Hongjun Song

Cell. Author manuscript; available in PMC 2018 Nov 2.

Published in final edited form as: Cell. 2017 Nov 2; 171(4): 877–889.e17. Published online 2017 Sep 28. doi: 10.1016/j.cell.2017.09.003

PMCID:: PMC5679435

Abstract Article PDF–2.1M

Select item 563068117.

Mettl3-/Mettl14-mediated mRNA N⁶-methyladenosine modulates murine spermatogenesis

Zhen Lin, Phillip J Hsu, Xudong Xing, Jianhuo Fang, Zhike Lu, Qin Zou, Ke-Jia Zhang, Xiao Zhang, Yuchuan Zhou, Teng Zhang, Youcheng Zhang, Wanlu Song, Guifang Jia, Xuerui Yang, Chuan He, Ming-Han Tong

Cell Res. 2017 Oct; 27(10): 1216–1230. Published online 2017 Sep 15. doi: 10.1038/cr.2017.117

PMCID:: PMC5630681

Abstract Article PDF–3.7M

Select item 558784518.

Mettl3-mediated m⁶A regulates spermatogonial differentiation and meiosis initiation

Kai Xu, Ying Yang, Gui-Hai Feng, Bao-Fa Sun, Jun-Qing Chen, Yu-Fei Li, Yu-Sheng Chen, Xin-Xin Zhang, Chen-Xin Wang, Li-Yuan Jiang, Chao Liu, Ze-Yu Zhang, Xiu-Jie Wang, Qi Zhou, Yun-Gui Yang, Wei Li

Cell Res. 2017 Sep; 27(9): 1100–1114. Published online 2017 Aug 15. doi: 10.1038/cr.2017.100

PMCID:: PMC5587845

Abstract Article PDF–8.6M

Select item 550921819.

m⁶A RNA methylation promotes XIST-mediated transcriptional repression

Deepak P. Patil, Chun-Kan Chen, Brian F. Pickering, Amy Chow, Constanza Jackson, Mitchell Guttman, Samie R. Jaffrey

Nature. Author manuscript; available in PMC 2017 Jul 13.

Published in final edited form as: Nature. 2016 Sep 15; 537(7620): 369–373. Published online 2016 Sep 7. doi: 10.1038/nature19342

PMCID:: PMC5509218

Abstract Article PDF–4.9M

Select item 549512720.

m⁶A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

Shengdong Ke, Amy Pandya-Jones, Yuhki Saito, John J. Fak, Cathrine Broberg Vågbø, Shay Geula, Jacob H. Hanna, Douglas L. Black, James E. Darnell, Jr., Robert B. Darnell

Genes Dev. 2017 May 15; 31(10): 990–1006. doi: 10.1101/gad.301036.117