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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 97039422.

Mouse models of NADK2 deficiency analyzed for metabolic and gene expression changes to elucidate pathophysiology

G C Murray, P Bais, C L Hatton, A L D Tadenev, B R Hoffmann, T J Stodola, K H Morelli, S L Pratt, D Schroeder, R Doty, O Fiehn, S W M John, C J Bult, G A Cox, R W Burgess

Hum Mol Genet. 2022 Dec 1; 31(23): 4055–4074. Published online 2022 Jul 7. doi: 10.1093/hmg/ddac151

PMCID:: PMC9703942

Abstract Article PDF–3.4M

Select item 96976573.

iPLA2β-Null Mice Show HCC Protection by an Induction of Cell-Cycle Arrest after Diethylnitrosamine Treatment

Adriana Andrade, Tanja Poth, Alexander Brobeil, Uta Merle, Walee Chamulitrat

Int J Mol Sci. 2022 Nov; 23(22): 13760. Published online 2022 Nov 9. doi: 10.3390/ijms232213760

PMCID:: PMC9697657

Abstract Article PDF–1.7M

Select item 82279994.

iPLA₂β Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury

Tingting Jin, Jun Lin, Yingchao Gong, Xukun Bi, Shasha Hu, Qingbo Lv, Jiaweng Chen, Xiaoting Li, Jiaqi Chen, Wenbin Zhang, Meihui Wang, Guosheng Fu

Cells. 2021 Jun; 10(6): 1446. Published online 2021 Jun 9. doi: 10.3390/cells10061446

PMCID:: PMC8227999

Abstract Article PDF–51M

Select item 82061555.

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

Delin Chen, Bo Chu, Xin Yang, Zhaoqi Liu, Ying Jin, Ning Kon, Raul Rabadan, Xuejun Jiang, Brent R. Stockwell, Wei Gu

Nat Commun. 2021; 12: 3644. Published online 2021 Jun 15. doi: 10.1038/s41467-021-23902-6

PMCID:: PMC8206155

Abstract Article PDF–3.0M

Select item 79594956.

PLA2G6 guards placental trophoblasts against ferroptotic injury

Ofer Beharier, Vladimir A. Tyurin, Julie P. Goff, Jennifer Guerrero-Santoro, Kazuhiro Kajiwara, Tianjiao Chu, Yulia Y. Tyurina, Claudette M. St Croix, Callen T. Wallace, Samuel Parry, W. Tony Parks, Valerian E. Kagan, Yoel Sadovsky

Proc Natl Acad Sci U S A. 2020 Nov 3; 117(44): 27319–27328. Published online 2020 Oct 21. doi: 10.1073/pnas.2009201117

PMCID:: PMC7959495

Abstract Article PDF–3.2M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 77035708.

Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages

Ajay Suresh Akhade, Shaikh M. Atif, Bhavana S. Lakshmi, Neha Dikshit, Kelly T. Hughes, Ayub Qadri, Naeha Subramanian

Proc Natl Acad Sci U S A. 2020 Nov 24; 117(47): 29811–29822. Published online 2020 Nov 11. doi: 10.1073/pnas.2002747117

PMCID:: PMC7703570

Abstract Article PDF–1.8M

Select item 76029699.

Metabolic Effects of Selective Deletion of Group VIA Phospholipase A₂ from Macrophages or Pancreatic Islet Beta-Cells

John Turk, Haowei Song, Mary Wohltmann, Cheryl Frankfater, Xiaoyong Lei, Sasanka Ramanadham

Biomolecules. 2020 Oct; 10(10): 1455. Published online 2020 Oct 17. doi: 10.3390/biom10101455

PMCID:: PMC7602969

Abstract Article PDF–4.3M

Select item 756596810.

Rescue of Hepatic Phospholipid Remodeling Defect in iPLA₂β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver

Walee Chamulitrat, Chutima Jansakun, Huili Li, Gerhard Liebisch

Biomolecules. 2020 Sep; 10(9): 1332. Published online 2020 Sep 17. doi: 10.3390/biom10091332

PMCID:: PMC7565968

Abstract Article PDF–3.2M

Select item 672166011.

iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation

Yanan Ming, Xingya Zhu, Sabine Tuma-Kellner, Alexandra Ganzha, Gerhard Liebisch, Hongying Gan-Schreier, Walee Chamulitrat

Cells. 2019 Aug; 8(8): 879. Published online 2019 Aug 12. doi: 10.3390/cells8080879

PMCID:: PMC6721660

Abstract Article PDF–3.0M

Select item 667185012.

Neuroaxonal Dystrophy Caused by Group VIA Phospholipase A₂ Deficiency in Mice: A Model of Human Neurodegenerative Disease

Koei Shinzawa, Hisae Sumi, Masahito Ikawa, Yosuke Matsuoka, Masaru Okabe, Saburo Sakoda, Yoshihide Tsujimoto

J Neurosci. 2008 Feb 27; 28(9): 2212–2220. doi: 10.1523/JNEUROSCI.4354-07.2008

PMCID:: PMC6671850

Abstract Article PDF–893K

Select item 664313513.

Amorphous solid dispersion of Berberine mitigates apoptosis via iPLA₂β/Cardiolipin/Opa1 pathway in db/db mice and in Palmitate-treated MIN6 β-cells

Junnan Li, Hongwei Du, Meishuang Zhang, Zhi Zhang, Fei Teng, Yali Zhao, Wenyou Zhang, Yang Yu, Linjing Feng, Xinming Cui, Ming Zhang, Tzongshi Lu, Fengying Guan, Li Chen

Int J Biol Sci. 2019; 15(7): 1533–1545. Published online 2019 Jun 2. doi: 10.7150/ijbs.32020

PMCID:: PMC6643135

Abstract Article PDF–2.1M

Select item 662336714.

Neuroaxonal Dystrophy in Calcium-Independent Phospholipase A₂β Deficiency Results from Insufficient Remodeling and Degeneration of Mitochondrial and Presynaptic Membranes

Goichi Beck, Yuki Sugiura, Koei Shinzawa, Shinsuke Kato, Mitsutoshi Setou, Yoshihide Tsujimoto, Saburo Sakoda, Hisae Sumi-Akamaru

J Neurosci. 2011 Aug 3; 31(31): 11411–11420. doi: 10.1523/JNEUROSCI.0345-11.2011

PMCID:: PMC6623367

Abstract Article PDF–7.3M

Select item 645951015.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 645829316.

SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player

Anna Zakrzewicz, Katrin Richter, Dariusz Zakrzewicz, Kathrin Siebers, Jelena Damm, Alisa Agné, Andreas Hecker, J. Michael McIntosh, Walee Chamulitrat, Gabriela Krasteva-Christ, Ivan Manzini, Ritva Tikkanen, Winfried Padberg, Sabina Janciauskiene, Veronika Grau

Front Immunol. 2019; 10: 664. Published online 2019 Apr 4. doi: 10.3389/fimmu.2019.00664

PMCID:: PMC6458293

Abstract Article PDF–1.5M

Select item 590784217.

Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma

Meiyi Li, Chen Li, Wei-Xin Liu, Conghui Liu, Jingru Cui, Qingrun Li, Hong Ni, Yingcheng Yang, Chaochao Wu, Chunlei Chen, Xing Zhen, Tao Zeng, Mujun Zhao, Lei Chen, Jiarui Wu, Rong Zeng, Luonan Chen

J Mol Cell Biol. 2017 Dec; 9(6): 489–503. Published online 2017 Jul 14. doi: 10.1093/jmcb/mjx021

PMCID:: PMC5907842

Abstract Article PDF–1.8M

Select item 509541718.

Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A₂ (iPLA₂) to Promote Microglia Chemotaxis on Laminin

Sang-Hyun Lee, Neetu Sud, Narae Lee, Selvaraj Subramaniyam, Chang Y. Chung

J Biol Chem. 2016 Nov 4; 291(45): 23645–23653. Published online 2016 Sep 21. doi: 10.1074/jbc.M116.732610

PMCID:: PMC5095417

Abstract Article PDF–1.8M

Select item 508774319.

Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA₂β (Group VIA Phospholipase A₂)

Jason W. Ashley, William D. Hancock, Alexander J. Nelson, Robert N. Bone, Hubert M. Tse, Mary Wohltmann, John Turk, Sasanka Ramanadham

J Biol Chem. 2016 Oct 28; 291(44): 23268–23281. Published online 2016 Sep 20. doi: 10.1074/jbc.M116.754945

PMCID:: PMC5087743

Abstract Article PDF–1.8M

Select item 493817120.

Genetic Ablation of Calcium-independent Phospholipase A₂γ Induces Glomerular Injury in Mice

Hanan Elimam, Joan Papillon, Daniel R. Kaufman, Julie Guillemette, Lamine Aoudjit, Richard W. Gross, Tomoko Takano, Andrey V. Cybulsky

J Biol Chem. 2016 Jul 8; 291(28): 14468–14482. Published online 2016 May 12. doi: 10.1074/jbc.M115.696781

PMCID:: PMC4938171

Abstract Article PDF–3.8M

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