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Select item 102297431.

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN

Kaini Zhang, Chen Yang, Xin Zhou, Jin Liang, Jianjin Guo, Min Li, Yi Zhang, Shulin Shao, Peng Sun, Kai Li, Jingjing Huang, Fang Chen, Xiubin Liang, Dongming Su

Cell Mol Life Sci. 2023 Jun; 80(6): 168. Published online 2023 May 30. doi: 10.1007/s00018-023-04820-w

PMCID:: PMC10229743

Abstract Article PDF–2.9M

Select item 101561752.

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes

Kheewoong Baek, Daniel C. Scott, Lukas T. Henneberg, Moeko T. King, Matthias Mann, Brenda A. Schulman

Cell. 2023 Apr 27; 186(9): 1895–1911.e21. doi: 10.1016/j.cell.2023.02.035

Correction in:: Cell. 2023 May 25; 186(11): 2492.

PMCID:: PMC10156175

Abstract Article

Select item 100226863.

Myosin-X recruits lamellipodin to filopodia tips

Ana Popović, Mitro Miihkinen, Sujan Ghimire, Rafael Saup, Max L. B. Grönloh, Neil J. Ball, Benjamin T. Goult, Johanna Ivaska, Guillaume Jacquemet

J Cell Sci. 2023 Mar 1; 136(5): jcs260574. Published online 2023 Mar 2. doi: 10.1242/jcs.260574

PMCID:: PMC10022686

Abstract Article

Select item 97933594.

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

Saisai Guo, Xiaobo Lei, Yan Chang, Jianyuan Zhao, Jing Wang, Xiaojing Dong, Qian Liu, Zixiong Zhang, Lidan Wang, Dongrong Yi, Ling Ma, Quanjie Li, Yongxin Zhang, Jiwei Ding, Chen Liang, Xiaoyu Li, Fei Guo, Jianwei Wang, Shan Cen

Signal Transduct Target Ther. 2022; 7: 400. Published online 2022 Dec 27. doi: 10.1038/s41392-022-01239-w

PMCID:: PMC9793359

Abstract Article PDF–3.7M

Select item 97475865.

The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection

MuChun Tsai, Wissam Osman, Jessica Adair, Rabab ElMergawy, Lexie Chafin, Finny Johns, Daniela Farkas, Ajit Elhance, James Londino, Rama K. Mallampalli

J Biol Chem. 2022 Dec; 298(12): 102698. Published online 2022 Nov 13. doi: 10.1016/j.jbc.2022.102698

PMCID:: PMC9747586

Abstract Article PDF–2.6M

Select item 93941196.

Fbxo45‐mediated NP‐STEP₄₆ degradation via K6‐linked ubiquitination sustains ERK activity in lung cancer

Qian Wang, Ci Xu, Renjie Cai, Weishu An, Haihua Yuan, Ming Xu

Mol Oncol. 2022 Aug; 16(16): 3017–3033. Published online 2022 Aug 5. doi: 10.1002/1878-0261.13290

PMCID:: PMC9394119

Abstract Article PDF–7.4M

Select item 93205527.

E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism

Jun Shao, Qian Feng, Weifan Jiang, Yuting Yang, Zhiqiang Liu, Liang Li, Wenlong Yang, Yufeng Zou

Aging (Albany NY) 2022 Jul 15; 14(13): 5493–5510. Published online 2022 Jul 8. doi: 10.18632/aging.204163

PMCID:: PMC9320552

Abstract Article PDF–1.8M

Select item 91714118.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910523510.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 891832211.

Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation

Linhui Wu, Ke Yu, Kai Chen, Xuelian Zhu, Zheng Yang, Qi Wang, Junjie Gao, Yingying Wang, Tong Cao, Hui Xu, Xueshan Pan, Lixia Wang, Jun Xia, Yuyun Li, Zhiwei Peter Wang, Jia Ma

Cell Death Dis. 2022 Mar; 13(3): 231. Published online 2022 Mar 12. doi: 10.1038/s41419-022-04675-2

PMCID:: PMC8918322

Abstract Article PDF–5.2M

Select item 864194712.

Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

Xiao-Tong Lin, Hong-Qiang Yu, Lei Fang, Ye Tan, Ze-Yu Liu, Di Wu, Jie Zhang, Hao-Jun Xiong, Chuan-Ming Xie

eLife. 2021; 10: e70715. Published online 2021 Nov 15. doi: 10.7554/eLife.70715

PMCID:: PMC8641947

Abstract Article PDF–10M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810667714.

DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1

Hye-Youn Kim, Young-Mi Kim, Suntaek Hong

Cell Death Dis. 2021 May; 12(5): 461. Published online 2021 May 8. doi: 10.1038/s41419-021-03757-x

PMCID:: PMC8106677

Abstract Article PDF–5.1M

Select item 742732715.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 720600816.

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation

Kai T. Richter, Yvonne T. Kschonsak, Barbara Vodicska, Ingrid Hoffmann

Cell Death Differ. 2020 Feb; 27(2): 758–772. Published online 2019 Jul 8. doi: 10.1038/s41418-019-0385-7

PMCID:: PMC7206008

Abstract Article PDF–2.8M

Select item 613095017.

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

Muriel Desbois, Oliver Crawley, Paul R. Evans, Scott T. Baker, Ikuo Masuho, Ryohei Yasuda, Brock Grill

J Biol Chem. 2018 Sep 7; 293(36): 13897–13909. Published online 2018 Jul 11. doi: 10.1074/jbc.RA118.002176

PMCID:: PMC6130950

Abstract Article PDF–2.5M

Select item 571159518.

Composition and regulation of the cellular repertoire of SCF ubiquitin ligases

Justin M. Reitsma, Xing Liu, Kurt M. Reichermeier, Annie Moradian, Michael J. Sweredoski, Sonja Hess, Raymond J. Deshaies

Cell. Author manuscript; available in PMC 2018 Nov 30.

Published in final edited form as: Cell. 2017 Nov 30; 171(6): 1326–1339.e14. Published online 2017 Nov 2. doi: 10.1016/j.cell.2017.10.016

PMCID:: PMC5711595

Abstract Article PDF–2.4M

Select item 554076119.

Naturally Generated Decoy of the Prostate Apoptosis Response-4 Protein Overcomes Therapy Resistance in Tumors

Nikhil Hebbar, Ravshan Burikhanov, Nidhi Shukla, Shirley Qiu, Yanming Zhao, Kojo S. J. Elenitoba-Johnson, Vivek M. Rangnekar

Cancer Res. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Cancer Res. 2017 Aug 1; 77(15): 4039–4050. Published online 2017 Jun 16. doi: 10.1158/0008-5472.CAN-16-1970

PMCID:: PMC5540761

Abstract Article PDF–1014K

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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