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Items: 1 to 20 of 400

1.
BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway
Elena Prosdocimi, Veronica Carpanese, Luca Matteo Todesca, Tatiana Varanita, Magdalena Bachmann, Margherita Festa, Daniele Bonesso, Mireia Perez-Verdaguer, Andrea Carrer, Angelo Velle, Roberta Peruzzo, Silvia Muccioli, Davide Doni, Luigi Leanza, Paola Costantini, Frank Stein, Mandy Rettel, Antonio Felipe, Michael J. Edwards, Erich Gulbins, Laura Cendron, Chiara Romualdi, Vanessa Checchetto, Ildiko Szabo
Sci Adv. 2024 Sep 6; 10(36): eadn9361. Published online 2024 Sep 4. doi: 10.1126/sciadv.adn9361
PMCID:
PMC11373599
AbstractArticlePDF–11M
2.
SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis
Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Myles C. Hodgson, Luana N. Santos, Samantha Le Sommer, Bin Fang, John M. Koomen, Markus Seeliger, Cheng-Kui Qu, Armelle Yart, Maria I. Kontaridis, Kiran Mahajan, Nupam P. Mahajan
Nat Commun. 2024; 15: 5629. Published online 2024 Jul 4. doi: 10.1038/s41467-024-49978-4
PMCID:
PMC11224269
AbstractArticlePDF–2.1M
3.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
4.
How do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms?
T. Edouard, A. Montagner, M. Dance, F. Conte, A. Yart, B. Parfait, M. Tauber, J. P. Salles, P. Raynal
Cell Mol Life Sci. 2007 Jul; 64(13): 1585–1590. Published online 2007 Apr 23. doi: 10.1007/s00018-007-6509-0
PMCID:
PMC11136329
AbstractArticlePDF–123K
5.
SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD
Sanghyeon Lee, Jungho Kim, Hyun-Hee Ryu, Hanbyul Jang, DoEun Lee, Seungha Lee, Jae-man Song, Yong-Seok Lee, Young Ho Suh
Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2316819121. Published online 2024 Apr 24. doi: 10.1073/pnas.2316819121
PMCID:
PMC11066993
AbstractArticlePDF–4.6M
6.
Spectrum of Mutations in PTPN11 in Russian Cohort
Anna Orlova, Daria Guseva, Nina Demina, Aleksander Polyakov, Oksana Ryzhkova
Genes (Basel) 2024 Mar; 15(3): 345. Published online 2024 Mar 7. doi: 10.3390/genes15030345
PMCID:
PMC10970286
AbstractArticlePDF–942K
7.
Clinical Variability in a Family with Noonan Syndrome with a Homozygous PTPN11 Gene Variant in Two Individuals
Ruken Yıldırım, Edip Ünal, Şervan Özalkak, Akçahan Akalın, Ayça Aykut, Nevzat Yılmaz
J Clin Res Pediatr Endocrinol. 2024 Mar; 16(1): 76–83. Published online 2024 Mar 11. doi: 10.4274/jcrpe.galenos.2023.2023-5-16
PMCID:
PMC10938517
AbstractArticlePDF–503K
8.
M-CSF secreted by gastric cancer cells exacerbates the progression of gastric cancer by increasing the expression of SHP2 in tumor-associated macrophages
Shaohua Zhang, Dongfei Ren, Huiyu Hou, Li Yao, Hufang Yuan
Aging (Albany NY) 2023 Dec 31; 15(24): 15525–15534. Published online 2023 Dec 29. doi: 10.18632/aging.205390
PMCID:
PMC10781482
AbstractArticlePDF–906K
9.
The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China
Jinjun Yang, Lei Zhao, Yu Wu, Ting Niu, Yuping Gong, Xinchuan Chen, Xiaoou Huang, Jiazhuo Liu, Yang Dai, Hongbing Ma
Cancer Med. 2023 Dec; 12(23): 21111–21117. Published online 2023 Nov 8. doi: 10.1002/cam4.6669
PMCID:
PMC10726903
AbstractArticlePDF–1.2M
10.
Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis
Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley
J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295
PMCID:
PMC10641524
AbstractArticlePDF–3.8M
11.
Fgf2 and Ptpn11 play a role in cerebral injury caused by sevoflurane anesthesia
Lin Zhang, Lingyan Xu
Medicine (Baltimore) 2023 Nov 10; 102(45): e36108. Published online 2023 Nov 10. doi: 10.1097/MD.0000000000036108
PMCID:
PMC10637467
AbstractArticlePDF–1.3M
12.
PTPN11 Mosaicism Causes a Spectrum of Pigmentary and Vascular Neurocutaneous Disorders and Predisposes to Melanoma
Satyamaanasa Polubothu, Nicole Bender, Siobhan Muthiah, Davide Zecchin, Charalambos Demetriou, Sara Barberan Martin, Sony Malhotra, Jana Travnickova, Zhiqiang Zeng, Markus Böhm, Sebastien Barbarot, Catherine Cottrell, Olivia Davies, Eulalia Baselga, Nigel P. Burrows, Virginie Carmignac, Joey Santiago Diaz, Christine Fink, Holger A. Haenssle, Rudolf Happle, Mark Harland, Jacquelyn Majerowski, Pierre Vabres, Marie Vincent, Julia A. Newton-Bishop, D. Tim Bishop, Dawn Siegel, E. Elizabeth Patton, Maya Topf, Neil Rajan, Beth Drolet, Veronica A. Kinsler
J Invest Dermatol. 2023 Jun; 143(6): 1042–1051.e3. doi: 10.1016/j.jid.2022.09.661
PMCID:
PMC10602917
AbstractArticlePDF–2.8M
13.
MUC1-C IS NECESSARY FOR SHP2 ACTIVATION AND BRAF INHIBITOR RESISTANCE IN BRAF(V600E) MUTANT COLORECTAL CANCER
Yoshihiro Morimoto, Nami Yamashita, Haruka Hirose, Atsushi Fushimi, Naoki Haratake, Tatsuaki Daimon, Atrayee Bhattacharya, Rehan Ahmad, Yozo Suzuki, Hidekazu Takahashi, Donald W. Kufe
Cancer Lett. Author manuscript; available in PMC 2024 Apr 10.
Published in final edited form as: Cancer Lett. 2023 Apr 10; 559: 216116. Published online 2023 Mar 5. doi: 10.1016/j.canlet.2023.216116
PMCID:
PMC10408991
AbstractArticlePDF–2.8M
14.
LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection
Yuantao Li, Jingjing Guo, Haixia Zhang, Zhidan Li, Yushan Ren, Yuzhu Jiang, Xianbing Liu, Xuemei Hu
Parasit Vectors. 2023; 16: 237. Published online 2023 Jul 17. doi: 10.1186/s13071-023-05856-4
PMCID:
PMC10353217
AbstractArticlePDF–4.9M
15.
Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families
Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell
J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468
PMCID:
PMC10323252
AbstractArticle
16.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
17.
SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage
Fengli Wang, Lingjuan Wang, Shiming Gan, Shenglei Feng, Sijin Ouyang, Xiaoli Wang, Shuiqiao Yuan
Research (Wash D C) 2023; 6: 0091. Published online 2023 Apr 12. doi: 10.34133/research.0091
PMCID:
PMC10202183
AbstractArticlePDF–18M
18.
Ganglioglioma with adverse clinical outcome and atypical histopathological features were defined by alterations in PTPN11/KRAS/NF1 and other RAS-/MAP-Kinase pathway genes
Lucas Hoffmann, Roland Coras, Katja Kobow, Javier A. López-Rivera, Dennis Lal, Costin Leu, Imad Najm, Peter Nürnberg, Jochen Herms, Patrick N. Harter, Christian G. Bien, Thilo Kalbhenn, Markus Müller, Tom Pieper, Till Hartlieb, Manfred Kudernatsch, Hajo Hamer, Sebastian Brandner, Karl Rössler, Ingmar Blümcke, Samir Jabari
Acta Neuropathol. 2023; 145(6): 815–827. Published online 2023 Mar 27. doi: 10.1007/s00401-023-02561-5
Correction in:
Acta Neuropathol. 2023; 145(6): 851–855.
PMCID:
PMC10175344
AbstractArticlePDF–3.7M
19.
Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages
Li Du, Yichun Ji, Bing Xin, Jiemeng Zhang, Li-Chun Lu, Christopher K. Glass, Gen-Sheng Feng
Cell Mol Gastroenterol Hepatol. 2023; 15(6): 1351–1369. Published online 2023 Feb 23. doi: 10.1016/j.jcmgh.2023.02.011
PMCID:
PMC10140795
AbstractArticlePDF–7.5M
20.
Potential clinical use of azacitidine and MEK inhibitor combination therapy in PTPN11-mutated juvenile myelomonocytic leukemia
Santhosh Kumar Pasupuleti, Karen Chao, Baskar Ramdas, Rahul Kanumuri, Lakshmi Reddy Palam, Sheng Liu, Jun Wan, Colleen Annesley, Mignon L. Loh, Elliot Stieglitz, Michael J. Burke, Reuben Kapur
Mol Ther. 2023 Apr 5; 31(4): 986–1001. Published online 2023 Feb 3. doi: 10.1016/j.ymthe.2023.01.030
PMCID:
PMC10124140
AbstractArticlePDF–5.8M

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