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Select item 111061931.

PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway

Jun Li, Da Teng, Wenjuan Jia, Lei Gong, Haibin Dong, Chunxiao Wang, Lihui Zhang, Bowen Xu, Wenlong Wang, Lin Zhong, Jianxun Wang, Jun Yang

Inflamm Res. 2024; 73(6): 1033–1046. Published online 2024 Apr 17. doi: 10.1007/s00011-024-01881-w

PMCID:: PMC11106193

Abstract Article PDF–2.8M

Select item 110992082.

KMT2D regulates activation, localization, and integrin expression by T-cells

Sarah J. Potter, Li Zhang, Michael Kotliar, Yuehong Wu, Caitlin Schafer, Kurtis Stefan, Leandros Boukas, Dima Qu’d, Olaf Bodamer, Brittany N. Simpson, Artem Barski, Andrew W. Lindsley, Hans T. Bjornsson

Front Immunol. 2024; 15: 1341745. Published online 2024 May 3. doi: 10.3389/fimmu.2024.1341745

PMCID:: PMC11099208

Abstract Article PDF–5.8M

Select item 109912843.

Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment

Jie Li, Christopher R. Chin, Hsia-Yuan Ying, Cem Meydan, Matthew R. Teater, Min Xia, Pedro Farinha, Katsuyoshi Takata, Chi-Shuen Chu, Yiyue Jiang, Jenna Eagles, Verena Passerini, Zhanyun Tang, Martin A. Rivas, Oliver Weigert, Trevor J. Pugh, Amy Chadburn, Christian Steidl, David W. Scott, Robert G. Roeder, Christopher E. Mason, Roberta Zappasodi, Wendy Béguelin, Ari M. Melnick

Nat Commun. 2024; 15: 2879. Published online 2024 Apr 3. doi: 10.1038/s41467-024-47012-1

PMCID:: PMC10991284

Abstract Article PDF–7.3M

Select item 108159134.

KMT2D Deficiency Causes Sensorineural Hearing Loss in Mice and Humans

Allison J. Kalinousky, Teresa R. Luperchio, Katrina M. Schrode, Jacqueline R. Harris, Li Zhang, Valerie B. DeLeon, Jill A. Fahrner, Amanda M. Lauer, Hans T. Bjornsson

Genes (Basel) 2024 Jan; 15(1): 48. Published online 2023 Dec 28. doi: 10.3390/genes15010048

PMCID:: PMC10815913

Abstract Article PDF–1.9M

Select item 106162235.

Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A

Xiang-Min Meng, Shu-Bao Liu, Tian Deng, De-Yong Li, Lu You, Hao Hong, Qi-Pu Feng, Bing-Mei Zhu

J Cardiovasc Transl Res. 2023; 16(5): 1032–1049. Published online 2023 Mar 22. doi: 10.1007/s12265-023-10373-x

PMCID:: PMC10616223

Abstract Article PDF–5.4M

Select item 103301006.

KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity

Shuang Lu, Hong Sun Kim, Yubo Cao, Karan Bedi, Lili Zhao, Ishwarya Venkata Narayanan, Brian Magnuson, Yumei Gu, Jing Yang, Zhujun Yi, Sepideh Babaniamansour, Sargis Shameon, Chang Xu, Michelle T. Paulsen, Ping Qiu, Sivakumar Jeyarajan, Mats Ljungman, Dafydd Thomas, Yali Dou, Howard Crawford, Marina Pasca di Magliano, Kai Ge, Bo Yang, Jiaqi Shi

Int J Cancer. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Int J Cancer. 2023 Aug 1; 153(3): 552–570. Published online 2023 May 4. doi: 10.1002/ijc.34528

PMCID:: PMC10330100

Abstract Article PDF–1.5M

Select item 103236297.

KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition

Jing Xu, Ailing Zhong, Shan Zhang, Mei Chen, Lanxin Zhang, Xiaohang Hang, Jianan Zheng, Baohong Wu, Xintong Deng, Xiangyu Pan, Zhongwang Wang, Lu Qi, Kaidou Shi, Shujun Li, Yiyun Wang, Manli Wang, Xuelan Chen, Qi Zhang, Pengpeng Liu, Robert Peter Gale, Chong Chen, Yu Liu, Ting Niu

Adv Sci (Weinh) 2023 Jul; 10(19): 2206098. Published online 2023 May 4. doi: 10.1002/advs.202206098

PMCID:: PMC10323629

Abstract Article PDF–3.9M

Select item 101751928.

Restraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis

Kairong Cui, Zuojia Chen, Yaqiang Cao, Shuai Liu, Gang Ren, Gangqing Hu, Difeng Fang, Danping Wei, Chengyu Liu, Jinfang Zhu, Chuan Wu, Keji Zhao

Immunity. Author manuscript; available in PMC 2024 May 9.

Published in final edited form as: Immunity. 2023 May 9; 56(5): 944–958.e6. Published online 2023 Apr 10. doi: 10.1016/j.immuni.2023.03.006

PMCID:: PMC10175192

Abstract Article PDF–3.7M

Select item 99831719.

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation

Ryan M. Boileau, Kevin X. Chen, Robert Blelloch

Genome Biol. 2023; 24: 41. Published online 2023 Mar 3. doi: 10.1186/s13059-023-02883-3

PMCID:: PMC9983171

Abstract Article PDF–6.9M

Select item 989245410.

Lysine methyltransferase Kmt2d regulates naive CD8⁺ T cell activation-induced survival

Jaekwan Kim, Thomas Nguyen, Jeffrey Cifello, Raheel Ahmad, Yongqing Zhang, Qian Yang, Ji-Eun Lee, Xiang Li, Yan Kai, Supriyo De, Weiqun Peng, Kai Ge, Nan-ping Weng

Front Immunol. 2022; 13: 1095140. Published online 2023 Jan 19. doi: 10.3389/fimmu.2022.1095140

PMCID:: PMC9892454

Abstract Article PDF–7.8M

Select item 892863011.

Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme

Morag A. Lewis, Neil J. Ingham, Jing Chen, Selina Pearson, Francesca Di Domenico, Sohinder Rekhi, Rochelle Allen, Matthew Drake, Annelore Willaert, Victoria Rook, Johanna Pass, Thomas Keane, David J. Adams, Abigail S. Tucker, Jacqueline K. White, Karen P. Steel

BMC Biol. 2022; 20: 67. Published online 2022 Mar 17. doi: 10.1186/s12915-022-01257-8

PMCID:: PMC8928630

Abstract Article PDF–27M

Select item 860733212.

KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling

Liping Pang, Hua Tian, Xuejun Gao, Weiping Wang, Xiaoyan Wang, Zhichun Zhang

Biosci Rep. 2021 Nov 26; 41(11): BSR20211148. Published online 2021 Nov 18. doi: 10.1042/BSR20211148

PMCID:: PMC8607332

Abstract Article PDF–3.2M

Select item 850052413.

Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation

Alec Wright, Arielle Hall, Tara Daly, Tatiana Fontelonga, Sarah Potter, Caitlin Schafer, Andrew Lindsley, Christina Hung, Olaf Bodamer, Emanuela Gussoni

FASEB J. 2021 Nov; 35(11): e21955. Published online 2021 Oct 6. doi: 10.1096/fj.202100823R

PMCID:: PMC8500524

Abstract Article PDF–1.9M

Select item 844324914.

Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation

Teresa Romeo Luperchio, Leandros Boukas, Li Zhang, Genay Pilarowski, Jenny Jiang, Allison Kalinousky, Kasper D Hansen, Hans T Bjornsson

eLife. 2021; 10: e65884. Published online 2021 Aug 31. doi: 10.7554/eLife.65884

PMCID:: PMC8443249

Abstract Article PDF–7.0M

Select item 795509815.

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

Young-Kwon Park, Ji-Eun Lee, Zhijiang Yan, Kaitlin McKernan, Tommy O’Haren, Weidong Wang, Weiqun Peng, Kai Ge

Nat Commun. 2021; 12: 1630. Published online 2021 Mar 12. doi: 10.1038/s41467-021-21893-y

PMCID:: PMC7955098

Abstract Article PDF–5.5M

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 780145317.

The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus

Christian Huisman, Young A. Kim, Shin Jeon, Bongjin Shin, Jeonghoon Choi, Su Jeong Lim, Sung Min Youn, Younjung Park, Medha K. C., Sangsoo Kim, Soo-Kyung Lee, Seunghee Lee, Jae W. Lee

Nat Commun. 2021; 12: 256. Published online 2021 Jan 11. doi: 10.1038/s41467-020-20511-7

PMCID:: PMC7801453

Abstract Article PDF–5.6M

Select item 779050918.

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb, and DNA methylation

Delphine Douillet, Christie C Sze, Caila Ryan, Andrea Piunti, Avani P Shah, Michal Ugarenko, Stacy A Marshall, Emily J Rendleman, Didi Zha, Kathryn A Helmin, Zibo Zhao, Kaixiang Cao, Marc A Morgan, Benjamin D Singer, Elizabeth Bartom, Edwin R Smith, Ali Shilatifard

Nat Genet. Author manuscript; available in PMC 2021 Jan 7.

Published in final edited form as: Nat Genet. 2020 Jun; 52(6): 615–625. Published online 2020 May 11. doi: 10.1038/s41588-020-0618-1

PMCID:: PMC7790509

Abstract Article PDF–4.3M

Select item 764975019.

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

Mayinuer Maitituoheti, Emily Z. Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K. Singh, Ayush T. Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B. Amin, Sneha Sharma, Maura Williams, Neha S. Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B. Axelrad, Nazanin E. Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q. Chang, Davis R. Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, Kunal Rai

Cell Rep. Author manuscript; available in PMC 2020 Nov 9.

Published in final edited form as: Cell Rep. 2020 Oct 20; 33(3): 108293. doi: 10.1016/j.celrep.2020.108293

PMCID:: PMC7649750

Abstract Article PDF–3.6M

Select item 745625120.

Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction

Lin Liu, Chenyun Ding, Tingting Fu, Zhenhua Feng, Ji-Eun Lee, Liwei Xiao, Zhisheng Xu, Yujing Yin, Qiqi Guo, Zongchao Sun, Wanping Sun, Yan Mao, Likun Yang, Zheng Zhou, Danxia Zhou, Leilei Xu, Zezhang Zhu, Yong Qiu, Kai Ge, Zhenji Gan

J Clin Invest. 2020 Sep 1; 130(9): 4710–4725. Published online 2020 Aug 4. doi: 10.1172/JCI136155

PMCID:: PMC7456251

Abstract Article PDF–9.2M

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