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Items: 1 to 20 of 30

1.
Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation
Xi Yang, Shi-Ting Wu, Rui Gao, Rui Wang, Yixuan Wang, Zhenkun Dong, Lu Wang, Chunxiao Qi, Xiaohong Wang, M. Lienhard Schmitz, Renjing Liu, Zhiming Han, Lu Wang, Xiangjian Zheng
JCI Insight. 2023 Mar 8; 8(5): e160372. Published online 2023 Mar 8. doi: 10.1172/jci.insight.160372
PMCID:
PMC10077477
AbstractArticlePDF–26M
2.
STK25 inhibits PKA signaling by phosphorylating PRKAR1A
Xiaokan Zhang, Bryan Z. Wang, Michael Kim, Trevor R. Nash, Bohao Liu, Jenny Rao, Roberta Lock, Manuel Tamargo, Rajesh Kumar Soni, John Belov, Eric Li, Gordana Vunjak-Novakovic, Barry Fine
Cell Rep. Author manuscript; available in PMC 2022 Sep 6.
Published in final edited form as: Cell Rep. 2022 Aug 16; 40(7): 111203. doi: 10.1016/j.celrep.2022.111203
PMCID:
PMC9446420
AbstractArticlePDF–813K
3.
Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is atheroprotective
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Commun Biol. 2022; 5: 379. Published online 2022 Apr 19. doi: 10.1038/s42003-022-03309-9
PMCID:
PMC9018782
AbstractArticlePDF–11M
4.
Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways
Yeshwant Kurhe, Mara Caputo, Emmelie Cansby, Ying Xia, Sima Kumari, Sumit Kumar Anand, Brian W. Howell, Hanns-Ulrich Marschall, Margit Mahlapuu
Cell Mol Gastroenterol Hepatol. 2022; 13(2): 405–423. Published online 2021 Oct 6. doi: 10.1016/j.jcmgh.2021.09.018
PMCID:
PMC8688184
AbstractArticlePDF–13M
5.
STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development
Tohru Matsuki, Akio Iio, Masashi Ueda, Yumi Tsuneura, Brian W. Howell, Atsuo Nakayama
J Neurosci. 2021 Oct 27; 41(43): 8887–8903. doi: 10.1523/JNEUROSCI.0523-21.2021
PMCID:
PMC8549536
AbstractArticlePDF–6.2M
6.
Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting
Rui Wang, Shi-Ting Wu, Xi Yang, Yude Qian, Jaesung P. Choi, Rui Gao, Siliang Song, Yixuan Wang, Tao Zhuang, Justin J.L. Wong, Yuzhen Zhang, Zhiming Han, Hua A. Lu, Stephen I. Alexander, Renjing Liu, Yin Xia, Xiangjian Zheng
JCI Insight. 2021 Jun 22; 6(12): e142838. Published online 2021 Jun 22. doi: 10.1172/jci.insight.142838
PMCID:
PMC8262504
AbstractArticlePDF–6.9M
7.
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Margit Mahlapuu
JCI Insight. 2020 Dec 17; 5(24): e140483. Published online 2020 Dec 17. doi: 10.1172/jci.insight.140483
PMCID:
PMC7819747
AbstractArticlePDF–69M
8.
Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver
Annika Nerstedt, Yeshwant Kurhe, Emmelie Cansby, Mara Caputo, Lei Gao, Egor Vorontsov, Marcus Ståhlman, Esther Nuñez-Durán, Jan Borén, Hanns-Ulrich Marschall, Douglas G. Mashek, Darren N. Saunders, Carina Sihlbom, Andrew J. Hoy, Margit Mahlapuu
J Lipid Res. 2020 Feb; 61(2): 178–191. Published online 2019 Dec 19. doi: 10.1194/jlr.RA119000316
PMCID:
PMC6997604
AbstractArticlePDF–2.3M
9.
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics
Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea
Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253
PMCID:
PMC6692770
AbstractArticlePDF–7.7M
10.
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle
Urszula Chursa, Esther Nuñez-Durán, Emmelie Cansby, Manoj Amrutkar, Silva Sütt, Marcus Ståhlman, Britt-Marie Olsson, Jan Borén, Maria E. Johansson, Fredrik Bäckhed, Bengt R. Johansson, Carina Sihlbom, Margit Mahlapuu
Diabetologia. 2017; 60(3): 553–567. Published online 2016 Dec 16. doi: 10.1007/s00125-016-4171-5
PMCID:
PMC6518105
AbstractArticlePDF–1.6M
11.
Identification of the kinase STK25 as an upstream activator of LATS signaling
Sanghee Lim, Nicole Hermance, Tenny Mudianto, Hatim M. Mustaly, Ian Paolo Morelos Mauricio, Marc A. Vittoria, Ryan J. Quinton, Brian W. Howell, Hauke Cornils, Amity L. Manning, Neil J. Ganem
Nat Commun. 2019; 10: 1547. Published online 2019 Apr 4. doi: 10.1038/s41467-019-09597-w
PMCID:
PMC6449379
AbstractArticlePDF–2.9M
12.
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury
Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa
PLoS Genet. 2016 Sep; 12(9): e1006355. Published online 2016 Sep 30. doi: 10.1371/journal.pgen.1006355
PMCID:
PMC5045200
AbstractArticlePDF–2.9M
13.
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model
Manoj Amrutkar, Emmelie Cansby, Urszula Chursa, Esther Nuñez-Durán, Belén Chanclón, Marcus Ståhlman, Vincent Fridén, Louise Mannerås-Holm, Anna Wickman, Ulf Smith, Fredrik Bäckhed, Jan Borén, Brian W. Howell, Margit Mahlapuu
Diabetes. 2015 Aug; 64(8): 2791–2804. Published online 2015 Apr 6. doi: 10.2337/db15-0060
PMCID:
PMC4876789
AbstractArticlePDF–2.4M
14.
Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration
Tohru Matsuki, Jianhua Chen, Brian W Howell
Neural Dev. 2013; 8: 21. Published online 2013 Nov 13. doi: 10.1186/1749-8104-8-21
PMCID:
PMC3874637
AbstractArticlePDF–2.1M
15.
STK25 Protein Mediates TrkA and CCM2 Protein-dependent Death in Pediatric Tumor Cells of Neural Origin
Barbara Costa, Michelle J. Kean, Volker Ast, James D. R. Knight, Alice Mett, Zehava Levy, Derek F. Ceccarelli, Beatriz Gonzalez Badillo, Roland Eils, Rainer König, Anne-Claude Gingras, Mike Fainzilber
J Biol Chem. 2012 Aug 24; 287(35): 29285–29289. Published online 2012 Jul 10. doi: 10.1074/jbc.C112.345397
PMCID:
PMC3436191
AbstractArticlePDF–910K
16.
Identification of Stk25 as a Genetic Modifier of Tau Phosphorylation in Dab1-Mutant Mice
Tohru Matsuki, Mariam Zaka, Rita Guerreiro, Marcel P. van der Brug, Jonathan A. Cooper, Mark R. Cookson, John A. Hardy, Brian W. Howell
PLoS One. 2012; 7(2): e31152. Published online 2012 Feb 15. doi: 10.1371/journal.pone.0031152
PMCID:
PMC3280280
AbstractArticlePDF–472K
17.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
18.
Over-expression of Ste20-related proline/alanine rich kinase (SPAK) exacerbates experimental colitis in mice
Yutao Yan, Hamed Laroui, Sarah A. Ingersoll, Saravanan Ayyadurai, Moiz Charania, Stephen Yang, Guillaume Dalmasso, Tracy S. Obertone, Hang Nguyen, Shanthi V. Sitaraman, Didier Merlin
J Immunol. Author manuscript; available in PMC 2012 Aug 1.
Published in final edited form as: J Immunol. 2011 Aug 1; 187(3): 1496–1505. Published online 2011 Jun 24. doi: 10.4049/jimmunol.1002910
PMCID:
PMC3140558
AbstractArticlePDF–2.6M
19.
Reelin and Stk25 Have Opposing Roles in Neuronal Polarization and Dendritic Golgi Deployment
Tohru Matsuki, Russell T. Matthews, Jonathan A. Cooper, Marcel P. van der Brug, Mark R. Cookson, John A. Hardy, Eric C. Olson, Brian W. Howell
Cell. Author manuscript; available in PMC 2011 Nov 24.
Published in final edited form as: Cell. 2010 Nov 24; 143(5): 826–836. doi: 10.1016/j.cell.2010.10.029
PMCID:
PMC3033572
AbstractArticlePDF–2.3M
20.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M

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