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Items: 1 to 20 of 41

1.
Structural basis of regulated m7G tRNA modification by METTL1-WDR4
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P. Nowak, Thibault Viennet, Esteban Orellana, Shourya S. Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric Fischer, Richard I. Gregory
Nature. Author manuscript; available in PMC 2024 Jun 15.
Published in final edited form as: Nature. 2023 Jan; 613(7943): 391–397. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05566-4
PMCID:
PMC11179147
AbstractArticlePDF–5.7M
2.
PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target
Shaifali Singh, Nai Yang Yeat, Ya-Ting Wang, Shu-Yu Lin, I-Ying Kuo, Kuen-Phon Wu, Won-Jing Wang, Wen-Ching Wang, Wu-Chou Su, Yi-Ching Wang, Ruey-Hwa Chen
Cell Death Dis. 2023 Oct; 14(10): 671. Published online 2023 Oct 11. doi: 10.1038/s41419-023-06201-4
Correction in:
Cell Death Dis. 2024 Jul; 15(7): 468.
PMCID:
PMC10567730
AbstractArticlePDF–6.4M
3.
Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1
Xiaohuan Jin, Zeyuan Guan, Na Hu, Chunjie He, Ping Yin, Zhou Gong, Delin Zhang
Cell Discov. 2023; 9: 65. Published online 2023 Jun 27. doi: 10.1038/s41421-023-00562-y
PMCID:
PMC10300002
ArticlePDF–974K
4.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
5.
The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia
Sadek Amhaz, Batiste Boëda, Mouna Chouchène, Sabrina Colasse, Florent Dingli, Damarys Loew, Julien Henri, Céline Prunier, Laurence Levy
BMC Biol. 2023; 21: 73. Published online 2023 Apr 7. doi: 10.1186/s12915-023-01576-4
PMCID:
PMC10080908
AbstractArticlePDF–3.2M
6.
Structures and Mechanisms of tRNA Methylation by METTL1-WDR4
Victor M. Ruiz-Arroyo, Rishi Raj, Kesavan Babu, Otgonbileg Onolbaatar, Paul H. Roberts, Yunsun Nam
Nature. Author manuscript; available in PMC 2023 Jul 4.
Published in final edited form as: Nature. 2023 Jan; 613(7943): 383–390. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05565-5
PMCID:
PMC9930641
AbstractArticlePDF–3.4M
7.
Association of RNA m7G Modification Gene Polymorphisms with Pediatric Glioma Risk
Jinhong Zhu, Xiaoping Liu, Wei Chen, Yuxiang Liao, Jiabin Liu, Li Yuan, Jichen Ruan, Jing He
Biomed Res Int. 2023; 2023: 3678327. Published online 2023 Jan 24. doi: 10.1155/2023/3678327
PMCID:
PMC9889142
AbstractArticlePDF–385K
8.
Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation
Pei-Rung Wu, Shang-Yin Chiang, Robert Midence, Wen-Chao Kao, Chun-Lun Lai, I-Cheng Cheng, Shen-Ju Chou, Chih-Cheng Chen, Chih-Yang Huang, Ruey-Hwa Chen
Cell Death Dis. 2023 Jan; 14(1): 52. Published online 2023 Jan 21. doi: 10.1038/s41419-022-05442-z
PMCID:
PMC9867761
AbstractArticlePDF–10M
9.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
10.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
11.
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang
J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009
PMCID:
PMC9058836
AbstractArticlePDF–2.9M
12.
METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression
Jieyi Ma, Hui Han, Ying Huang, Chunlong Yang, Siyi Zheng, Tiancai Cai, Jiong Bi, Xiaohui Huang, Ruiming Liu, Libin Huang, Yifeng Luo, Wen Li, Shuibin Lin
Mol Ther. 2021 Dec 1; 29(12): 3422–3435. Published online 2021 Aug 8. doi: 10.1016/j.ymthe.2021.08.005
PMCID:
PMC8636169
AbstractArticlePDF–4.3M
13.
Aberrant expression of WDR4 affects the clinical significance of cancer immunity in pan-cancer
Hanqian Zeng, Shiwen Xu, Erjie Xia, Suzita Hirachan, Adheesh Bhandari, Yanyan Shen
Aging (Albany NY) 2021 Jul 31; 13(14): 18360–18375. Published online 2021 Jul 19. doi: 10.18632/aging.203284
PMCID:
PMC8351698
AbstractArticlePDF–5.2M
14.
MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma
Peng Xia, Hao Zhang, Kequan Xu, Xiang Jiang, Meng Gao, Ganggang Wang, Yingyi Liu, Ye Yao, Xi Chen, Weijie Ma, Zhonglin Zhang, Yufeng Yuan
Cell Death Dis. 2021 Jul; 12(7): 691. Published online 2021 Jul 9. doi: 10.1038/s41419-021-03973-5
PMCID:
PMC8270967
AbstractArticlePDF–7.0M
15.
Reciprocal interaction between SIRT6 and APC/C regulates genomic stability
Helin Wang, Kangze Feng, Qingtao Wang, Haiteng Deng
Sci Rep. 2021; 11: 14253. Published online 2021 Jul 9. doi: 10.1038/s41598-021-93684-w
PMCID:
PMC8270898
AbstractArticlePDF–2.6M
16.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
17.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
18.
Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development
Pu Wang, Feng Yan, Zhijun Li, Yanbao Yu, Scott E. Parnell, Yue Xiong
J Clin Invest. 2019 Oct 1; 129(10): 4393–4407. Published online 2019 Sep 9. doi: 10.1172/JCI129107
PMCID:
PMC6763242
AbstractArticlePDF–12M
19.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu
Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3
PMCID:
PMC6742646
AbstractArticlePDF–1.2M
20.
Mutations in WDR4 as a new cause of Galloway-Mowat syndrome
Daniela A. Braun, Shirlee Shril, Aditi Sinha, Ronen Schneider, Weizhen Tan, Shazia Ashraf, Tobias Hermle, Tilman Jobst-Schwan, Eugen Widmeier, Amar J. Majmundar, Ankana Daga, Jillian K. Warejko, Makiko Nakayama, David Schapiro, Jing Chen, Merlin Airik, Jia Rao, Johanna Magdalena Schmidt, Charlotte A. Hoogstraten, Hannah Hugo, Jitendra Meena, Monkol Lek, Kristen M. Laricchia, Arvind Bagga, Friedhelm Hildebrandt
Am J Med Genet A. Author manuscript; available in PMC 2019 Nov 1.
Published in final edited form as: Am J Med Genet A. 2018 Nov; 176(11): 2460–2465. Published online 2018 Aug 6. doi: 10.1002/ajmg.a.40489
PMCID:
PMC6289609
AbstractArticlePDF–566K

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