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Select item 110504201.

Is a Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism a Risk Factor for Nephrolithiasis in Sarcoidosis?

Marjolein Drent, Petal Wijnen, Otto Bekers, Aalt Bast

Int J Mol Sci. 2024 Apr; 25(8): 4448. Published online 2024 Apr 18. doi: 10.3390/ijms25084448

PMCID:: PMC11050420

Abstract Article PDF–531K

Select item 108536722.

New insights into the role of VKORC1 polymorphisms for optimal warfarin dose selection in Caribbean Hispanic patients through an external validation of a population PK/PD model

Karine Rodríguez-Fernández, Gledys Reynaldo-Fernández, Stephanie Reyes-González, Camila de las Barreras, Leyanis Rodríguez-Vera, Cornelis Vlaar, Jean-Christophe M. Monbaliu, Torsten Stelzer, Jorge Duconge, Victor Mangas-Sanjuan

Biomed Pharmacother. Author manuscript; available in PMC 2024 Feb 9.

Published in final edited form as: Biomed Pharmacother. 2024 Jan; 170: 115977. Published online 2023 Dec 6. doi: 10.1016/j.biopha.2023.115977

PMCID:: PMC10853672

Abstract Article PDF–883K

Select item 104707913.

Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke

Silvina Iluţ, Ştefan Cristian Vesa, Vitalie Văcăraş, Diana Şipoş-Lascu, Cristina Bârsan, Raluca Maria Pop, Sorin Crişan, Antonia Eugenia Macarie, Camelia Alexandra Coadă, Lăcrămioara Perju-Dumbravă, Dafin Fior Muresanu, Anca Dana Buzoianu

Medicine (Baltimore) 2023 Aug 25; 102(34): e34836. Published online 2023 Aug 25. doi: 10.1097/MD.0000000000034836

PMCID:: PMC10470791

Abstract Article PDF–661K

Select item 103789784.

Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia

Sebastian Giraldo-Ocampo, Lorena Diaz-Ordoñez, Yisther Katherine Silva-Cuero, Juan David Gutierrez-Medina, Estephania Candelo, Javier A. Diaz, Harry Pachajoa

Medicine (Baltimore) 2023 Jul 28; 102(30): e34204. Published online 2023 Jul 28. doi: 10.1097/MD.0000000000034204

PMCID:: PMC10378978

Abstract Article PDF–630K

Select item 102254825.

Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state

Shuang Li, Jie Sun, Shixuan Liu, Fengbo Zhou, Michael L. Gross, Weikai Li

Blood Adv. 2023 May 23; 7(10): 2271–2282. Published online 2022 Dec 14. doi: 10.1182/bloodadvances.2021006876

PMCID:: PMC10225482

Abstract Article PDF–3.2M

Select item 102021836.

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage

Fengli Wang, Lingjuan Wang, Shiming Gan, Shenglei Feng, Sijin Ouyang, Xiaoli Wang, Shuiqiao Yuan

Research (Wash D C) 2023; 6: 0091. Published online 2023 Apr 12. doi: 10.34133/research.0091

PMCID:: PMC10202183

Abstract Article PDF–18M

Select item 100878047.

Association of VKORC1 polymorphisms and major bleedings in patients who are treated with vitamin K antagonists

D. Max van Heteren, Willem M. Lijfering, Felix J. M. van der Meer, Pieter H. Reitsma, Jesse J. Swen, Mettine H. A. Bos, Nienke van Rein

J Intern Med. 2023 Jan; 293(1): 124–127. Published online 2022 Sep 20. doi: 10.1111/joim.13569

PMCID:: PMC10087804

Article PDF–192K

Select item 99906318.

The role of CYP2C9*2, CYP2C9*3 and VKORC1-1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study

Marcela Forgerini, Gustavo Urbano, Tales Rubens De Nadai, Sabrina Setembre Batah, Alexandre Todorovic Fabro, Patrícia De Carvalho Mastroianni

J Pharm Pharm Sci. 2023; 26: 11136. Published online 2023 Jan 30. doi: 10.3389/jpps.2023.11136

PMCID:: PMC9990631

Abstract Article PDF–661K

Select item 82360789.

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs

Katherine M. Almasy, Jonathan P. Davies, Lars Plate

Mol Cell Proteomics. 2021; 20: 100120. Published online 2021 Jun 27. doi: 10.1016/j.mcpro.2021.100120

PMCID:: PMC8236078

Abstract Article PDF–4.6M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 815066211.

Variation in VKORC1 Is Associated with Vascular Dementia

Jure Mur, Daniel L. McCartney, Daniel I. Chasman, Peter M. Visscher, Graciela Muniz-Terrera, Simon R. Cox, Tom C. Russ, Riccardo E. Marioni

J Alzheimers Dis. 2021; 80(3): 1329–1337. Prepublished online 2021 Feb 26. Published online 2021 Apr 6. doi: 10.3233/JAD-201256

PMCID:: PMC8150662

Abstract Article PDF–207K

Select item 800701312.

Gene variants of coagulation related proteins that interact with SARS-CoV-2

David Holcomb, Aikaterini Alexaki, Nancy Hernandez, Ryan Hunt, Kyle Laurie, Jacob Kames, Nobuko Hamasaki-Katagiri, Anton A. Komar, Michael DiCuccio, Chava Kimchi-Sarfaty

PLoS Comput Biol. 2021 Mar; 17(3): e1008805. Published online 2021 Mar 17. doi: 10.1371/journal.pcbi.1008805

PMCID:: PMC8007013

Abstract Article PDF–2.1M

Select item 794640713.

Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation

Shixuan Liu, Shuang Li, Guomin Shen, Narayanasami Sukumar, Andrzej M. Krezel, Weikai Li

Science. Author manuscript; available in PMC 2021 Mar 10.

Published in final edited form as: Science. 2021 Jan 1; 371(6524): eabc5667. Published online 2020 Nov 5. doi: 10.1126/science.abc5667

PMCID:: PMC7946407

Abstract Article PDF–1.6M

Select item 783582314.

Identification of the Primary Factors Determining the Specificity of Human VKORC1 Recognition by Thioredoxin-Fold Proteins

Maxim Stolyarchuk, Julie Ledoux, Elodie Maignant, Alain Trouvé, Luba Tchertanov

Int J Mol Sci. 2021 Jan; 22(2): 802. Published online 2021 Jan 14. doi: 10.3390/ijms22020802

PMCID:: PMC7835823

Abstract Article PDF–13M

Select item 772476015.

Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies

Jonathan P. Davies, Katherine M. Almasy, Eli F. McDonald, Lars Plate

ACS Infect Dis. Author manuscript; available in PMC 2024 Mar 5.

Published in final edited form as: ACS Infect Dis. 2020 Dec 11; 6(12): 3174–3189. Published online 2020 Dec 2. doi: 10.1021/acsinfecdis.0c00500

PMCID:: PMC7724760

Abstract Article PDF–2.1M

Select item 746261316.

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

Melissa A Chiasson, Nathan J Rollins, Jason J Stephany, Katherine A Sitko, Kenneth A Matreyek, Marta Verby, Song Sun, Frederick P Roth, Daniel DeSloover, Debora S Marks, Allan E Rettie, Douglas M Fowler

eLife. 2020; 9: e58026. Published online 2020 Sep 1. doi: 10.7554/eLife.58026

PMCID:: PMC7462613

Abstract Article PDF–3.9M

Select item 744661417.

Vitamin K epoxide reductase complex subunit 1 (VKORC1) gene polymorphism as determinant of differences in Covid-19-related disease severity

Rob Janssen, Jona Walk

Med Hypotheses. 2020 Nov; 144: 110218. Published online 2020 Aug 25. doi: 10.1016/j.mehy.2020.110218

PMCID:: PMC7446614

Abstract Article PDF–567K

Select item 742732718.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 739697719.

CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation

Stefan Cristian Vesa, Sonia Irina Vlaicu, Vitalie Vacaras, Sorin Crisan, Octavia Sabin, Sergiu Pasca, Adrian Pavel Trifa, Tamas Rusz-Fogarasi, Madalina Sava, Anca Dana Buzoianu

Genes (Basel) 2020 Jul; 11(7): 822. Published online 2020 Jul 20. doi: 10.3390/genes11070822

PMCID:: PMC7396977

Abstract Article PDF–671K

Select item 736383520.

The effect of the VKORC1 promoter variant on warfarin responsiveness in the Saudi WArfarin Pharmacogenetic (SWAP) cohort

Maha Al Ammari, Mohammed AlBalwi, Khizra Sultana, Ibrahim B. Alabdulkareem, Bader Almuzzaini, Nada S. Almakhlafi, Mohammed Aldrees, Jahad Alghamdi

Sci Rep. 2020; 10: 11613. Published online 2020 Jul 15. doi: 10.1038/s41598-020-68519-9

PMCID:: PMC7363835

Abstract Article PDF–1.0M

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