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Select item 109961561.

Common Mutation in the HFE Gene Modifies Recovery After Intracerebral Hemorrhage

Timothy B. Helmuth, Rashmi Kumari, Kondaiah Palsa, Elizabeth B. Neely, Becky Slagle-Webb, Scott D. Simon, James R. Connor

Stroke. Author manuscript; available in PMC 2024 Apr 5.

Published in final edited form as: Stroke. 2023 Nov; 54(11): 2886–2894. Published online 2023 Sep 26. doi: 10.1161/STROKEAHA.123.043799

PMCID:: PMC10996156

Abstract Article PDF–1.3M

Select item 102193402.

Hfe Actions in Kupffer Cells Are Dispensable for Hepatic and Systemic Iron Metabolism

Paul Knoop, Dilay Yilmaz, Rossana Paganoni, Peter Steele-Perkins, Andreas Gruber, Banu Akdogan, Hans Zischka, Kerstin Leopold, Maja Vujić Spasić

Int J Mol Sci. 2023 May; 24(10): 8948. Published online 2023 May 18. doi: 10.3390/ijms24108948

PMCID:: PMC10219340

Abstract Article PDF–2.7M

Select item 99363063.

Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia

Xia Xiao, Gillian A. Moschetta, Yang Xu, Allison L. Fisher, Víctor M. Alfaro-Magallanes, Som Dev, Chia-Yu Wang, Jodie L. Babitt

Blood. 2023 Jan 26; 141(4): 422–432. Published online 2022 Nov 4. doi: 10.1182/blood.2022017811

PMCID:: PMC9936306

Abstract Article

Select item 99179164.

Protein Susceptibility to Peroxidation by 4-Hydroxynonenal in Hereditary Hemochromatosis

Sandra Sánchez-Jaut, Susana Pérez-Benavente, Paloma Abad, Darío Méndez-Cuadro, Antonio Puyet, Amalia Diez, Gonzalo Galicia-Poblet, Elena Gómez-Domínguez, María J. Moran-Jiménez, José M. Bautista, Isabel G. Azcárate

Int J Mol Sci. 2023 Feb; 24(3): 2922. Published online 2023 Feb 2. doi: 10.3390/ijms24032922

PMCID:: PMC9917916

Abstract Article PDF–2.4M

Select item 94450235.

In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice

Alice Rovai, BoMee Chung, Qingluan Hu, Sebastian Hook, Qinggong Yuan, Tibor Kempf, Florian Schmidt, Dirk Grimm, Steven R. Talbot, Lars Steinbrück, Jasper Götting, Jens Bohne, Simon A. Krooss, Michael Ott

Nat Commun. 2022; 13: 5215. Published online 2022 Sep 5. doi: 10.1038/s41467-022-32906-9

PMCID:: PMC9445023

Abstract Article PDF–1.8M

Select item 89632086.

Iron Promotes Cardiac Doxorubicin Retention and Toxicity Through Downregulation of the Mitochondrial Exporter ABCB8

Archita Venugopal Menon, Jonghan Kim

Front Pharmacol. 2022; 13: 817951. Published online 2022 Mar 11. doi: 10.3389/fphar.2022.817951

PMCID:: PMC8963208

Abstract Article PDF–2.6M

Select item 86341927.

Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice

Manfred Nairz, Christoph Metzendorf, Maja Vujic-Spasic, Anna-Maria Mitterstiller, Andrea Schroll, David Haschka, Alexander Hoffmann, Laura von Raffay, Richard Sparla, Christian W. Huck, Heribert Talasz, Patrizia L. Moser, Martina U. Muckenthaler, Günter Weiss

Haematologica. 2021 Dec 1; 106(12): 3149–3161. Published online 2020 Oct 13. doi: 10.3324/haematol.2019.241745

PMCID:: PMC8634192

Abstract Article PDF–1.5M

Select item 83866998.

HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation

Juan Liu, Xiaopeng Wu, Hailong Wang, Jiayu Wei, Qian Wu, Xingbo Wang, Yan Yan, Jun Cui, Junxia Min, Fudi Wang, Jiyong Zhou

Autophagy. 2021; 17(8): 1962–1977. Published online 2020 Aug 18. doi: 10.1080/15548627.2020.1804683

Correction in:: Autophagy. 2022 Oct 12 : 1–2.

PMCID:: PMC8386699

Abstract Article PDF–16M

Select item 77319099.

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload

Maja Vujić Spasić, Richard Sparla, Katarzyna Mleczko-Sanecka, Mary C. Migas, Katja Breitkopf-Heinlein, Steven Dooley, Sophie Vaulont, Robert E. Fleming, Martina U. Muckenthaler

Biochim Biophys Acta. Author manuscript; available in PMC 2020 Dec 11.

Published in final edited form as: Biochim Biophys Acta. 2013 Jan; 1832(1): 76–84. Published online 2012 Aug 31. doi: 10.1016/j.bbadis.2012.08.013

PMCID:: PMC7731909

Abstract Article PDF–1.8M

Select item 755714910.

Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice

Sathish Sivaprakasam, Bojana Ristic, Nithya Mudaliar, Abdul N. Hamood, Jane Colmer-Hamood, Mitchell S. Wachtel, Anna G. Nevels, Kameswara R. Kottapalli, Vadivel Ganapathy

Biochem J. 2020 Oct 16; 477(19): 3867–3883. Prepublished online 2020 Sep 21. Published online 2020 Oct 12. doi: 10.1042/BCJ20200392

PMCID:: PMC7557149

Abstract Article PDF–10M

Select item 723001911.

Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice

Andrew T. Hale, Rachel E. Brown, Zigmund Luka, Benjamin H. Hudson, Pranathi Matta, Christopher S. Williams, John D. York

Adv Biol Regul. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Adv Biol Regul. 2020 May; 76: 100694. Published online 2020 Jan 26. doi: 10.1016/j.jbior.2020.100694

PMCID:: PMC7230019

Abstract Article PDF–1.8M

Select item 720064412.

Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2

Bojana Ristic, Sathish Sivaprakasam, Monisha Narayanan, Vadivel Ganapathy

Biochem J. 2020 Apr 30; 477(8): 1499–1513. Prepublished online 2020 Apr 2. Published online 2020 Apr 29. doi: 10.1042/BCJ20190873

PMCID:: PMC7200644

Abstract Article PDF–6.1M

Select item 717140713.

Gnpat does not play an essential role in systemic iron homeostasis in murine model

Peng An, Jiaming Wang, Hao Wang, Li Jiang, Jia Wang, Junxia Min, Fudi Wang

J Cell Mol Med. 2020 Apr; 24(7): 4118–4126. Published online 2020 Feb 28. doi: 10.1111/jcmm.15068

PMCID:: PMC7171407

Abstract Article PDF–1.5M

Select item 698090214.

Transferrin and H-ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype

Brian Chiou, Elizabeth B. Neely, Dillon S. Mcdevitt, Ian A. Simpson, James R. Connor

J Neurochem. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: J Neurochem. 2020 Feb; 152(3): 381–396. Published online 2019 Aug 22. doi: 10.1111/jnc.14834

PMCID:: PMC6980902

Abstract Article PDF–2.4M

Select item 691245315.

Mild Iron Overload as Seen in Individuals Homozygous for the Alpha-1 Antitrypsin Pi*Z Variant Does Not Promote Liver Fibrogenesis in HFE Knockout Mice

Nurdan Guldiken, Karim Hamesch, Shari Malan Schuller, Mahmoud Aly, Cecilia Lindhauer, Carolin V. Schneider, Malin Fromme, Christian Trautwein, Pavel Strnad

Cells. 2019 Nov; 8(11): 1415. Published online 2019 Nov 9. doi: 10.3390/cells8111415

PMCID:: PMC6912453

Abstract Article PDF–2.6M

Select item 670755816.

Mouse models of hereditary hemochromatosis do not develop early liver fibrosis in response to a high fat diet

John Wagner, Carine Fillebeen, Tina Haliotis, Edouard Charlebois, Angeliki Katsarou, Jeannie Mui, Hojatollah Vali, Kostas Pantopoulos

PLoS One. 2019; 14(8): e0221455. Published online 2019 Aug 23. doi: 10.1371/journal.pone.0221455

PMCID:: PMC6707558

Abstract Article PDF–7.4M

Select item 633866017.

Brain iron loading impairs DNA methylation and alters GABAergic function in mice

Qi Ye, Malav Trivedi, Yiting Zhang, Mark Böhlke, Helal Alsulimani, JuOae Chang, Timothy Maher, Richard Deth, Jonghan Kim

FASEB J. 2019 Feb; 33(2): 2460–2471. Published online 2018 Oct 2. doi: 10.1096/fj.201801116RR

PMCID:: PMC6338660

Abstract Article

Select item 624113018.

Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis

Márcio Simão, António Camacho, Agnès Ostertag, Martine Cohen-Solal, I. Jorge Pinto, Graça Porto, Ea Hang Korng, M. Leonor Cancela

PLoS One. 2018; 13(11): e0207441. Published online 2018 Nov 14. doi: 10.1371/journal.pone.0207441

Correction in:: PLoS One. 2019; 14(4): e0216377.

PMCID:: PMC6241130

Abstract Article PDF–5.9M

Select item 585114419.

A role for sex and a common HFE gene variant in brain iron uptake

Kari A Duck, Elizabeth B Neely, Ian A Simpson, James R Connor

J Cereb Blood Flow Metab. 2018 Mar; 38(3): 540–548. Published online 2017 Mar 28. doi: 10.1177/0271678X17701949

PMCID:: PMC5851144

Abstract Article PDF–457K

Select item 581301820.

Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

Kapil Chaudhary, Wanwisa Promsote, Sudha Ananth, Rajalakshmi Veeranan-Karmegam, Amany Tawfik, Pachiappan Arjunan, Pamela Martin, Sylvia B. Smith, Muthusamy Thangaraju, Oleg Kisselev, Vadivel Ganapathy, Jaya P. Gnana-Prakasam

Sci Rep. 2018; 8: 3025. Published online 2018 Feb 14. doi: 10.1038/s41598-018-21276-2