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Select item 106436741.

UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis

Christophe Le Clorennec, Divya Subramonian, Yuchen Huo, Peter E. Zage

Cell Death Dis. 2023 Nov; 14(11): 739. Published online 2023 Nov 13. doi: 10.1038/s41419-023-06252-7

PMCID:: PMC10643674

Abstract Article PDF–10M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 102350803.

A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling

Yingcheng Lyu, Binghua Tan, Lin Li, Ruihao Liang, Kai Lei, Kefeng Wang, Duoguang Wu, Huayue Lin, Minghui Wang

Cell Death Dis. 2023 Jun; 14(6): 346. Published online 2023 Jun 1. doi: 10.1038/s41419-023-05865-2

PMCID:: PMC10235080

Abstract Article PDF–12M

Select item 99711814.

The SWIB/MDM2 motif of UBE4B activates the p53 pathway

H. Helena Wu, Sarah Leng, Yasser Abuetabh, Consolato Sergi, David D. Eisenstat, Roger Leng

Mol Ther Nucleic Acids. 2023 Mar 14; 31: 466–481. Published online 2023 Feb 4. doi: 10.1016/j.omtn.2023.02.002

PMCID:: PMC9971181

Abstract Article PDF–4.7M

Select item 98457395.

Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development

Xiangxing Kong, Xin Shu, Jiachuan Wang, Dandan Liu, Yingchun Ni, Weiqi Zhao, Lebo Wang, Zhihua Gao, Jiadong Chen, Bing Yang, Xing Guo, Zhiping Wang

Development. 2022 Dec 15; 149(24): dev201286. Published online 2022 Dec 20. doi: 10.1242/dev.201286

PMCID:: PMC9845739

Abstract Article

Select item 97922146.

Upregulated UBE4B expression correlates with poor prognosis and tumor immune infiltration in hepatocellular carcinoma

Xuyang Shao, Jun Zhu, Yanlong Shi, Hanlu Fang, Jingsi Chen, Yixiao Zhang, Jingyan Wang, Haokun Jian, Sheng Lan, Fei Jiang, Fei Zhong, Yewei Zhang, Chenxi Cao

Aging (Albany NY) 2022 Dec 15; 14(23): 9632–9646. Published online 2022 Dec 5. doi: 10.18632/aging.204414

PMCID:: PMC9792214

Abstract Article PDF–2.1M

Select item 95893717.

SF3B4 Depletion Retards the Growth of A549 Non-Small Cell Lung Cancer Cells via UBE4B-Mediated Regulation of p53/p21 and p27 Expression

Hyungmin Kim, Jeehan Lee, Soon-Young Jung, Hye Hyeon Yun, Jeong-Heon Ko, Jeong-Hwa Lee

Mol Cells. 2022 Oct 31; 45(10): 718–728. Published online 2022 Aug 23. doi: 10.14348/molcells.2022.0037

PMCID:: PMC9589371

Abstract Article PDF–2.3M

Select item 93485768.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92792859.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 926261410.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 916356011.

Differential Degradation of TRA2A and PYCR2 Mediated by Ubiquitin E3 Ligase E4B

Yao Lu, Bo Jiang, Kangli Peng, Shasha Li, Xiangnan Liu, Bufan Wang, Yuntian Chen, Tiepeng Wang, Bo Zhao

Front Cell Dev Biol. 2022; 10: 833396. Published online 2022 May 20. doi: 10.3389/fcell.2022.833396

PMCID:: PMC9163560

Abstract Article PDF–2.1M

Select item 817256412.

UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation

Manivannan Subramanian, Seung Jae Hyeon, Tanuza Das, Yoon Seok Suh, Yun Kyung Kim, Jeong-Soo Lee, Eun Joo Song, Hoon Ryu, Kweon Yu

Nat Commun. 2021; 12: 3291. Published online 2021 Jun 2. doi: 10.1038/s41467-021-23597-9

Correction in:: Nat Commun. 2021; 12: 4257.

PMCID:: PMC8172564

Abstract Article PDF–4.3M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 779042314.

The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation

Suchitra Mohanty, Teng Han, Young Bong Choi, Alfonso Lavorgna, Jiawen Zhang, Edward William Harhaj

PLoS Pathog. 2020 Dec; 16(12): e1008504. Published online 2020 Dec 23. doi: 10.1371/journal.ppat.1008504

PMCID:: PMC7790423

Abstract Article PDF–2.8M

Select item 756688115.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 753013316.

The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion

Monica Gireud-Goss, Sahily Reyes, Ritika Tewari, Anthony Patrizz, Matthew D. Howe, Julia Kofler, M. Neal Waxham, Louise D. McCullough, Andrew J. Bean

Mol Cell Neurosci. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Mol Cell Neurosci. 2020 Oct; 108: 103542. Published online 2020 Aug 22. doi: 10.1016/j.mcn.2020.103542

PMCID:: PMC7530133

Abstract Article PDF–798K

Select item 727904917.

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired

Marioara Chiritoiu, Gabriela N. Chiritoiu, Cristian V. A. Munteanu, Florin Pastrama, N. Erwin Ivessa, Stefana M. Petrescu

Int J Mol Sci. 2020 May; 21(10): 3468. Published online 2020 May 14. doi: 10.3390/ijms21103468

PMCID:: PMC7279049

Abstract Article PDF–12M

Select item 720679318.

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling

Jin Huk Choi, Xue Zhong, William McAlpine, Tzu-Chieh Liao, Duanwu Zhang, Beibei Fang, Jamie Russell, Sara Ludwig, Evan Nair-Gill, Zhao Zhang, Kuan-wen Wang, Takuma Misawa, Xiaoming Zhan, Mihwa Choi, Tao Wang, Xiaohong Li, Miao Tang, Qihua Sun, Liyang Yu, Anne R. Murray, Eva Marie Y. Moresco, Bruce Beutler

Science. Author manuscript; available in PMC 2020 May 8.

Published in final edited form as: Science. 2019 May 10; 364(6440): eaau0812. doi: 10.1126/science.aau0812

PMCID:: PMC7206793

Abstract Article PDF–2.2M

Select item 711512819.

Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan

Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam

Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525

PMCID:: PMC7115128

Abstract Article PDF–1.6M

Select item 680480920.

Low UBE4B expression increases sensitivity of chemoresistant neuroblastoma cells to EGFR and STAT5 inhibition

Kimiya Memarzadeh, David J. Savage, Andrew J. Bean

Cancer Biol Ther. 2019; 20(12): 1416–1429. Published online 2019 Sep 1. doi: 10.1080/15384047.2019.1647049

PMCID:: PMC6804809

Abstract Article PDF–6.4M

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