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Items: 1 to 20 of 43

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection
Fabio V. Marinho, Camila Brito, Ana Carolina V. S. C. de Araujo, Sergio C. Oliveira
Front Immunol. 2024; 15: 1341464. Published online 2024 Feb 8. doi: 10.3389/fimmu.2024.1341464
PMCID:
PMC10885698
AbstractArticlePDF–5.3M
3.
Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis
Jangho Lee, Ji-Hye Song, Jae-Ho Park, Min-Yu Chung, Seung-Hyun Lee, Sae-Bom Jeon, So Hee Park, Jin-Taek Hwang, Hyo-Kyoung Choi
Exp Mol Med. 2023 Jan; 55(1): 143–157. Published online 2023 Jan 6. doi: 10.1038/s12276-022-00919-5
PMCID:
PMC9898513
AbstractArticlePDF–5.7M
4.
Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2
Jennifer Loschwitz, Nora Steffens, Xue Wang, Moritz Schäffler, Klaus Pfeffer, Daniel Degrandi, Birgit Strodel
Sci Rep. 2023; 13: 679. Published online 2023 Jan 13. doi: 10.1038/s41598-023-27520-8
PMCID:
PMC9839784
AbstractArticlePDF–7.0M
5.
Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling
Shouya Feng, Daniel Enosi Tuipulotu, Abhimanu Pandey, Weidong Jing, Cheng Shen, Chinh Ngo, Melkamu B. Tessema, Fei-Ju Li, Daniel Fox, Anukriti Mathur, Anyang Zhao, Runli Wang, Klaus Pfeffer, Daniel Degrandi, Masahiro Yamamoto, Patrick C. Reading, Gaetan Burgio, Si Ming Man
Nat Commun. 2022; 13: 4395. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32127-0
PMCID:
PMC9338265
AbstractArticlePDF–3.0M
6.
Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target
Haizhou Wang, Yabo Zhou, Yangyang Zhang, Shilin Fang, Meng Zhang, Haiou Li, Fei Xu, Lan Liu, Jing Liu, Qiu Zhao, Fan Wang
J Immunother Cancer. 2022; 10(4): e004302. Published online 2022 Apr 5. doi: 10.1136/jitc-2021-004302
PMCID:
PMC8984016
AbstractArticlePDF–15M
7.
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi, James P. Cooney, Kathryn C. Davidson, Mary Speir, Tirta M. Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A. Conos, Hazel Tye, Seong H. Chow, Arfatur Rahman, Raymond S. Norton, Thomas Naderer, Sandra E. Nicholson, Gaetan Burgio, Si Ming Man, Joanna R. Groom, Marco J. Herold, Edwin D. Hawkins, Kate E. Lawlor, Andreas Strasser, John Silke, Marc Pellegrini, Hamid Kashkar, Rebecca Feltham, James E. Vince
Immunity. 2022 Mar 8; 55(3): 423–441.e9. Published online 2022 Feb 8. doi: 10.1016/j.immuni.2022.01.003
PMCID:
PMC8822620
AbstractArticlePDF–6.5M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
David E. Place, R. K. Subbarao Malireddi, Jieun Kim, Peter Vogel, Masahiro Yamamoto, Thirumala-Devi Kanneganti
Nat Commun. 2021; 12: 496. Published online 2021 Jan 21. doi: 10.1038/s41467-020-20807-8
PMCID:
PMC7820603
AbstractArticlePDF–5.2M
10.
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar, Evan Peter Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, Balaji Banoth, R.K. Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel, Richard Webby, Colleen Beth Jonsson, Thirumala-Devi Kanneganti
Cell. 2021 Jan 7; 184(1): 149–168.e17. Published online 2020 Nov 19. doi: 10.1016/j.cell.2020.11.025
PMCID:
PMC7674074
AbstractArticlePDF–9.9M
11.
Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7
Peifa Yu, Yang Li, Yunlong Li, Zhijiang Miao, Maikel P. Peppelenbosch, Qiuwei Pan
J Biol Chem. 2020 Jun 5; 295(23): 8036–8047. Published online 2020 Apr 30. doi: 10.1074/jbc.RA120.013544
PMCID:
PMC7278355
AbstractArticlePDF–3.0M
12.
Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion
David E. Place, Benoit Briard, Parimal Samir, Rajendra Karki, Anannya Bhattacharya, Clifford S. Guy, Jennifer L. Peters, Sharon Frase, Peter Vogel, Geoffrey Neale, Masahiro Yamamoto, Thirumala-Devi Kanneganti
PLoS Pathog. 2020 Mar; 16(3): e1008364. Published online 2020 Mar 9. doi: 10.1371/journal.ppat.1008364
PMCID:
PMC7082077
AbstractArticlePDF–6.9M
13.
Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection
Nora Steffens, Cornelia Beuter-Gunia, Elisabeth Kravets, Artur Reich, Larissa Legewie, Klaus Pfeffer, Daniel Degrandi
mBio. 2020 Jan-Feb; 11(1): e02993-19. Published online 2020 Jan 21. doi: 10.1128/mBio.02993-19
PMCID:
PMC6974569
AbstractArticlePDF–4.3M
14.
TCR affinity biases Th cell differentiation by regulating CD25, Eef1e1, and Gbp2
Dmitri I. Kotov, Jason S. Mitchell, Thomas Pengo, Christiane Ruedl, Sing Sing Way, Ryan A. Langlois, Brian T. Fife, Marc K. Jenkins
J Immunol. Author manuscript; available in PMC 2020 May 1.
Published in final edited form as: J Immunol. 2019 May 1; 202(9): 2535–2545. Published online 2019 Mar 11. doi: 10.4049/jimmunol.1801609
PMCID:
PMC6478541
AbstractArticlePDF–1.7M
15.
TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis
Yiting Tang, Rui Zhang, Qianqian Xue, Ran Meng, Xiangyu Wang, Yanliang Yang, Lingli Xie, Xianzhong Xiao, Timothy R. Billiar, Ben Lu
Mol Med. 2018; 24: 66. Published online 2018 Dec 27. doi: 10.1186/s10020-018-0065-y
PMCID:
PMC6307235
AbstractArticlePDF–3.9M
16.
Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa
Arjun Balakrishnan, Rajendra Karki, Brent Berwin, Masahiro Yamamoto, Thirumala-Devi Kanneganti
Cell Death Discov. 2018; 4: 66. Published online 2018 Jun 27. doi: 10.1038/s41420-018-0068-z
Correction in:
Cell Death Discov. 2019; 5: 116.
PMCID:
PMC6060091
AbstractArticlePDF–1.7M
17.
LPS targets host guanylate‐binding proteins to the bacterial outer membrane for non‐canonical inflammasome activation
José Carlos Santos, Mathias S Dick, Brice Lagrange, Daniel Degrandi, Klaus Pfeffer, Masahiro Yamamoto, Etienne Meunier, Pawel Pelczar, Thomas Henry, Petr Broz
EMBO J. 2018 Mar 15; 37(6): e98089. Published online 2018 Feb 19. doi: 10.15252/embj.201798089
PMCID:
PMC5852652
AbstractArticlePDF–2.3M
18.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
19.
IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11–NLRP3 inflammasomes
Si Ming Man, Rajendra Karki, Miwa Sasai, David E. Place, Sannula Kesavardhana, Jamshid Temirov, Sharon Frase, Qifan Zhu, R.K. Subbarao Malireddi, Teneema Kuriakose, Jennifer L. Peters, Geoffrey Neale, Scott A. Brown, Masahiro Yamamoto, Thirumala-Devi Kanneganti
Cell. Author manuscript; available in PMC 2017 Oct 6.
Published in final edited form as: Cell. 2016 Oct 6; 167(2): 382–396.e17. Published online 2016 Sep 29. doi: 10.1016/j.cell.2016.09.012
PMCID:
PMC5074697
AbstractArticlePDF–3.5M
20.
The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation
David Langlais, Luis B. Barreiro, Philippe Gros
J Exp Med. 2016 Apr 4; 213(4): 585–603. doi: 10.1084/jem.20151764
PMCID:
PMC4821649
AbstractArticlePDF–3.1M

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