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Items: 1 to 20 of 153

1.
Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells
Lucia Cappabianca, Marianna Ruggieri, Michela Sebastiano, Maddalena Sbaffone, Ilaria Martelli, Pierdomenico Ruggeri, Monica Di Padova, Antonietta Rosella Farina, Andrew Reay Mackay
Int J Mol Sci. 2024 May; 25(10): 5475. Published online 2024 May 17. doi: 10.3390/ijms25105475
PMCID:
PMC11122047
AbstractArticlePDF–14M
2.
TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression
Yu Zhang, Zhenlin Huang, Keqiang Li, Guoqing Xie, Yuankang Feng, Zihao Wang, Ningyang Li, Ruoyang Liu, Yinghui Ding, Jun Wang, Jinjian Yang, Zhankui Jia
J Exp Clin Cancer Res. 2024; 43: 16. Published online 2024 Jan 11. doi: 10.1186/s13046-023-02920-w
PMCID:
PMC10782585
AbstractArticlePDF–11M
3.
Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors
Yoichi Naito, Saori Mishima, Kiwamu Akagi, Naomi Hayashi, Akira Hirasawa, Tomoro Hishiki, Ataru Igarashi, Masafumi Ikeda, Shigenori Kadowaki, Hiroaki Kajiyama, Motohiro Kato, Hirotsugu Kenmotsu, Yasuhiro Kodera, Keigo Komine, Takafumi Koyama, Osamu Maeda, Mitsuru Miyachi, Hiroshi Nishihara, Hiroyuki Nishiyama, Shouichi Ohga, Wataru Okamoto, Eiji Oki, Shigeru Ono, Masashi Sanada, Ikuo Sekine, Tadao Takano, Kayoko Tao, Keita Terashima, Katsuya Tsuchihara, Yasushi Yatabe, Takayuki Yoshino, Eishi Baba
Int J Clin Oncol. 2023; 28(7): 827–840. Published online 2023 May 22. doi: 10.1007/s10147-023-02345-7
PMCID:
PMC10310565
AbstractArticlePDF–779K
4.
Transcriptomics reveals the effects of NTRK1 on endoplasmic reticulum stress response-associated genes in human neuronal cell lines
Bo Jiao, Mi Zhang, Caixia Zhang, Xueqin Cao, Baowen Liu, Ningbo Li, Jiaoli Sun, Xianwei Zhang
PeerJ. 2023; 11: e15219. Published online 2023 Apr 12. doi: 10.7717/peerj.15219
PMCID:
PMC10105561
AbstractArticlePDF–8.4M
5.
Human TrkAR649W mutation impairs nociception, sweating and cognitive abilities: a mouse model of HSAN IV
Paola Pacifico, Giovanna Testa, Rosy Amodeo, Marco Mainardi, Alexia Tiberi, Domenica Convertino, Juan Carlos Arevalo, Laura Marchetti, Mario Costa, Antonino Cattaneo, Simona Capsoni
Hum Mol Genet. 2023 Apr 15; 32(8): 1380–1400. Published online 2022 Dec 20. doi: 10.1093/hmg/ddac295
PMCID:
PMC10077510
AbstractArticlePDF–2.9M
6.
Neurotrophin Pathway Receptors NGFR and TrkA Control Perineural Invasion, Metastasis and Pain in Oral Cancer
Coleen Doan, Bradley E. Aouizerat, Yi Ye, Dongmin Dang, Kesava Asam, Aditi Bhattacharya, Timothy Howard, Yogin K. Patel, Dan T. Viet, Johnny D. Figueroa, Jiang F. Zhong, Carissa M. Thomas, Anthony B. Morlandt, Gary Yu, Nicholas F. Callahan, Clint T. Allen, Anupama Grandhi, Alan S. Herford, Paul C. Walker, Khanh Nguyen, Stephanie C. Kidd, Steve C. Lee, Jared C. Inman, Jason M. Slater, Chi T. Viet
Adv Biol (Weinh) Author manuscript; available in PMC 2023 Sep 1.
Published in final edited form as: Adv Biol (Weinh). 2022 Sep; 6(9): e2200190. Published online 2022 Aug 4. doi: 10.1002/adbi.202200190
PMCID:
PMC9533666
AbstractArticlePDF–1.9M
7.
Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1‐rearranged tumor cells
Chiaki Suzuki, Akihiro Nishiyama, Sachiko Arai, Shoichiro Tange, Atsushi Tajima, Azusa Tanimoto, Koji Fukuda, Yohei Takumi, Hiroshi Kotani, Shinji Takeuchi, Naohiro Yanagimura, Koushiro Ohtsubo, Norio Yamamoto, Koichi Omori, Seiji Yano
Cancer Sci. 2022 Jul; 113(7): 2323–2335. Published online 2022 May 11. doi: 10.1111/cas.15354
PMCID:
PMC9277414
AbstractArticlePDF–5.8M
8.
Physical and functional interactome atlas of human receptor tyrosine kinases
Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo
EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041
PMCID:
PMC9171411
AbstractArticlePDF–1.9M
9.
Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells
Sarah Trouvilliez, Julien Cicero, Romain Lévêque, Léo Aubert, Cyril Corbet, Alexandre Van Outryve, Karolin Streule, Pierre-Olivier Angrand, Pamela Völkel, Romain Magnez, Guillaume Brysbaert, Caroline Mysiorek, Fabien Gosselet, Roland Bourette, Eric Adriaenssens, Xavier Thuru, Chann Lagadec, Jérôme de Ruyck, Véronique Orian-Rousseau, Xuefen Le Bourhis, Robert-Alain Toillon
J Exp Clin Cancer Res. 2022; 41: 110. Published online 2022 Mar 28. doi: 10.1186/s13046-022-02314-4
PMCID:
PMC8962522
AbstractArticlePDF–6.1M
10.
NGF/TRKA Promotes ADAM17-Dependent Cleavage of P75 in Ovarian Cells: Elucidating a Pro-Tumoral Mechanism
Maritza P. Garrido, Christopher Vallejos, Silvanna Girardi, Fernando Gabler, Alberto Selman, Fernanda López, Margarita Vega, Carmen Romero
Int J Mol Sci. 2022 Feb; 23(4): 2124. Published online 2022 Feb 15. doi: 10.3390/ijms23042124
PMCID:
PMC8877415
AbstractArticlePDF–3.1M
11.
Efficacy and Safety of Larotrectinib in Patients With Tropomyosin Receptor Kinase Fusion–Positive Lung Cancers
Alexander Drilon, Daniel S. W. Tan, Ulrik N. Lassen, Serge Leyvraz, Yongmei Liu, Jyoti D. Patel, Lee Rosen, Benjamin Solomon, Ricarda Norenberg, Laura Dima, Nicoletta Brega, Lin Shen, Victor Moreno, Shivaani Kummar, Jessica J. Lin
JCO Precis Oncol. 2022; 6: e2100418. Published online 2022 Jan 27. doi: 10.1200/PO.21.00418
PMCID:
PMC8830513
AbstractArticlePDF–544K
12.
The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19
Carla Usai, Joseph M. Gibbons, Corinna Pade, Wenhao Li, Sabina R. M. Jacobs, Áine McKnight, Patrick T. F. Kennedy, Upkar S. Gill
Front Immunol. 2021; 12: 813300. Published online 2022 Jan 14. doi: 10.3389/fimmu.2021.813300
PMCID:
PMC8795736
AbstractArticlePDF–6.3M
13.
Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer’s Disease
Klaudia Barabás, Julianna Kobolák, Soma Godó, Tamás Kovács, Dávid Ernszt, Miklós Kecskés, Csaba Varga, Tibor Z. Jánosi, Takahiro Fujiwara, Akihiro Kusumi, Annamária Téglási, András Dinnyés, István M. Ábrahám
Int J Mol Sci. 2021 Dec; 22(24): 13260. Published online 2021 Dec 9. doi: 10.3390/ijms222413260
PMCID:
PMC8708879
AbstractArticlePDF–2.5M
14.
TRIP12 Ubiquitination of Glucocerebrosidase Contributes to Neurodegeneration in Parkinson’s Disease
Bo Am Seo, Donghoon Kim, Heehong Hwang, Min Seong Kim, Shi-Xun Ma, Seung-Hwan Kwon, Sin Ho Kweon, Hu Wang, Je Min Yoo, Seulah Choi, Sang Ho Kwon, Sung-Ung Kang, Tae-In Kam, Kwangsoo Kim, Senthilkumar S Karuppagounder, Bong Gu Kang, Saebom Lee, Hyejin Park, Sangjune Kim, Wei Yan, Yong-Shi Li, Sheng-Han Kuo, Javier Redding-Ochoa, Olga Pletnikova, Juan C. Troncoso, Gabsang Lee, Xiaobo Mao, Valina L. Dawson, Ted M. Dawson, Han Seok Ko
Neuron. Author manuscript; available in PMC 2022 Dec 1.
Published in final edited form as: Neuron. 2021 Dec 1; 109(23): 3758–3774.e11. Published online 2021 Oct 12. doi: 10.1016/j.neuron.2021.09.031
PMCID:
PMC8639668
AbstractArticlePDF–2.6M
15.
Identification of novel variations in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis
Shang Li, Hua‐ying Hu, Jun‐Jun Xu, Zhan‐ke Feng, Yong‐qing Sun, Xu Chen, Kai Yang, Ya‐zhou Li, Dong‐liang Zhang
Mol Genet Genomic Med. 2021 Nov; 9(11): e1839. Published online 2021 Oct 21. doi: 10.1002/mgg3.1839
PMCID:
PMC8606206
AbstractArticlePDF–1.2M
16.
Effects of Reactive Oxygen and Nitrogen Species on TrkA Expression and Signalling: Implications for proNGF in Aging and Alzheimer’s Disease
Erika Kropf, Margaret Fahnestock
Cells. 2021 Aug; 10(8): 1983. Published online 2021 Aug 4. doi: 10.3390/cells10081983
PMCID:
PMC8392605
AbstractArticlePDF–1.3M
17.
Cytomorphologic Features of NTRK-Rearranged Thyroid Carcinoma
Kartik Viswanathan, Ying-Hsia Chu, William C. Faquin, Peter M. Sadow
Cancer Cytopathol. Author manuscript; available in PMC 2021 Nov 1.
Published in final edited form as: Cancer Cytopathol. 2020 Nov; 128(11): 812–827. Published online 2020 Oct 19. doi: 10.1002/cncy.22374
PMCID:
PMC8350964
AbstractArticlePDF–1.6M
18.
NTRK fusion in Japanese colorectal adenocarcinomas
Yuya Yamashiro, Taisei Kurihara, Takuo Hayashi, Yoshiyuki Suehara, Takashi Yao, Shunsuke Kato, Tsuyoshi Saito
Sci Rep. 2021; 11: 5635. Published online 2021 Mar 11. doi: 10.1038/s41598-021-85075-y
PMCID:
PMC7952565
AbstractArticlePDF–2.2M
19.
TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition
María Luisa Franco, Irmina García-Carpio, Raquel Comaposada-Baró, Juan J Escribano-Saiz, Lucía Chávez-Gutiérrez, Marçal Vilar
Life Sci Alliance. 2021 Apr; 4(4): e202000844. Published online 2021 Feb 3. doi: 10.26508/lsa.202000844
PMCID:
PMC7898468
AbstractArticlePDF–3.2M
20.
KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia
Chengwan Zhang, Li Shen, Yifu Zhu, Ran Xu, Zhikui Deng, Xiaoning Liu, Yihan Ding, Chunling Wang, Yuye Shi, Liye Bei, Dongping Wei, Rick F. Thorne, Xu Dong Zhang, Liang Yu, Song Chen
Theranostics. 2021; 11(6): 2691–2705. Published online 2021 Jan 1. doi: 10.7150/thno.50571
PMCID:
PMC7806474
AbstractArticlePDF–3.0M

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