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Select item 107089241.

EYA2 tyrosine phosphatase inhibition reduces MYC and prevents medulloblastoma progression

Arthur R Wolin, Melanie Y Vincent, Taylor Hotz, Stephen C Purdy, Sheera R Rosenbaum, Connor J Hughes, Jessica Y Hsu, Michael U J Oliphant, Brock Armstrong, Veronica Wessells, Marileila Varella-Garcia, Matthew D Galbraith, Angela Pierce, Dong Wang, Sujatha Venkataraman, Etienne Danis, Bethany Veo, Natalie Serkova, Joaquin M Espinosa, Daniel L Gustafson, Rajeev Vibhakar, Heide L Ford

Neuro Oncol. 2023 Dec; 25(12): 2287–2301. Published online 2023 Jul 24. doi: 10.1093/neuonc/noad128

PMCID:: PMC10708924

Abstract Article PDF–25M

Select item 88199612.

Structure–activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase

Jothi Anantharajan, Nithya Baburajendran, Grace Lin, Yong Yao Loh, Weijun Xu, Nur Huda Binte Ahmad, Shuang Liu, Anna E. Jansson, John Wee Liang Kuan, Elizabeth Yihui Ng, Yee Khoon Yeo, Alvin W. Hung, Joma Joy, Jeffrey Hill, Heide L. Ford, Rui Zhao, Thomas H. Keller, CongBao Kang

Protein Sci. 2022 Feb; 31(2): 422–431. Published online 2021 Nov 18. doi: 10.1002/pro.4234

PMCID:: PMC8819961

Abstract Article PDF–2.7M

Select item 85041853.

Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe

Guoxin Zhang, Zhen Dong, Ryan C. Gimple, Arthur Wolin, Qiulian Wu, Zhixin Qiu, Lisa M. Wood, Jia Z. Shen, Li Jiang, Linjie Zhao, Deguan Lv, Briana C. Prager, Leo J.Y. Kim, Xiuxing Wang, Lingdi Zhang, Ryan L. Anderson, Jeffrey K. Moore, Shideng Bao, Thomas H. Keller, Grace Lin, Congbao Kang, Petra Hamerlik, Rui Zhao, Heide L. Ford, Jeremy N. Rich

J Exp Med. 2021 Nov 1; 218(11): e20202669. Published online 2021 Oct 7. doi: 10.1084/jem.20202669

PMCID:: PMC8504185

Abstract Article PDF–12M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81577595.

EYA2 suppresses the progression of hepatocellular carcinoma via SOCS3-mediated blockade of JAK/STAT signaling

Ze-Kun Liu, Can Li, Ren-Yu Zhang, Ding Wei, Yu-Kui Shang, Yu-Le Yong, Ling-Min Kong, Nai-Shan Zheng, Ke Liu, Meng Lu, Man Liu, Cai-Xia Hu, Xiao-Zhen Yang, Zhi-Nan Chen, Huijie Bian

Mol Cancer. 2021; 20: 79. Published online 2021 May 27. doi: 10.1186/s12943-021-01377-9

PMCID:: PMC8157759

Abstract Article PDF–4.8M

Select item 71699836.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 66014947.

Eya2 Is Overexpressed in Human Prostate Cancer and Regulates Docetaxel Sensitivity and Mitochondrial Membrane Potential through AKT/Bcl-2 Signaling

Zhongyuan Liu, Long Zhao, Yongsheng Song

Biomed Res Int. 2019; 2019: 3808432. Published online 2019 Jun 16. doi: 10.1155/2019/3808432

PMCID:: PMC6601494

Abstract Article PDF–2.4M

Select item 56634658.

A Global Analysis of The Receptor Tyrosine Kinase – Protein Phosphatase Interactome

Zhong Yao, Katelyn Darowski, Nicole St-Denis, Victoria Wong, Fabian Offensperger, Annabel Villedieu, Shahreen Amin, Ramy Malty, Hiroyuki Aoki, Hongbo Guo, Yang Xu, Caterina Iorio, Max Kotlyar, Andrew Emili, Igor Jurisica, Benjamin G Neel, Mohan Babu, Anne-Claude Gingras, Igor Stagljar

Mol Cell. Author manuscript; available in PMC 2017 Oct 31.

Published in final edited form as: Mol Cell. 2017 Jan 19; 65(2): 347–360. Published online 2017 Jan 5. doi: 10.1016/j.molcel.2016.12.004

PMCID:: PMC5663465

Abstract Article PDF–2.1M

Select item 56278749.

Eya2 overexpression promotes the invasion of human astrocytoma through the regulation of ERK/MMP9 signaling

Zhifeng Wen, Chuansheng Liang, Qichen Pan, Yunjie Wang

Int J Mol Med. 2017 Nov; 40(5): 1315–1322. Published online 2017 Sep 13. doi: 10.3892/ijmm.2017.3132

PMCID:: PMC5627874

Abstract Article PDF–1020K

Select item 555087010.

The EGFR/miR-338-3p/EYA2 axis controls breast tumor growth and lung metastasis

Yingchun Liang, Xiaojie Xu, Tao Wang, Ying Li, Wenye You, Jing Fu, Yang Liu, Shuai Jin, Quanbo Ji, Wei Zhao, Qi Song, Ling Li, Tian Hong, Junjian Huang, Zhaohui Lyu, Qinong Ye

Cell Death Dis. 2017 Jul; 8(7): e2928. Published online 2017 Jul 13. doi: 10.1038/cddis.2017.325

PMCID:: PMC5550870

Abstract Article PDF–4.4M

Select item 554841311.

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling

Parveen Kumar, Prathyusha Munnangi, KVS Rammohan Chowdary, Varun J. Shah, Swapnil R. Shinde, Nanci R. Kolli, Rachita R. Halehalli, Hampapathalu A. Nagarajaram, Subbareddy Maddika

J Proteome Res. 2017 Aug 4; 16(8): 2789–2801. Published online 2017 Jul 4. doi: 10.1021/acs.jproteome.7b00065

PMCID:: PMC5548413

Abstract Article PDF–5.2M

Select item 553161112.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 547283513.

Eya2, a Target Activated by Plzf, Is Critical for PLZF-RARA-Induced Leukemogenesis

Ryoichi Ono, Masahiro Masuya, Satomi Ishii, Naoyuki Katayama, Tetsuya Nosaka

Mol Cell Biol. 2017 Jul 1; 37(13): e00585-16. Prepublished online 2017 Apr 17. Published online 2017 Jun 15. doi: 10.1128/MCB.00585-16

PMCID:: PMC5472835

Abstract Article PDF–5.9M

Select item 501331514.

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family

Xu Li, Kim My Tran, Kathryn E. Aziz, Alexey V. Sorokin, Junjie Chen, Wenqi Wang

Mol Cell Proteomics. 2016 Sep; 15(9): 3030–3044. Published online 2016 Jul 18. doi: 10.1074/mcp.M116.060277

PMCID:: PMC5013315

Abstract Article PDF–3.2M

Select item 488513215.

Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2

Yuncang Yuan, Shangyong Zheng, Qian Li, Xudong Xiang, Tangxin Gao, Pengzhan Ran, Lijuan Sun, Qionglin Huang, Fei Xie, Jing Du, Chunjie Xiao

Acta Biochim Biophys Sin (Shanghai) 2016 Mar; 48(3): 220–228. Published online 2016 Feb 1. doi: 10.1093/abbs/gmv139

PMCID:: PMC4885132

Abstract Article PDF–828K

Select item 433654016.

The SIX1-EYA transcriptional complex as a therapeutic target in cancer

Melanie A Blevins, Christina Garlington Towers, Aaron N. Patrick, Rui Zhao, Heide L. Ford

Expert Opin Ther Targets. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Expert Opin Ther Targets. 2015 Feb; 19(2): 213–225. Published online 2015 Jan 2. doi: 10.1517/14728222.2014.978860

PMCID:: PMC4336540

Abstract Article PDF–543K

Select item 405802817.

Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth

Audrey Vincent, Seung-Mo Hong, Chaoxin Hu, Noriyuki Omura, Angela Young, Haeryoung Kim, Jun Yu, Spencer Knight, Michael Ayars, Margaret Griffith, Isabelle Van Seuningen, Anirban Maitra, Michael Goggins

Oncotarget. 2014 May; 5(9): 2575–2587. Published online 2014 Mar 22. doi: 10.18632/oncotarget.1842

PMCID:: PMC4058028

Abstract Article PDF–4.6M

Select item 404894218.

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

Suk-Kyeong Jung, Dae Gwin Jeong, Sang J. Chung, Jae Hoon Kim, Byoung Chul Park, Nicholas K. Tonks, Seong Eon Ryu, Seung Jun Kim

FASEB J. 2010 Feb; 24(2): 560–569. doi: 10.1096/fj.09-143891

PMCID:: PMC4048942

Abstract Article

Select item 392573619.

CDK6 binds and promotes the degradation of the EYA2 protein

Dawn Kohrt, Jennifer Crary, Marc Zimmer, Aaron N Patrick, Heide L Ford, Philip W Hinds, Martha J Grossel

Cell Cycle. 2014 Jan 1; 13(1): 62–71. Published online 2013 Oct 12. doi: 10.4161/cc.26755

PMCID:: PMC3925736

Abstract Article PDF–1.2M

Select item 381232420.

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans

J L Del-Aguila, A L Beitelshees, R M Cooper-DeHoff, A B Chapman, J G Gums, K Bailey, Y Gong, S T Turner, J A Johnson, E Boerwinkle

Pharmacogenomics J. 2014 Feb; 14(1): 35–40. Published online 2013 Feb 12. doi: 10.1038/tpj.2013.3

PMCID:: PMC3812324

Abstract Article PDF–662K

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