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Select item 114918121.

Na_V1.1 contributes to the cell cycle of human mesenchymal stem cells by regulating AKT and CDK2

Mohammed Fouad Zakaria, Hiroki Kato, Soichiro Sonoda, Kenichi Kato, Norihisa Uehara, Yukari Kyumoto-Nakamura, Mohammed Majd Sharifa, Liting Yu, Lisha Dai, Haruyoshi Yamaza, Shunichi Kajioka, Fusanori Nishimura, Takayoshi Yamaza

J Cell Sci. 2024 Oct 1; 137(19): jcs261732. Published online 2024 Oct 10. doi: 10.1242/jcs.261732

PMCID:: PMC11491812

Abstract Article

Select item 113877702.

CRLF1 bridges AKT and mTORC2 through SIN1 to inhibit pyroptosis and enhance chemo-resistance in ovarian cancer

Cong Xiang, Li Chen, Shilei Zhu, Yue Chen, Haodong Huang, Chunmao Yang, Yugang Chi, Yanzhou Wang, Yunlong Lei, Xiongwei Cai

Cell Death Dis. 2024 Sep; 15(9): 662. Published online 2024 Sep 10. doi: 10.1038/s41419-024-07035-4

PMCID:: PMC11387770

Abstract Article PDF–6.3M

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111587264.

Concomitant activation of AKT with extracellular‐regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss

Noriko Mori, Satoru Kyo, Junko Sakaguchi, Yasunari Mizumoto, Satoshi Ohno, Yoshiko Maida, Manabu Hashimoto, Masahiro Takakura, Masaki Inoue

Cancer Sci. 2007 Dec; 98(12): 1881–1888. Published online 2007 Oct 9. doi: 10.1111/j.1349-7006.2007.00630.x

PMCID:: PMC11158726

Abstract Article PDF–2.2M

Select item 111586395.

Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs

Miyako Yanagihara, Masayoshi Katano, Noriko Takahashi‐Sasaki, Kiyonori Kimata, Kazunari Taira, Toshiwo Andoh

Cancer Sci. 2005 Sep; 96(9): 620–626. Published online 2005 Aug 26. doi: 10.1111/j.1349-7006.2005.00088.x

PMCID:: PMC11158639

Abstract Article PDF–189K

Select item 111584836.

Increased phosphorylation of Akt in triple‐negative breast cancers

Shinobu Umemura, Sei Yoshida, Yoshikazu Ohta, Kenichiro Naito, R. Yoshiyuki Osamura, Yutaka Tokuda

Cancer Sci. 2007 Dec; 98(12): 1889–1892. Published online 2007 Sep 24. doi: 10.1111/j.1349-7006.2007.00622.x

PMCID:: PMC11158483

Abstract Article PDF–666K

Select item 111582907.

Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer

Fusanori Yotsumoto, Tatsuya Fukami, Hiroshi Yagi, Akihiro Funakoshi, Toshiyuki Yoshizato, Masahide Kuroki, Shingo Miyamoto

Cancer Sci. 2010 Nov; 101(11): 2351–2360. Published online 2010 Jul 7. doi: 10.1111/j.1349-7006.2010.01671.x

PMCID:: PMC11158290

Abstract Article PDF–769K

Select item 111582248.

Roles of AKT1 and AKT2 in non‐small cell lung cancer cell survival, growth, and migration

Myoung W. Lee, Dae S. Kim, Joo H. Lee, Bum S. Lee, Soo H. Lee, Hye L. Jung, Ki W. Sung, Heung T. Kim, Keon H. Yoo, Hong H. Koo

Cancer Sci. 2011 Oct; 102(10): 1822–1828. Published online 2011 Aug 5. doi: 10.1111/j.1349-7006.2011.02025.x

PMCID:: PMC11158224

Abstract Article PDF–1.7M

Select item 111426409.

Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

Jiali Chen, Qinghe Zeng, Xu Wang, Rui Xu, Weidong Wang, Yuliang Huang, Qi Sun, Wenhua Yuan, Pinger Wang, Di Chen, Peijian Tong, Hongting Jin

eLife. 2024; 13: RP93087. Published online 2024 May 31. doi: 10.7554/eLife.93087

PMCID:: PMC11142640

Abstract Article PDF–17M

Select item 1113890510.

Role of Akt/protein kinase B in the activity of transcriptional coactivator p300

J. Chen, S. S. Halappanavar, J. R. St-Germain, B. K. Tsang, Q. Li

Cell Mol Life Sci. 2004 Jun; 61(13): 1675–1683. doi: 10.1007/s00018-004-4103-9

PMCID:: PMC11138905

Abstract Article PDF–406K

Select item 1113773611.

A miRNA-21-Mediated PTEN/Akt/NF-κB Axis Promotes Chronic Obstructive Pulmonary Disease Pathogenesis

Xiaoyan Sai, Chu Qin, Zixiao Zhang, Haoda Yu, Tao Bian

Int J Chron Obstruct Pulmon Dis. 2024; 19: 1141–1151. Published online 2024 May 25. doi: 10.2147/COPD.S453593

PMCID:: PMC11137736

Abstract Article PDF–5.5M

Select item 1113603512.

Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB

S. Facchin, M. Ruzzene, C. Peggion, G. Sartori, G. Carignani, O. Marin, F. Brustolon, R. Lopreiato, L. A. Pinna

Cell Mol Life Sci. 2007 Oct; 64(19-20): 2680. Published online 2007 Aug 23. doi: 10.1007/s00018-007-7179-7

PMCID:: PMC11136035

Abstract Article PDF–409K

Select item 1111352513.

Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27^KIP1/p15^INK4b signaling

Shuang Liu, Xinyue Wang, Qian Zhao, Shu Liu, Huishan Zhang, Junchao Shi, Na Li, Xiaohua Lei, Huashan Zhao, Zhili Deng, Yujing Cao, Lina Ning, Guoliang Xia, Enkui Duan

Cell Mol Life Sci. 2015 Aug; 72(15): 2949–2960. Published online 2015 Mar 10. doi: 10.1007/s00018-015-1877-3

PMCID:: PMC11113525

Abstract Article PDF–5.7M

Select item 1111350514.

Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas

Lili Li, Jianming Ying, Xin Tong, Lan Zhong, Xianwei Su, Tingxiu Xiang, Xingsheng Shu, Rong Rong, Lei Xiong, Hongyu Li, Anthony T. C. Chan, Richard F. Ambinder, Yajun Guo, Qian Tao

Cell Mol Life Sci. 2014 Jun; 71(11): 2179–2192. Published online 2013 Oct 25. doi: 10.1007/s00018-013-1485-z

PMCID:: PMC11113505

Abstract Article PDF–4.5M

Select item 1110565915.

Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia

Dominik C. Fuhrmann, Ilka Wittig, Stefan Dröse, Tobias Schmid, Nathalie Dehne, Bernhard Brüne

Cell Mol Life Sci. 2018 Aug; 75(16): 3051–3067. Published online 2018 Feb 20. doi: 10.1007/s00018-018-2779-y

PMCID:: PMC11105659

Abstract Article PDF–4.5M

Select item 1110532616.

Henriikka Kentala, Annika Koponen, Helena Vihinen, Juho Pirhonen, Gerhard Liebisch, Zoltan Pataj, Annukka Kivelä, Shiqian Li, Leena Karhinen, Eeva Jääskeläinen, Robert Andrews, Leena Meriläinen, Silke Matysik, Elina Ikonen, You Zhou, Eija Jokitalo, Vesa M. Olkkonen

Cell Mol Life Sci. 2018 Nov; 75(21): 4041–4057. Published online 2018 Jun 12. doi: 10.1007/s00018-018-2850-8