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Items: 1 to 20 of 258

1.
Nr1h4 and Thrb ameliorate ER stress and provide protection in the MPTP mouse model of Parkinson’s
Nancy Ahuja, Shalini Gupta, Rashmi Arora, Ella Bhagyaraj, Drishti Tiwari, Sumit Kumar, Pawan Gupta
Life Sci Alliance. 2024 Jul; 7(7): e202302416. Published online 2024 Apr 12. doi: 10.26508/lsa.202302416
PMCID:
PMC11015051
AbstractArticlePDF–4.9M
2.
Farnesoid X receptor mediates macrophage-intrinsic responses to suppress colitis-induced colon cancer progression
Xingchen Dong, Ming Qi, Chunmiao Cai, Yu Zhu, Yuwenbin Li, Sally Coulter, Fei Sun, Christopher Liddle, Nataliya V. Uboha, Richard Halberg, Wei Xu, Paul Marker, Ting Fu
JCI Insight. 2024 Jan 23; 9(2): e170428. Published online 2024 Jan 23. doi: 10.1172/jci.insight.170428
PMCID:
PMC10906220
AbstractArticlePDF–4.4M
3.
Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)
Lei Zhang, Jiabing Chen, Xiaoying Yang, Chuangpeng Shen, Jiawen Huang, Dong Zhang, Naihua Liu, Chaonan Liu, Yadi Zhong, Yingjian Chen, Kaijia Tang, Jingyi Guo, Tianqi Cui, Siwei Duan, Jiayu Li, Shangyi Huang, Huafeng Pan, Huabing Zhang, Xiaoqiang Tang, Yongsheng Chang, Yong Gao
Signal Transduct Target Ther. 2024; 9: 20. Published online 2024 Jan 24. doi: 10.1038/s41392-023-01727-7
PMCID:
PMC10806020
AbstractArticlePDF–9.2M
4.
Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling
Dan-Qin Sun, Fuqiang Yuan, Meng-Zhu Fu, Meng-Yang Zhong, Shi-Liang Zhang, Yan Lu, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng, Wei-Jie Yuan
Mol Metab. 2024 Jan; 79: 101841. Published online 2023 Nov 28. doi: 10.1016/j.molmet.2023.101841
PMCID:
PMC10755488
AbstractArticlePDF–5.1M
5.
Farnesoid X Receptor Agonist GW4064 Protects Lipopolysaccharide-Induced Intestinal Epithelial Barrier Function and Colorectal Tumorigenesis Signaling through the αKlotho/βKlotho/FGFs Pathways in Mice
Hsuan-Miao Liu, Zi-Yu Chang, Ching-Wei Yang, Hen-Hong Chang, Tzung-Yan Lee
Int J Mol Sci. 2023 Dec; 24(23): 16932. Published online 2023 Nov 29. doi: 10.3390/ijms242316932
PMCID:
PMC10706872
AbstractArticlePDF–4.8M
6.
Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia
Hongtao Xu, Fang Fang, Kaizhang Wu, Jiangping Song, Yaqian Li, Xingyu Lu, Juncheng Liu, Liuyang Zhou, Wenqing Yu, Fei Yu, Jie Gao
Microbiome. 2023; 11: 262. Published online 2023 Nov 25. doi: 10.1186/s40168-023-01709-5
PMCID:
PMC10675972
AbstractArticlePDF–8.3M
7.
Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation
Phillip Wulfridge, Adam Davidovich, Anna C. Salvador, Gabrielle C. Manno, Rakel Tryggvadottir, Adrian Idrizi, M. Nazmul Huda, Brian J. Bennett, L. Garry Adams, Kasper D. Hansen, David W. Threadgill, Andrew P. Feinberg
PLoS Genet. 2023 Oct; 19(10): e1010997. Published online 2023 Oct 23. doi: 10.1371/journal.pgen.1010997
PMCID:
PMC10621921
AbstractArticlePDF–2.9M
8.
Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis
Juliane Tschuck, Lea Theilacker, Ina Rothenaigner, Stefanie A. I. Weiß, Banu Akdogan, Van Thanh Lam, Constanze Müller, Roman Graf, Stefanie Brandner, Christian Pütz, Tamara Rieder, Philippe Schmitt-Kopplin, Michelle Vincendeau, Hans Zischka, Kenji Schorpp, Kamyar Hadian
Nat Commun. 2023; 14: 6908. Published online 2023 Oct 30. doi: 10.1038/s41467-023-42702-8
PMCID:
PMC10616197
AbstractArticlePDF–2.3M
9.
Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose and renal injury in db/db mice
Yuxiang Qiu, Ningsu Kang, Xi Wang, Yao Yao, Jun Cui, Xiaoyan Zhang, Lu Zheng
PeerJ. 2023; 11: e16155. Published online 2023 Sep 29. doi: 10.7717/peerj.16155
PMCID:
PMC10544308
AbstractArticlePDF–26M
10.
Hepatic farnesoid X receptor is necessary to facilitate ductular reaction and expression of heme biosynthetic genes
Angela E. Dean, Emilian Jungwirth, Katrin Panzitt, Martin Wagner, Sayeepriyadarshini Anakk
Hepatol Commun. 2023 Oct; 7(10): e0213. Published online 2023 Sep 11. doi: 10.1097/HC9.0000000000000213
PMCID:
PMC10497251
AbstractArticlePDF–1.6M
11.
FXR Maintains the Intestinal Barrier and Stemness by Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction Diseases
Zequn Li, Haijiang Dong, Suchen Bian, Hao Wu, Wenfeng Song, Xing Jia, Jian Chen, Xingxin Zhu, Long Zhao, Zefeng Xuan, Cheng Jin, Mengqiao Zhou, Shusen Zheng, Penghong Song
Int J Mol Sci. 2023 Sep; 24(17): 13494. Published online 2023 Aug 30. doi: 10.3390/ijms241713494
PMCID:
PMC10487515
AbstractArticlePDF–4.4M
12.
Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain
Yuning Wu, Yuxin Qiu, Minzhi Su, Linjie Wang, Qingjuan Gong, Xuhong Wei
CNS Neurosci Ther. 2023 Jul; 29(7): 1981–1998. Published online 2023 Mar 7. doi: 10.1111/cns.14154
PMCID:
PMC10324360
AbstractArticlePDF–24M
13.
Aquaporin-8 ameliorates hepatic steatosis through farnesoid X receptor in obese mice
Minqi Xiang, Xu Qian, Luyu Han, Hui Wang, Jiqiu Wang, Weiren Liu, Yanyun Gu, Shuangshuang Yao, Jian Yang, Yifei Zhang, Ying Peng, Zhiguo Zhang
iScience. 2023 Apr 21; 26(4): 106561. Published online 2023 Apr 1. doi: 10.1016/j.isci.2023.106561
Correction in:
iScience. 2023 Sep 15; 26(9): 107724.
PMCID:
PMC10130924
AbstractArticlePDF–5.2M
14.
Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis via regulation of gut microbiota and bile acid signaling in a mouse model in vivo
Hongshan Li, Yingfei Xi, Xin Xin, Qin Feng, Yiyang Hu
Front Pharmacol. 2023; 14: 1148737. Published online 2023 Apr 3. doi: 10.3389/fphar.2023.1148737
PMCID:
PMC10106595
AbstractArticlePDF–4.3M
15.
Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy
Bo Tang, Li Tang, Shengpeng Li, Shuang Liu, Jialin He, Pan Li, Sumin Wang, Min Yang, Longhui Zhang, Yuanyuan Lei, Dianji Tu, Xuefeng Tang, Hua Hu, Qin Ouyang, Xia Chen, Shiming Yang
Nat Commun. 2023; 14: 1305. Published online 2023 Mar 9. doi: 10.1038/s41467-023-36981-4
PMCID:
PMC9998625
AbstractArticlePDF–10M
16.
Intestinal Farnesoid X Receptor Modulates Duodenal Surface Area but Does Not Control Glucose Absorption in Mice
Jiufang Yang, Theo H. van Dijk, Martijn Koehorst, Rick Havinga, Jan Freark de Boer, Folkert Kuipers, Tim van Zutphen
Int J Mol Sci. 2023 Feb; 24(4): 4132. Published online 2023 Feb 18. doi: 10.3390/ijms24044132
PMCID:
PMC9961586
AbstractArticlePDF–5.4M
17.
FXR mediates ILC-intrinsic responses to intestinal inflammation
Ting Fu, Yuwenbin Li, Tae Gyu Oh, Fritz Cayabyab, Nanhai He, Qin Tang, Sally Coulter, Morgan Truitt, Paul Medina, Mingxiao He, Ruth T. Yu, Annette Atkins, Ye Zheng, Christopher Liddle, Michael Downes, Ronald M. Evans
Proc Natl Acad Sci U S A. 2022 Dec 20; 119(51): e2213041119. Published online 2022 Dec 12. doi: 10.1073/pnas.2213041119
PMCID:
PMC9907109
AbstractArticlePDF–2.8M
18.
Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet
Payel Kundu, Ines L. Paraiso, Jaewoo Choi, Cristobal L. Miranda, Chrissa Kioussi, Claudia S. Maier, Gerd Bobe, Jan F. Stevens, Jacob Raber
Dis Model Mech. 2022 Nov 1; 15(11): dmm049820. Published online 2022 Nov 25. doi: 10.1242/dmm.049820
PMCID:
PMC9713832
AbstractArticle
19.
Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury
Xiaoying Liu, Mahmoud Khalafalla, Chuhan Chung, Yevgeniy Gindin, Susan Hubchak, Brian LeCuyer, Alyssa Kriegermeier, Danny Zhang, Wei Qiu, Xianzhong Ding, Deyu Fang, Richard Green
J Lipid Res. 2022 Nov; 63(11): 100289. Published online 2022 Sep 24. doi: 10.1016/j.jlr.2022.100289
PMCID:
PMC9638814
AbstractArticlePDF–4.5M
20.
The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice
Xiaoxin X. Wang, Cen Xie, Andrew E. Libby, Suman Ranjit, Jonathan Levi, Komuraiah Myakala, Kanchan Bhasin, Bryce A. Jones, David J. Orlicky, Shogo Takahashi, Alexander Dvornikov, David E. Kleiner, Stephen M. Hewitt, Luciano Adorini, Jeffrey B. Kopp, Kristopher W. Krausz, Avi Rosenberg, James L. McManaman, Charles E. Robertson, Diana Ir, Daniel N. Frank, Yuhuan Luo, Frank J. Gonzalez, Enrico Gratton, Moshe Levi
J Biol Chem. 2022 Nov; 298(11): 102530. Published online 2022 Oct 7. doi: 10.1016/j.jbc.2022.102530
PMCID:
PMC9638804
AbstractArticlePDF–10M

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